Biological and Physical Anthropology Commons^™

High Prevalence Of Cerebrovascular Calcifications And Clinical Correlates In Indigenous Bolivian Forager‐Horticulturalists: A Population‐Based Observational Study, Giuseppe Barisano, Bavrina Bigjahan, Grant Schleifer, Maria Ashna, Wendy J. Mack, M. Linda Sutherland, James D. Sutherland, Helena C. Chui, Meng Law, Thomas J. Fischbach, Andrei Irimia, Nikhil N. Chaudhari, Daniel K. Cummings, Paul L. Hooper, Jacob E. Aronoff, Ellen E. Walters, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Jesus Bani Cuata, Kenneth Buetow, Caleb E. Finch, Michael D. Gurven, Jonathan Stieglitz, Gregory S. Thomas, Randall C. Thompson, Benjamin Trumble, Hillard Kaplan, Margaret Gatz

ESI Publications

Background

Methods

Oxytocin Varies Across The Life Course In A Sex-Specific Way In A Human Subsistence Population, Abigail E. Colby, Dominik C. Jud, Valerie Baettig, Jordan S. Martin, Camila Scaff, Michael D. Gurven, Benjamin C. Trumble, Bret A. Beheim, Paul L. Hooper, Daniel K. Cummings, Hillard Kaplan, Jonathan Stieglitz, Arnulfo Cary Ista, Adrian V. Jaeggi

ESI Publications

Oxytocin, a hormone linked to reproduction and health, may mediate life-history trade-offs across the human life course. Yet, how oxytocin naturally varies with age remains poorly understood. Here, working with the Tsimane, forager-horticulturalists of lowland Bolivia, we collected the largest sample of oxytocin measurements to date (n = 1,242 samples, n = 405 individuals, age = 2 to 84 y, 51% female), and i) examined how oxytocin varies throughout the life course in females and males, and ii) investigated potential drivers of age- and sex-specific variation. Our sample provides rare insight into the relationship between oxytocin and age in a …

Ectopic Adipose Tissue In Subsistence Populations With Minimal Coronary Disease, Large Left Atria, And Very Low Rates Of Atrial Fibrillation, Randall C. Thompson, Benjamin C. Trumble, Daniel K. Cummings, Angela D. Neunuebel, Paul L. Hooper, Samuel Wann, Adel H. Allam, Frances Neunuebel, Benjamin D. Gans, Samantha I. King, Edmond Seabright, Caleb E. Finch, Margaret Gatz, Kenneth Buetow, Michael I. Miyamoto, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Christopher J. Ward, Madeleine J. Lee, Ashna Mahadev, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Tianyu Cao, Jonathan Stieglitz, Cameron M. Quick, Gregory S. Thomas, Jagat Narula, Damini Dey, Michael Gurven, Hillard Kaplan

ESI Publications

Background

Methods

Will There Be A Pill For That? ‘Money Dysmorphia’ And The Medicalization Of Struggles For Subsistence, Bojan Savic

Emancipations: A Journal of Critical Social Analysis

This article questions the rationality, operation, and effects of money dysmorphia as an emerging mental health diagnosis. It critiques the medicalization of financial angst amid the capitalist “polycrisis”, showing how the individuation and somatic pathologization of class subordination, socioeconomic precarity, and struggles for subsistence obscure capitalist inequalities, depoliticize them, and shield them from critique. I identify five concurrent strategies through which struggles for subsistence are medicalized: trivialization, reversal of social import, repetition, direct depoliticization, and the substitution of inequality with poverty. Furthermore, I show how the medicalizing discourse reifies money dysmorphia by constructing its social costs. The article concludes by …

Physical Activity Mediates Age Differences In Cognition Among Tsimane Forager-Horticulturalists, Phoebe E. Imms, Nikhil N. Chaudhari, Daniel Cummings, Daniel Eid Rodriguez, Giuseppe Barisano, Paul L. Hooper, M. Katherine Sayre, Edmond Seabright, Randall C. Thompson, M. Linda Sutherland, James D. Sutherland, Benjamin C. Trumble, Michael Gurven, Jonathan Stieglitz, Caleb E. Finch, Hillard S. Kaplan, Wendy J. Mack, Margaret Gatz, Andrei Irimia

ESI Publications

Background: The Tsimane and Moseten of the Bolivian Amazon are highly physically active and exhibit low rates of cognitive impairment and brain atrophy.

