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Articles 721 - 750 of 2919
Full-Text Articles in Psychology
Defending Human Difference By Raising The Bar, Joe Gough
Defending Human Difference By Raising The Bar, Joe Gough
Animal Sentience
Chapman & Huffman (C&H) offer a theory of why we humans want to believe that we are different: to justify our cruelty to animals. This commentary offers further supporting evidence of this and examines more closely what the claim that humans are ‘different’ amounts to. It also considers some methodological issues in animal psychology closely related to C&H ‘s theory. These problems result from a common strategy for defending hypotheses about human difference.
Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani
Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani
Graduate Theses, Dissertations, and Problem Reports (ETD)
Inappropriate response and magnitude of cardiovascular reactivity (CVR) to stress is a proposed mechanism through which environmental stressors are linked with poor cardiovascular health outcomes (Chida & Steptoe, 2010; Krantz & Manuck, 1984). Studies of reactivity to various laboratory tasks commonly control for factors known to influence CVR such as smoking, medication use, caffeine intake, and BMI; however, few have considered the influence of sleep on CVR. In order to determine whether sleep characteristics need to be assessed and considered in studies of CVR, this study aimed to examine the association between indices of sleep quality and the magnitude and …
Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick
Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction. Research on food addiction has increased in recent years, but there are few studies focusing on college-attending young adults, who may be at risk of developing food addiction due to the stress of the college environment. Additionally, causes and characteristics of food addiction are under-explored.
Aim. This dissertation aims to 1) determine the impact of adverse childhood experiences (ACEs) and other early life influences on the development of food addiction in college-attending young adults and 2) determine the psychosocial and behavioral characteristics of young adults with food addiction.
Methods. A sequential explanatory mixed-methods design was used for aims 1 …
Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang
Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang
Linguistics Graduate Dissertations
In this dissertation, I seek to construct a model of meaning variation built upon variability in linguistic structure, conceptual structure, and cognitive makeup, and in doing so, exemplify an approach to studying meaning that is both linguistically principled and neuropsychologically grounded. As my test case, I make use of the English lexical item ‘have' by proposing a novel analysis of its meaning based on its well-described variability in English and its embed- ding into crosslinguistically consistent patterns of variation and change.
I support this analysis by investigating its real-time comprehension patterns through behavioral, electropsychophysiological, and hemodynamic brain data, thereby incorporating …
Behavioral Patterns Of Goldfish (Carassius Auratus) Exploring A “Fish Tower”, Sasha Prasad-Shreckengast
Behavioral Patterns Of Goldfish (Carassius Auratus) Exploring A “Fish Tower”, Sasha Prasad-Shreckengast
Theses and Dissertations
Fish are held in captivity at some of the highest numbers of any taxa, but their curiosity is rarely studied. With this study, we set the groundwork to investigate the presence and nature of curiosity in goldfish (Carassius auratus) via novel free-choice exploration opportunities by creating a “fish tower."
Pushing It To The Limit: Determining Asian Elephant (Elephas Maximus) Olfactory Sensitivity And Discrimination Through A Behavioral Choice Task, Matthew S. Rudolph
Pushing It To The Limit: Determining Asian Elephant (Elephas Maximus) Olfactory Sensitivity And Discrimination Through A Behavioral Choice Task, Matthew S. Rudolph
Theses and Dissertations
Elephants have shown remarkable olfactory capabilities. Their sense of smell impacts their foraging choices, behavior, and ultimately, survival. Being able to detect a target odor can allow elephants to locate specific resources, identify threats, and find receptive conspecifics. Previous studies have shown that elephants can consistently detect target odors, but have not identified the limits of this detection. Thus, to investigate the extent of elephants’ odor detection capabilities, we tested Asian elephants in a two-step odor discrimination task. First, we investigated whether elephants could detect odors at varying levels of dilution after a training procedure, and then whether they could …
Using The Behaviour Change Wheel Program Planning Model To Design Games For Health: Development Study, Michael C Robertson, Tom Baranowski, Debbe Thompson, Karen M Basen-Engquist, Maria Chang Swartz, Elizabeth J Lyons
Using The Behaviour Change Wheel Program Planning Model To Design Games For Health: Development Study, Michael C Robertson, Tom Baranowski, Debbe Thompson, Karen M Basen-Engquist, Maria Chang Swartz, Elizabeth J Lyons
Faculty, Staff and Students Publications
BACKGROUND: Games for health are a promising approach to health promotion. Their success depends on achieving both experiential (game) and instrumental (health) objectives. There is little to guide game for health (G4H) designers in integrating the science of behavior change with the art of game design.
