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Autoradiography; Bayesian analysis; Image analysis; Markov random elds; RJMCMC; Swendsen-Wang algorithm
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Full-Text Articles in Statistical Models
Bayesian Bivariate Image Analysis With Application To Dual Autoradiography, Timothy D. Johnson, Morand Piert
Bayesian Bivariate Image Analysis With Application To Dual Autoradiography, Timothy D. Johnson, Morand Piert
The University of Michigan Department of Biostatistics Working Paper Series
We present a Bayesian bivariate image model and apply it to a study that was designed to investigate the relationship between hypoxia and angiogenesis in an animal tumor model. Two radiolabeled tracers (one measuring angio- genesis, the other measuring hypoxia) were simultaneously injected into the animals, the tumors removed and autoradiographic images of the tracer concentrations were obtained. We model correlation between tracers with a mixture of bivariate normal distributions and the spatial correlation inherent in the images by means of the celebrated Potts model. Although the Potts model is typically used for image segmentation, we use it solely as …