Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Econometrics (828)
- Finance (505)
- International and Area Studies (488)
- Asian Studies (476)
- Business (473)
-
- Finance and Financial Management (248)
- Growth and Development (239)
- International Economics (220)
- Behavioral Economics (212)
- Economic Theory (207)
- Public Affairs, Public Policy and Public Administration (115)
- Labor Economics (112)
- Political Economy (101)
- Public Economics (94)
- Health Economics (93)
- Industrial Organization (89)
- Macroeconomics (89)
- Sociology (84)
- Real Estate (65)
- Medicine and Health Sciences (56)
- Physical Sciences and Mathematics (44)
- Law (41)
- Education (38)
- Income Distribution (38)
- Transportation (35)
- Economic Policy (34)
- Political Science (33)
- Technology and Innovation (31)
- Keyword
-
- Singapore (110)
- China (46)
- Panel data (28)
- Specification test (28)
- COVID-19 (27)
-
- Monetary policy (25)
- Economic growth (24)
- Fixed effects (24)
- Bootstrap (23)
- Strategy-proofness (23)
- Employment (22)
- Inflation (22)
- Development (19)
- High-frequency data (19)
- Growth (17)
- Pandemic (17)
- Cointegration (16)
- Heterogeneity (16)
- Asia (15)
- Dynamic panel (15)
- Realized volatility (15)
- Structural change (15)
- Autoregression (14)
- Business cycles (14)
- Economic development (14)
- Empirical likelihood (14)
- Endogeneity (14)
- Financial frictions (14)
- Incentive compatibility (14)
- Interactive fixed effects (14)
- Publication Year
- Publication
-
- Research Collection School Of Economics (1733)
- Research Collection Lee Kong Chian School Of Business (199)
- Dissertations and Theses Collection (Open Access) (160)
- Perspectives@SMU (76)
- Asian Management Insights (45)
-
- Research Collection School of Social Sciences (42)
- Sim Kee Boon Institute for Financial Economics (42)
- Research Collection Yong Pung How School Of Law (33)
- Knowledge@SMU (21)
- Research Collection School Of Accountancy (17)
- Research Collection College of Integrative Studies (16)
- Research Collection School of Economics (10)
- Institute of Societal Leadership Research Collection (9)
- SMU Economics and Statistics Working Paper Series (8)
- Research Collection School Of Computing and Information Systems (7)
- ROSA Research Briefs (6)
- Research@SMU: Connecting the Dots (5)
- Digital Narratives of Asia (4)
- Dissertations and Theses Collection (4)
- ROSA Journal Articles and Publications (3)
- Social Space (3)
- Library Events (2)
- PhD Student’s Publications Collection (2)
- Research@SMU Infographics (2)
- Student Publications (2)
- 2016 ABLD-EBSLG-APBSLG Joint Conference & Meeting (1)
- Lien Centre for Social Innovation: Research (1)
- Research Collection Library (1)
- Research Collection School of Accountancy (1)
- SMU Press Releases and News (1)
- Publication Type
Articles 631 - 660 of 2456
Full-Text Articles in Economics
Macroeconomic Stabilization In The Digital Age, John Beirne, David Fernandez
Macroeconomic Stabilization In The Digital Age, John Beirne, David Fernandez
Research Collection Lee Kong Chian School Of Business
Macroeconomic Stabilization in the Digital Age provides insights into factors affecting the macroeconomic management of the economy in the digital age. Policy makers need to be aware of the increasing prominence of the digital economy and digital finance and seek to better understand how continued digitalization will affect policies aimed at managing the economy. For emerging market economies (EMEs), macroeconomic policy challenges have been exacerbated by the digital finance revolution in the aftermath of the global financial crisis and the coronavirus disease (COVID-19) pandemic, when many EMEs experienced large and volatile capital flows. Policy makers must also navigate through fluctuating …
The Potential Impacts Of Covid-19 On The Global Value Chains: Gvc Positioning And Linkages, Gerald Foong, Pao-Li Chang
The Potential Impacts Of Covid-19 On The Global Value Chains: Gvc Positioning And Linkages, Gerald Foong, Pao-Li Chang
