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Articles 1 - 9 of 9
Full-Text Articles in Forensic Science and Technology
Diagnosing Mushroom Toxicities, Eetu Mäkinen
Diagnosing Mushroom Toxicities, Eetu Mäkinen
Themis: Research Journal of Justice Studies and Forensic Science
Although mushroom poisonings or “mycetisms” occur more frequently than is commonly recognized, they are often misdiagnosed due to their relative rarity, diverse clinical presentations, and the broad chemical variety of the toxins involved. More than a hundred different mushroom-derived toxins have been identified to cause at least 14 different poisoning syndromes or “toxidromes”, several of which can result in death through means such as organ failure. Understanding the toxicology of these mushroom toxins is essential for diagnosis in both clinical and forensic settings. Modern analytical techniques, such as liquid-chromatography–tandem mass spectrometry (LC–MS/MS) and enzyme-linked immunosorbent assays (ELISA), have improved the …
The Effect Of Henna And Bleach Treatments On Cocaine Hair External Contamination, Alexandra Dombroski
The Effect Of Henna And Bleach Treatments On Cocaine Hair External Contamination, Alexandra Dombroski
Student Theses
Hair external contamination is a challenging phenomenon that may compromise hair testing interpretation. Previous research has found that cosmetic hair treatments can decrease concentrations of drugs that are already present in the hair shaft, however little is known about the impact of these treatments on the hair when the drugs are deposited externally. The aims of the present study were to explore how henna and bleach treatments influence cocaine external contamination. Sixteen authentic hair samples were collected from volunteers with varying hair colors and shapes and were confirmed negative for cocaine and benzoylecgonine by a fully validated LC-MS/MS method. Each …
Effects Of External Decontamination Of Methamphetamine In Juvenile Hair, Rebecca Mitrani
Effects Of External Decontamination Of Methamphetamine In Juvenile Hair, Rebecca Mitrani
Student Theses
Methamphetamine is a common illicit substance abused in the United States. Hair is one matrix that is analyzed to determine the presence and concentration of methamphetamine. When hair is analyzed, an external decontamination step is commonly performed prior to drug extraction to avoid a potential positive result from environmental exposure in someone that has not ingested the drug themselves. In child-custody scenarios, however, it is important to know if a child is often around such illicit substances. This study serves to assess if there is a significant difference in methamphetamine concentrations in samples from children up to 12 years old …
Elisa Validation Method For The Detection Of Ketamine In Hair, Daria A. Centonza
Elisa Validation Method For The Detection Of Ketamine In Hair, Daria A. Centonza
Student Theses
An ELISA method was developed and validated to detect ketamine in human hair samples. Ketamine is an anesthetic drug that causes memory loss, dissociative sensations, and hallucinations. Due to these adverse effects, ketamine is a common drug used in drug facilitated sexual assaults (DFSAs). It is very important to be able to detect the substances used in DFSAs over a longer period of time due to the delayed reporting of these crimes. Victims, often out of fear and from the sedative/memory loss effects of the drugs, tend to report these crimes when it is too late to use urine and …
Assessment Of Quechers Extraction Protocol For The Lc-Ms/Ms Detection Of Emerging Fentanyl Analogs In Biological Specimens For Clinical And Forensic Purposes, Kylea M. Morris
Graduate Theses, Dissertations, and Problem Reports (ETD)
Drug abuse within the United States is a dynamic and pervasive issue that affects the quality and life expectancy of our society. One of the major drug classes that are constantly utilized is opioids. Opioids are prescribed for pain management in patients suffering from cancer and other medical illnesses. Long-term use of opioids could lead to tolerance in humans, which poses a risk of reaching fatal overdose levels. Unfortunately, opioids are abused recreationally, and in some instances, individuals are unaware of the presence of dangerous synthetic drugs like fentanyl, hidden in materials such as heroin, cocaine, oxycodone, and methamphetamine. Recent …
Investigation Of Postmortem Methamphetamine Cases Submitted To The New York City Office Of Chief Medical Examiner, Isaiah Jewell
Investigation Of Postmortem Methamphetamine Cases Submitted To The New York City Office Of Chief Medical Examiner, Isaiah Jewell
Student Theses
Methamphetamine (N-methylamphetamine) is a central nervous system stimulant (CNS) and sympathomimetic drug with a high addiction potential. In the United States, there has been a significant increase in the presence of methamphetamine in recent years, specifically in the Northeastern region of the country. The New York City Office of Chief Medical Examiner (NYC-OCME) postmortem methamphetamine casework from 2018 and 2019 was analyzed and revealed that the presence of the drug increased drastically within a span of one year, jumping from 65 cases in 2018 to 99 cases in 2019. Males were overwhelmingly responsible for much of the casework, taking up …
Development Of A Gas Chromatography-Mass Spectrometry (Gc/Ms) Method For The Quantification Of Vitamin E And Vitamin E Acetate In Electronic Cigarettes, Matthew Adreance
Development Of A Gas Chromatography-Mass Spectrometry (Gc/Ms) Method For The Quantification Of Vitamin E And Vitamin E Acetate In Electronic Cigarettes, Matthew Adreance
Master of Science in Forensic Science Directed Research Projects
Electronic cigarettes (e-cigs) are a medium of facilitating drug use that is gaining notoriety in the public eyes. E-cigs were originally designed to be “safer” alternatives to traditional cigarettes, providing the same or similar nicotine dosage without the other side compounds found in tobacco and traditional cigarettes. Typical e-cigs use e-liquids composed of propylene glycol (PG) and/or vegetable glycerin (VG) bases, various flavoring agents, and varying concentrations of nicotine depending on manufacturer or use. With the advent of the growing legalization of cannabis and CBD/THC products in many states and jurisdictions, e-cigs have become a popular medium to ingest these …
Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth
Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth
Student Theses
A liquid chromatography tandem mass spectrometry (LC-MSMS) method was developed and validated to detect for the presence of zolpidem in human hair samples. Zolpidem is a sedative hypnotic whose adverse effects make it a common drug found in drug facilitated crimes (DFC). It is important to be able to detect and quantitate the drug after a long period of time due to the victim’s delayed reporting of the crime. Hair’s long window of detection makes it a useful matrix for DFC investigations. The linear range of the assay was targeted at 2 pg/mg to 1,000 pg/mg and experiments designed to …
Forensic Markers Of Lampricide Toxicity In Oncorhynchsus Mykiss, Chris White
Forensic Markers Of Lampricide Toxicity In Oncorhynchsus Mykiss, Chris White
Theses and Dissertations (Comprehensive)
The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) has been used for decades to control invasive sea lamprey (Petromyzon marinus) populations in the Great Lakes, normally with little harm to other fish populations. However, due to the nature of lampricide treatments and the chemical properties of TFM, adverse effects to non-target fishes and non-target mortality occasionally occur. However, investigations of non-target mortality can be complex, particularly if fish deaths are not noticed immediately, due to decomposition of the carcasses. The objectives of this thesis were to expose rainbow trout (Oncorhynchsus mykiss) to TFM in order to: (i) identify forensic markers …