OBJECTIVE: The aim of this study is to extend the Behaviour Change Wheel program planning model to develop Challenges for Healthy Aging: Leveraging Limits for Engaging Networked Game-Based Exercise (CHALLENGE), a G4H centered on increasing physical activity in insufficiently active older women.
METHODS: We present and apply the G4H Mechanics, Experiences, and Change (MECHA) …
Probiotic Intervention Improves Recovery Of Hippocampal Memory And Hippocampal Atrophy Following Disruption From High-Fat Diet In Adult Rats, Sanyourah A. El-Hulu
Probiotic Intervention Improves Recovery Of Hippocampal Memory And Hippocampal Atrophy Following Disruption From High-Fat Diet In Adult Rats, Sanyourah A. El-Hulu
Honors Scholars Collaborative Projects
Presently, lifestyle factors such as chronic high-fat diet (HFD) consumption occurs concomitantly with weight gain and obesity (Gil-Cardoso et al., 2017; Stranahan et al., 2008). In turn, obesity has been associated with impairments to mental functioning, specifically to memory. Human epidemiological studies show that HFD intake containing saturated, and omega-6-fatty acids is associated with worse performance on a cognitive task whereas a lower fat diet containing omega-3-fatty acids is associated with a protective effect against cognitive decline (Zhang et al., 2006; Uranga et al., 2010). One explanation for this is the critical role of the gut bacteria in brain health. …
Long-Term Effects Of Adolescent Fluoxetine Exposure On Hippocampal Gene Expression In Male C57bl/6 Mice, Anapaula Themann
Long-Term Effects Of Adolescent Fluoxetine Exposure On Hippocampal Gene Expression In Male C57bl/6 Mice, Anapaula Themann
Open Access Theses & Dissertations
Mood-related disorders, including depression and anxiety, are prevalent among children and adolescents. This poses a public health challenge, given their adverse impact on these young populations. Treatment with the selective serotonin reuptake inhibitor fluoxetine (FLX) is the first line of pharmacological intervention in pediatric patients suffering from affect-related illnesses. Although the use of this antidepressant has been deemed efficacious in the juvenile population, the enduring neurobiological consequences of adolescent FLX exposure are not well understood. For this reason, we explored for persistent molecular adaptations, in the adult hippocampus, as a function of adolescent FLX pretreatment. To do this, we administered …
Development And Validation Of A Lifestyle Behavior Tool In Overweight And Obese Women Through Qualitative And Quantitative Approaches, Chee Wai Ku, Loo Rachel, Cheryl Lim, Jacinth Jia Xin Tan, Joey Ho, Wee Meng Han, Xiang Wen Ng, Jerry Chan, See Ling Loy
Development And Validation Of A Lifestyle Behavior Tool In Overweight And Obese Women Through Qualitative And Quantitative Approaches, Chee Wai Ku, Loo Rachel, Cheryl Lim, Jacinth Jia Xin Tan, Joey Ho, Wee Meng Han, Xiang Wen Ng, Jerry Chan, See Ling Loy
Research Collection School of Social Sciences
There is a paucity of effective intervention tools for overweight/obese women to assess, guide and monitor their eating behavior. This study aimed to develop a lifestyle intervention tool, assess its acceptability and usefulness, and verify its construct validity in overweight/obese women. The 6P tool (Portion, Proportion, Pleasure, Phase, Physicality, Psychology) was developed and 15 women with a body mass index (BMI) ≥ 25 kg/m2 were interviewed to assess its perceived acceptability and usefulness. Subsequently, the revised 6P tool was tested in 46 women with a BMI ≥ 25 kg/m2. The Three-Factor Eating Questionnaire (TFEQ), International Physical Activity Questionnaire-Short (IPAQ), and …
Multiple Approaches To Auditory Rhythm: Development Of Sustained Musical Beat And The Relation To Language, Development Of Rhythmic Categories Via Iterated Production, And A Meta-Analytic Study Of Neural Entrainment To Beat, Karli Marie Nave
UNLV Theses, Dissertations, Professional Papers, and Capstones
Rhythm is ubiquitous to human communication, coordination, and experience of music. In this dissertation, I address three empirical questions through three different methodologies, all of which contribute to the growing body of literature on human auditory rhythm processing. In Chapter 2, I present a registered report detailing the results of independent conceptual replications of Nozaradan, Peretz, Missal, & Mouraux (2011), all using the same vetted protocol. Listeners performed the same tasks as in Nozaradan et al. (2011), with the addition of behavioral measures of perception. In neuroscience, neural correlates to musical beat perception have been identified, yet little to no …