Methods: We use structural equation modelling to examine how their physical activity levels mediate the relationship between (1) age and cognition, and (2) age and cognition via brain volume (BV).

Results: Tsimane males (n = 305, mean ± SD age = 59.94 ± 9.68) and Tsimane females (n = 265, mean ± SD age = 59.28 ± 9.79) exhibit significantly higher levels of physical activity than Moseten males (n = 106, mean ± SD …

Cost-Effective Solutions For High-Throughput Enzymatic Dna Methylation Sequencing, Amy Longtin, Marina M. Watowich, Baptiste Sadoughi, Rachel M. Petersen, Sarah F. Brosnan, Kenneth Buetow, Qiuyin Cai, Cayo Biobank Research Unit, Vanderbilt University, Michael D. Gurven, James P. Higham, Heather M. Highland, Yi-Ting Huang, Hillard Kaplan, Thomas S. Kraft, Yvonne A. L. Lim, Jirong Long, Amanda D. Melin, Michael J. Montagne, Jamie Roberson, Kee Seong Ng, Michael L. Platt, India A. Schneider-Crease, Jonathan Stieglitz, Benjamin C. Trumble, Vivek Venkataraman, Ian J. Wallace, Jie Wu, Noah Snyder-Mackler, Angela Jones, Alexander G. Bick, Amanda J. Lea

ESI Publications

Characterizing DNA methylation patterns is important for addressing key questions in evolutionary biology, development, geroscience, and medical genomics. While costs are decreasing, whole-genome DNA methylation profiling remains prohibitively expensive for most population-scale studies, creating a need for cost-effective, reduced representation approaches (i.e., assays that rely on microarrays, enzyme digests, or sequence capture to target a subset of the genome). Most common whole genome and reduced representation techniques rely on bisulfite conversion, which can damage DNA resulting in DNA loss and sequencing biases. Enzymatic methyl sequencing (EM-seq) was recently proposed to overcome these issues, but thorough benchmarking of EM-seq combined with …

Increases In Regional Brain Volume Across Two Native South American Male Populations, Nikhil N. Chaudhari, Phoebe E. Imms, Nathan F. Chowdhury, Margaret Gatz, Benjamin Trumble, Wendy J. Mack, E. Meng Law, M. Linda Sutherland, James D. Sutherland, Christopher J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, David E. Michalik, Michael I. Miyamoto, Guido Lombardi, Daniel Cummings, Edmond Seabright, Sarah Alami, Angela R. Garcia, Daniel E. Rodriguez, Raul Quispe Gutierrez, Adrian J. Copajira, Paul L. Hooper, Kenneth Buetow, Jonathan Stieglitz, Michael D. Gurven, Gregory S. Thomas, Hillard Kaplan, Caleb E. Finch, Andrei Irimia

ESI Publications

Industrialized environments, despite benefits such as higher levels of formal education and lower rates of infections, can also have pernicious impacts upon brain atrophy. Partly for this reason, comparing age-related brain volume trajectories between industrialized and non-industrialized populations can help to suggest lifestyle correlates of brain health. The Tsimane, indigenous to the Bolivian Amazon, derive their subsistence from foraging and horticulture and are physically active. The Moseten, a mixed-ethnicity farming population, are physically active but less than the Tsimane. Within both populations (N = 1024; age range = 46–83), we calculated regional brain volumes from computed tomography and compared …

Poor Oral Health Is Associated With Inflammation, Aortic Valve Calcification, And Brain Volume Among Forager-Farmers, Benjamin C. Trumble, Matthew Schwartz, Andrew T. Ozga, Gary T. Schwartz, Christopher M. Stojanowski, Carrie L. Jenkins, Thomas Kraft, Angela R. Garcia, Daniel K. Cummings, Paul L. Hooper, Daniel Eid Rodriguez, Kenneth Buetow, Bret Beheim, Andrei Irimia, Gregory S. Thomas, Randall C. Thompson, Horus Team, Margaret Gatz, Jonathan Stieglitz, Caleb E. Finch, Michael Gurven, Hillard Kaplan