Research Collection School Of Economics
Apart from the public health crisis entailed by the Coronavirus Disease 2019 (COVID-19) pandemic, it has also propagated a pandemic-induced economic shock globally. One transmission channel is via the inter-country linkages arising from the trade in intermediate inputs, which is a pertinent characteristic of global value chains (GVCs), and resulting in a "supply-chain contagion" as termed by Baldwin and Tomiura (2020). In this paper, we propose measures of bilteral downstreamness and upstreamness, the extent of a country's GVC participation, and the position of a country in GVCs by leveraging upon the gross export decomposition framework as laid out by Borin …
Housing Equity And Household Consumption In Retirement: Evidence From The Singapore Life Panel©, Lipeng Chen, Liang Jiang, Sock Yong Phang, Jun Yu
Housing Equity And Household Consumption In Retirement: Evidence From The Singapore Life Panel©, Lipeng Chen, Liang Jiang, Sock Yong Phang, Jun Yu
Research Collection School Of Economics
Housing affordability for elderly homeowners involves an entirely different set of issues as compared to housing affordability for first-time homeowners. To afford to ‘age-in-place’ may require homeowners to access channels that enable them to withdraw their housing equity to finance consumption in retirement. We utilize data from the Singapore Life Panel© survey to empirically investigate the impact of housing equity on the consumption of elderly households. Based on panel analysis, we find housing equity value has no significant impact on non-durable consumption for elderly people. The conclusion holds for a battery of robustness checks. Moreover, heterogeneity analyses based on subsamples …
Persistent And Rough Volatility, Xiaobin Liu, Shuping Shi, Jun Yu
Persistent And Rough Volatility, Xiaobin Liu, Shuping Shi, Jun Yu
Research Collection School Of Economics
This paper contributes to an ongoing debate on volatility dynamics. We introduce a discrete-time fractional stochastic volatility (FSV) model based on the fractional Gaussian noise. The new model has the same limit as the fractional integrated stochastic volatility (FISV) model under the in-fill asymptotic scheme. We study the theoretical properties of both models and introduce a memory signature plot for a model-free initial assessment. A simulated maximum likelihood (SML) method, which maximizes the time-domain log-likelihoods obtained by the importance sampling technique, is employed to estimate the model parameters. Simulation studies suggest that the SML method can accurately estimate both models. …
Robust Virtual Implementation With Almost Complete Information, Takashi Kunimoto
Robust Virtual Implementation With Almost Complete Information, Takashi Kunimoto
Research Collection School Of Economics
Artemov, Kunimoto, and Serrano (2013a,b, henceforth, AKS) study a mechanism design problem where arbitrary restrictions are placed on the set of first-order beliefs of agents. Calling these restrictions Δ, they adopt Δ-rationalizability (Battigalli and Siniscalchi, 2003) and show that Δ-incentive compatibility and Δ-measurability are necessary and sufficient conditions for robust virtual implementation, which implies that virtual implementation is possible uniformly over all type spaces consistent with Δ-restrictions. By appropriately defining Δ in order to restrict attention to complete information environments and thereafter explicitly modelling the assumption of complete information in the language of type spaces, I re-establish the permissive implementation …
A Ricardian Rationale For The Wto Rules On R&D Subsidies, Yumi Koh, Gea M. Lee
A Ricardian Rationale For The Wto Rules On R&D Subsidies, Yumi Koh, Gea M. Lee
Research Collection School Of Economics
The WTO subsidy rules use two key criteria, specificity and adverse effects, to regulate R&D subsidies. Using the model of Dornbusch et al. (1977), we offer a Ricardian rationale for the regulatory criteria.
