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Articles 4891 - 4920 of 22573
Full-Text Articles in Social and Behavioral Sciences
Minds Circumscribed By Fear. A Review Of Garrisoned Minds: Women And Armed Conflicts In South Asia, Edited By Lazmi Murthy And Mitu Varma, Kushal Srivastava
Minds Circumscribed By Fear. A Review Of Garrisoned Minds: Women And Armed Conflicts In South Asia, Edited By Lazmi Murthy And Mitu Varma, Kushal Srivastava
Dignity: A Journal of Analysis of Exploitation and Violence
No abstract provided.
2022 September, Morehead State University. Office Of Communications & Marketing.
2022 September, Morehead State University. Office Of Communications & Marketing.
Morehead State Press Release Archive, 1961 to the Present
Press releases for September of 2022.
Latinas In The Labor Market, Lorna Rivera, Vishakha Agarwal, Phillip Granberry
Latinas In The Labor Market, Lorna Rivera, Vishakha Agarwal, Phillip Granberry
Gastón Institute Publications
In Massachusetts, the share of Latinas in the overall population has been rapidly increasing. From 2000 to 2019, the number of Latinas increased by 81.5%1 even as the number of Non-Latina women declined by about 5.8% during that same period. The share of Non-Latina White women in the Massachusetts female population dropped from approximately 82% in 2000 to 71% in 2019.
This report offers an in-depth look at the difference between the median wage income and other labor market outcomes of Latina and Non-Latina women in the Massachusetts workforce. (A great majority of Non-Latina women workers in Massachusetts are White …
Executive Compensation And The Potential For Additional Efficiency Gains: Evidence From The Indian Manufacturing Sector, Levent Kutlu, Usha Nair-Reichert
Executive Compensation And The Potential For Additional Efficiency Gains: Evidence From The Indian Manufacturing Sector, Levent Kutlu, Usha Nair-Reichert
School of Economics and Finance Faculty Publications
We examine the relationship between executive compensation and technical efficiency. We highlight heterogeneity in this relationship, identify opportunities for within-sector efficiency gains, and the channels through which such gains occur. Previous research mainly focuses on excessive executive compensation that does not reflect firm performance. We develop unique measures for executive overcompensation and undercompensation, and account for endogeniety. Using firm-level data for the Indian chemical, textile, and pharmaceutical sectors during 2004–2015, we conclude that the median firm overcompensates and large firms undercompensate their executives. Overcompensation decreases firms’ profits as increased executive costs outweigh the benefits of efficiency gains. Firms in the …
Critical Care Nurse Burnout, Moral Distress, And Mental Health During The Covid-19 Pandemic: A United States Survey, Jill L. Guttormson, Kelly Calkins, Natalie S. Mcandrew, Jacklynn M. Fitzgerald, Holly Lynn Losurdo, Danielle Loonsfoot
Critical Care Nurse Burnout, Moral Distress, And Mental Health During The Covid-19 Pandemic: A United States Survey, Jill L. Guttormson, Kelly Calkins, Natalie S. Mcandrew, Jacklynn M. Fitzgerald, Holly Lynn Losurdo, Danielle Loonsfoot
Psychology Faculty Research and Publications
Background
The COVID-19 pandemic has and will continue to have a tremendous influence on intensive care unit (ICU) nurses’ mental health.
Objectives
The purpose of this study was to describe the impact of COVID-19 on nurse moral distress, burnout, and mental health.
Methods
Between October 2020 and January 2021 this descriptive study recruited a national sample of nurses who worked in the ICU during the COVID-19 pandemic through American Association of Critical Care Nurses newsletters and social media.
Results
A total of 488 survey responses were received from critical care nurses working in the U.S. during the COVID pandemic. Over …
Strengthening The Procedural Fidelity Research-To-Practice Loop In Animal Behavior, Tiffany Kodak, Samantha Bergmann, Mindy Waite
Strengthening The Procedural Fidelity Research-To-Practice Loop In Animal Behavior, Tiffany Kodak, Samantha Bergmann, Mindy Waite
Psychology Faculty Research and Publications
Procedural fidelity is the extent to which components of an intervention are implemented as designed. Procedural fidelity is measured as a dependent variable and manipulated as an independent variable. In research and practice, procedural-fidelity data should be collected, monitored, and reported. Procedural fidelity as an independent variable has been investigated in humans using parametric analyses, and the current article summarizes some of the research conducted on the effects of procedural-fidelity errors in behavior-reduction and skill-acquisition interventions. Connections were drawn to applied animal researchers and the work of animal behavior practitioners to produce implications for practice with human and animal clients …
Remodeling Of The Cortical Structure Connectome In Posttraumatic Stress Disorder: Results From The Enigma-Pgc Posttraumatic Stress Disorder Consortium, Jacklynn M. Fitzgerald
Remodeling Of The Cortical Structure Connectome In Posttraumatic Stress Disorder: Results From The Enigma-Pgc Posttraumatic Stress Disorder Consortium, Jacklynn M. Fitzgerald
Psychology Faculty Research and Publications
Background
Posttraumatic Stress Disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA).