ESI Publications

Poor oral health is associated with cardiovascular disease and dementia. Potential pathways include sepsis from oral bacteria, systemic inflammation, and nutritional deficiencies. However, in post-industrialized populations, links between oral health and chronic disease may be confounded because the lower socioeconomic exposome (poor diet, pollution, low physical activity) often entails insufficient dental care. We assessed tooth loss, caries, and damaged teeth, in relation to cardiovascular and brain aging among the Tsimane, a subsistence population living a relatively traditional forager-horticulturalist lifestyle with poor dental health, but minimal cardiovascular disease and dementia. Dental health was assessed by a physician in 739 participants aged …

Testosterone Is Positively Associated With Coronary Artery Calcium In A Low Cardiovascular Disease Risk Population, Benjamin Trumble, Jacob Negrey, Stephanie V. Koebele, Randall C. Thompson, L. Samuel Wann, Adel H. Allam, Bret Beheim, M. Linda Sutherland, James D. Sutherland, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Guido P. Lombardi, Angela R. Garcia, Daniel K. Cummings, Edmond Seabright, Sarah Alami, Thomas S. Kraft, Paul L. Hooper, Kenneth Buetow, Andrei Irimia, Margaret Gatz, Jonathan Stieglitz, Michael D. Gurven, Hillard Kaplan, Gregory S. Thomas, Tsimane Health And Life History Project Teams

ESI Publications

Background

In industrialized populations, low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here, we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk and low coronary artery calcium scores.

Methodology

In this cross-sectional community-based study, 719 Tsimane forager-horticulturalists in the Bolivian Amazon aged 40+ years underwent computed tomography (49.8% male, mean age 57.6 years).

Results

Coronary artery calcium levels were low; 84.5% had no coronary artery calcium. Zero-inflated negative binomial models …

Apolipoprotein-Ε4 Is Associated With Higher Fecundity In A Natural Fertility Population, Benjamin Trumble, Mia Charifson, Tom Kraft, Angela R. Garcia, Daniel K. Cummings, Paul L. Hooper, Amanda J. Lea, Daniel Eid Rodriguez, Stephanie V. Koebele, Kenneth Buetow, Bret Beheim, Riana Minocher, Maguin Gutierrez, Gregory S. Thomas, Margaret Gatz, Jonathan Stieglitz, Caleb E. Finch, Hillard Kaplan, Michael Gurven

ESI Publications

In many populations, the apolipoprotein-ε4 (APOE-ε4) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE-ε4 allele remains prevalent. We assess the impact of APOE-ε4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility population of forager-horticulturalists. Among 795 women aged 13 to 90 (20% APOE-ε4 carriers), those with at least one APOE-ε4 allele had 0.3 to 0.5 more children than (ε3/ε3) …

Energetic Costs Of Testosterone In Two Subsistence Populations, Benjamin C. Trumble, Herman Pontzer, Jonathan Stieglitz, Daniel K. Cummings, Brian Wood, Melissa Emery Thompson, David Raichlen, Bret Beheim, Gandhi Yetish, Hillard Kaplan, Michael Gurven

ESI Publications

Objective

Testosterone plays a role in mediating energetic trade-offs between growth, maintenance, and reproduction. Investments in a high testosterone phenotype trade-off against other functions, particularly survival-enhancing immune function and cellular repair; thus only individuals in good condition can maintain both a high testosterone phenotype and somatic maintenance. While these effects are observed in experimental manipulations, they are difficult to demonstrate in free-living animals, particularly in humans. We hypothesize that individuals with higher testosterone will have higher energetic expenditures than those with lower testosterone.

