Statistical Models Commons^™

C2bat: A Novel Method For Association Between Ge- Netic Markers And Multiple Phenotypes, Melissa Naylor, Christoph Lange

Harvard University Biostatistics Working Paper Series

The purpose of this technical report is to describe a novel method developed to detect association between a genetic marker and multiple phenotypes. In order to obtain a one-degree of freedom test, a generalized principal component approach is suggested that aggregates the information about the genetic effect in the first prin- cipal component, while the remain principal components contain only environment noise. A limited simulation study is done validating the method. For scenarios in which the genetic effect is constant across all measurements and there is no envi- ronmental correlation between the measurements, preliminary results suggest that this method has …