Methods
Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n …
Evaluation Of The Control Of Water Sanitation And Hygiene Related Disease Through Community Hygiene Club Intervention In Rwanda, Amans Ntakarutimana, Elias Nyandwi, Nadine Rujeni, Chantal Marie Ingabire Dr, Kato Jonas Njunwa, Théoneste Ntakirutimana, Gaspard Rwanyiziri, Joseph Tuyishimire, Schaddrack Ngabonziza
Evaluation Of The Control Of Water Sanitation And Hygiene Related Disease Through Community Hygiene Club Intervention In Rwanda, Amans Ntakarutimana, Elias Nyandwi, Nadine Rujeni, Chantal Marie Ingabire Dr, Kato Jonas Njunwa, Théoneste Ntakirutimana, Gaspard Rwanyiziri, Joseph Tuyishimire, Schaddrack Ngabonziza
Journal of Social, Behavioral, and Health Sciences
This article consists of a review article reporting the results of previous evaluations of the control of water, sanitation, and hygiene (WASH) related disease through the Community Hygiene Club (CHC) intervention from 2010 to 2020. CHC constitutes the main intervention for the control of WASH-related disease in Rwanda and is implemented countrywide. The study objective was to evaluate if the CHC intervention significantly reduced the prevalence of WASH-related disease after 10 years of its implementation in Rwanda. The study utilized online existing policy documents, research reports, and experiences on the CHC intervention in Rwanda published between 2010 and 2020. We …
Towards An Optimal Bus Frequency Scheduling: When The Waiting Time Matters, Songsong Mo, Zhifeng Bao, Baihua Zheng, Zhiyong Peng
Towards An Optimal Bus Frequency Scheduling: When The Waiting Time Matters, Songsong Mo, Zhifeng Bao, Baihua Zheng, Zhiyong Peng
Research Collection School Of Computing and Information Systems
Reorganizing bus frequencies to cater for actual travel demands can significantly save the cost of the public transport system. This paper studies the bus frequency optimization problem considering the user satisfaction. Specifically, for the first time to our best knowledge, we study how to schedule the buses such that the total number of passengers who could receive their bus services within the waiting time threshold can be maximized. We propose two variants of the problem, FAST and FASTCO, to cater for different application needs and prove that both are NP-hard. To solve FAST effectively and efficiently, we first present an …
Learning To Solve Multiple-Tsp With Time Window And Rejections Via Deep Reinforcement Learning, Rongkai Zhang, Cong Zhang, Zhiguang Cao, Wen Song, Puay Siew Tan, Jie Zhang, Bihan Wen, Justin Dauwels
Learning To Solve Multiple-Tsp With Time Window And Rejections Via Deep Reinforcement Learning, Rongkai Zhang, Cong Zhang, Zhiguang Cao, Wen Song, Puay Siew Tan, Jie Zhang, Bihan Wen, Justin Dauwels
Research Collection School Of Computing and Information Systems
We propose a manager-worker framework (the implementation of our model is publically available at: https://github.com/zcaicaros/manager-worker-mtsptwr) based on deep reinforcement learning to tackle a hard yet nontrivial variant of Travelling Salesman Problem (TSP), i.e. multiple-vehicle TSP with time window and rejections (mTSPTWR), where customers who cannot be served before the deadline are subject to rejections. Particularly, in the proposed framework, a manager agent learns to divide mTSPTWR into sub-routing tasks by assigning customers to each vehicle via a Graph Isomorphism Network (GIN) based policy network. A worker agent learns to solve sub-routing tasks by minimizing the cost in terms of both …
A Method To Develop A Statewide Resource Guide, Needs Assessment, And Service Inventory To Respond To Human Trafficking, Andrea Nichols, Kathleen Preble
A Method To Develop A Statewide Resource Guide, Needs Assessment, And Service Inventory To Respond To Human Trafficking, Andrea Nichols, Kathleen Preble
Dignity: A Journal of Analysis of Exploitation and Violence
The extant research literature indicates that human trafficking survivors have a myriad of service needs, including acute and long-term needs. A statewide resource guide, needs assessment, and service inventory were developed for Missouri through community action research involving a partnership with an anti-trafficking coalition, a consortium of funders, and a series of small research teams. This article details the evolution of a resource guide and describes the methods used to 1) develop a statewide resource guide for human trafficking survivors and the service providers who work with them, 2) evaluate the resource guide, 3) create a statewide/regional service inventory based …