Methods

Total energetic expenditure (TEE) was quantified using doubly labeled water in n = 40 Tsimane forager-horticulturalists …

Reproductive Inequality In Humans And Other Mammals, Cody T. Ross, Paul L. Hooper, Jennifer E. Smith, Adrian V. Jaeggi, Eric Alden Smith, Sergey Gavrilets, Fatema Tuz Zohora, John Ziker, Dimitris Xygalatas, Emily E. Wroblewski, Brian Wood, Bruce Winterhalder, Kai P. Willführ, Aiyana K. Willard, Kara Walker, Christopher Von Rueden, Eckart Voland, Claudia Valeggia, Bapu Vaitla, Samuel Urlacher, Mary Towner, Chun-Yi Sum, Lawrence S. Sugiyama, Karen B. Strier, Kathrine Starkweather, Daniel Major-Smith, Mary Shenk, Rebecca Sear, Edmond Seabright, Ryan Schacht, Brooke Scelza, Shane Scaggs, Jonathan Salerno, Caissa Revilla-Minaya, Daniel Redhead, Anne Pusey, Benjamin Grant Purzycki, Eleanor A. Power, Anne Pisor, Jenni Pettay, Susan Perry, Abigail E. Page, Luis Pacheco-Cobos, Kathryn Oths, Seung-Yun Oh, David Nolin, Daniel Nettle, Cristina Moya, Andrea Bamberg Migliano, Karl J. Mertens, Rita A. Mcnamara, Richard Mcelreath, Siobhan Mattison, Eric Massengill, Frank Marlowe, Felicia Madimenos, Shane Macfarlan, Virpi Lummaa, Roberto Lizarralde, Ruizhe Liu, Melissa A. Liebert, Sheina Lew-Levy, Paul Leslie, Joseph Lanning, Karen Kramer, Jeremy Koster, Hillard S. Kaplan, Bayarsaikhan Jamsranjav, A. Magdalena Hurttado, Kim Hill, Barry Hewlett, Samili Helle, Thomas Headland, Janet Headland, Michael Gurven, Gianluca Grimalda, Russell Greaves, Christopher D. Golden, Irene Godoy, Mhairi Gibson, Claire El Mouden, Mark Dyble, Patricia Draper, Sean Downey, Angelina L. Demarco, Helen Elizabeth Davis, Stefani Crabtree, Carmen Cortez, Heidi Colleran, Emma Cohen, Gregory Clark, Julia Clark, Mark A. Caudell, Chelsea E. Carminito, John Bunce, Adam Boyette, Samuel Bowles, Tami Blumenfield, Bret Beheim, Stephen Beckerman, Quentin Atkinson, Coren Apicella, Nurul Alam, Monique Borgerhoff Mulder

ESI Publications

To address claims of human exceptionalism, we determine where humans fit within the greater mammalian distribution of reproductive inequality. We show that humans exhibit lower reproductive skew (i.e., inequality in the number of surviving offspring) among males and smaller sex differences in reproductive skew than most other mammals, while nevertheless falling within the mammalian range. Additionally, female reproductive skew is higher in polygynous human populations than in polygynous nonhumans mammals on average. This patterning of skew can be attributed in part to the prevalence of monogamy in humans compared to the predominance of polygyny in nonhuman mammals, to the limited …

Atherosclerosis In Indigenous Tsimane: A Contemporary Perspective, Randall C. Thompson, Gregory S. Thomas, Angela D. Neuneubel, Ashna Mahadev, Benjamin Trumble, Edmond Seabright, Daniel K. Cummings, Jonathan Stieglitz, Michael Gurven, Hillard Kaplan

ESI Publications

The Horus and other research teams have found that atherosclerosis is not uncommon in ancient people through the study of their mummified remains (Murphy et al., 2003; Allam et al., 2009, 2011; Thompson et al., 2013, 2014). However, some have postulated that traditional hunter-gatherers are in some ways healthier than modern people and that they had very little atherosclerotic disease (O’Keefe et al., 2010). The aim of this study was to evaluate the burden of atherosclerosis in a population alive today but living a traditional lifestyle similar to that experienced by past populations. This led to the Tsimane Health and …