Boosting Brain Waves Improves Memory, Richard J. Addante, Mairy Yousif, Rosemarie Valencia, Constance Greenwood, Raechel Marino
Boosting Brain Waves Improves Memory, Richard J. Addante, Mairy Yousif, Rosemarie Valencia, Constance Greenwood, Raechel Marino
Psychology Student Publications
Have you ever wanted to improve your memory? Or have you struggled to remember what you studied? Memory uses special patterns of activity in the brain. This experiment tested a new way to create brain wave patterns that help with memory. We wanted to see if we could improve memory by using lights and sounds that teach the brain waves to be in sync. People wore special goggles that made flashes of light and headphones that made beeping noises. This trained the brain through a process called entrainment. The entrainment put the brain in sync at a specific brain wave …
Sex And The Streets: The Open Secret Of Sexual Abuse Among Pakistan's Two Million Street Children, Amir Humza Sohail, Muhammad Hassaan Arif Maan, Sachal Sohail
Sex And The Streets: The Open Secret Of Sexual Abuse Among Pakistan's Two Million Street Children, Amir Humza Sohail, Muhammad Hassaan Arif Maan, Sachal Sohail
Medical College Documents
Background: About two million children live on the streets in Pakistan. Their complicated past and dire living conditions make them susceptible to many psychological and physical problems, including sexual abuse.
Main body: With little research on the topic, the prevalence of sexual intercourse among street children is reported to be as high as 88% in Pakistan. With commercial sex a common practice among the street children, public places such as bus terminals and parks have become foci of prostitution and sexual exploitation. A growing concern is the spread of HIV/AIDS among the affected children due to a general lack of …
The Predictive Influence Of Challenging Behavior On Parent Stress In Young Children With Autism Spectrum Disorder, Paige Weir
LSU Master's Theses
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication, restricted interest, and repetitive patterns of behavior. Individuals with ASD also exhibit challenging behaviors that affect parent and caregiver stress directly. However, researchers have not yet examined the predictive influence of specific challenging behaviors on parent stress, particularly in young children (i.e., infants and toddlers) with ASD. Therefore, the current study expands existing literature by a) investigating the influence that challenging behaviors of young children with ASD have on parent stress and b) examining the unique contribution that each behavior (i.e., aggressive/disruptive behavior, stereotypy, and self-injurious …
The Giver: Vision & Memory, Alexander J. Dontre
The Giver: Vision & Memory, Alexander J. Dontre
All Faculty and Staff Scholarship
A memory hole is the banishment of problematic thoughts. We exile that which we prefer not to exist. Enter the perilous Memory Hole: The Psychology of Dystopia, to explore a legion of social and psychological themes through the lens of dystopian literature. The crushing fist of 1984 annihilating thoughts from existence as a means of persuasion. The exquisite seduction of addiction as an agent of control in Brave New World. Incineration of the written word to bask in the embers of peace of mind in Fahrenheit 451. Each chapter weaves in and out of the dystopian realms forged …
Evaluation Of A School-Based Dissemination Of The Movement Guidelines For Young Children In Hong Kong: Study Protocol, Catherine M. Capio, Catalina S. M. Ng, Kevin K. H. Chung, Rachel A. Jones, Cindy H. P. Sit
Evaluation Of A School-Based Dissemination Of The Movement Guidelines For Young Children In Hong Kong: Study Protocol, Catherine M. Capio, Catalina S. M. Ng, Kevin K. H. Chung, Rachel A. Jones, Cindy H. P. Sit
Health Sciences Faculty Publications
Background