Property In Whose Name? Intrahousehold Bargaining Over Homeownership In China, Jia Yu, Cheng Cheng
Property In Whose Name? Intrahousehold Bargaining Over Homeownership In China, Jia Yu, Cheng Cheng
Research Collection School of Social Sciences
Previous research typically examined homeownership inequality across individuals or households, overlooking the intrahousehold allocation of homeownership. Using couple-level data of the 2016 China Family Panel Studies, our study addresses the gap by examining the bargaining over homeownership between husbands and wives in China. Descriptive results reveal a large gender gap in homeownership: only about one-quarter of couples listed the wife as an owner on the Housing Ownership Certificate, whereas about 92% listed the husband. The gender gap in ownership, however, has narrowed among couples married after 2000. Multivariate analyses show that economic autonomy, relative resources, housing purchase conditions, and modernization …
Access To Power: Electricity And The Infrastructural State In Pakistan, Ijlal Naqvi
Access To Power: Electricity And The Infrastructural State In Pakistan, Ijlal Naqvi
Research Collection School of Social Sciences
Pakistan would desperately like to produce enough electricity, but it usually doesn’t. This is the rare issue on which government and private sector can unite, and it is the cause of suffering for rich and poor alike across the entirety of the country. Despite prioritization by successive governments, targeted reforms shaped by international development actors, and featuring prominently in Chinese Belt and Road Investments, the Pakistani power sector still stifles economic and social life across the country. This book explores state capacity in Pakistan by following the material infrastructure of electricity across the provinces and down into cities and homes. …
Lived Religion In A Digital Age: Technology, Affect And The Pervasive Space-Times Of “New” Religious Praxis, Quan Gao, Orlando Woods, Lily Kong, Siew Ying Shee
Lived Religion In A Digital Age: Technology, Affect And The Pervasive Space-Times Of “New” Religious Praxis, Quan Gao, Orlando Woods, Lily Kong, Siew Ying Shee
Research Collection College of Integrative Studies
This paper explores how Christian practices of prayer are being reconfigured through digital media in Singapore. Although digital technologies are an area of burgeoning interest amongst social and cultural geographers, the ways in which these technologies reconfigure the space-times of religious praxis and engender new affective relations or subjectivities of religion have not yet been embraced. This paper fills the lacuna by bringing existing studies on religion, technology and affect into constructive conversation with each other. By elaborating on digital prayer as an affective assemblage of religious practice, we show how digital technologies blur institutional boundaries and create new affordances …
Individual Perceptions Of Climate Anomalies And Collective Action: Evidence From An Artefactual Field Experiment In Malaysian Borneo, Terry Van Gevelt, T. Zamanb, K.N. Chanc, M.M. Bennettd
Individual Perceptions Of Climate Anomalies And Collective Action: Evidence From An Artefactual Field Experiment In Malaysian Borneo, Terry Van Gevelt, T. Zamanb, K.N. Chanc, M.M. Bennettd
Research Collection College of Integrative Studies
We explore the effect of individual perceptions of climate anomalies on collective action within a context of environmental complexity and uncertainty. To do so, we construct two competing propositions that are theoretically robust but with very different real-world implications. Our first proposition suggests that collective action to adapt to climate change is likely to be more effective when perceptions of climate anomalies converge within a community. Our second proposition suggests the opposite: that convergence is likely to hinder adaptation behaviour. We use a community co-designed measure of perceptions and an artefactual field experiment to test our propositions and explore the …
Desert Arcologies And Path Dependencies, Sayd Randle
Desert Arcologies And Path Dependencies, Sayd Randle
Research Collection College of Integrative Studies