Frm Financial Risk Meter, Andrija Mihoci, Michael Althof, Cathy Yi-Hsuan Chen, Wolfgang Karl Hardle
Frm Financial Risk Meter, Andrija Mihoci, Michael Althof, Cathy Yi-Hsuan Chen, Wolfgang Karl Hardle
Sim Kee Boon Institute for Financial Economics
A systemic risk measure is proposed accounting for links and mutual dependencies between financial institutions utilizing tail event information. Financial Risk Meter (FRM) is based on least absolute shrinkage and selection operator quantile regression designed to capture tail event co-movements. The FRM focus lies on understanding active set data characteristics and the presentation of interdependencies in a network topology. Two FRM indices are presented, namely, FRM@Americas and FRM@Europe. The FRM indices detect systemic risk at selected areas and identify risk factors. In practice, FRM is applied to the return time series of selected financial institutions …
Teres: Tail Event Risk Expectile Shortfall, Andrija Mihoci, Wolfgang Karl Hardle, Cathy Yi-Hsuan Chen
Teres: Tail Event Risk Expectile Shortfall, Andrija Mihoci, Wolfgang Karl Hardle, Cathy Yi-Hsuan Chen
Sim Kee Boon Institute for Financial Economics
We propose a generalized risk measure for expectile-based expected shortfall estimation. The generalization is designed with a mixture of Gaussian and Laplace densities. Our plug-in estimator is derived from an analytic relationship between expectiles and expected shortfall. We investigate the sensitivity and robustness of the expected shortfall to the underlying mixture parameter specification and the risk level. Empirical results from the US, German and UK stock markets and for selected NASDAQ blue chip companies indicate that expected shortfall can be successfully estimated using the proposed method on a monthly, weekly, daily and intra-day basis using a 1-year or 1-day time …
A Taxonomy Of Non-Dictatorial Domains, Shurojit Chatterji, Huaxia Zeng
A Taxonomy Of Non-Dictatorial Domains, Shurojit Chatterji, Huaxia Zeng
Research Collection School Of Economics
We provide an exhaustive classification of all preference domains that allow the design of unanimous social choice functions (henceforth, rules) that are non-dictatorial and strategy-proof. This taxonomy is based on a richness assumption and employs a simple property of two-voter rules called invariance. The preference domains that form the classification are semi-single-peaked domains (introduced by Chatterji et al. (2013)) and semi-hybrid domains (introduced here) which are two appropriate weakenings of the single-peaked domains, and which, more importantly, are shown to allow strategy-proof rules to depend on non-peak information of voters’ preferences. As a refinement of the classification, single-peaked domains and …
Does Early Access To Pension Wealth Improve Health?, Seonghoon Kim, Kanghyock Koh
Does Early Access To Pension Wealth Improve Health?, Seonghoon Kim, Kanghyock Koh
Research Collection School Of Economics
We examine the health impacts of early access to public pension wealth by exploiting a unique policy in Singapore allowing individuals to withdraw a proportion of their pension savings after their 55th birthday. For the identification, we employ a regression discontinuity design by comparing individuals before and after their 55th birthday. To address anticipated and lagged health impacts, we adopt the donut regression discontinuity approach. Using nationally representative monthly panel data, we find that early access to pension wealth improves self‐reported overall health.
Forecasting Large Covariance Matrix With High-Frequency Data: A Factor Approach For The Correlation Matrix, Yingjie Dong, Yiu Kuen Tse
Forecasting Large Covariance Matrix With High-Frequency Data: A Factor Approach For The Correlation Matrix, Yingjie Dong, Yiu Kuen Tse
Research Collection School Of Economics
We apply the factor approach to the correlation matrix to forecast large covariance matrix of asset returns using high-frequency data, using the principal component method to model the underlying latent factors of the correlation matrix. The realized variances are separately forecasted using the Heterogeneous Autoregressive model. The forecasted variances and correlations are then combined to forecast large covariance matrix. Our proposed method is found to perform better in reporting smaller forecast errors than some selected competitors. Empirical application to a portfolio of 100 NYSE and NASDAQ stocks shows that our method provides lower out-of-sample realized variance in selecting global minimum …
Financial Knowledge And Portfolio Complexity In Singapore, Benedict S. K. Koh, Olivia S. Mitchell, Susann Rohwedder
Financial Knowledge And Portfolio Complexity In Singapore, Benedict S. K. Koh, Olivia S. Mitchell, Susann Rohwedder
Research Collection Lee Kong Chian School Of Business
Financial literacy in Singapore has not been analyzed in much detail, despite the fact that this is one of the world’s most rapidly aging nations. Using the Singapore Life Panel®, we explore older Singaporeans’ levels of financial knowledge and compare them to those observed in the United States. We assess portfolio complexity for these older households, to examine how financial literacy is related to outcomes of interest. We show that older Singaporeans’ levels of financial literacy are comparable overall to those in the United States, even though older Singaporeans score slightly lower on some dimensions (knowledge of interest and inflation), …