Natural Selection Of Immune And Metabolic Genes Associated With Health In Two Lowland Bolivian Populations, Amanda J. Lea, Angela Garcia, Jesusa Arevalo, Julien F. Ayroles, Kenneth Buetow, Steve W. Cole, Daniel Eid Rodriguez, Maguin Gutierrez, Heather M. Highland, Paul L. Hooper, Anne Justice, Thomas Kraft, Kari E. North, Jonathan Stieglitz, Hillard Kaplan, Benjamin C. Trumble, Michael Gurven

ESI Publications

A growing body of work has addressed human adaptations to diverse environments using genomic data, but few studies have connected putatively selected alleles to phenotypes, much less among underrepresented populations such as Amerindians. Studies of natural selection and genotype–phenotype relationships in underrepresented populations hold potential to uncover previously undescribed loci underlying evolutionarily and biomedically relevant traits. Here, we worked with the Tsimane and the Moseten, two Amerindian populations inhabiting the Bolivian lowlands. We focused most intensively on the Tsimane, because long-term anthropological work with this group has shown that they have a high burden of both macro and microparasites, as …

Prevalence Of Dementia And Mild Cognitive Impairment In Indigenous Bolivian Forager-Horticulturalists, Margaret Gatz, Wendy J. Mack, Helena C. Chui, E. Meng Law, Giuseppe Barisano, M. Linda Sutherland, James D. Sutherland, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Juan Copajira Adrian, Jesus Bani Cuata, Amy R. Borenstein, Ellen E. Waters, Andrei Irimia, Christopher J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, Michael I. Miyamoto, David E. Michalik, Daniel K. Cummings, Edmond Seabright, Angela R. Garcia, Paul L. Hooper, Thomas S. Kraft, Caleb E. Finch, Gregory S. Thomas, Jonathan Stieglitz, Benjamin C. Trumble, Michael D. Gurven, Hillard Kaplan

ESI Publications

Introduction

We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle.

Methods

Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans.

Results

Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. …

Human Milk Oligosaccharide Compositions Illustrate Global Variations In Early Nutrition, Anita Vinjamuri, Jasmine C. C. Davis, Sarah M. Totten, Lauren D. Wu, Laura D. Klein, Melanie Martin, Ea Quinn, Brooke Scelza, Alicia Breakey, Michael Gurven, Grazyna Jasienska, Hillard Kaplan, Claudia Valeggia, Katie Hinde, Jennifer T. Smilowitz, Robin M. Bernstein, Angela M. Zivkovic, Michael J. Barratt, Jeffrey I. Gordon, Mark A. Underwood, David A. Mills, J. Bruce German, Carlito B. Lebrilla

ESI Publications

Background

Human milk oligosaccharides (HMOs) are an abundant class of compounds found in human milk and have been linked to the development of the infant, and specifically the brain, immune system, and gut microbiome.

Objectives

Advanced analytical methods were used to obtain relative quantitation of many structures in approximately 2000 samples from over 1000 mothers in urban, semirural, and rural sites across geographically diverse countries.

Methods

LC-MS−based analytical methods were used to profile the compounds with broad structural coverage and quantitative information. The profiles revealed their structural heterogeneity and their potential biological roles. Comparisons of HMO compositions were made between …

Embracing Entrepreneurship, Naomy Sengebwila, Naomy Nyendwa Sengebwila

Doctor of Ministry Projects and Theses

Embracing Entrepreneurship

How Christian Social Innovation and Entrepreneurship can Lead to Sustainable Communities in Zambia and Globally

Embracing Entrepreneurship

A Dissertation Presented to the Faculty of Perkins School of Theology Southern Methodist University in Partial Fulfillment of the Requirements for the degree of Doctor of Ministry by

Name of Student

Naomy Nyendwa Sengebwila

Name of Student: Naomy Nyendwa Sengebwila

Date: 03/31/2021

How Christian Social Innovation and Entrepreneurship Can Lead to Sustainable Communities in Zambia and globally