In Phoenix, Arizona last year, the local high temperature topped 100 degrees Fahrenheit on 145 days, a new record. Of those 145, 53 days saw top temperatures above 110 and 14 days exceeded 115 – also new peaks. Taken together, these numbers strongly suggest that to live out 2020 in Phoenix was to inhabit an environment sliding towards a painful, and perhaps even hellish, new baseline. Of course, numbers are known to occlude at least as much as they reveal. But in the case of Arizona’s largest metropolitan area, they’re useful for framing a certain conventional wisdom about the place: …
Visualizing Politics In Indonesia: The Design And Distribution Of Election Posters, Colm A. Fox
Visualizing Politics In Indonesia: The Design And Distribution Of Election Posters, Colm A. Fox
Research Collection School of Social Sciences
Where studies have shown that visuals are the primary means of political communication, research continues to focus largely on text-based information. To add to our understanding of visual-political communications, this article analyses Indonesian election posters since the 1950s. Drawing on historical materials and on a content analysis of 4,000 election posters, it asks why election posters have been designed and distributed in particular ways. Findings indicate that in the past, posters used singular, though powerful, social symbols to mobilize demographic groups behind political parties. However, contemporary posters are more visually complex and more candidate-centered, making arguments as to what the …
Exhibiting Transnationalism After Vietnam: The Alpha Gallery In Pursuit Of An Authentic Southeast Asian Art Form, Wen-Qing (Wei Wenqing) Ngoei
Exhibiting Transnationalism After Vietnam: The Alpha Gallery In Pursuit Of An Authentic Southeast Asian Art Form, Wen-Qing (Wei Wenqing) Ngoei
Research Collection School of Social Sciences
This essay examines how the Alpha Gallery, an independent artists cooperative established by Malaysians and Singaporeans, curated and staged art shows in the 1970s that advanced its project to unearth and promote an intrinsically Southeast Asian aesthetic. The cooperative pursuit a transnational vision of inter-regional connections between the Bengali Art Renaissance of the early twentieth century and Balinese folk art. It also harbored ambitions of sparking a cultural renaissance in Southeast Asia, though these were ultimately unfulfilled. Importantly, as this essay shows, the cooperative’s transnational vision mirrored the racist thinking and paternalism of Euro-American colonial discourses about civilizing the region’s …
Fundamental Social Motives Measured Across Forty-Two Cultures In Two Waves, C. M. Pick, ..., Norman P. Li
Fundamental Social Motives Measured Across Forty-Two Cultures In Two Waves, C. M. Pick, ..., Norman P. Li
Research Collection School of Social Sciences
How does psychology vary across human societies? The fundamental social motives framework adopts an evolutionary approach to capture the broad range of human social goals within a taxonomy of ancestrally recurring threats and opportunities. These motives—self-protection, disease avoidance, affiliation, status, mate acquisition, mate retention, and kin care—are high in fitness relevance and everyday salience, yet understudied cross-culturally. Here, we gathered data on these motives in 42 countries (N = 15,915) in two cross-sectional waves, including 19 countries (N = 10,907) for which data were gathered in both waves. Wave 1 was collected from mid-2016 through late 2019 (32 countries, N …
In Covid-19 Health Messaging, Loss Framing Increases Anxiety With Little-To-No Concomitant Benefits: Experimental Evidence From 84 Countries, Charles A. Dorison, Et. Al., Andree Hartanto
In Covid-19 Health Messaging, Loss Framing Increases Anxiety With Little-To-No Concomitant Benefits: Experimental Evidence From 84 Countries, Charles A. Dorison, Et. Al., Andree Hartanto
Research Collection School of Social Sciences
The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., “If you do not practice these steps, you can endanger yourself and others”) or potential gains (e.g., “If you practice these steps, you can protect yourself and others”)? Collecting data in 48 languages from 15,929 participants in 84 countries, we experimentally tested the effects of message …
Potential And Pitfalls Of Mobile Mental Health Apps In Traditional Treatment: An Umbrella Review, Jerica Koh, Germaine Y. Q. Tng, Andree Hartanto
