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2023

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Articles 1 - 30 of 143

Full-Text Articles in Cognitive Science

Puppy Love And [Information] Play: An Intersection Of Theatre, Queer Kink, And Consent, Emily Kitchens Dec 2023

Puppy Love And [Information] Play: An Intersection Of Theatre, Queer Kink, And Consent, Emily Kitchens

Faculty Articles

This note from the field centers on a nexus of queer kink subcultures and consent-based intimacy work in theatre. I report, investigate and wrangle with the process of incorporating queer kink aesthetics into the production of Love and Information by Caryl Churchill I directed at KSU February 2023. What I have learned and hope to demonstrate throughout the paper, is that queer kink subcultures are often paradigmatic examples of communities built on consent, and we as performing arts practitioners can more visibly expand the margins of our cultural competency dialogues to not only include them but look to them as …


Effects Of Screen Time On Children's Brain Development: A Scoping Review, Niloofar Jannesar, Todd E. Davenport, Lindsay Gietzen Dec 2023

Effects Of Screen Time On Children's Brain Development: A Scoping Review, Niloofar Jannesar, Todd E. Davenport, Lindsay Gietzen

Pacific Journal of Health

In this scoping review, the effects of screen time on cognitive, linguistic, and social-emotional development in children were studied by examining peer-reviewed articles published between 2018 and 2023. A total of 17 peer-reviewed articles were used in the study. The research reported that screen media provide a learning avenue, though it could be detrimental when children spend their time watching more than appropriate screen media. Furthermore, the study indicated that excessive screen media use may harm children’s executive function, which affects academic performance and language development. Related studies have also shown a correlation between excess screen use and problems like …


Direct Relationships Between The Five Internal Senses: The Extremes And In-Between Of The Inner Experience, Sydnie Hoyt, Camryn O'Neal, Miranda Brannum, Sara Bagley Dec 2023

Direct Relationships Between The Five Internal Senses: The Extremes And In-Between Of The Inner Experience, Sydnie Hoyt, Camryn O'Neal, Miranda Brannum, Sara Bagley

The Confluence

Inner experience of all 5 modalities were investigated to determine if there were correlations amongst them and how visual mental imagery and internal hearing were used in an applied story. Our sample (N = 137) completed the Vividness of Visual Imagery Questionnaire (VVIQ; Marks, 1973) and the Plymouth Sensory Imagery Questionnaire (Psi-Q; Andrade et al., 2013) to obtain trait measures of the different modalities within the inner experience. Results showed statistically significant positive correlations between each of the trait measures of the 5 sensory modalities (visual mental imagery, inner hearing, taste, smell, and touch). Based on their VVIQ total scores, …


Hearing Loss As A Risk Factor For Cognitive Decline In The Elderly: A Rapid Review, Natalie Large, Nannette Nicholson Dec 2023

Hearing Loss As A Risk Factor For Cognitive Decline In The Elderly: A Rapid Review, Natalie Large, Nannette Nicholson

Internet Journal of Allied Health Sciences and Practice

Purpose: The aim of this rapid review was to identify and evaluate evidence exploring hearing loss as a risk factor for cognitive decline in the elderly population. Methods: A literature search was performed in three databases: CINAHL, Cochrane Central, and PubMed. The PRISMA template was used to record the search and selection process. Search criteria included older adults aged 65 and up with diagnosed or self-reported hearing loss and no previous diagnosis of dementia or Alzheimer’s disease. Participants were excluded if they had been diagnosed with dementia or tested for it before the study began. Hearing loss was categorized using …


Clausewitzian Theory Of War In The Age Of Cognitive Warfare, Amber Brittain-Hale, Amber Brittain-Hale Dec 2023

Clausewitzian Theory Of War In The Age Of Cognitive Warfare, Amber Brittain-Hale, Amber Brittain-Hale

Education Division Scholarship

We can reconceptualise warfare by contrasting Clausewitz with the modern practice of cognitive warfare, as evidenced by Ukraine’s defence methodologies. The strategic orchestration of ‘infopolitik’ and the sophisticated use of social media can shape narratives and public perception. This article revisits Clausewitz’s tenet of war as a political instrument and juxtaposes it with contemporary conflict’s multidimensional tactics. By scrutinising Ukraine’s digital and psychological warfare tactics, one may question the applicability of Clausewitz’s framework, seeking to understand if these novel dimensions of warfare compel a redefinition or an expansion of his thesis to navigate the complexities of contemporary geopolitical confrontations.