TABLE OF CONTENTS

ACKNOWLEDGMENTS . . . . . . . . . . . . . . . . . . . . …

Very Low Prevalence And Incidence Of Atrial Fibrillation Among Bolivian Forager-Farmers, Christopher J. Rowan, Michael A. Eskander, Edmond Seabright, Daniel Eid Rodriguez, Edhitt Cortez Linares, Raul Quispe Gutierrez, Juan Copajira Adrian, Daniel Cummings, Bret Beheim, Kirsten Tolstrup, Abinash Achrekar, Thomas Kraft, David E. Michalik, Michael I. Miyamoto, Adel H. Allam, L. Samuel Wann, Jagat Narula, Benjamin C. Trumble, Jonathan Stieglitz, Randall C. Thompson, Gregory S. Thomas, Hillard S. Kaplan, Michael D. Gurven

ESI Publications

Background: Atrial fibrillation is the most common arrhythmia in post-industrialized populations. Older age, hypertension, obesity, chronic inflammation, and diabetes are significant atrial fibrillation risk factors, suggesting that modern urban environments may promote atrial fibrillation.

Objective: Here we assess atrial fibrillation prevalence and incidence among tropical horticulturalists of the Bolivian Amazon with high levels of physical activity, a lean diet, and minimal coronary atherosclerosis, but also high infectious disease burden and associated inflammation.

Methods: Between 2005–2019, 1314 Tsimane aged 40–94 years (52% female) and 534 Moseten Amerindians aged 40–89 years (50% female) underwent resting 12-lead electrocardiograms to assess atrial fibrillation prevalence. …

Computed Tomography Shows High Fracture Prevalence Among Physically Active Forager-Horticulturalists With High Fertility, Jonathan Stieglitz, Benjamin C. Trumble, Horus Study Team, Caleb E. Finch, Dong Li, Matthew J. Budoff, Hillard Kaplan, Michael D. Gurven

ESI Publications

Modern humans have more fragile skeletons than other hominins, which may result from physical inactivity. Here, we test whether reproductive effort also compromises bone strength, by measuring using computed tomography thoracic vertebral bone mineral density (BMD) and fracture prevalence among physically active Tsimane forager-horticulturalists. Earlier onset of reproduction and shorter interbirth intervals are associated with reduced BMD for women. Tsimane BMD is lower versus Americans, but only for women, contrary to simple predictions relying on inactivity to explain skeletal fragility. Minimal BMD differences exist between Tsimane and American men, suggesting that systemic factors other than fertility (e.g. diet) do not …

The Dynamics Of Men's Cooperation And Social Status In A Small-Scale Society, Christopher Von Rueden, Daniel Redhead, Rick O'Gorman, Hillard Kaplan, Michael Gurven

ESI Publications

We propose that networks of cooperation and allocation of social status co-emerge in human groups. We substantiate this hypothesis with one of the first longitudinal studies of cooperation in a preindustrial society, spanning 8 years. Using longitudinal social network analysis of cooperation among men, we find large effects of kinship, reciprocity and transitivity in the nomination of cooperation partners over time. Independent of these effects, we show that (i) higher-status individuals gain more cooperation partners, and (ii) individuals gain status by cooperating with individuals of higher status than themselves. We posit that human hierarchies are more egalitarian relative to other …

Kinship Ties Across The Lifespan In Human Communities, Jeremy Koster, Dieter Lukas, David Nolin, Eleanor Power, Alexandra Alvergne, Ruth Mace, Cody T. Ross, Karen Kramer, Russell Graves, Mark Caudell, Shane Macfarlan, Eric Schniter, Robert Quinlan, Siobhan Mattison, Adam Reynolds, Chun Yi-Sim, Eric Massengill

ESI Publications

A hypothesis for the evolution of long post-reproductive lifespans in the human lineage involves asymmetries in relatedness between young immigrant females and the older females in their new groups. In these circumstances, inter-generational reproductive conflicts between younger and older females are predicted to resolve in favor of the younger females, who realize fewer inclusive fitness benefits from ceding reproduction to others. This conceptual model anticipates that immigrants to a community initially have few kin ties to others in the group, gradually showing greater relatedness to group members as they have descendants who remain with them in the group. We examine …

