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University of Mississippi

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Full-Text Articles in Forensic Science and Technology

Structural Integrity And Stability Of Dna In Ionic Liquid And Near-Infrared Indolizine Squaraine Dye, Ember Yeji Suh May 2023

Structural Integrity And Stability Of Dna In Ionic Liquid And Near-Infrared Indolizine Squaraine Dye, Ember Yeji Suh

Honors Theses

Luminol, the most common presumptive test for blood at a crime scene, has multiple issues, such as false positive results with chemical agents, no luminescence due to “active oxygen” cleaning agents on bloodstains, and inability to penetrate textile materials. A combination of indolizine squaraine dye and ionic liquid (IL), or Dye Enhanced Textile Emission for Crime Tracking (DETECT), have shown potential to address these issues. The purpose of this study was to assess the binding mechanism of CG (1:1) and SO3SQ dye to HSA and how the mechanism can explain the W214 fluorescence quenching effect and to determine …

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Development Of A Non-Invasive Dna Extraction Method From Teeth, Monalisa Heng Apr 2022

Development Of A Non-Invasive Dna Extraction Method From Teeth, Monalisa Heng

Honors Theses

Forensic dentistry has evolved from simple morphological investigations to genetic and molecular analysis. One of the most important techniques is DNA analysis which requires viable samples from an individual or crime site. The orofacial region can be a good source for DNA samples because the tissues can resist environmental, thermal, electrical, and mechanical challenges. Teeth are especially useful as a source of genetic material because the DNA located in the pulp is surrounded by protective mineral tissue. The DNA in the pulp tissue is currently accessed through destructive methods involving crushing, pulverization, and splitting the tooth. Unfortunately, destructive methods destroy …

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Investigation Of The History Of Fingerprinting, Advancements In The Field, And Development Of Potential Methods That Could Improve The Detection Of Endogenous And Exogenous Drugs In Latent Prints, Kristen Malloy May 2020

Investigation Of The History Of Fingerprinting, Advancements In The Field, And Development Of Potential Methods That Could Improve The Detection Of Endogenous And Exogenous Drugs In Latent Prints, Kristen Malloy

Honors Theses

When someone thinks of fingerprinting, they are most likely going to picture how a latent print is matched to the fingerprint of a suspect based on ridge pattern analysis. However, there is much more information that can be obtained from a latent print. The work performed in this thesis focuses the detection of exogenous and endogenous drugs in latent prints. The experiments performed analyzed fingerprints from volunteers that were contaminated with one of three common painkillers: acetaminophen, acetylsalicylic acid (ASA), and ibuprofen. Three different instruments were tested for this purpose: MALDI-MS, ATR-FTIR, and LC-MS. Based on the results gathered, it …

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Analyses Of Prosecutorial Power And Discretion In Mississippi: Evaluating Proposals To Address Misconduct And Abuse, Lucy Pruitt Apr 2020

Analyses Of Prosecutorial Power And Discretion In Mississippi: Evaluating Proposals To Address Misconduct And Abuse, Lucy Pruitt

Honors Theses

This thesis seeks to create a policy proposal in order to address incidences of prosecutorial misconduct and abuse of discretion in the Mississippi criminal justice system. To do so, the author has summarized and analyzed seven criminal cases in which defendants have become victims of prosecutorial misconduct in order to shed light on the lack of prosecutorial accountability in the state’s criminal justice system. In an attempt to solve the problem, the author has developed a novel grading rubric in order to objectively and systematically analyze and evaluate previously proposed policy recommendations by legal experts and justice organizations. The successes …

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Cannabinoid Conundrum: A Study Of Anti-Epileptic Efficacy And Drug Policy, Kennedy Dickson Jan 2019

Cannabinoid Conundrum: A Study Of Anti-Epileptic Efficacy And Drug Policy, Kennedy Dickson

Honors Theses

Cannabis is the most commonly used, cultivated, and trafficked drug worldwide. The use and acceptance of marijuana is evolving rapidly, as indicated by the volume of new State cannabis legislation across the U.S. Many of the changes in state laws have occurred without significant input from medical or scientific communities. Additionally, marijuana policy in the US is convoluted with significant inconsistencies between state and federal law. The status of marijuana as a Schedule I drug under the Controlled Substance Act creates numerous restrictions and issues that impact the industry as a whole. The most promising development has been the 2018 …

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Development Of A Dart-Mass Spectral Database For 3d-Printed Firearm Polymers, And Airborne Mercury At Three Lakes In North Mississippi, Parker Ball Jan 2019

Development Of A Dart-Mass Spectral Database For 3d-Printed Firearm Polymers, And Airborne Mercury At Three Lakes In North Mississippi, Parker Ball

Honors Theses

This research focuses on two studies: a development towards a DART-mass spectral database for 3D-printed firearm polymers, and a test for airborne mercury concentrations at three lakes in North Mississippi. With the relatively recent developments in 3D-printing technology, 3D-printed firearms have become increasingly prevalent as they have become more accessible to the public. Despite its growing popularity, little research has been done regarding the forensic analysis of evidence from 3D-printed firearms. Using DART-MS in conjunction with thermal desorption techniques, we obtained the mass spectra for 50 different commercially available 3D-printing polymers. Chemometric analysis was done to account for the high …

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A Study Of The Kratom Alkaloids And Their Binding To The Μ-Opioid Receptor, Reba Elizabeth Ann Chamblee Jan 2019

A Study Of The Kratom Alkaloids And Their Binding To The Μ-Opioid Receptor, Reba Elizabeth Ann Chamblee

Honors Theses

Kratom, a plant commonly found in southeast Asia, has traditionally been used for medicinal treatments. Recently, however, the popularity of the drug has significantly increased due to its euphoric effects, leading to it being used as an alternative to illegal opioids. Several alkaloid compounds have been isolated from the leaves of the plant. The main alkaloids seen are the following five alkaloids: mitragynine, 7-hydroxymitragynine, speciociliatine, speciogynine, and paynantheine. Two alkaloids, mitragynine and 7-hydroxymitragynine, have exhibited high potencies and are potentially even more potent than morphine. Previous studies have indicated that the main mediator of the psychoactive effects is the opioid …

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Investigating The Binding Of Fentanyl And Fentanyl Analogs To The Μ-Opioid Receptor, Marissa Anne Teske Jan 2019

Investigating The Binding Of Fentanyl And Fentanyl Analogs To The Μ-Opioid Receptor, Marissa Anne Teske

Honors Theses

In 1960, Dr. Paul Janssen of the Janssen Company synthesized fentanyl. It is a rapid-acting analgesic that, unlike similar analgesics around that time, did not have negative cardiovascular effects. Fentanyl, and its derivatives, are strong μ-opioid receptor agonists. Rates of fatal opioid overdoses involving fentanyl have increases rapidly over the past two decades Due to these increasing concerns related to fentanyl and its derivatives, it is important to not only study fentanyl and its known derivatives, but to also study and understand potential new derivatives and how all these compounds interact with the opioid receptors. This study examined the interactions …

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