Exploring Local Elected Officials' Capacity To Govern Effectively, Mario King Dec 2023

Exploring Local Elected Officials' Capacity To Govern Effectively, Mario King

Dissertations

A successful local government exemplifies inclusivity, innovation, and deliberate decision-making, all advancing responsible management of taxpayers' resources. In this qualitative investigation, a phenomenological approach is employed to delve into the lived experiences of local elected officials. The aim of this study was to gain insights into the capacity of these local elected officials for success in governance. Subsequently, the insights from these local elected officials' experiences are harnessed to evaluate their influence and impact on municipal performance.

The management of municipal performance encompasses the provision of social services, the maintenance of fiscal operations, and adherence to statutory obligations (Avellaneda, 2008). …


Forgetting Our Dreams, Emily Ambery Dec 2023

Forgetting Our Dreams, Emily Ambery

D.U.Quark

No abstract provided.


Mrs. Dalloway As A Window For Understanding Life, Kristen Venegas Dec 2023

Mrs. Dalloway As A Window For Understanding Life, Kristen Venegas

English (MA) Theses

Virginia Woolf’s Mrs. Dalloway may be dismissed as fiction, and fiction consequently is dismissed as fantasy. However, the novel enables readers to practice an intellectual exercise of meta-awareness that extends beyond the pages and onto real world phenomena. Under a cognitive neuroscience perspective, Mrs. Dalloway is a literary masterpiece due to its hyper- realistic execution of the intimacies of life. Through the narrative style of free-indirect discourse, Woolf illustrates what occurs in the minds of characters as they develop their own perceptions of reality and identity, exposes the fear and inadequacies of mankind’s distress in times of chaos and disorder …


Value Added By Using Joint Displays In Mixed Methods Research, Elizabeth Svoboda Dec 2023

Value Added By Using Joint Displays In Mixed Methods Research, Elizabeth Svoboda

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Mixed methods research collects, analyzes, and integrates rigorous qualitative and quantitative methods to gain a deeper understanding of a phenomenon than would be gained by using either method alone. Integration is one of the key features of mixed methods research and consists of mixing qualitative and quantitative research in a systematic way to generate new inferences or follow-up studies. However, the process of integration can be challenging to draw on expertise in both qualitative and quantitative methods, decide when and how to integrate qualitative and quantitative research, and combine multiple data sources in a coherent way to generate new inferences. …


What’S In A Word? A Study Of Emotional Valence, Trisha Patel, Cameron Smith, Olivia Williams, Raul Rodriguez-Calva Nov 2023

What’S In A Word? A Study Of Emotional Valence, Trisha Patel, Cameron Smith, Olivia Williams, Raul Rodriguez-Calva

Science University Research Symposium (SURS)

Cognitive stress affects humans mentally and physically, and specifically may impact emotional recognition. Previous studies have focused on the perceived emotional valence of nouns vs. adjectives and the emotional recognition of photographs. While this has led to the creation of an emotional valence database, there has yet to be a study to explore how stress can change perceived emotional valence. Using data from the Affective Norms for English Words (ANEW), the Portland Arithmetic Stress Test (PAST), and the Montreal Imaging Stress Task (MIST), a study was created to explore how participants emotional valence of words would change after being placed …


Destigmatizing Working With Dyslexic Learners, Riley N. Dandurand Nov 2023

Destigmatizing Working With Dyslexic Learners, Riley N. Dandurand

The Writing Center Journal

In the field of writing center research there is a paucity of information regarding tutoring students with dyslexia. This comes as no surprise considering it is only in the last 50 years that there has been a conscious effort to include those who have exceptionalities in all areas of education. In addition to a lack of research and training there is another issue that arises with disclosing exceptionalities. Those studying dyslexia have found that students are hesitant to disclose their learning disability because of the stigma and feelings of differentiation from their peers (Brizee et al., 2012). The question then …