Potential And Pitfalls Of Mobile Mental Health Apps In Traditional Treatment: An Umbrella Review, Jerica Koh, Germaine Y. Q. Tng, Andree Hartanto
Research Collection School of Social Sciences
While the rapid growth of mobile mental health applications has offered an avenue of support unbridled by physical distance, time, and cost, the digitalization of traditional interventions has also triggered doubts surrounding their effectiveness and safety. Given the need for a more comprehensive and up-to-date understanding of mobile mental health apps in traditional treatment, this umbrella review provides a holistic summary of their key potential and pitfalls. A total of 36 reviews published between 2014 and 2022—including systematic reviews, meta-analyses, scoping reviews, and literature reviews—were identified from the Cochrane library, Medline (via PubMed Central), and Scopus databases. The majority of …
Cultivating Positivity To Achieve A Resilient Society: A Critical Narrative Review From Psychological Perspectives, Andree Hartanto, K. T. A. Sandeeshwara Kasturiratna, Xun Ci Soh
Cultivating Positivity To Achieve A Resilient Society: A Critical Narrative Review From Psychological Perspectives, Andree Hartanto, K. T. A. Sandeeshwara Kasturiratna, Xun Ci Soh
Research Collection School of Social Sciences
With the rapid speed of globalization and technological breakthroughs, current social issues have become more complex than in past decades. As many issues such as pandemics, terrorism, and interracial conflict are realistically unpredictable, the idea of resilience offers an intuitively plausible and attainable strategy to deal with these potential adversities. The current narrative review explores the cultivation of positive emotions and traits as a plausible way to achieve a resilient society. Based on research in the social and industrial organizational psychology literature, we reviewed the role of positive emotions and traits on resilience. Lastly, we highlight important experiences and interventions …
Secured Transactions Law In Asia: Principles, Perspectives And Reform By Louise Gullifer And Dora Neo, Wee Ling Loo
Secured Transactions Law In Asia: Principles, Perspectives And Reform By Louise Gullifer And Dora Neo, Wee Ling Loo
Research Collection Yong Pung How School Of Law
Secured Transactions Law in Asia: Principles, Perspectives and Reform is the third in a series of works that critically examine secured transactions law reform around the world. From a focus on reforms in Europe in the first book to reforms in Africa in the second, this third volume looks at Asia, and specifically at reforms in 13 major Asian jurisdictions: China, Indonesia, Japan, Philippines, South Korea, Taiwan, Thailand, Vietnam, Brunei Darussalam, Bangladesh, India, Pakistan and Singapore. The collection of essays by leading experts from academia, legal practice and the World Bank Group was first presented at a 2018 conference jointly …
Social Media Mining Under The Covid-19 Context: Progress, Challenges, And Opportunities, Xiao Huang, Siqin Wang, Mengxi Zhang, Tao Hu, Alexander Hohl, Bing She, Jianxin Li, Xiao Liu, Oliver Gruebner, Regina Liu, Xiao Li, Zhewei Liu, Xinyue Ye, Zhenlong Li
Social Media Mining Under The Covid-19 Context: Progress, Challenges, And Opportunities, Xiao Huang, Siqin Wang, Mengxi Zhang, Tao Hu, Alexander Hohl, Bing She, Jianxin Li, Xiao Liu, Oliver Gruebner, Regina Liu, Xiao Li, Zhewei Liu, Xinyue Ye, Zhenlong Li
Geosciences Faculty Publications and Presentations
Social media platforms allow users worldwide to create and share information, forging vast sensing networks that allow information on certain topics to be collected, stored, mined, and analyzed in a rapid manner. During the COVID-19 pandemic, extensive social media mining efforts have been undertaken to tackle COVID-19 challenges from various perspectives. This review summarizes the progress of social media data mining studies in the COVID-19 contexts and categorizes them into six major domains, including early warning and detection, human mobility monitoring, communication and information conveying, public attitudes and emotions, infodemic and misinformation, and hatred and violence. We further document essential …
Infrared Thermography In The Built Environment: A Multi-Scale Review, Miguel Martin, Adrian Chong, Filip Biljecki, Clayton Miller
Infrared Thermography In The Built Environment: A Multi-Scale Review, Miguel Martin, Adrian Chong, Filip Biljecki, Clayton Miller
