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Articles 1 - 8 of 8
Full-Text Articles in Animal Studies
Perinatal Inflammation And Oxidative Stress Alter Adult Rat (Rattus Norvegicus) Motor Behavior, Alexander Young
Perinatal Inflammation And Oxidative Stress Alter Adult Rat (Rattus Norvegicus) Motor Behavior, Alexander Young
Honors College Theses
Recent evidence in comparative animal models suggests that early life exposure to elevated inflammation (via LPS exposure) and oxidative stress (via acetaminophen exposure) may synergistically interact to alter typical neurodevelopmental trajectories, resulting in lasting effects on both behavior and gut-brain neurochemistry. The current study observed emotional and motor behaviors and collected fecal-boli to measure Tyrosine (TE) levels in male and female Long-Evans (Rattus norvegicus) rats. Subjects were either treated with [1] saline [2] lipopolysaccharide (LPS) to introduce an inflammatory state, [3] acetaminophen (APAP) to introduce oxidative stress, or [4] a dual-hit of both LPS + APAP on postnatal day (PD) …
Effects Of Perinatal Exposure To Lipopolysaccharide And Acetaminophen On Learning In Adult Long-Evans Rats, Lucy A. Sivils
Effects Of Perinatal Exposure To Lipopolysaccharide And Acetaminophen On Learning In Adult Long-Evans Rats, Lucy A. Sivils
College of Graduate Studies: Theses & Dissertations
The present study investigated the individual and combined effects of elevated perinatal inflammation, oxidative stress caused by acetaminophen (APAP) exposure, or elevated inflammation and oxidative stress on adult learning behaviors in Long-Evans rats. While prior studies have examined these factors independently, the combined effects of inflammation and oxidative stress via APAP exposure during early development on learning-related behaviors remain unexplored. The present research aimed to address this gap by the analysis of potential long-term neurodevelopmental consequences of lipopolysaccharide (LPS)-induced inflammation and APAP-induced oxidative stress. LPS, APAP, or LPS + APAP was administered during the perinatal period: postnatal days (PD) 9, …
Exploring Police K-9 Deaths, Their Causes, And Possible Remedies, John Wise
Exploring Police K-9 Deaths, Their Causes, And Possible Remedies, John Wise
College of Graduate Studies: Theses & Dissertations
Police K-9s face daily dangers due to their work. Data collected by the Officer Down Memorial Page from 2000-2023 on K-9 deaths (N = 405) shows that of K-9s that die in the line of duty, many fall victim to heat stroke. Research was conducted comparing heat stroke to all other causes of death. Through an exploration into the history of mankind’s use of working dogs, the unique capabilities of both dogs and K-9 specific dog breeds and applying Routine Activity Theory and Lifestyle Routine Activity Theory to police K-9s, this study’s objective is to bring awareness to, and …
The Biobehavioral Effects Of Embryonic Exposure To Neural Inflammation And Oxidative Stress In Zebrafish, Dalton J. Anderson
The Biobehavioral Effects Of Embryonic Exposure To Neural Inflammation And Oxidative Stress In Zebrafish, Dalton J. Anderson
Honors College Theses
The purpose of this research is to improve understanding of the neurodevelopmental effects of embryonic exposure to elevated inflammation and oxidative stress induced by the antipyretic drug acetaminophen (APAP). Our study was the first to examine the interactive effects of APAP and inflammation in zebrafish embryos and how the treatments affect brain development and larval behavior. Experimental groups of zebrafish larvae were exposed to lipopolysaccharide (LPS) to induce inflammation, APAP, or LPS + APAP and larval behavior was analyzed using Ethovision automated behavioral tracking software. We also measured changes in whole-brain Glycogen Synthase Kinase 3 Beta (GSK3B) and GSK3B phosphorylation, …
Developing Sensory Behavioral Assays For Zebrafish Autism Model, Shannon Wagner
Developing Sensory Behavioral Assays For Zebrafish Autism Model, Shannon Wagner
Honors College Theses
Individuals of all ages can suffer from a wide variety of symptoms and disabilities that could be diagnosed as Autism Spectrum Disorder (ASD). Due to new methods and technology, individuals are now being diagnosed in the first two years of their life, which is when the signs of ASD are initially exhibited. Individuals diagnosed with ASD share many similar disabilities and symptoms such as hyperactivity to social, visual, and auditory stimuli, as well as hyposensitivity to olfactory stimuli. Neural circuit-based alterations are widely considered as a cause for these behavioral aberrations. We have created behavioral assays using zebrafish larvae to …
Differentiating The Effects Of Animal-Assisted Versus Equine Facilitated Psychotherapy On Positive Psychological Outcomes Through A Stress Induction Context, Catherine J.V. Jones
Differentiating The Effects Of Animal-Assisted Versus Equine Facilitated Psychotherapy On Positive Psychological Outcomes Through A Stress Induction Context, Catherine J.V. Jones
College of Graduate Studies: Theses & Dissertations
The unique benefits of Equine Facilitated Psychotherapy (EFP) such as the human-horse bond, a non-traditional therapy setting, and performing altruistic acts are thought to facilitate positive change in humans. One mechanism by which positive changes occur is through improved coping and resilience in the face of stress. To date, only a handful of correlational studies speak to the potential effects of EFP on resilience-based outcomes. Thus, this study sought to address this gap in the literature by exploring the benefits of EFP compared to traditional Animal Assisted Therapy (AAT) in an experimental context. Specifically, we examined the effects of different …
An Analysis Of White-Tailed Deer, Odocoileus Virginianus, Killed In Deer Vehicle Accidents On Bulloch County, Ga Roadways, Mackenzie P. Payne 4003933
An Analysis Of White-Tailed Deer, Odocoileus Virginianus, Killed In Deer Vehicle Accidents On Bulloch County, Ga Roadways, Mackenzie P. Payne 4003933
Honors College Theses
White-tailed deer, Odocoileus virginianus, are native to Georgia. With over 1.2 million individuals in the state, White-tailed deer have been implicated in a large number of motor vehicle collisions (ca. 1 million) each year. It is unknown, however, if deer are more likely to be killed: 1) if they are of particular ages (or classes), and 2) in areas with specific road characteristics. We addressed these two questions by collecting the remains of 20 White-tailed deer killed in deer vehicle collisions (“deer vehicle accidents” - DVAs) in Bulloch County, GA. When a deer was located, the road characteristics were …
Are We Smart Enough To Know How Smart Animals Are?, Frans De Waal
Are We Smart Enough To Know How Smart Animals Are?, Frans De Waal
Norman Fries Distinguished Lectureship Series (2002-2022)
No abstract provided.