Healthy movement behaviors in early childhood are believed to track to adulthood, potentially imparting protective benefits against non-communicable diseases. Highlighting the collaborative and complementary roles of parents and educators in promoting health of young children, this study aims to enable parents and teachers to successfully promote healthy movement behaviors in young children. Guidelines for physical activity, sedentary screen time, and sleep of children aged 2 to 6 years will be systematically disseminated to parents and teachers of children enrolled in early childhood education centers (ECECs) in Hong Kong. An evaluation will be conducted to assess the implementation process and …
Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader
Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader
Honors Projects
Traumatic brain injuries (TBIs) have been labeled as a modern-day epidemic, increasing exponentially with the advancement of technology and society. Gaining a better understanding of the cognitive paths, including the chemical and electrical signals of the brain, neural correlates, and possible interventions for TBI patients allows for the best possible outcome for every patient, and allows for the further advancement of care. By revising and reassessing the ways in which TBIs are categorized and described the prognosis for recovery paints a more realistic view for each individual patient case. The symptoms and impairments that may occur post-injury can be monitored …
Do Infants Avoid A Traversable Slope Leading Into Deep Water?, Carolina Burnay, Chris Button, Rita Cordovil, David Anderson, James Croft
Do Infants Avoid A Traversable Slope Leading Into Deep Water?, Carolina Burnay, Chris Button, Rita Cordovil, David Anderson, James Croft
Research outputs 2014 to 2021
Ramps used to access swimming pools are designed with a shallow slope that affords easy access for all including infants. Locomotor experience has been linked to infants’ avoidance of falling into the water from drop-offs; however, the effect of such experience on infants’ behavior when a slope is offered to access the water has not been addressed. Forty-three crawling infants (Mage = 10.63 ± 1.91 months; Mcrawling = 2.38 ± 1.77 months) and 34 walking infants (Mage = 14.90 ± 2.18 months; Mwalking = 2.59 ± 1.56 months) were tested on a new Water …
Genetic Analysis Of Endometriosis And Depression Identifies Shared Loci And Implicates Causal Links With Gastric Mucosa Abnormality, Emmanuel Adewuyi, Divya Mehta, Yadav Sapkota, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R. Griffiths, Grant W. Montgomery, Daniel I. Chasman, Dale R. Nyholt
Genetic Analysis Of Endometriosis And Depression Identifies Shared Loci And Implicates Causal Links With Gastric Mucosa Abnormality, Emmanuel Adewuyi, Divya Mehta, Yadav Sapkota, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R. Griffiths, Grant W. Montgomery, Daniel I. Chasman, Dale R. Nyholt
Research outputs 2014 to 2021
Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (PFsig-permuted = 9.99 × 10−4). Linkage disequilibrium score regression (LDSC) analysis estimated a positive and highly significant genetic correlation between the two traits (rG = 0.27, P = 8.85 × 10−27). A meta-analysis of endometriosis and depression GWAS (sample size = …
The Motion Aftereffect: Mechanisms And Variants, Erica E. Hassoun
The Motion Aftereffect: Mechanisms And Variants, Erica E. Hassoun
The Cardinal Edge
The motion aftereffect causes a visual stimulus to undergo apparent motion. An adapting stimulus, which moves in a specific direction, adapts motion-responsive neurons in the middle temporal area (V5) to that direction of motion. Viewing a second stimulus, a test stimulus, produces apparent motion in the direction opposite that of the initial stimulus. Neural networks involved in attention and working memory are also implicated in the motion aftereffect. There is still little known regarding the mechanisms of the motion aftereffect, despite extensive documentation in the literature. This review discusses established knowledge of the motion aftereffect, focusing primarily on the middle …
During Natural Viewing, Neural Processing Of Visual Targets Continues Throughout Saccades, Atanas D. Stankov, Jonathan Touryan, Stephen Gordon, Anthony J. Ries, Jason Ki, Lucas C. Parra
During Natural Viewing, Neural Processing Of Visual Targets Continues Throughout Saccades, Atanas D. Stankov, Jonathan Touryan, Stephen Gordon, Anthony J. Ries, Jason Ki, Lucas C. Parra
Publications and Research
