Animal Studies Commons^™

Systematic Reviews Of Animal Experiments Demonstrate Poor Human Clinical And Toxicological Utility, Andrew Knight

Experimentation Collection

The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxicological utility of animal experiments. In 20 reviews in which clinical utility was examined, the authors concluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one …

Comparison Of Treatment Effects Between Animal Experiments And Clinical Trials: Systematic Review, Pablo Perel, Ian Roberts, Emily Sena, Philipa Wheble, Catherine Briscoe, Peter Sandercock, Malcolm Macleod, Luciano E. Mignini, Pradeep Jayaram, Khalid S. Khan

Validation of Animal Experimentation Collection

Objective To examine concordance between treatment effects in animal experiments and clinical trials.

Study design Systematic review.

Data sources Medline, Embase, SIGLE, NTIS, Science Citation Index, CAB, BIOSIS.

Study selection Animal studies for interventions with unambiguous evidence of a treatment effect (benefit or harm) in clinical trials: head injury, antifibrinolytics in haemorrhage, thrombolysis in acute ischaemic stroke, tirilazad in acute ischaemic stroke, antenatal corticosteroids to prevent neonatal respiratory distress syndrome, and bisphosphonates to treat osteoporosis.

Review methods Data were extracted on study design, allocation concealment, number of randomised animals, type of model, intervention, and outcome.

Results Corticosteroids did not show …

The Poor Contribution Of Chimpanzee Experiments To Biomedical Progress, Andrew Knight

Experimentation Collection

Biomedical research on captive chimpanzees incurs substantial nonhuman animal welfare, ethical, and financial costs that advocates claim result in substantial advancements in biomedical knowledge. However, demonstrating minimal contribution toward the advancement of biomedical knowledge generally, subsequent papers did not cite 49.5% (47/95), of 95 experiments randomly selected from a population of 749 published worldwide between 1995 and 2004. Only 14.7% (14/95) were cited by 27 papers that abstracts indicated described well-developed methods for combating human diseases. However, detailed examination of these medical papers revealed that in vitro studies, human clinical and epidemiological studies, molecular assays and methods, and genomic studies …

Overcoming Ideology: Why It Is Necessary To Create A Culture In Which The Ethical Review Of Protocols Can Flourish, Bernard E. Rollin

Experimentation Collection

My objective in this commentary is to describe and discuss a major threat to the continued thriving of science in our society, which is all the more insidious because it is largely unrecognized by those in the scientific community who are in a position to rectify the problem. Astute people in that community are well aware of many threats to science that include but are not limited to the following: appalling public scientific illiteracy; the unfortunate resurgence of “magic thinking”—reflected in turn in the reappearance of Creationism, which is hostile to evolution—and the billions of dollars spent on evidentially baseless …

Emerging Near-Real Time Forage Monitoring Technology With Application To Large Herbivore Management In Mongolia, Dennis P. Sheehy, Jerry W. Stuth, Douglas E. Johnson, Jay Angerer, Douglas Tolleson

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

Large herbivore livestock and wildlife in Mongolia depend almost entirely for substance on forage standing crop produced each year on natural pastureland. Consequently, both livestock and wildlife are continuously subject to environmental risk, especially drought and severe winter storms, while livestock are also subject to financial risk. As consumption-based livestock production changes to commercialized livestock production, steps taken by the livestock herder to avert both environmental and financial risk to livestock can increase environmental risk to large wild herbivores. A realistic and workable pastureland and risk management system will be critical for conservation of large herbivore habitat. New technologies are …

The Land Is In Your Hands : A Practical Guide For Owners Of Small Rural Landholdings In Western Australia, Department Of Agriculture And Food, Wa

Bulletins 4000 -

This Bulletin discusses various aspects of managing a small farm or property in Western Australia, including soil and land care, vegetation and plant control on farm holdings, water resource management, biosecurity, plant, animal and insect pest control and livestock management.