Variation Among Populations In The Immune Protein Composition Of Mother's Milk Reflects Subsistence Pattern, Laura D. Klein, Jincui Huang, Elizabeth A. Quinn, Melanie A. Martin, Alicia A. Breakey, Michael Gurven, Hillard Kaplan, Claudia Valeggia, Grazyna Jasienska, Brooke Scelza, Carlito B. Lebrilla, Katie Hinde

ESI Publications

Lay Summary: Adaptive immune proteins in mothers’ milk are more variable than innate immune proteins across populations and subsistence strategies. These results suggest that the immune defenses in milk are shaped by a mother’s environment throughout her life.

Background and objectives: Mother’s milk contains immune proteins that play critical roles in protecting the infant from infection and priming the infant’s developing immune system during early life. The composition of these molecules in milk, particularly the acquired immune proteins, is thought to reflect a mother’s immunological exposures throughout her life. In this study, we examine the composition of innate …

Marital Violence And Fertility In A Relatively Egalitarian High-Fertility Population, Jonathan Stieglitz, Benjamin C. Trumble, Hillard Kaplan, Michael Gurven

ESI Publications

Ultimate and proximate explanations of men’s physical intimate partner violence (IPV) against women have been proposed. An ultimate explanation posits that IPV is used to achieve a selfish fitness-relevant outcome, and predicts that IPV is associated with greater marital fertility. Proximate IPV explanations contain either complementary strategic components (for example, men’s desire for partner control), non-strategic components (for example, men’s self-regulatory failure), or both strategic and non-strategic components involving social learning. Consistent with an expectation from an ultimate IPV explanation, we find that IPV predicts greater marital fertility among Tsimané forager-horticulturalists of Bolivia (n = 133 marriages, 105 women). This …

Correction To: 'Greater Wealth Inequality, Less Polygyny: Rethinking The Polygyny Threshold Model', Cody T. Ross, Monique Borgerhoff Mulder, Seung-Yun Oh, Samuel Bowles, Bret Beheim, John Bunce, Mark Caudell, Gregory Clark, Heidi Colleran, Carmen Cortez, Patricia Draper, Russell D. Greaves, Michael Gurven, Thomas Headland, Janet Headland, Kim Hill, Barry Hewlett, Hillard Kaplan, Jeremy Koster, Karen Kramer, Frank Marlowe, Richard Mcelereath, David Nolin, Marsha Quinlan, Robert Quinlan, Caissa Revilla-Minaya, Brooke Scelza, Ryan Schacht, Mary Shenk, Ray Uehara, Eckart Voland, Kai Willführ, Bruce Winterhalder, John Ziker, Christopher Von Rueden

ESI Publications

No abstract provided.

Greater Wealth Inequality, Less Polygyny: Rethinking The Polygyny Threshold Model, Cody T. Ross, Monique Borgerhoff Mulder, Seung-Yun Oh, Samuel Bowles, Bret Beheim, John Bunce, Mark Caudell, Gregory Clark, Heidi Colleran, Carmen Cortez, Patricia Draper, Russell D. Greaves, Michael Gurven, Thomas Headland, Janet Headland, Kim Hill, Barry Hewlett, Hillard Kaplan, Jeremy Koster, Karen Kramer, Frank Marlowe, Richard Mcelreath, David Nolin, Marsha Quinlan, Robert Quinlan, Caissa Revilla-Minaya, Brooke Scelza, Ryan Schacht, Mary Shenk, Ray Uehara, Eckart Voland, Kai Willführ, Bruce Winterhalder, John Ziker, Christopher Von Rueden

ESI Publications

Monogamy appears to have become the predominant human mating system with the emergence of highly unequal agricultural populations that replaced relatively egalitarian horticultural populations, challenging the conventional idea—based on the polygyny threshold model—that polygyny should be positively associated with wealth inequality. To address this polygyny paradox, we generalize the standard polygyny threshold model to a mutual mate choice model predicting the fraction of women married polygynously. We then demonstrate two conditions that are jointly sufficient to make monogamy the predominant marriage form, even in highly unequal societies. We assess if these conditions are satisfied using individual-level data from 29 human …

