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Full-Text Articles in Forensic Science and Technology
Investigating The Binding Of Fentanyl And Fentanyl Analogs To The Μ-Opioid Receptor, Marissa Anne Teske
Investigating The Binding Of Fentanyl And Fentanyl Analogs To The Μ-Opioid Receptor, Marissa Anne Teske
Honors Theses
In 1960, Dr. Paul Janssen of the Janssen Company synthesized fentanyl. It is a rapid-acting analgesic that, unlike similar analgesics around that time, did not have negative cardiovascular effects. Fentanyl, and its derivatives, are strong μ-opioid receptor agonists. Rates of fatal opioid overdoses involving fentanyl have increases rapidly over the past two decades Due to these increasing concerns related to fentanyl and its derivatives, it is important to not only study fentanyl and its known derivatives, but to also study and understand potential new derivatives and how all these compounds interact with the opioid receptors. This study examined the interactions …
Cannabinoid Conundrum: A Study Of Anti-Epileptic Efficacy And Drug Policy, Kennedy Dickson
Cannabinoid Conundrum: A Study Of Anti-Epileptic Efficacy And Drug Policy, Kennedy Dickson
Honors Theses
Cannabis is the most commonly used, cultivated, and trafficked drug worldwide. The use and acceptance of marijuana is evolving rapidly, as indicated by the volume of new State cannabis legislation across the U.S. Many of the changes in state laws have occurred without significant input from medical or scientific communities. Additionally, marijuana policy in the US is convoluted with significant inconsistencies between state and federal law. The status of marijuana as a Schedule I drug under the Controlled Substance Act creates numerous restrictions and issues that impact the industry as a whole. The most promising development has been the 2018 …
Development Of A Dart-Mass Spectral Database For 3d-Printed Firearm Polymers, And Airborne Mercury At Three Lakes In North Mississippi, Parker Ball
Honors Theses
This research focuses on two studies: a development towards a DART-mass spectral database for 3D-printed firearm polymers, and a test for airborne mercury concentrations at three lakes in North Mississippi. With the relatively recent developments in 3D-printing technology, 3D-printed firearms have become increasingly prevalent as they have become more accessible to the public. Despite its growing popularity, little research has been done regarding the forensic analysis of evidence from 3D-printed firearms. Using DART-MS in conjunction with thermal desorption techniques, we obtained the mass spectra for 50 different commercially available 3D-printing polymers. Chemometric analysis was done to account for the high …
A Study Of The Kratom Alkaloids And Their Binding To The Μ-Opioid Receptor, Reba Elizabeth Ann Chamblee
A Study Of The Kratom Alkaloids And Their Binding To The Μ-Opioid Receptor, Reba Elizabeth Ann Chamblee
Honors Theses
Kratom, a plant commonly found in southeast Asia, has traditionally been used for medicinal treatments. Recently, however, the popularity of the drug has significantly increased due to its euphoric effects, leading to it being used as an alternative to illegal opioids. Several alkaloid compounds have been isolated from the leaves of the plant. The main alkaloids seen are the following five alkaloids: mitragynine, 7-hydroxymitragynine, speciociliatine, speciogynine, and paynantheine. Two alkaloids, mitragynine and 7-hydroxymitragynine, have exhibited high potencies and are potentially even more potent than morphine. Previous studies have indicated that the main mediator of the psychoactive effects is the opioid …