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Articles 1381 - 1410 of 3184
Full-Text Articles in Psychology
Wellbeing And Marriage: Does Marriage Improve Mental Health?, Maranda L. (Kahl) Joyce
Wellbeing And Marriage: Does Marriage Improve Mental Health?, Maranda L. (Kahl) Joyce
Undergraduate Economic Review
With the decline in marriage rates and the rise in mental health issues, understanding the potential correlation between marital status and overall mental health is of economic importance. This research explores the potential effects of marital status on mental health in the U.S., using microdata from the 2016 Behavior Risk Factor Surveillance System. The role of marital status is examined on three different dependent variables. My results suggest that marriage is associated with a decrease in number of days of poor mental health, a decrease in the likelihood of a depressive disorder diagnosis, and an increase in overall life satisfaction.
A Comprehensive Examination Of The Immediate Recovery Of Children Following Tonsillectomy And Adenoidectomy, Bryan K. Lao, Zeev N. Kain, Dina Khoury, Brooke N. Jenkins, Jeremy Prager, Robert S. Stevenson, Brenda Golianu, Jeannie Zuk, Jeffrey I. Gold, Qiu Zhong, Michelle A. Fortier
A Comprehensive Examination Of The Immediate Recovery Of Children Following Tonsillectomy And Adenoidectomy, Bryan K. Lao, Zeev N. Kain, Dina Khoury, Brooke N. Jenkins, Jeremy Prager, Robert S. Stevenson, Brenda Golianu, Jeannie Zuk, Jeffrey I. Gold, Qiu Zhong, Michelle A. Fortier
Psychology Faculty Articles and Research
Objectives
Using multiple well-validated measures and a large sample size, the goal of this paper was to describe the immediate clinical and behavioral recovery of children following tonsillectomy with or without an adenoidectomy (T&A) during the first two weeks following surgery.
Study design
Observational, longitudinal study.
Setting
Four major pediatric hospitals in the U.S. consisting of Children's Hospital of Orange County, Children's Hospital of Los Angeles, Lucile Packard Children's Hospital, and Children's Hospital Colorado.
Subjects
and Methods: Participants included 827 patients between 2 and 15 years of age who underwent tonsillectomy with or without adenoidectomy surgery. Baseline and demographic …
Examination Of Sleep Disturbance, Anxiety Sensitivity, And Depression In An Undergraduate Sample, Dasha Grace
Examination Of Sleep Disturbance, Anxiety Sensitivity, And Depression In An Undergraduate Sample, Dasha Grace
Honors Theses
Sleep contributes to overall well-being, mental health, and daily functioning. Sleep disturbances negatively affect psychological, physiological, and biological processing, and the quality of sleep is similarly affected by these processes. The effects of sleep disturbance call for a greater understanding of depression and anxiety sensitivity among college students. Studies have found that sleep disturbance affects nearly 90% of the college student population. The aims of the current study were to examine: 1) types and rates of sleep disturbance among a sample of college students, 2) associations between sleep disturbance, AS, and depression symptoms, and 3) AS and depression symptoms by …
Naming The Pain: A Model And Method For Therapeutically Assessing The Psychological Impact Of Racism, Connesia Handford
Naming The Pain: A Model And Method For Therapeutically Assessing The Psychological Impact Of Racism, Connesia Handford
Dissertations, 2020-current
This study is an exploratory applied research project piloting a therapeutic assessment model and method for addressing racial trauma. Therapeutic Assessment for the Psychological Impact of Racial Encounters (TAPIRE) hopes to illuminate the impact of racial trauma, process racial identity and experience, and explore effective intervention techniques to address a client’s particular relationship with racial identity and distress. Four measures, in addition to a clinical interview, were used to assess different aspects of one’s identity structure, racist experiences, and self-treatment. The four-session process concluded with each participant receiving an assessment report that included information gathered as well as an individualized …
The Watson Room: Mitigating Compassion Fatigue In Oncology Nurses, Patricia A. Viscardi
The Watson Room: Mitigating Compassion Fatigue In Oncology Nurses, Patricia A. Viscardi
Doctors of Nursing Practice (DNP) Final Projects, 2020-current
Aim: The aim of this project was to plan, develop, and implement “The Watson Room” or “Quiet Room” in an inpatient oncology nursing population and evaluate changes in Professional Quality of Life (ProQOL).