Conceptual Meaning In Phonology: Multimodal Iconic Expressions In Discourse Focus, David Páez Acevedo Nov 2023

Conceptual Meaning In Phonology: Multimodal Iconic Expressions In Discourse Focus, David Páez Acevedo

Linguistics ETDs

In everyday communication, speakers go beyond words to synchronize speech sounds and gestures, adding nuanced meanings. For instance, in Colombian Spanish, recounting the distant past involves elongating words, modulating pitch, and using expressive hand movements. This dissertation explores this phenomenon, termed Multimodal Iconic Expressions (MMIEs), using Cognitive Linguistics and Cognitive Grammar. The quantitative study uncovers correlations between verb aspect, nominal quantification, and speech duration, revealing phono-iconic connections. The qualitative study examines construal operations giving rise to MMIEs across semantic domains. MMIEs predominantly appear in discourse Focus, with durative events and mass-like quantities exhibiting pronounced phono-iconic associations. Patterns include stress and …


Book Review: Kings, Conquerors, Psychopaths: From Alexander To Hitler To The Corporation, Tim Bakken Nov 2023

Book Review: Kings, Conquerors, Psychopaths: From Alexander To Hitler To The Corporation, Tim Bakken

Genocide Studies and Prevention: An International Journal

The book Kings, Conquerors, Psychopaths is a survey of a vast amount of human wrongdoing. It lays bare the motivations of aggressors who wish to subjugate nations or groups of people and corporate executives and government bureaucrats who make discretionary decisions that harm people. Along with cataloging mass killings by despots and soldiers, the book includes stories about Ponzi-schemers and the deaths of automobile drivers and passengers who were killed by vehicle defects known to the manufacturer. The book posits that “[p]owerful, elite forces are trying to force us backward toward a non-democratic state, one where power, wealth, and prerogative …


Writing Philosophical Autoethnography: A Review, Niroj Dahal Nov 2023

Writing Philosophical Autoethnography: A Review, Niroj Dahal

The Qualitative Report

As a book reviewer, I am penning down my thoughts restlessly on the book, Writing Philosophical Autoethnography, with a diverse audience in mind, encompassing readers, writers, and researchers of all levels from various disciplines in the social sciences and education. This groundbreaking work, edited by Alec Grant and published by Routledge, masterfully blends philosophy and autoethnography (Grant, 2023). The book distinguishes itself through its philosophical depth, with each chapter demonstrating a profound engagement with philosophical debates and theories rooted in Western philosophical traditions. This approach sets it apart from other autoethnographic works where philosophical concepts often appear to be …


Oh No, We're Moving, Devina Parker Nov 2023

Oh No, We're Moving, Devina Parker

Psychology Division Scholarship

This wonderful book helps children identify and express their feelings, face the challenges that come with moving to a new place, and ease difficult emotions such as worry and fear. Devina's compassionate storytelling and insightful guidance provide invaluable support to young readers and their families during times of transition.


Depaul Digest Oct 2023

Depaul Digest

DePaul Magazine

College of Education Professor Jason Goulah fosters hope, happiness and global citizenship through DePaul’s Institute for Daisaku Ikeda Studies in Education. Associate Journalism Professor Jill Hopke shares how to talk about climate change. News briefs from DePaul’s 10 colleges and schools: Occupational Therapy Standardized Patient Program, Financial Planning Certificate program, Business Education in Technology and Analytics Hub, Racial Justice Initiative, Teacher Quality Partnership grant, Intimate Partner Violence and Brain Injury collaboration, School of Music Career Closet, Sports Photojournalism course, DePaul Migration Collaborative’s Solutions Lab, Inclusive Screenwriting courses. New appointments: School of Music Dean John Milbauer, College of Education Dean Jennifer …


Motivational Interviewing May Resolve Vaccine Hesitancy, Scott L. Baughan Oct 2023

Motivational Interviewing May Resolve Vaccine Hesitancy, Scott L. Baughan

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Gagneur A, Lemaître T, Gosselin V, et al. A postpartum vaccination promotion intervention using motivational interviewing techniques improves short-term vaccine coverage: PromoVac study. BMC public health. 2018;18(1):811. https://doi.org/10.1186/s12889-018-5724-y

for a juvenile patient with a caregiver who is skeptical about the safety of routine vaccinations.


