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Full-Text Articles in Statistical Models
Bayesian Kinetic Modeling For Tracer-Based Metabolomic Data, Xu Zhang
Bayesian Kinetic Modeling For Tracer-Based Metabolomic Data, Xu Zhang
Theses and Dissertations--Statistics
Kinetic modeling of the time dependence of metabolite concentrations including the unstable isotope labeled species is an important approach to simulate metabolic pathway dynamics. It is also essential for quantitative metabolic flux analysis using tracer data. However, as the metabolic networks are complex including extensive compartmentation and interconnections, the parameter estimation for enzymes that catalyze individual reactions needed for kinetic modeling is challenging. As the pa- rameter space is large and multi-dimensional while kinetic data are comparatively sparse, the estimation procedure (especially the point estimation methods) often en- counters multiple local maximum such that standard maximum likelihood methods may yield …