Background: Oncology Nurses are at high risk for compassion fatigue (CF), burn-out (BO), and secondary traumatic stress (STS) related to the effects of living the traumas of oncology patients and their families through their cancer journey and the innate stress in a complex and intense workplace. High levels of compassion fatigue, burn-out, and secondary traumatic stress that are poorly managed reduces the nurse’s ability to self-regulate their …
Student Beliefs About What Factors Influence Their Gpa, Emma R. Denelsbeck
Student Beliefs About What Factors Influence Their Gpa, Emma R. Denelsbeck
Senior Honors Projects, 2020-current
There are many different factors that contribute to grade point averages (GPAs) in college. Students may attribute their academic performance and GPAs to any number of different variables such as stress levels, sleep quality and alcohol use. The current study investigated what students believed had an effect on their GPA, and if these differed based on concussion history. This study examined if students thought that concussions affected their GPA. Participants were University students who completed an online survey consisting of the Texas Evaluation of Concussion History (TECH), and the Depression, Anxiety, and Stress Scale (DASS-21). The results of a Mann-Whitney …
Assessing The Utility Of A Brief Abstinence Test To Reduce Smartphone And Social Media Use, Taylor B. Stanley
Assessing The Utility Of A Brief Abstinence Test To Reduce Smartphone And Social Media Use, Taylor B. Stanley
Masters Theses, 2020-current
The purpose of the current study is to investigate the efficacy of implementing a Brief Abstinence Test (BAT) for reducing smartphone and social media (SM) use among college students. A BAT is a temporally condensed version of contingency management (CM), a reinforcement-based behavioral intervention. Participants (N = 32, males = 6) self-reported using an iPhone updated to iOS 12 and using SM on their iPhones for at least two hours per day. Once enrolled, participants completed an online battery of health-related questionnaires and learned how to capture electronically their smartphone-use data. Participants experienced a BAT for one week, during …
Cognitive Reappraisal Of Negative Emotional Images In Borderline Personality Disorder: Content Analysis, Perceived Effectiveness, And Diagnostic Specificity, Alexander R. Daros, Achala H. Rodrigo, Nikoo Norouzian, Bri S. Darboh, Kateri Mcrae, Anthony C. Ruocco
Cognitive Reappraisal Of Negative Emotional Images In Borderline Personality Disorder: Content Analysis, Perceived Effectiveness, And Diagnostic Specificity, Alexander R. Daros, Achala H. Rodrigo, Nikoo Norouzian, Bri S. Darboh, Kateri Mcrae, Anthony C. Ruocco
Psychology: Faculty Scholarship
Individuals with borderline personality disorder (BPD) report using cognitive reappraisal less often than healthy individuals despite the long-term benefits of the emotion regulation strategy on emotional stability. Individuals with BPD, mixed anxiety and/or depressive disorders (MAD), and healthy controls (HC) completed an experimental task to investigate the tactics contained in cognitive reappraisal statements vocalized for high and low emotional intensity photographs. Self-reported effectiveness after using cognitive reappraisal to decrease negative emotions was also evaluated. Although BPD and MAD used a similar number of cognitive reappraisal tactics, they perceived themselves as less effective at reducing their negative emotions compared to HC. …
Cognitive Behavioral Therapy For Comorbid Posttraumatic Stress Disorder, Traumatic Brain Injury, And Associated Sleep Disturbances, Aubretia D. Snyder
Cognitive Behavioral Therapy For Comorbid Posttraumatic Stress Disorder, Traumatic Brain Injury, And Associated Sleep Disturbances, Aubretia D. Snyder
Intuition: The BYU Undergraduate Journal of Psychology
With an increasing number of veterans returning from combat with significant head injuries, research interests have begun to turn to the neuropsychological relationship between traumatic brain injury and posttraumatic stress disorder. Research has found that these dysfunctions often occur together and that both disorders may cause an exacerbation of symptoms in one another. This relationship may be negatively affected further by the presence of sleep disturbances. The complexity of this relationship requires extra consideration in regards to treatment, and cognitive behavioral therapy may be effective in treating this comorbid condition. This paper discusses the functional relationship of posttraumatic stress disorder …
The Relationship Between Sport Commitment With Off-Season Training Time And Previous In-Season Playing Time In College-Aged Soccer Players 2020., Luke Zuber
Master's Theses
