Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Statistical Models
A Statistical Framework For The Analysis Of Chip-Seq Data, Pei Fen Kuan, Dongjun Chung, Guangjin Pan, James A. Thomson, Ron Stewart, Sunduz Keles
A Statistical Framework For The Analysis Of Chip-Seq Data, Pei Fen Kuan, Dongjun Chung, Guangjin Pan, James A. Thomson, Ron Stewart, Sunduz Keles
Sunduz Keles
Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has revolutionalized experiments for genome-wide profiling of DNA-binding proteins, histone modifications, and nucleosome occupancy. As the cost of sequencing is decreasing, many researchers are switching from microarray-based technologies (ChIP-chip) to ChIP-Seq for genome-wide study of transcriptional regulation. Despite its increasing and well-deserved popularity, there is little work that investigates and accounts for sources of biases in the ChIP-Seq technology. These biases typically arise from both the standard pre-processing protocol and the underlying DNA sequence of the generated data.
We study data from a naked DNA sequencing experiment, which sequences non-cross-linked DNA after deproteinizing and …
Are (The Log-Odds Of) Hospital Mortality Rates Normally Distributed In Ontario? Implications For Studying Variations In Outcomes Of Medical Care, Peter C. Austin
Are (The Log-Odds Of) Hospital Mortality Rates Normally Distributed In Ontario? Implications For Studying Variations In Outcomes Of Medical Care, Peter C. Austin
Peter Austin
Objective: Hierarchical regression models are used to examine variations in outcomes following the provision of medical care across providers. These models frequently assume a normal distribution for the provider-specific random effects. Poincaré said, “Everyone believes in the normal law, the experimenters because they imagine it a mathematical theorem, and the mathematicians because they think it an experimental fact”. Our objective was to examine the appropriateness of this assumption when examining variations in mortality.
Study design and setting: We used Bayesian model selection methods to compare hierarchical regression models in which the provider-specific random effects were either a normal distribution or …