Relatively little is known about visual processing during free-viewing visual search in realistic dynamic environments. Free-viewing is characterized by frequent saccades. During saccades, visual processing is thought to be suppressed, yet we know that the presaccadic visual content can modulate postsaccadic processing. To better understand these processes in a realistic setting, we study here saccades and neural responses elicited by the appearance of visual targets in a realistic virtual environment. While subjects were being driven through a 3D virtual town, they were asked to discriminate between targets that appear on the road. Using a system identification approach, we separated overlapping …
A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic, Al Amira Safa Shehab
A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic, Al Amira Safa Shehab
Dissertations, Theses, and Capstone Projects
Deep breathing practices have shown promise in reducing stress, anxiety, and depression in different populations, including young adults. Specifically, resonant frequency breathing can exert an impact on stress response systems through the vagus nerve and the hypothalamo-pituitary-adrenal (HPA) axis. This may induce reductions in stress and improvement in emotion regulation. Young adults, including college students, tend to be at a higher risk for psychological distress, as they face several psychosocial challenges. The COVID-19 pandemic has imposed new and unique stressors that resulted in higher levels of stress and emotional symptoms and it has been shown that this may have placed …
Informed Consent: Foundations And Applications, Joanna Smolenski
Informed Consent: Foundations And Applications, Joanna Smolenski
Dissertations, Theses, and Capstone Projects
Since its advent in the 20th century, informed consent has become a cornerstone of ethical healthcare, and obtaining it a core obligation in medical contexts. In my dissertation, I aim to examine the theoretical underpinnings of informed consent and identify what values it is taken to protect. I will suggest that the fundamental motivation behind informed consent rests in something I’ll call bodily self-sovereignty, which I argue involves a coupling of two groups of values: autonomy and non-domination on the one hand, and self-ownership and personal integrity on the other. I will then go on to consider two 'case …
Contributions Of Reward Identity And Time Prediction Errors To Pavlovian Learning, Daniel B. Siegel
Contributions Of Reward Identity And Time Prediction Errors To Pavlovian Learning, Daniel B. Siegel
Dissertations, Theses, and Capstone Projects
Some models of associative learning attempt to explain effects such as blocking and unblocking as reflecting a prediction error (PE): Associative strength, and thereby learning, are said to be greater when the unconditioned stimulus (US) received following a cue deviates from one’s expectations. Some models of PE-motivated behavior and PE-relevant brain activity represent the US as a single quantitative variable for outcome value, and that learning therefore only occurs when outcome value differs from expectations. There is growing evidence to suggest that changes in other dimensions of reward, such as identity and timing, also contribute to learning. In Experiment 1, …
Desire, Culture, And The Body, Zoey Lavallee
Desire, Culture, And The Body, Zoey Lavallee
Dissertations, Theses, and Capstone Projects
What is the nature of desire? In this dissertation I develop a theory of desire according to which desires are essentially enculturated states that play the role of presenting favorable outcomes that act as inputs to intention formation, and thereby intentional action. This analysis of desire debunks a common assumption shared by prominent accounts of desire in philosophy of mind, what can be called the dualist assumption: that bodily desires such as urges and appetites differ in kind from conceptual desires that are typically described as higher cognitive attitudes. I argue that the desires traditionally understood as bodily or appetitive …
Impact Of Human Presence And Visual Access On Barking Behavior In Shelter Dogs, Emily W. Dowling, Jessie A. Catchpole, Christina M. Walthers, Madison J. Pattillo
Impact Of Human Presence And Visual Access On Barking Behavior In Shelter Dogs, Emily W. Dowling, Jessie A. Catchpole, Christina M. Walthers, Madison J. Pattillo
Symposium of Student Scholars