Sport commitment is defined as “…the desire and resolve to continue sport participation” (Scanlan, Carpenter, Schmidt, Simons, & Keeler, 1993, p. 6). Since the first definition, the concept has been further refined to reflect a more multidimensional paradigm. Overall, sport commitment is thought to be comprised of the dimensions of enthusiastic commitment and constrained commitment (Scanlan, Chow, Sousa, Scanlan, & Knifsend, 2016). Those constructs can be broken down further to 12 subconstructs that are represented in the Sport Commitment – 2 (SC; Scanlan, Chow, Sousa, Scanlan, & Knifsend, 2016), in order to evaluate the source and level of an individual’s …
Polysubstance Exposure And Its Relationship To Pharmacological Treatment Characteristics, Parker Miller
Polysubstance Exposure And Its Relationship To Pharmacological Treatment Characteristics, Parker Miller
Undergraduate Honors Theses
Neonatal Abstinence Syndrome (NAS) remains an ever-growing public health issue and a continued avenue for future research. The research question for this retrospective study was whether polysubstance exposure is related to the dose of medication the infant received or to the number of opioid-medications required to treat the infants’ withdrawal symptoms? The hypothesis for the retrospective study was there will be a significant relationship between polysubstance exposure and the dose of medication the infant received as well as the number of opioid-medications required to treat the infants’ withdrawal symptoms. A bivariate correlational indicated that there was not a significant association …
Art And The Pursuit Of Happiness: How Artists Use Art To Promote Their Emotional Well-Being, August Namuth, Bruce Chase
Art And The Pursuit Of Happiness: How Artists Use Art To Promote Their Emotional Well-Being, August Namuth, Bruce Chase
Theses/Capstones/Creative Projects
Artists have used art’s positive mental and physical health effects for as long as art has been around. Art is known to have many therapeutic and mood benefiting effects, from reduced anxiety and stress levels, to increased confidence and a sense of purpose. Many different clinical studies have found art to be beneficial to people who have suffered from PTSD, bipolar disorder, strokes, and cancer pain. Despite the clearly beneficial effects of creativity associated with art, artists suffer from disorders such as depression, bipolar disorder, and schizophrenia at a much higher rate than the general population. This study sought to …
Safe Patient Handling – A Case For National Legislation, David O. Oba
Safe Patient Handling – A Case For National Legislation, David O. Oba
Dissertations and Theses (Open Access)
Introduction: This study examined the effectiveness of Safe Patient Handling (SPH) legislations in difference states across the country. In January 2006, the state of Texas legislated the Safe Patient Handling and Movement Practices Act which required all hospitals and nursing homes to implement safe patient handling and movement program. To date, 10 other states have enacted law or regulations to control work-related musculoskeletal disorders (MSDs) among healthcare workers (HW). Despite the effectiveness of these policies in the individual states, MSDs remain prevalent among HW nationwide. Hence, the call for national legislation. Methods: Using the state-level incidence rate data from the …
Physician Hospital Arrangement Influence On Nonprofit Hospital Quality,Financial Performance And Community Benefit Expenditures, Andrea Cervin
Physician Hospital Arrangement Influence On Nonprofit Hospital Quality,Financial Performance And Community Benefit Expenditures, Andrea Cervin
Dissertations and Theses (Open Access)
Federal policy has encouraged hospitals to provide certain quality outcomes and cost containment. Hospitals have responded by forming physician hospital organizations in attempts to achieve quality outcomes and capture reimbursements. At the same time, federal policy has awarded hospitals with nonprofit status with the requirement to provide community benefits in exchange for the tax exemption they receive. With the formation of physician hospital organizations, there remains the question of whether hospitals are achieving desired quality metrics and whether hospitals are financially viable. There is also public and media interest recently regarding whether nonprofit hospitals fulfill their obligations for community benefit …
THe EFfect Of UNconventional GAs And OIl DRilling EMissions On ASthma And REspiratory DIseases In The BArnett SHale Of TExas, Stella A. Okoroafor
THe EFfect Of UNconventional GAs And OIl DRilling EMissions On ASthma And REspiratory DIseases In The BArnett SHale Of TExas, Stella A. Okoroafor
Dissertations and Theses (Open Access)
Unconventional gas and oil drilling (UGOD) has increased substantially in the United States for more than a decade. The resultant environmental unsafe air pollution effects of UGOD both locally and regionally have been well documented in the literature. Despite the dramatic increase in unconventional well drilling and the toxicant exposure, the health consequences of UGOD remain largely uncertain. This study assesses the relationship between active wells and healthcare use for respiratory diseases by zip code from 2004 to 2008 in the Barnett shale area of Texas. The first modern shale gas well was drilled in the Barnett shale area of …
