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Full-Text Articles in Statistical Models
Empirical Bayes Analysis Of Rna-Seq Data For Detection Of Gene Expression Heterosis, Jarad Niemi, Eric Mittman, Will Landau, Dan Nettleton
Empirical Bayes Analysis Of Rna-Seq Data For Detection Of Gene Expression Heterosis, Jarad Niemi, Eric Mittman, Will Landau, Dan Nettleton
Dan Nettleton
An important type of heterosis, known as hybrid vigor, refers to the enhancements in the phenotype of hybrid progeny relative to their inbred parents. Although hybrid vigor is extensively utilized in agriculture, its molecular basis is still largely unknown. In an effort to understand phenotypic heterosis at the molecular level, researchers are measuring transcript abundance levels of thousands of genes in parental inbred lines and their hybrid offspring using RNA sequencing (RNA-seq) technology. The resulting data allow researchers to search for evidence of gene expression heterosis as one potential molecular mechanism underlying heterosis of agriculturally important traits. The null hypotheses …
Log-Negative Binomial Regression As A Generalized Linear Model, Joseph Hilbe
Log-Negative Binomial Regression As A Generalized Linear Model, Joseph Hilbe
Joseph M Hilbe
The negative binomial (NB) is a member of the exponential family of discrete probability distributions. The nature of the distribution is itself well understood, but its contribution to regression modeling, in particular as a generalized linear model (GLM), has not been appreciated. The mathematical properties of the negative binomial are derived and GLM algorithms are developed for both the canonical and log form. Geometric regression is seen as an instance of the NB. The log forms of both may be effectively used to model types of POisson-overdispersed count data. A GLM-type algorithm is created for a general log-negative binomial regression …