Interim Rationalizable Implementation Of Functions, Takashi Kunimoto, Rene Saran, Roberto Serrano
Interim Rationalizable Implementation Of Functions, Takashi Kunimoto, Rene Saran, Roberto Serrano
Research Collection School Of Economics
This paper investigates rationalizable implementation of social choice functions (SCFs) in incomplete information environments. We identify weak interim rationalizable monotonicity (weak IRM) as a novel condition and show that weak IRM is a necessary and almost sufficient condition for rationalizable implementation. We show by means of an example that interim rationalizable monotonicity (IRM), found in the literature, is strictly stronger than weak IRM as its name suggests, and that IRM is not necessary for rationalizable implementation, as had been previously claimed. The same example also demonstrates that Bayesian monotonicity, the key condition for full Bayesian implementation, is not necessary for …
Between Lives And Economy: Optimal Covid-19 Containment Policy In Open Economies, Wen-Tai Hsu, Hsuan-Chih Luke Lin, Yang Han
Between Lives And Economy: Optimal Covid-19 Containment Policy In Open Economies, Wen-Tai Hsu, Hsuan-Chih Luke Lin, Yang Han
Research Collection School Of Economics
This paper studies optimal containment policy for combating a pandemic in an open-economy context. It does so via quantitative analyses using a model that incorporates a standard epidemiological compartmental model in a multi-country, multi-sector Ricardian model of international trade with full-fledged input-output linkages. We devise a novel approach in computing optimal national policies in the long run, and contrast these policies with a baseline in which countries maintain their current policies until vaccine availability. The welfare gains under optimal policies are asymmetric as the gains for the set of countries which should tighten up the containment measures are much larger …
Unconditional Quantile Regression With High-Dimensional Data, Yuya Sasaki, Takuya Ura, Yichong Zhang
Unconditional Quantile Regression With High-Dimensional Data, Yuya Sasaki, Takuya Ura, Yichong Zhang
Research Collection School Of Economics
Credible counterfactual analysis requires high-dimensional controls. This paper considers estimation and inference for heterogeneous counterfactual effects with high-dimensional data. We propose a novel doubly robust score for double/debiased estimation and inference for the unconditional quantile regression (Firpo, Fortin, and Lemieux, 2009) as a measure of heterogeneous counterfactual marginal effects. We propose a multiplier bootstrap inference for the Lasso double/debiased estimator, and develop asymptotic theories to guarantee that the bootstrap works. Simulation studies support our theories. Applying the proposed method to Job Corps survey data, we find that i) marginal effects of counterfactually extending the duration of the exposure to the …
Selective Reshaping: China's Paradigm Shift In International Economic Governance, Heng Wang
Selective Reshaping: China's Paradigm Shift In International Economic Governance, Heng Wang
Research Collection Yong Pung How School Of Law
In contrast with the selective adaptation approach toward external norms seen in its accession to the World Trade Organization, China increasingly plays a proactive role on the international stage, with the Belt and Road Initiative at the center of these activities. How can we understand this new approach by China toward international economic governance? What is responsible for China's shifting approach, and what are the implications of this shift? The paper presents selective reshaping as a new theoretical framework, and argues that China is shifting toward the selective reshaping of institutions and rules within the global economic order. Within this …
Swinging Shale: Shale Oil, Global Oil Market, And The Geopolitics Of Oil, Inwook Kim
Swinging Shale: Shale Oil, Global Oil Market, And The Geopolitics Of Oil, Inwook Kim
Research Collection School of Social Sciences
Is shale oil “revolutionizing” the global oil market and the geopolitics of oil? If so, how? While two aspects of the shale boom—a new source of supply and a cause for the price collapse in 2014–2015—dominate the conventional wisdom, I argue that the most revolutionary change is the least understood aspect of shale oil—shale oil producers’ rise as new swing suppliers due to its unique extraction technique and cost structure. Shale oil producers also differ from traditional swing producers in motives, contexts, and an amount of accessible excess capacity such that while shale oil lowers the medium-term price ceiling, it …
The Optimal Degree Of Reciprocity In Tariff Reduction, Pao-Li Chang
The Optimal Degree Of Reciprocity In Tariff Reduction, Pao-Li Chang
Research Collection School Of Economics
This paper characterizes the optimal reciprocal trade policy in the environment of Melitz (2003) with firm productivity heterogeneity. With all the conflicting effects of import tariffs on welfare considered, the optimal degree of reciprocity in multilateral tariff reduction is shown to be free trade.
Universal Minimum Wage Is Not Suitable For Singapore, Zhengxiao Wu
Universal Minimum Wage Is Not Suitable For Singapore, Zhengxiao Wu
Research Collection School Of Economics
In a commentary, SMU Senior Lecturer of Statistics Wu Zhengxiao examined the concept of a universal minimum wage, and discussed how it is not suitable for Singapore.