A Geospatial Examination Of The Association Between Geographic Food Access And Food Insecurity In Central Texas: The Role Of Race/Ethnicity And Urbanicity, Kathryn Janda
Dissertations and Theses (Open Access)
Food insecurity is a public health issue that affects one in ten Americans, one in seven Central Texans, and is associated with malnutrition, chronic disease, and obesity. Geographic food access is the most intervened upon aspect of food insecurity and is often measured objectively through mapping software, such as ArcGIS. Yet when geographic food access is only measured in terms of distance to food retail, analyses do not full capture the nuances of community context. Thus, other sources of data, like survey data, and demographic indicators, such as race/ethnicity and urbanicity, should be incorporated into the research exploring the association …
Determining The Drivers Of Quality Of Life In Hiv Patints Treated With Antiretroviral Therapy In Subsaharan Africa, Oubote Sangbana
Determining The Drivers Of Quality Of Life In Hiv Patints Treated With Antiretroviral Therapy In Subsaharan Africa, Oubote Sangbana
Dissertations and Theses (Open Access)
During the last decade, HIV in sub-Saharan Africa has shifted from a fatal disease to a chronic condition thanks to the expansion of antiretroviral therapy (ART). As a result, the focus of care has transitioned from survival to quality of life (QoL), and the latter has become a significant outcome measure during patient follow up. Yet, the determinants of QoL among HIV patients in western and central Africa are not well known. The objective of this dissertation was to determine the main factors associated with QoL among ART-treated HIV adult patients in western and central Africa to ensure healthcare providers …
Utility Of Plasma Biomarkers In The Validation Of Reported Loc & Pta For Gcs 13-15 Patients: A Track-Tbi Pilot Study, Jeffrey Brennan
Utility Of Plasma Biomarkers In The Validation Of Reported Loc & Pta For Gcs 13-15 Patients: A Track-Tbi Pilot Study, Jeffrey Brennan
Dissertations and Theses (Open Access)
Depending on a brain injury patient to accurately report their duration of unconsciousness and amnesia is clearly flawed. We constructed biomarker-based models to validate these self-reported measurements using a GCS 13-15 subset of participants from TRACK-TBI, a multi-institutional study on traumatic brain injury. Potential covariates were assessed for significant interactions with biomarker level. We report that the predictions of LOC and PTA failed. GFAP exhibited the most consistent serum level increase between categories of both LOC and PTA. Given a number of issues with the study sample, we recommend continued investigation on the prediction of LOC and PTA using a …
Demographic Predictors Of Adult Behaviors In The Pediatric Postoperative Environment, Natasha H. Hikita, Amber Osorno, Carlie Taurosa, Michelle A. Fortier, Zeev N. Kain, Brooke N. Jenkins
Demographic Predictors Of Adult Behaviors In The Pediatric Postoperative Environment, Natasha H. Hikita, Amber Osorno, Carlie Taurosa, Michelle A. Fortier, Zeev N. Kain, Brooke N. Jenkins
Student Scholar Symposium Abstracts and Posters
Over 85% of children experience postoperative pain. If poorly treated, pediatric postoperative pain may lead to various negative health outcomes. Adult behaviors may be associated with child experiences in the postoperative environment. For example, adult behaviors such as distraction, humor, and coping advice divert a child’s attention away from their pain and thus, may significantly reduce child postoperative distress. In contrast, adult behaviors such as empathy, reassurance, and apology direct a child’s attention towards their pain which may increase a child’s overall postoperative distress. Moreover, patient demographic factors, like child ethnicity, may significantly alter the frequency of use of these …
Pediatric Postoperative Pain Medication: Child Sex And Ethnicity Interact To Predict Parent Medication Attitudes, Vivian Luong, Harshitha V. Venkatesh, Michelle Fortier, Zeev N. Kain, Brooke N. Jenkins
Pediatric Postoperative Pain Medication: Child Sex And Ethnicity Interact To Predict Parent Medication Attitudes, Vivian Luong, Harshitha V. Venkatesh, Michelle Fortier, Zeev N. Kain, Brooke N. Jenkins
Student Scholar Symposium Abstracts and Posters
Over 85% of children experience significant pain after surgery. Despite this presence of pain, research suggests that a quarter of these children receive very little or even no pain medication at home. Such poor pain management in children can have harmful long-term consequences, both physically and psychologically. Previous research indicates that the amount of pain medication administered to children in the home may be significantly impacted by beliefs and attitudes parents have regarding analgesics. Given this, the purpose of the present study is to identify which demographic factors are associated with certain parent analgesic attitudes or misconceptions among pediatric patients …