Sex Differences In Political Leadership In An Egalitarian Society, Christopher Von Rueden, Sarah Alami, Hillard Kaplan, Michael Gurven

ESI Publications

We test the contribution of sex differences in physical formidability, education, and cooperation to the acquisition of political leadership in a small-scale society. Among forager-farmers from the Bolivian Amazon, we find that men are more likely to exercise different forms of political leadership, including verbal influence during community meetings, coordination of community projects, and dispute resolution. We show that these differences in leadership are not due to gender per se but are associated with men’s greater number of cooperation partners, greater access to schooling, and greater body size and physical strength. Men’s advantage in cooperation partner number is tied to …

Low Perceived Control Over Health Is Associated With Lower Treatment Uptake In A High Mortality Population Of Bolivian Forager-Farmers, Sarah Alami, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven

ESI Publications

Indigenous people worldwide suffer from higher rates of morbidity and mortality than neighboring populations. In addition to having limited access to public health infrastructure, indigenous people may also have priorities and health perceptions that deter them from seeking adequate modern healthcare. Here we propose that living in a harsh and unpredictable environment reduces motivation to pursue deliberate, costly action to improve health outcomes. We assess whether variation in Health Locus of Control (HLC), a psychological construct designed to capture self-efficacy with respect to health, explains variation in treatment uptake behavior among Tsimane Amerindians (N=690; age range: 40–89 years; 55.8% female; …

Overweight And Obesity: Correlates And Temporal Trends In Global Context, Rajesh Gautam, Amir H. Golnabi, D K. Adak, P Bharati

Department of Mathematics Faculty Scholarship and Creative Works

This work attempts to highlight the global magnitude of the obesity and examining the evolutionary perspective with focus on the correlates and temporal trend. It is based on a wide literature survey following PRISMA. The data on country wise prevalence was obtained after systematic review of over 500 articles and websites on the prevalence of obesity. A total of 301 entries/data points were found for 84 countries. Regression analysis was computed for 177 countries based on prediction made by WHO to identify the correlates. To find out the regional variation, data on height and weight of two different national surveys …

Coronary Atherosclerosis In Indigenous South American Tsimane: A Cross-Sectional Cohort Study, Hillard Kaplan, Randall C. Thompson, Benjamin C. Trumble, L. Samuel Wann, Adel H. Allam, Bret Beheim, Bruno Frohlich, M. Linda Sutherland, James D. Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Guido P. Lombardi, Ram Bedi, Angela R. Garcia, James K. Min, Jagat Narula, Caleb E. Finch, Michael Gurven, Gregory S. Thomas

ESI Publications

Background—Conventional coronary artery disease risk factors might potentially explain at least 90% of the attributable risk of coronary artery disease. To better understand the association between the pre-industrial lifestyle and low prevalence of coronary artery disease risk factors, we examined the Tsimane, a Bolivian population living a subsistence lifestyle of hunting, gathering, fishing, and farming with few cardiovascular risk factors, but high infectious inflammatory burden.

Methods—We did a cross-sectional cohort study including all individuals who self-identified as Tsimane and who were aged 40 years or older. Coronary atherosclerosis was assessed by coronary artery calcium (CAC) scoring done with …

The Tsimane Health And Life History Project: Integrating Anthropology And Biomedicine, Michael Gurven, Jonathan Stieglitz, Benjamin C. Trumble, Aaron D. Blackwell, Bret Beheim, Helen Davis, Hillard Kaplan, Paul L. Hooper

ESI Publications

The Tsimane Health and Life History Project, an integrated bio-behavioral study of the human life course, is designed to test competing hypotheses of human life-history evolution. One aim is to understand the bidirectional connections between life history and social behavior in a highfertility, kin-based context lacking amenities of modern urban life (e.g. sanitation, banks, electricity). Another aim is to understand how a high pathogen burden influences health and well-being during development and adulthood. A third aim addresses how modernization shapes human life histories and sociality. Here we outline the project’s goals, history, and main findings since its inception in 2002. …