Open Access. Powered by Scholars. Published by Universities.®

Statistical Models Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 9 of 9

Full-Text Articles in Statistical Models

Gene Set Testing By Distance Correlation, Sho-Hsien Su Dec 2020

Gene Set Testing By Distance Correlation, Sho-Hsien Su

Graduate Theses and Dissertations

Pathways are the functional building blocks of complex diseases such as cancers. Pathway-level studies may provide insights on some important biological processes. Gene set test is an important tool to study the differential expression of a gene set between two groups, e.g., cancer vs normal. The differential expression of a gene set could be due to the difference in mean, variability, or both. However, most existing gene set tests only target the mean difference but overlook other types of differential expression. In this thesis, we propose to use the recently developed distance correlation for gene set testing. To assess the …


Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das Dec 2020

Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das

Electronic Theses and Dissertations

Recently, gene set analysis has become the first choice for gaining insights into the underlying complex biology of diseases through high-throughput genomic studies, such as Microarrays, bulk RNA-Sequencing, single cell RNA-Sequencing, etc. It also reduces the complexity of statistical analysis and enhances the explanatory power of the obtained results. Further, the statistical structure and steps common to these approaches have not yet been comprehensively discussed, which limits their utility. Hence, a comprehensive overview of the available gene set analysis approaches used for different high-throughput genomic studies is provided. The analysis of gene sets is usually carried out based on …


A Management Strategy Evaluation Of The Impacts Of Interspecific Competition And Recreational Fishery Dynamics On Vermilion Snapper (Rhomboplites Aurorubens) In The Gulf Of Mexico, Megumi C. Oshima Dec 2020

A Management Strategy Evaluation Of The Impacts Of Interspecific Competition And Recreational Fishery Dynamics On Vermilion Snapper (Rhomboplites Aurorubens) In The Gulf Of Mexico, Megumi C. Oshima

Dissertations

In the Gulf of Mexico (GOM), Vermilion Snapper (Rhomboplites auroruben), are believed to compete with Red Snapper directly for prey and habitat. The two species share similar diets and have significant spatial overlap in the Gulf. Red Snapper are thought to be the dominate competitor, forcing Vermilion Snapper to feed on less nutritious prey when local resources are depleted. In addition to ecological pressures, GOM Vermilion Snapper support substantial commercial and recreational fisheries. Over the past decade, recreational landings have steadily increased, reaching a historical high in 2018. One cause may be stricter regulations for similar target species such as …


Stochastic Modeling Of Ovarian Follicle Growth In Adult Female Rats, Zhaozhi Li Nov 2020

Stochastic Modeling Of Ovarian Follicle Growth In Adult Female Rats, Zhaozhi Li

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Structural Analysis Of The Multifunctional Spoiie Regulatory Protein Of Clostridioides Difficile., Blythe Emily Bunkers Jul 2020

Structural Analysis Of The Multifunctional Spoiie Regulatory Protein Of Clostridioides Difficile., Blythe Emily Bunkers

Graduate Theses and Dissertations

Clostridioides (formally Clostridium) difficile is a medically relevant pathogen pertinent to infectious disease research. C. difficile is distinctly known for its ability to produce two toxins, enterotoxin A and cytotoxin B, and the propensity to colonize the mammalian gastrointestinal tract. It is known that metabolism is tightly correlated with sporulation in endospore producers such as C. difficile, but an interesting and novel regulatory relationship found by the Ivey lab has yet to be understood. The relationship explored in this study is observed between the sporulation factor, SpoIIE, which represses expression of an ABC peptide transporter, app. In this study, two …


Statistical Inference Of Adaptation At Multiple Genomic Scales Using Supervised Classification And A Hidden Markov Model, Lauren A. Sugden May 2020

Statistical Inference Of Adaptation At Multiple Genomic Scales Using Supervised Classification And A Hidden Markov Model, Lauren A. Sugden

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modeling Species Distribution And Habitat Suitability Of American Ginseng (Panax Quinquefolius) In Virginia, Jacob D. J. Peters May 2020

Modeling Species Distribution And Habitat Suitability Of American Ginseng (Panax Quinquefolius) In Virginia, Jacob D. J. Peters

Masters Theses, 2020-current

American ginseng (Panax quinquefolius) is a well-known and sought-after medicinal plant native to North America that is facing increased threat of extinction due to overharvesting, herbivory, and habitat loss. Species distribution and habitat suitability models may be valuable to landowners interested in sustainable harvest or to institutions interested in the conservation and restoration of the species. With unequal sampling efforts across a region of interest, it is likely that some locations with appropriate habitat may be misrepresented in model predictions. This study refined a state-derived species distribution model for ginseng through increased sampling effort across the Cumberland Plateau …


An Analysis Of Dredge Efficiency For Surfclam And Ocean Quahog Commercial Dredges, Leanne Poussard May 2020

An Analysis Of Dredge Efficiency For Surfclam And Ocean Quahog Commercial Dredges, Leanne Poussard

Master's Theses

Between 1997 and 2011, The National Marine Fisheries Service conducted 50 depletion experiments to estimate survey gear efficiency and stock density for Atlantic surfclam (Spisula solidissima) and ocean quahog (Arctica islandica) populations using commercial hydraulic dredges. The Patch Model was formulated to estimate gear efficiency and organism density from the data. The range of efficiencies estimated is substantial, leading to uncertainty in the application of these estimates in stock assessment. Analysis of depletion experiment simulations showed that uncertainty in the estimates of gear efficiency from depletion experiments was reduced by higher numbers of dredge tows per experiment, more tow overlap …


484— Modeling Social Distancing Methods And Their Effectiveness In Combating The Spread Of Ebola, Rachel Fair Apr 2020

484— Modeling Social Distancing Methods And Their Effectiveness In Combating The Spread Of Ebola, Rachel Fair

GREAT Day Posters

Ebola Virus Disease (EVD) is a rare but severe disease that is transmitted among humans through direct-contact with, and close proximity to, infected bodily fluids. From 2014-16, West Africa experienced the largest Ebola outbreak ever recorded, infecting over 28,000 people, and killing over 11,000. Although the symptoms of EVD are treatable, the disease can be extremely deadly, with an average of 50% EVD cases resulting in fatality. In areas where healthcare is scarce and vaccinations are not readily available, the practices of social distancing and self-quarantining have been shown to be highly effective in combating the spread of EVD. To …