Level And Source Of Supplemental Selenium For Beef Steers, Scott Fry, Elizabeth B. Kegley, M. Ellen Davis, Michael D. Ratcliff, Douglas L. Galloway, Ron A. Dvorak

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Selenium (Se) is deficient in many Arkansas soils; therefore, an experiment was conducted on steers to evaluate the effects of two supplemental Se sources on performance, blood metabolites, and immune function. Thirty Angus-crossbred steers were blocked by weight and assigned within block to one of 15 pens (two steers/pen). Pens were assigned randomly within blocks to one of three dietary treatments consisting of a corn-soybean meal supplement devoid of supplemental Se (negative control, NC) or corn-soybean meal supplements providing 1.7 mg supplemental Se/d as sodium selenite (inorganic Se, ISe) or as Se yeast (organic Se, OSe). Steers were offered fescue …

The Other Side Of Silence: Rachel Carson’S Views Of Animals, Marc Bekoff, Jan Nystrom

Animal Welfare Collection

The publication of Rachel Carson’s Silent Spring in 1962 is widely regarded as one of the major events that launched the modern environmental movement. Silent Spring is a compelling blend of stories, natural history, human values, and biological facts. In this essay we consider Carson’s attitude toward animals in Silent Spring and in other texts. Despite the facts that she was raised to love Nature and animals, little direct attention has been given to Carson’s views about our moral responsibilities to, and the moral standing of animals. Carson favored responsible stewardship, was more of an animal welfarist and environmentalist/conservation biologist …

Laboratory Routines Cause Animal Stress, Jonathan P. Balcombe, Neal D. Barnard, Chad Sandusky

Laboratory Experiments Collection

Eighty published studies were appraised to document the potential stress associated with three routine laboratory procedures commonly performed on animals: handling, blood collection, and orogastric gavage. We defined handling as any non-invasive manipulation occurring as part of routine husbandry, including lifting an animal and cleaning or moving an animal's cage. Significant changes in physiologic parameters correlated with stress (e.g., serum or plasma concentrations of corticosterone, glucose, growth hormone or prolactin, heart rate, blood pressure, and behavior) were associated with all three procedures in multiple species in the studies we examined. The results of these studies demonstrated that animals responded with …

Animal Model Research: The Apples And Oranges Quandary, Kenneth J. Shapiro

Experimentation Collection

In this paper, I explore the premises underlying the problem of the evaluation of animal models. I argue that the presence of similarities and differences between the model and the modelled, although historically and currently a dominant antinomy framing evaluation, is not a bottom-line consideration. What is critical is 1) whether we learn and 2) whether we improve treatment through the animal model research. Similarity between model and modelled and the closely related concept of validity are not coterminus with these critical evaluative measures. In fact, differences between the model and modelled also can provide impetus to new understanding and …

Laboratory-Scale Evaluation Of Incandescent And Compact Florescent Lamps For Poultry House Lighting, Leanne Gabriel, Donald M. Johnson

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

This laboratory-scale study compared 1000- and 2000-h rated 60W incandescent lamps and 6000-h rated 60W-equivalent compact florescent lamps over 6000 h of simulated broiler-house operation. The four original 1000-h incandescent lamps were replaced 22 times and the four 2000-h incandescent lamps were replaced 14 times. None of the four compact florescent lamps failed during the 6000-h experiment, although one was broken due to human error. Both types of incandescent lamps had significantly higher (p < .0001) mean illuminance (lx) than did the compact florescent lamps. The compact florescent lamps used significantly less (p < .0001) power (W) and had significantly higher (p < .0001) efficiency (lx/W) than the incandescent lamps. Despite a higher initial purchase price, the total cost (purchase + replacement + electrical) of operating compact florescent lamps was approximately 36% lower than the total cost of operating either type of incandescent lamp over the 6000 h period. The results of this study indicate that even at a least-cost price for electricity ($0.04/kW/h), growers can reduce total broiler-house lighting costs by replacing incandescent lamps with compact florescent lamps.

Behavioral Evaluation Of The Psychological Welfare And Environmental Requirements Of Agricultural Research Animals: Theory, Measurement, Ethics, And Practical Implications, Lesley A. King

Experimentation Collection

The welfare of agricultural research animals relies not only on measures of good health but also on the presence of positive emotional states and the absence of aversive or unpleasant subjective states such as fear, frustration, or association with pain. Although subjective states are not inherently observable, their interaction with motivational states can be measured through assessment of motivated behavior, which indicates the priority animals place on obtaining or avoiding specific environmental stimuli and thus allows conclusions regarding the impact of housing, husbandry, and experimental procedures on animal welfare. Preference tests and consumer demand models demonstrate that animal choices are …

Pain And Distress Associated With Polyclonal Antibody Production: Discussion And Recommendations, The Humane Society Of The United States

ANIMAL RESEARCH

The Humane Society of the United States (HSUS) held a workshop in August 2002 in order to develop recommendations for minimizing pain and distress associated with polyclonal antibody (Pab) production. A small group of experts in the fields of antibody production, animal welfare, in vitro alternatives, and/or regulatory compliance participated in the roundtable discussion. The workshop was a scientifically based meeting, and recommendations were based on the extensive experience of the workshop participants as well as published literature regarding the relevant issues.