Shelters can be stressful for dogs due to lack of predictability and control, social isolation, and busy environments. Providing dogs with more social opportunities and environmental predictability may improve their welfare. Barking may indicate stress and contribute to noise levels that are harmful to dogs and people. We investigated the impact of human presence and line of sight on barking. We manipulated line of sight by partially removing a crate barrier to allow the dogs visual access to other dogs and a better view of the room. We collected data on barking on 17 focal dogs as well as overall …
Positron Emission Tomography From 1930 To 1990: The Epistemology And Process Of Scientific Instrumentation, Rick Shang
Positron Emission Tomography From 1930 To 1990: The Epistemology And Process Of Scientific Instrumentation, Rick Shang
Arts & Sciences Graduate Student Theses and Dissertations
Positron Emission Tomography (PET) is a groundbreaking detection system that, among many other applications, enabled neuroscience researchers to detect and image physiological changes in the brain associated with cognitive operations as subjects perform a task. This technology helped researchers learn to explore the physiological basis of human cognition in new ways and was the immediate forerunner of functional Magnetic Resonance Imaging (fMRI), a technology that continues to dominate the neurosciences. PET was also the founding invention of a new field of cognitive science: human functional neuroimaging. Indeed, some would say that PET encouraged a particular way of understanding the brain …
The Disunity Of Perception, Benjamin Austin Henke
The Disunity Of Perception, Benjamin Austin Henke
Arts & Sciences Graduate Student Theses and Dissertations
This dissertation argues for disunity in perceptual processing: rather than outputting to a single ‘centralized’ cognitive system, separate perceptual processing pathways produce different person-level representations for different purposes. I argue that this disunity has important implications for abstract theorizing in the philosophy and cognitive science of perception, for experimental methodology, and for our understanding of the normative role of perception itself. The first three chapters explore models in cognitive neuroscience which support perceptual disunity. In Chapter 1, I argue that a version of Milner and Goodale’s (2006) influential ‘two visual streams hypothesis’ survives its recent empirical challenges. In Chapter 2, …
Positron Emission Tomography From 1930 To 1990: The Epistemology And Process Of Scientific Instrumentation, Rick Shang
Positron Emission Tomography From 1930 To 1990: The Epistemology And Process Of Scientific Instrumentation, Rick Shang
Arts & Sciences Graduate Student Theses and Dissertations
Positron Emission Tomography (PET) is a groundbreaking detection system that, among many other applications, enabled neuroscience researchers to detect and image physiological changes in the brain associated with cognitive operations as subjects perform a task. This technology helped researchers learn to explore the physiological basis of human cognition in new ways and was the immediate forerunner of functional Magnetic Resonance Imaging (fMRI), a technology that continues to dominate the neurosciences. PET was also the founding invention of a new field of cognitive science: human functional neuroimaging. Indeed, some would say that PET encouraged a particular way of understanding the brain …
Having A High-Activity Catechol-O-Methyltransferase Allele Is Associated With Elevated Anxiety And Lower Salivary Dehydroepiandrosterone But Also Lower Alpha Amylase In Children With Chromosome 22q11.2 Deletion Syndrome., Jessie Beebe
LSU New Orleans Theses and Dissertations
Chromosome 22q11.2 deletion syndrome (22q11.2DS) results from a hemizygous deletion located on the long arm of chromosome 22. The most common deletion sizes affect between 30 and 90 genes. Individuals with 22q11.2DS may develop serious developmental and psychiatric disorders. The phenotype is highly variable, however, and may be influenced by allelic variation of the retained copies of genes covered by the deletion. I set out to examine the effects of two genes, catechol-O-methyltransferase (COMT) and proline dehydrogenase (PRODH), in relation to anxiety in children and adolescents with 22q11.2DS. Individuals with the major COMT allele (higher activity) have significantly higher anxiety …