The Impact Of Location On Healthcare Access For Individuals With Disabilities, Addison Kimber
The Impact Of Location On Healthcare Access For Individuals With Disabilities, Addison Kimber
Honors Scholar Theses
This paper analyzes healthcare access for individuals with disabilities living in rural areas. In current political discussion, we typically think of insurance coverage as the metric to analyze healthcare access. However, as demonstrated by studies of healthcare in the United Kingdom, people with disabilities continue to face barriers to health care even with universal healthcare systems. In particular, individuals in rural areas have less healthcare access than urban residents. This is due to factors including socioeconomic status, insurance coverage, access to competent care, and transportation. This study aims to understand if disability status exacerbates the issue of access in rural …
Mindful Yoga As A Means Of Reducing College Student Stress, Jaylee K. Oliver
Mindful Yoga As A Means Of Reducing College Student Stress, Jaylee K. Oliver
Honors Theses
Thousands of years ago, yoga was intended to refocus and prepare an individual for self-exploration. Today, the “colloquial yoga” has manifested as an exercise fad. The aim of this study was to further investigate yoga as a stress reducing technique among a sample of college students. This study examined yoga as a distinct discipline by comparing 3 separate conditions (yoga, active-control, and neutral-control). This research aimed to demonstrate an overall decrease in perceived stress, increase in self-esteem, and increase in ability to psychologically detach from stressors after engaging in a yoga practice, as compared to the two control conditions. Overall, …
Sample Size Calculations For Longitudinal Mediation Analysis With Continuous-Time Markov Chain Variables, Abigail Christine Sedory
Sample Size Calculations For Longitudinal Mediation Analysis With Continuous-Time Markov Chain Variables, Abigail Christine Sedory
Dissertations and Theses (Open Access)
Mediation is a type of analysis used to determine the causal mechanism linking a predictor and an outcome through a mediator variable. Various research has examined the inclusion of different variable types for the predictor, mediator, and outcome. However, no studies include the presence of a continuous-time Markov chain (CTMC) as any of the components in a mediating model. If researchers wanted to design a study with a CTMC in the mediating process, one of the first steps would be to determine the minimum number of subjects or observations needed to detect a significant mediating effect. Therefore, in this study, …
Nudging Quality Improvement In Cancer Care: Influence Of A Clinical Decision Support System To Nudge Adherance To Evidence Based Guidelines In Adult Cancers, Debra Patt
Dissertations and Theses (Open Access)
Cancer care is changing rapidly. Understanding of the increasing subtypes of cancer and exponentially increasing therapeutic interventions are unprecedented due to the rapid pace of scientific discovery and clinical innovation. This immense change within the field, lends itself to quality control initiatives, especially among general oncology providers who see a wide array of cancer types as general oncologists will see many different tumor types, and most of which have several potential treatment choices that have grown over time. Evidence-based pathways are an effective way to nudge quality control by presenting choice architecture at the point of care to facilitate guideline …
Understanding Participation In A Workplace Physical Activity Intervention Using Self-Determination Theory: The Booster Break Study, Kathleen Ochipa
Understanding Participation In A Workplace Physical Activity Intervention Using Self-Determination Theory: The Booster Break Study, Kathleen Ochipa
Dissertations and Theses (Open Access)
Abstract: Sedentary behavior can lead to premature mortality, cardiovascular disease, Type 2 diabetes, and cancer incidence. Office workers are at risk for high amounts of sedentary behavior. Even brief bouts of physical activity that interrupt sedentary behavior can improve office workers’ physical and mental health. The workplace is an optimal setting for increasing physical activity and reducing sedentary behavior among office workers. However, limited literature exists related to the characteristics of participants that adhere to workplace physical activity interventions. This study aimed to identify characteristics of participants who enrolled in the Booster Break program, a 15 minute once-daily intervention during …
Economic Evaluation Of Implementing Hpv Vaccine Promotion Interventions For Cervical Cancer In The United States, Chi-Fang Wu