Confirmation Report: Modelling Interlocutor Confusion In Situated Human Robot Interaction, Na Li Oct 2023

Confirmation Report: Modelling Interlocutor Confusion In Situated Human Robot Interaction, Na Li

Reports

Human-Robot Interaction (HRI) is an important but challenging field focused on improving the interaction between humans and robots such to make the interaction more intelligent and effective. However, building a natural conversational HRI is an interdisciplinary challenge for scholars, engineers, and designers. It is generally assumed that the pinnacle of human- robot interaction will be having fluid naturalistic conversational interaction that in important ways mimics that of how humans interact with each other. This of course is challenging at a number of levels, and in particular there are considerable difficulties when it comes to naturally monitoring and responding to the …


Blood-Based Transcriptomic Biomarkers Are Predictive Of Neurodegeneration Rather Than Alzheimer's Disease, Artur Shvetcov, Shannon Thomson, Jessica Spathos, Ann-Na Cho, Heather M Wilkins, Shea J Andrews, Fabien Delerue, Timothy A Couttas, Jasmeen Kaur Issar, Finula Isik, Simranpreet Kaur, Eleanor Drummond, Carol Dobson-Stone, Shantel L Duffy, Natasha M Rogers, Daniel Catchpoole, Wendy A Gold, Russell H Swerdlow, David A Brown, Caitlin A Finney Oct 2023

Blood-Based Transcriptomic Biomarkers Are Predictive Of Neurodegeneration Rather Than Alzheimer's Disease, Artur Shvetcov, Shannon Thomson, Jessica Spathos, Ann-Na Cho, Heather M Wilkins, Shea J Andrews, Fabien Delerue, Timothy A Couttas, Jasmeen Kaur Issar, Finula Isik, Simranpreet Kaur, Eleanor Drummond, Carol Dobson-Stone, Shantel L Duffy, Natasha M Rogers, Daniel Catchpoole, Wendy A Gold, Russell H Swerdlow, David A Brown, Caitlin A Finney

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is a growing global health crisis affecting millions and incurring substantial economic costs. However, clinical diagnosis remains challenging, with misdiagnoses and underdiagnoses being prevalent. There is an increased focus on putative, blood-based biomarkers that may be useful for the diagnosis as well as early detection of AD. In the present study, we used an unbiased combination of machine learning and functional network analyses to identify blood gene biomarker candidates in AD. Using supervised machine learning, we also determined whether these candidates were indeed unique to AD or whether they were indicative of other neurodegenerative diseases, such as …


Sex Differences In Stress Reactivity, Brain Morphology, And Oxytocin In The Hypothalamus Of The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Zacarias, Daniela Rodriguez, Alexandra Chalons, Sasawan Heingraj, Nicole Altamirano, Joseph Rafac, John L. Vandeberg, Mario Gil Oct 2023

Sex Differences In Stress Reactivity, Brain Morphology, And Oxytocin In The Hypothalamus Of The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Zacarias, Daniela Rodriguez, Alexandra Chalons, Sasawan Heingraj, Nicole Altamirano, Joseph Rafac, John L. Vandeberg, Mario Gil

Research Colloquium

Understanding the effects of stress on behavior and cognition is important due to its impact on mental health and wellbeing (Schneiderman et al. 2005). Translational animal research can contribute to the development of new treatments that can improve therapeutic outcomes and our understanding of the neurobiology of stress. In the present study, we complement behavioral stress reactivity with immunohistochemical localization of oxytocin in the hypothalamus, a neuropeptide that regulates stress (Neumann & Slattery, 2016). Oxytocin has potential therapeutic use for mental health disorders (Neumann & Slattery, 2016), and the effects of oxytocin seem to be sexually dimorphic (Love, 2018). Using …


“Minimum Necessary Rigor” In Empirically Evaluating Human–Ai Work Systems, Gary Klein, Robert R. Hoffman, William J. Clancey, Shane Mueller, Florian Jentsch, Mohammadreza Jalaeian Oct 2023

