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Casual Mediation Analyses With Structural Mean Models, Thomas R. Tenhave, Marshall Joffe, Kevin Lynch, Greg Brown, Stephen Maisto
Casual Mediation Analyses With Structural Mean Models, Thomas R. Tenhave, Marshall Joffe, Kevin Lynch, Greg Brown, Stephen Maisto
UPenn Biostatistics Working Papers
We represent a linear structural mean model (SMM)approach for analyzing mediation of a randomized baseline intervention's effect on a univariate follow-up outcome. Unlike standard mediation analyses, our approach does not assume that the mediating factor is randomly assigned to individuals (i.e., sequential ignorability). Hence, a comparison of the results of the proposed and standard approaches in with respect to mediation offers a sensitivity analyses of the sequential ignorability assumption. The G-estimation procedure for the proposed SMM represents an extension of the work on direct effects of randomized treatment effects for survival outcomes by Robins and Greenland (1994) (Section 5.0 and …