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Articles 1 - 2 of 2
Full-Text Articles in Cognitive Science
Ultrafast Two-Photon Imaging Of A High-Gain Voltage Indicator In Awake Behaving Mice, Vincent Villette, Mariya Chavarha, Ivan K Dimov, Jonathan Bradley, Lagnajeet Pradhan, Benjamin Mathieu, Stephen W Evans, Simon Chamberland, Dongqing Shi, Renzhi Yang, Benjamin B Kim, Annick Ayon, Abdelali Jalil, François St-Pierre, Mark J Schnitzer, Guoqiang Bi, Katalin Toth, Jun Ding, Stéphane Dieudonné, Michael Z Lin
Ultrafast Two-Photon Imaging Of A High-Gain Voltage Indicator In Awake Behaving Mice, Vincent Villette, Mariya Chavarha, Ivan K Dimov, Jonathan Bradley, Lagnajeet Pradhan, Benjamin Mathieu, Stephen W Evans, Simon Chamberland, Dongqing Shi, Renzhi Yang, Benjamin B Kim, Annick Ayon, Abdelali Jalil, François St-Pierre, Mark J Schnitzer, Guoqiang Bi, Katalin Toth, Jun Ding, Stéphane Dieudonné, Michael Z Lin
Faculty, Staff and Students Publications
Optical interrogation of voltage in deep brain locations with cellular resolution would be immensely useful for understanding how neuronal circuits process information. Here, we report ASAP3, a genetically encoded voltage indicator with 51% fluorescence modulation by physiological voltages, submillisecond activation kinetics, and full responsivity under two-photon excitation. We also introduce an ultrafast local volume excitation (ULoVE) method for kilohertz-rate two-photon sampling in vivo with increased stability and sensitivity. Combining a soma-targeted ASAP3 variant and ULoVE, we show single-trial tracking of spikes and subthreshold events for minutes in deep locations, with subcellular resolution and with repeated sampling over days. In the …
How To Create And Maintain An Effective Information Architecture And Navigation System For Science Gateway Websites, Noreen Y. Whysel, Omni Marketing Interactive
How To Create And Maintain An Effective Information Architecture And Navigation System For Science Gateway Websites, Noreen Y. Whysel, Omni Marketing Interactive
Publications and Research
Whether you have an existing Science Gateway website or are creating your first one, this hands-on tutorial will show you, step by step, how to create and update gateway websites so that their content is easier to find and easier to use.
As a Science Gateway provides its web-based tools and resources, it is essential that these sites utilize specific usability tests and other research methods to ensure positive and productive experiences with the sites. Successful information architecture (IA), intuitive site navigation, and clear user interfaces (UIs) all rely on knowing where various users expect to find needed information.
Since …