“Minimum Necessary Rigor” In Empirically Evaluating Human–Ai Work Systems, Gary Klein, Robert R. Hoffman, William J. Clancey, Shane Mueller, Florian Jentsch, Mohammadreza Jalaeian

Michigan Tech Publications

The development of AI systems represents a significant investment of funds and time. Assessment is necessary in order to determine whether that investment has paid off. Empirical evaluation of systems in which humans and AI systems act interdependently to accomplish tasks must provide convincing empirical evidence that the work system is learnable and that the technology is usable and useful. We argue that the assessment of human–AI (HAI) systems must be effective but must also be efficient. Bench testing of a prototype of an HAI system cannot require extensive series of large-scale experiments with complex designs. Some of the constraints …


Balanced Blended Space: Proposing A Universal Theoretical Framework For Combinative Reality, David Smith, Frederick Bianchi Oct 2023

Balanced Blended Space: Proposing A Universal Theoretical Framework For Combinative Reality, David Smith, Frederick Bianchi

Publications and Research

In today's fragmented societies, a unified framework for communication and collaboration across different realities is crucial. We introduce Balanced Blended Space (BBS) as a framework for describing combinative reality, encompassing virtual, physical, and conceptual realms, all intrinsically connected. Interactions within these environments shape our perceptual space. This paper outlines key axiomatic assumptions, criteria for a universal framework, and fundamental terminology. We identify deep symmetries enabling the BBS framework, including Cognitive and Computational Symmetry, Physical and Virtual Symmetry, Mediation Pathway Symmetry, Space-Time Symmetry, and Sensory Symmetry. We propose tests to determine its viability, emphasizing virtual intelligence as a collaborative partner. We …


Understanding The Resources, Barriers, Facilitators And Interests About Aging And Dementia Research Of Community Members From The Rio Grande Valley, Karla Daniela Lopez Lorenzo, Rosa V. Pirela Mavarez, Gabriela Osuna, Kendra Stine, Nathalie Chacon, Noe Garza, Gladys E. Maestre Sep 2023

Understanding The Resources, Barriers, Facilitators And Interests About Aging And Dementia Research Of Community Members From The Rio Grande Valley, Karla Daniela Lopez Lorenzo, Rosa V. Pirela Mavarez, Gabriela Osuna, Kendra Stine, Nathalie Chacon, Noe Garza, Gladys E. Maestre

Research Symposium

Background: One of ten people aged 65 develops Alzheimer’s Disease and it is one of the sixth-leading cause of death in the United States. The Rio Grande Valley (RGV) is mostly constituted by Hispanic/Latinos (93%), a population that has a 1.5X increased risk of AD onset. Nevertheless, there are not enough resources to support people living with dementia and their care partners. This study will leverage research efforts deployed by the RGV Alzheimer’s Disease Resource Center for Minority Aging Research to understand the social representations about the resources, barriers, facilitators, and interests of the RGV community about dementia and Alzheimer’s …


The Science Of Learning: Understanding The Learning Process And Its Implementation Into The Classroom, Robert Hawkins Sep 2023

The Science Of Learning: Understanding The Learning Process And Its Implementation Into The Classroom, Robert Hawkins

The Cardinal Edge

College and higher education is often seen as the next step for many students pursuing a particular career or field. These institutions strive to facilitate learning and maintain a rewarding academic environment. However, students often face various challenges when first attending college which is reflected by high levels of dropout and withdrawal from general education courses, especially for first-time students. In fact, according to the education data initiation, “at 4-year institutions, 18.4% of first-time, full-time college freshmen dropped out between 2019 and 2020” (Hansen & Checked, 2022). One of these challenges is understanding the process of learning on a fundamental …


Recommended Editions (1/3) Sep 2023

Recommended Editions (1/3)

The International Journal of Ecopsychology (IJE)

Introduction to Recommended Editions (1/3)

1) Open Semiotics (Vols. 1-4) Amir Biglari (Ed.)

2) The Reliability of UFO Witness Testimony, Vicente-Juan Ballester-Olmos and Richard W. Heiden, (Eds.)