Research Collection College of Integrative Studies
The paper presents a review on major contributions in infrared thermography to study the built environment at multiple scales. To elaborate the review, hundreds of studies conducted between the 1980s and 2020s were first selected based on their relevance to the scope. Afterward, the most relevant contributions were classified and chronologically sorted. From the classification, it is observed that most reviewed studies were conducted to evaluate the thermal performance of buildings or detect their defects using images collected by an infrared camera. At the same time, a considerable number of studies used thermal images obtained by a satellite to observe …
The Influence Of Nurse Manager Competency On Practice Environment, Missed Nursing Care, And Patient Care Quality: A Cross-Sectional Study Of Nurse Managers In U.S. Hospitals, Nora E. Warshawsky, Emily Cramer, Elizabeth M. Grandfield, Ann E. Schlotzhauer
The Influence Of Nurse Manager Competency On Practice Environment, Missed Nursing Care, And Patient Care Quality: A Cross-Sectional Study Of Nurse Managers In U.S. Hospitals, Nora E. Warshawsky, Emily Cramer, Elizabeth M. Grandfield, Ann E. Schlotzhauer
Psychological Science Faculty Research & Creative Works
Aims: Identify and examine drivers of nurse manager competency and high-quality practice environments. Background: Nurse managers are a key predictor of positive professional practice environments, which are, in turn, associated with nurse, patient, and organizational outcomes. However, little work has examined the factors that contribute to nurse manager competency. Methods: Nurse managers completed online surveys, which were matched to unit-level aggregate data of their subordinate direct care nurses' responses on the National Database of Nursing Quality Indicators. This resulted in a final sample of 541 nurse managers across 47 U.S. hospitals. Multilevel path analysis was utilized to assess a model …
Heterogeneity In The Prevalence Of Premature Hypertension Among Asian American Populations Compared With White Individuals: A National Health Interview Survey Study, Sina Kianoush, Mahmoud Al Rifai, Anwar T Merchant, Xiaoming Jia, Zainab Samad, Aneil Bhalla, Ayesha Khan, Dongshan Zhu, Salim Virani
Heterogeneity In The Prevalence Of Premature Hypertension Among Asian American Populations Compared With White Individuals: A National Health Interview Survey Study, Sina Kianoush, Mahmoud Al Rifai, Anwar T Merchant, Xiaoming Jia, Zainab Samad, Aneil Bhalla, Ayesha Khan, Dongshan Zhu, Salim Virani
Faculty, Staff and Students Publications
BACKGROUND: Differences in prevalence of risk factors such as hypertension may explain heterogeneity in cardiovascular risk across Asian American populations.
METHODS: We used National Health Interview Survey (NHIS) data from 2006 to 2018 among White, Chinese, Asian Indian, Filipino, and 'other Asians' (Japanese, Korean, and Vietnamese). Unadjusted and adjusted odds ratios (aOR) with 95% confidence intervals were reported using logistic regression models for the association between race and self-reported premature hypertension (ageold). Models were adjusted for sex, education, body mass index, smoking status, diabetes, and coronary heart disease.
RESULTS: We studied 99,864 participants with history of hypertension (mean age, 59.3 …
High Prevalence Of Osteopathy In Chronic Pancreatitis: A Cross-Sectional Analysis From The Proceed Study, Phil A Hart, Dhiraj Yadav, Liang Li, Savi Appana, William Fisher, Evan Fogel, Chris E Forsmark, Walter G Park, Stephen Pandol, Mark D Topazian, Stephen K Van Den Eden, Santhi Swaroop Vege, David Bradley, Jose Serrano, Darwin L Conwell
High Prevalence Of Osteopathy In Chronic Pancreatitis: A Cross-Sectional Analysis From The Proceed Study, Phil A Hart, Dhiraj Yadav, Liang Li, Savi Appana, William Fisher, Evan Fogel, Chris E Forsmark, Walter G Park, Stephen Pandol, Mark D Topazian, Stephen K Van Den Eden, Santhi Swaroop Vege, David Bradley, Jose Serrano, Darwin L Conwell
Center for Medical Ethics and Health Policy Staff Publications
Background & aims: Chronic pancreatitis (CP) is associated with osteopathy (osteoporosis or osteopenia). However, existing literature is mostly limited to retrospective or administrative studies that have not clearly defined the prevalence and risk factors. Our aim was to identify patient- and disease-related associations with osteopathy in a prospective cohort study of CP.