Economic Evaluation Of Implementing Hpv Vaccine Promotion Interventions For Cervical Cancer In The United States, Chi-Fang Wu
Dissertations and Theses (Open Access)
The HPV vaccine has been proven as a safe and effective method for preventing cervical cancer. However, the HPV vaccine coverage rate in the U.S. is suboptimal. Various interventions have been implemented to improve HPV vaccine coverage. However, evidence of the cost-effectiveness of HPV vaccine promotion interventions is lacking. We conducted an economic evaluation to assess HPV vaccine promotion interventions of cervical cancer in the U.S. Firstly, a systematic review was conducted to review evidence on interventions aimed at increasing HPV vaccine coverage and to summarize the cost and effectiveness of these interventions. We included 56 HPV vaccine promotion studies …
Comparison Of Interactive Electronic Versus Standard Document Method For Obtaining Patient Informed Consent, Jermaine Mcmillan
Comparison Of Interactive Electronic Versus Standard Document Method For Obtaining Patient Informed Consent, Jermaine Mcmillan
Dissertations and Theses (Open Access)
The primary objective of this study was to determine whether participants who received an interactive electronic consent (EC) had a better understanding of a medical procedure (apheresis) compared to those who received the standard document (SD) consent. The study was conducted with apheresis donors whose responses were used to determine if the EC facilitated better comprehension and retention of consent information by the study participants than by SD consenting methods. By comprehension, the goal was to have participants who can understand, summarize, or make judgments based on the content presented in the informed consent. By retention, the goal was to …
A Partial Likelihood Approach To Longitudinal Categorical Data Using A Continuous Time Semi-Markov Chain Model, Kusha A. Mohammadi
A Partial Likelihood Approach To Longitudinal Categorical Data Using A Continuous Time Semi-Markov Chain Model, Kusha A. Mohammadi
Dissertations and Theses (Open Access)
Longitudinal studies have been critical in understanding the characteristics of chronic diseases or interventions. Since many processes have natural multi-categorical responses over time, multi-state stochastic models have been used to estimate the transition rates between stages. Some multi-state models applied in practice assume the Markov property. The Markov property constrains the sojourn distribution to be exponentially distributed. While useful theoretical properties arise by the Markov assumption, we will consider a more flexible framework by allowing arbitrarily distributed waiting times. This describes a semi-Markov process which has already been applied to various fields in Public Health. Similar to Markov model developments, …
Pediatric Wound Care: What Can We Learn From A Systematic Review Of The Literature? Using A Systematic Review And A Clinical Consensus Group To Assess The Quality And Content Of Systematic Reviews Focusing On Pediatric Wound Care. Then Providing And Analytical Outline For Creation Of Pediatric Wound Care Guidelines For Evidence Based Clinical Practice, Ryan Krasnosky
Dissertations and Theses (Open Access)
Background: Wound care practices for neonatal and pediatric patients including the category of products, specific products within each category, and length of application of the products have created lack of standardized evidence-based guidelines for treatments in clinical practices. This dissertation addresses this concern by encompassing three crucial steps in developing evidence-based clinical guidelines for wound care specialists. Using a three-paper method, an expert consensus group was formed, a systematic review of reviews completed and a process for creating clinical decision trees created. Methods: Criteria for selection of the consensus group members included: 1) Research graduate active in Pediatric Wound Care …
Statistical Methods For Functional Annotation-Based Rare Variant Association Analysis, Yiding Ma
Statistical Methods For Functional Annotation-Based Rare Variant Association Analysis, Yiding Ma
Dissertations and Theses (Open Access)
Despite ongoing large-scale population-based whole-genome sequencing (WGS) projects such as the TOPMed program, WGS-based association analysis of complex traits remains a tremendous challenge. External biological knowledge, such as functional annotations based on the ENCODE, Epigenomics Roadmap and GTEx projects, may be helpful in distinguishing causal rare variants from neutral ones; however, each functional annotation can only provide certain aspects of the biological functions. Our knowledge for selecting informative annotations a priori is limited and incorporating non-informative annotations will introduce noise and lose power. In the first part of this dissertation, we propose FunSPU, a versatile and adaptive test that incorporates …