Spending Impact Of Covid-19 Stimulus Payments: Evidence From Card Transaction Data In South Korea, Kim, Kanghyock Koh, Wonjun Lyou
Spending Impact Of Covid-19 Stimulus Payments: Evidence From Card Transaction Data In South Korea, Kim, Kanghyock Koh, Wonjun Lyou
Research Collection School Of Economics
Various countries have implemented transfer programs to individuals since the Covid-19 outbreaks. However, the extent to which such transfers alleviate economic recessions is unclear. This paper analyzes a South Korean program, which provided vouchers redeemable only at small local businesses. We find that, due to the program, over 30% of households across all income groups increased their food and overall household spending, but the usage restriction may have affected consumer choice, distorting business competition. While the employment and sales of small businesses improved, the program’s fiscal sustainability is in question because of the large tax exemption.
The Optimal Degree Of Reciprocity In Tariff Reduction, Pao-Li Chang
The Optimal Degree Of Reciprocity In Tariff Reduction, Pao-Li Chang
Research Collection School Of Economics
This paper characterizes the optimal reciprocal trade policy in the environment of Melitz (2003) with firm productivity heterogeneity. In particular, without making parametric assumptions on firm productivity distribution, this paper derives the optimal degree of reciprocal tariff reductions that maximize the world welfare. A reciprocal import subsidy raises the industry productivity, lowering aggregate price; a reciprocal import tariff helps correct the markup distortion, increasing nominal income. With all the conflicting effects of import tariffs on welfare considered, the optimal degree of reciprocity in multilateral tariff reduction is shown to be free trade.
Order On Types Based On Monotone Comparative Statics, Takashi Kunimoto, Takuro Yamashita
Order On Types Based On Monotone Comparative Statics, Takashi Kunimoto, Takuro Yamashita
Research Collection School Of Economics
This paper introduces a novel concept of orders on types by which the so-called monotone comparative statics is valid in all supermodular games with incomplete information. We fully characterize this order in terms of what we call common optimism, providing a sense in which our order has a sharp epistemic interpretation. We say that type ti′ is higher than type ti in the order of the common optimism if ti′ is more optimistic about state than ti; ti′ is more optimistic that all players are more optimistic about state than ti; and so on, ad infinitum. First, we show that …
Maximum Likelihood Estimation For The Fractional Vasicek Model, Katsuto Tanaka, Weilin Xiao, Jun Yu
Maximum Likelihood Estimation For The Fractional Vasicek Model, Katsuto Tanaka, Weilin Xiao, Jun Yu
Research Collection School Of Economics
This paper estimates the drift parameters in the fractional Vasicek model from a continuous record of observations via maximum likelihood (ML). The asymptotic theory for the ML estimates (MLE) is established in the stationary case, the explosive case, and the boundary case for the entire range of the Hurst parameter, providing a complete treatment of asymptotic analysis. It is shown that changing the sign of the persistence parameter changes the asymptotic theory for the MLE, including the rate of convergence and the limiting distribution. It is also found that the asymptotic theory depends on the value of the Hurst parameter.
Estimation Of Conditional Average Treatment Effects With High-Dimensional Data, Qingliang Fan, Yu-Chin Hsu, Robert P. Lieli, Yichong Zhang
Estimation Of Conditional Average Treatment Effects With High-Dimensional Data, Qingliang Fan, Yu-Chin Hsu, Robert P. Lieli, Yichong Zhang
Research Collection School Of Economics
Given the unconfoundedness assumption, we propose new nonparametric estimators for the reduced dimensional conditional average treatment effect (CATE) function. In the first stage, the nuisance functions necessary for identifying CATE are estimated by machine learning methods, allowing the number of covariates to be comparable to or larger than the sample size. This is a key feature since identification is generally more credible if the full vector of conditioning variables, including possible transformations, is high-dimensional. The second stage consists of a low-dimensional kernel regression, reducing CATE to a function of the covariate(s) of interest. We consider two variants of the estimator …
Capital Controls And Macro-Prudential Housing Policies In Small Open Economies, Taojun Xie, Guay C. Lim, Hwee Kwan Chow
Capital Controls And Macro-Prudential Housing Policies In Small Open Economies, Taojun Xie, Guay C. Lim, Hwee Kwan Chow
Research Collection School Of Economics
We evaluate the effects of capital controls and macro-prudential policies in small open economies with a housing sector that is open to foreign ownership. The work is motivated by concerns that foreign investments also respond to housing investment opportunities resulting in potential house price inflation and issues about housing affordability. Our dynamic stochastic general equilibrium model features housing as an internationally traded investment. We also consider macro-prudential policies that are combinations of monetary and fiscal instruments. We investigate whether foreign investments in the housing markets are de-stabilising and whether there are appropriate policy responses to mitigate the negative effects of …
Do Short Sellers Use Textual Information? Evidence From Annual Reports, Hung Wan Kot, Frank Weikai Li, Ming Liu, K.C. John Wei
Do Short Sellers Use Textual Information? Evidence From Annual Reports, Hung Wan Kot, Frank Weikai Li, Ming Liu, K.C. John Wei
Research Collection Lee Kong Chian School Of Business
We examine short-sellers’ use of textual information in annual reports for shorting activities. We find that more uncertainty and negative words in annual reports are associated with greater abnormal shorting volume. Short selling motivated by textual information negatively predicts stock price reaction around the filing date of 10-K reports. We further provide some evidence that textual information used by short-sellers are related to revisions of analysts’ earnings forecasts, changes in firm fundamentals, and increasing crash risk subsequently. Our results suggest that textual information in annual reports forms an important part of short-sellers’ information advantage.