Methods: We studied 282 subjects with definitive CP enrolled in the PROCEED study who had a baseline dual-energy X-ray absorptiometry (DXA) scan. Osteopenia and osteoporosis were defined using the lowest T-scores. Clinical data were collected using standardized case report forms. Comparisons were performed with a multivariate logistic regression …
Rates Of Laboratory Adverse Events By Course In Paediatric Leukaemia Ascertained With Automated Electronic Health Record Extraction: A Retrospective Cohort Study From The Children’S Oncology Group, Tamara P Miller, Kelly D Getz, Yimei Li, Biniyam G Demissei, Peter C Adamson, Todd A Alonzo, Evanette Burrows, Lusha Cao, Sharon M Castellino, Marla H Daves, Brian T Fisher, Robert Gerbing, Robert W Grundmeier, Edward M Krause, Judy Lee, Philip J Lupo, Karen R Rabin, Mark Ramos, Michael E Scheurer, Jennifer J Wilkes, Lena E Winestone, Douglas S Hawkins, M Monica Gramatges, Richard Aplenc
Rates Of Laboratory Adverse Events By Course In Paediatric Leukaemia Ascertained With Automated Electronic Health Record Extraction: A Retrospective Cohort Study From The Children’S Oncology Group, Tamara P Miller, Kelly D Getz, Yimei Li, Biniyam G Demissei, Peter C Adamson, Todd A Alonzo, Evanette Burrows, Lusha Cao, Sharon M Castellino, Marla H Daves, Brian T Fisher, Robert Gerbing, Robert W Grundmeier, Edward M Krause, Judy Lee, Philip J Lupo, Karen R Rabin, Mark Ramos, Michael E Scheurer, Jennifer J Wilkes, Lena E Winestone, Douglas S Hawkins, M Monica Gramatges, Richard Aplenc
Center for Medical Ethics and Health Policy Staff Publications
Background: Adverse events are often misreported in clinical trials, leading to an incomplete understanding of toxicities. We aimed to test automated laboratory adverse event ascertainment and grading (via the ExtractEHR automated package) to assess its scalability and define adverse event rates for children with acute myeloid leukaemia and acute lymphoblastic leukaemia.
Methods: For this retrospective cohort study from the Children's Oncology Group (COG), we included patients aged 0-22 years treated for acute myeloid leukaemia or acute lymphoblastic leukaemia at Children's Healthcare of Atlanta (Atlanta, GA, USA) from Jan 1, 2010, to Nov 1, 2018, at the Children's Hospital of Philadelphia …
Vaccine-Linked Chemotherapy With A Low Dose Of Benznidazole Plus A Bivalent Recombinant Protein Vaccine Prevents The Development Of Cardiac Fibrosis Caused By Trypanosoma Cruzi In Chronically-Infected Balb/C Mice, Victor Manuel Dzul-Huchim, Maria Jesus Ramirez-Sierra, Pedro Pablo Martinez-Vega, Miguel Enrique Rosado-Vallado, Victor Ermilo Arana-Argaez, Jaime Ortega-Lopez, Fabian Gusovsky, Eric Dumonteil, Julio Vladimir Cruz-Chan, Peter Hotez, María Elena Bottazzi, Liliana Estefania Villanueva-Lizama
Vaccine-Linked Chemotherapy With A Low Dose Of Benznidazole Plus A Bivalent Recombinant Protein Vaccine Prevents The Development Of Cardiac Fibrosis Caused By Trypanosoma Cruzi In Chronically-Infected Balb/C Mice, Victor Manuel Dzul-Huchim, Maria Jesus Ramirez-Sierra, Pedro Pablo Martinez-Vega, Miguel Enrique Rosado-Vallado, Victor Ermilo Arana-Argaez, Jaime Ortega-Lopez, Fabian Gusovsky, Eric Dumonteil, Julio Vladimir Cruz-Chan, Peter Hotez, María Elena Bottazzi, Liliana Estefania Villanueva-Lizama
Center for Medical Ethics and Health Policy Staff Publications
Background: Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6-7 million people worldwide. Approximately 30% of chronic patients develop chronic chagasic cardiomyopathy (CCC) after decades. Benznidazole (BNZ), one of the first-line chemotherapy used for CD, induces toxicity and fails to halt the progression of CCC in chronic patients. The recombinant parasite-derived antigens, including Tc24, Tc24-C4, TSA-1, and TSA-1-C4 with Toll-like receptor 4 (TLR-4) agonist-adjuvants reduce cardiac parasite burdens, heart inflammation, and fibrosis, leading us to envision their use as immunotherapy together with BNZ. Given genetic immunization (DNA vaccines) encoding Tc24 and TSA-1 induce protective immunity in mice and …