Participants recognized that insufficient attention has been paid to animal welfare aspects of Pab production, in part because …

Environmental Guidelines For New And Existing Piggeries, A Latto, John Noonan, R. J. Taylor

Bulletins 4000 -

These guidelines apply to the management of Western Australia piggeries in Western Australia, including intensive Growing pigs under intensive conditions where the and extensive operations, straw-based housing and animals spend their entire life cycle indoors, is an combinations of these (otherwise referred to as semi- important part of the Western Australian and intensive housing).

Taking Animal Welfare Seriously: Minimizing Pain And Distress In Research Animals, The Humane Society Of The United States

ANIMAL RESEARCH

Pain and distress caused by specific research models and techniques raise serious concerns for those in the animal welfare community as well as in the scientific community. Yet good estimates of how much animal pain and/or animal distress is caused by particular techniques or methods are not yet available. The HSUS has compiled a preliminary list of research models and techniques that cause pain and distress. Analyses by the USDA and HSUS indicate that the majority of the animals reported in Column E are used in various testing procedures, with vaccine testing prominent among them. More data are needed to …

Evaluation Of Animal Model Research, Kenneth J. Shapiro

Experimentation Collection

It is argued that a concept of evaluation of animal models that is broader and more useful than validation is available. Productive generativity refers to the degree to which a model furthers understanding and leads to more-effective treatment interventions. Results of the application of this novel evaluative frame to several animal models of eating disorders show that this animal-based research has not been productive. The question of the relation between clinic and animal laboratory is discussed.

The Relationship Of Animal Protection Interests To Animal Damage Management: Historic Paths, Contemporary Concerns And The Uncertain Future, John Hadidian

Conservation Biology and Animal Welfare Collection

More than a decade ago Schmidt (1989) called for consideration of animal welfare to become a "firstorder" decision rule in wildlife management concerns, including animal damage control. Although there has been movement in that direction, this clearly has not yet come to pass. This paper takes a brief look at the interests we call animal damage management, animal welfare and protection, animal rights, and environmentalism in order to speculate about their shared concerns and the uncertain future before them. Since animal damage and the management of that damage cannot be abstracted from the environmental context in which they occur, this …

Pastoral Resources And Their Management In The Sandstone-Yalgoo-Paynes Find Area, Western Australia, A M E Van Vreeswyk, P. T. Godden

Agriculture reports

This report covers about 94,700 square kilometres of rangelands in the Sandstone-Yalgoo-Paynes Find area of Western Australia. The area lies within 27°S and 30°S latitudes, and 115°30'E and 120°E longitudes and includes the towns of Sandstone, Yalgoo and Paynes Find. The northern, southern, and eastern limits of the survey area are largely defined by the boundaries of the 1:250,000 scale series map sheets.The western limit is the boundary between the pastoral and agricultural area.

Unrelieved Pain And Distress In Animals: An Analysis Of Usda Data On Experimental Procedures, Martin Stephens, Philip Mendoza, Adrianna Weaver, Tamara Hamilton

Experimentation Collection

Pain and distress are core issues in the field of animal experimentation and in the controversy that surrounds it. We sought to add to the empirical base of the literature on pain and distress by examining government data on experimental procedures that caused unrelieved pain and distress (UPAD) in animals. Of the species regulated by the U.S. Department of Agriculture (USDA), most of the approximately 100,000 animals subjected to UP AD during the year analyzed (1992) were guinea pigs and hamsters. Most of these animals were used in industry laboratories for various testing procedures, primarily vaccine potency testing. We discuss …

Preference And Motivation Testing, David Fraser, Lindsay R. Matthews

Validation of Animal Experimentation Collection

Since the early 1970s, scientists have used preference tests (tests that require animals to choose between two or more different options or environments) as a means of answering questions about animal welfare. Preference tests have been used to establish animals' preferences for common housing options such as ambient temperature, illumination and preferred types of bedding and flooring; to improve the effectiveness of devices such as loading ramps and nest boxes; and to clarify how strongly animals avoid various aspects of confinement and methods of restraint.