Providing Child Care, Christine Ho, Sunha Myong
Providing Child Care, Christine Ho, Sunha Myong
Research Collection School Of Economics
Women’s economic empowerment has been hailed as one of the most remarkable revolutions in the past 50 years (Dunlop, 2010). Access to affordable childcare is one of the key determinants of fertility and maternal employment, with grandparents and governments often stepping up to provide much needed support to families. This chapter proposes a synthesis of the state of knowledge on child care and discusses policy relevant issues applicable to the Singapore context. Selected policies are documented and lessons from the international landscape are discussed. The chapter discusses how child care costs may affect fertility and maternal labour supply in Section …
Covid-19, Lockdown, And The Dynamics Of Subjective Well-Being, Terence C. Cheng, Kim, Kanghyock Koh
Covid-19, Lockdown, And The Dynamics Of Subjective Well-Being, Terence C. Cheng, Kim, Kanghyock Koh
Research Collection School Of Economics
We provide novel evidence on how the COVID-19 global health and economic crisis is affecting overall life satisfaction and domain-specific satisfaction using data from a monthly longitudinal survey of middle-aged and older Singaporeans. Using a difference-in-differences framework, we document large declines in overall life satisfaction and domain-specific satisfaction during the COVID-19 outbreak, except satisfaction with health. These declines coincide with the introduction of a nationwide lockdown, with life satisfaction remaining below its pre-pandemic levels even after the lockdown is lifted. We also find that individuals who report a drop in household income during the COVID-19 outbreak experience a decline in …
Skbi Big 5 Survey 2020 August, Singapore Management University
Skbi Big 5 Survey 2020 August, Singapore Management University
Sim Kee Boon Institute for Financial Economics
The COVID-19 pandemic led to whopping downward revisions to 2020 real GDP growth among the Big5 economies, on average greater than 7%-points (ranging from roughly 3.5%-points for China to more than 10%-points for India). The forecast revisions to headline inflation were less sizable and more uneven, perhaps because of the confluence of supply and demand influences. The 2021 median GDP forecast is expected to turn positive overall, with a balanced risk assessment for most of the Big5 (but a coin toss in IN and US), but the growth reversal is likely to be highly uneven. While China regains its prior …
Activation Of Trpa1 Nociceptor Promotes Systemic Adult Mammalian Skin Regeneration, Jenny J. Wei, Hali S. Kim, Casey A. Spencer, Donna Brennan-Crispi, Ying Zheng, Nicolette M. Johnson, Misha Rosenbach, Christopher Miller, Denis H. Y. Leung, George Cotsarelis, Thomas H. Leung
Activation Of Trpa1 Nociceptor Promotes Systemic Adult Mammalian Skin Regeneration, Jenny J. Wei, Hali S. Kim, Casey A. Spencer, Donna Brennan-Crispi, Ying Zheng, Nicolette M. Johnson, Misha Rosenbach, Christopher Miller, Denis H. Y. Leung, George Cotsarelis, Thomas H. Leung
Research Collection School Of Economics
Adult mammalian wounds, with rare exception, heal with fibrotic scars that severely disrupt tissue architecture and function. Regenerative medicine seeks methods to avoid scar formation and restore the original tissue structures. We show in three adult mouse models that pharmacologic activation of the nociceptor TRPA1 on cutaneous sensory neurons reduces scar formation and can also promote tissue regeneration. Local activation of TRPA1 induces tissue regeneration on distant untreated areas of injury, demonstrating a systemic effect. Activated TRPA1 stimulates local production of interleukin-23 (IL-23) by dermal dendritic cells, leading to activation of circulating dermal IL-17–producing γδ T cells. Genetic ablation of …