Physical Time Within Human Time Sep 2023

Physical Time Within Human Time

The International Journal of Ecopsychology (IJE)

A possible solution is offered to help resolve the “two times problem” regarding the veridical and illusory nature of time. First it is recognized that the flow (passage) of time is part of a wider array of temporal experiences referred to as manifest time, all of which need to be reconciled. Then, an information gathering and utilizing system (IGUS) model is used as a basis for a view of manifest time. The model IGUS robot of Hartle that solves the “unique present” debate is enhanced with veridical and (corresponding) illusory components of not only the flow of time but also …


Ufo Witness Testimony (Reliability)--'Flyer' Sep 2023

Ufo Witness Testimony (Reliability)--'Flyer'

The International Journal of Ecopsychology (IJE)

No abstract provided.


Multiancestry Analysis Of The Hla Locus In Alzheimer’S And Parkinson’S Diseases Uncovers A Shared Adaptive Immune Response Mediated By Hla-Drb1*04 Subtypes, Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar De Rojas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stéphanie Debette, Jean-François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Düzel, Daniela Galimberti, Guillermo Garcia-Ribas, José María García-Alberca, Pablo García-González, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jürgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre De Mendonça, Mercè Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Børge G Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A L Pijnenburg, Gerard Piñol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puerta, Jordi Pérez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A Ross, Luis Jose Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John Van Swieten, Raquel Sánchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhang, Eadb, Gr@Ace Study Group, Degesco Consortium, Demgene, Eadi, Gerad, Asian Parkinson’S Disease Genetics Consortium, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Ole A Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sánchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje Van Der Flier, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustín Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D Greicius, Emmanuel Mignot Sep 2023

Multiancestry Analysis Of The Hla Locus In Alzheimer’S And Parkinson’S Diseases Uncovers A Shared Adaptive Immune Response Mediated By Hla-Drb1*04 Subtypes, Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar De Rojas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stéphanie Debette, Jean-François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Düzel, Daniela Galimberti, Guillermo Garcia-Ribas, José María García-Alberca, Pablo García-González, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jürgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre De Mendonça, Mercè Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Børge G Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A L Pijnenburg, Gerard Piñol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puerta, Jordi Pérez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A Ross, Luis Jose Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John Van Swieten, Raquel Sánchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhang, Eadb, Gr@Ace Study Group, Degesco Consortium, Demgene, Eadi, Gerad, Asian Parkinson’S Disease Genetics Consortium, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Ole A Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sánchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje Van Der Flier, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustín Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D Greicius, Emmanuel Mignot

Faculty, Staff and Students Publications

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. …


A Framework For Confusion Mitigation In Task-Oriented Interactions, Na Li, Robert J. Ross Sep 2023

A Framework For Confusion Mitigation In Task-Oriented Interactions, Na Li, Robert J. Ross

Conference papers

Confusion is a mental state that can be triggered in task-oriented interactions and which can if left unattended lead to boredom, frustration, or disengagement from the task at hand. Previous work has demonstrated that confusion can be detected in situated human-robot interactions from visual and auditory cues. Therefore, in the next step, we propose appropriate interaction structures in this study, which should be used to mitigate confusion. We motivate and describe this dialogue mechanism through an information state-style dialogue framework and policies, and also outline the approach we are taking to integrate such a meta-conversational goal alongside core task-oriented considerations …


Recursive Functional Learning In Nonfluent Aphasia, Gerald C. Imaezue Sep 2023

Recursive Functional Learning In Nonfluent Aphasia, Gerald C. Imaezue

Dissertations, Theses, and Capstone Projects

People with nonfluent aphasia (PWNA) require feedback from an external agent as well self-feedback to facilitate performance of language production tasks. The extent to which PWNA can use self-feedback alone to improve their task performance is unknown. In addition, it is argued that self-feedback may reinforce or minimize performance errors over time. To test whether either is the case, we introduce an original learning mechanism, recursive functional learning, which uses self-feedback loops to optimize recursively multiple subsystems (cognitive and linguistic subsystems) that PWNA engage during task performance. We used this mechanism to underpin a novel automated procedure we developed, recursive …