Statistical Models Commons^™

Estimating And Testing Treatment Effects With Misclassified Multivariate Data, Zi Ye

Theses and Dissertations--Statistics

Clinical trials are often used to assess drug efficacy and safety. Participants are sometimes pre-stratified into different groups by diagnostic tools. However, these diagnostic tools are fallible. The traditional method ignores this problem and assumes the diagnostic devices are perfect. This assumption will lead to inefficient and biased estimators. In this era of personalized medicine and measurement-based care, the issues of bias and efficiency are of paramount importance. Despite the prominence, only few researches evaluated the treatment effect in the presence of misclassifications in some special cases and most others focus on assessing the accuracy of the diagnostic devices. In …