To use preference research to answer questions about animal welfare, three issues need to be …

Institutional Animal Care And Use Committees: A Flawed Paradigm Or Work In Progress?, John P. Gluck, F. Barbara Orlans

Animal Welfare Collection

In his challenging article, Steneck (1997) criticized the creation of the Institutional Animal Care and Use Committee (IACUC) system established by the 1985 amendments to the Animal Welfare Act. He saw the IACUC review and approval of biomedical and behavioral research with animals as an unnecessary "reassignment" of duties from existing animal care programs to IACUC committees. He argued that the committees are unable to do the work expected of them for basically three reasons: (a) the membership lacks the expertise in matters relevant to animal research and care, (b) there exists an inherent and disabling conflict of interest, and …

Effect Of Room Arrangement And Blood Sample Collection Sequence On Serum Thyroid Hormone And Cortisol Concentrations In Cynomolgus Macaques (Macacafascicularis), Bryan L. Flow, John T. Jaques

Research Methodology and Laboratory Animals Collection

We evaluated the relationship, in cynomolgus macaques (Macacafascicularis), between rank for order of blood collection with serum concentrations of 3,5,3'-triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), and serum cortisol. These relationships were determined for males and females that were housed in two room arrangements. For both room arrangements, males and females were housed separately. For room arrangement 1, macaques were housed on both sides of the animal holding room. The sides of the animal holding room were designated as side A or side B. Blood was initially collected from animals on side A, then from animals on side B. Animals …

Wildlife Conservation, Zoos And Animal Protection: A Strategic Analysis, Andrew N. Rowan

The publication consists of the proceedings of a workshop, sponsored by the Gilman Foundation, and held in April of 1994 at the White Oak Conservation Center in Florida. About thirty participants were invited from zoos, animal protection groups and academic institutions to discuss concepts such as wild, captive and tame; animal well-being in the wild and in zoos; and protecting individuals versus conserving populations. In order to maximize the time engaged in discussion, several individuals were identified to prepare target articles which were distributed to all participants before the meeting. These articles form the main chapters in this book. Other …

The Value And Utility Of Animals In Research, Andrew N. Rowan, Joan C. Weer

Validation of Animal Experimentation Collection

The Tufts University School of Veterinary Medicine, Center for Animals and Public Policy, sponsored an invitational seminar, The Value and Utility of Animals in Research, on October 14, 1993, at the Hyatt Regency Hotel in Baltimore, Maryland. This seminar was the second in a series of three organized by the Center for Animals and Public Policy and supported by The Pew Charitable Trusts to deal with issues relating to the use of animals in research. The first seminar, Biology Education and Animals: Opportunities and Issues, was held in the spring of 1993. The third meeting, at the National Press Club …

The Place Of Farm Animals In Humane Sustainable Agriculture, M. W. Fox

eBooks

It is not yet widely recognized that the livestock industry has become a major threat to the world's economy, the environment, consumer health, and the food security of nations and generations to come. Farm animals do have a place in ecologically sound agriculture, but, as will be shown, they have not been properly integrated either in the United States or in other developed and less-developed nations of the world.

Repositioning Arizona Lands, D. Dean Bibles

The Public Lands During the Remainder of the 20th Century: Planning, Law, and Policy in the Federal Land Agencies (Summer Conference, June 8-10)

10 pages.

Ski Development In National Forests, Harris D. Sherman, David S. Neslin, Ian K. Whitlock

The Public Lands During the Remainder of the 20th Century: Planning, Law, and Policy in the Federal Land Agencies (Summer Conference, June 8-10)

79 pages.

Carrying Capacity In The National Parks, Denis P. Galvin

The Public Lands During the Remainder of the 20th Century: Planning, Law, and Policy in the Federal Land Agencies (Summer Conference, June 8-10)

4 pages.

Blm Land Planning And Consistency Obligations To Provide For Protection Of Natural Values On Adjacent Protected Lands, William J. Lockhart

The Public Lands During the Remainder of the 20th Century: Planning, Law, and Policy in the Federal Land Agencies (Summer Conference, June 8-10)

60 pages.

Watershed Management And Water Quality Protection, Thomas E. Wilson

The Public Lands During the Remainder of the 20th Century: Planning, Law, and Policy in the Federal Land Agencies (Summer Conference, June 8-10)

11 pages.

Contains references (page 1).