Multivariate Analysis Commons^™

Colon Cancer Prognosis Prediction By Gene Expression Profiling, Alain Barrier, Sandrine Dudoit, Et Al.

U.C. Berkeley Division of Biostatistics Working Paper Series

Aims. This study assessed the possibility to build a prognosis predictor, based on microarray gene expression measures, in stage II and III colon cancer patients. Materials and Methods. Tumour (T) and non-neoplastic mucosa (NM) mRNA samples from 18 patients (9 with a recurrence, 9 with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. The k-nearest neighbour method was used for prognosis prediction using T and NM gene expression measures. Six-fold cross-validation was applied to select the number of neighbours and the number of informative genes to include in the predictors. Based on this information, one T-based and one NM-based …

Prevalence Of Degenerative Joint Disease In A Pre-Orthodontic Adolescent Sample, Marie Mansour

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this research was to determine a prevalence of degenerative joint disease in our pre-orthodontic adolescent patients age ten through seventeen. The prevalence was assessed according to gender. Severity of DJD was established for each patient and a "red flag" for diagnosis was identified. The purpose was also to establish norms for joint space for patients with and without degenerative joint disease. Correlations to distal condyle position and angle classification were described. 123 consecutive patients, 77 female and 46 male T1 NewTom records were reviewed. Severity of DJD was classified according to none, mild, moderate, and severe. Sagittal …

Evaluating Markers For Selecting A Patient's Treatment, Xiao Song, Margaret S. Pepe

UW Biostatistics Working Paper Series

Selecting the best treatment for a patient's disease may be facilitated by evaluating clinical characteristics or biomarker measurements at diagnosis. We consider how to evaluate the potential of such measurements to impact on treatment selection algorithms. For example, magnetic resonance neurographic imaging is potentially useful for deciding whether a patient should be treated surgically for carpal tunnel syndrome or if he/she should receive less invasive conservative therapy. We propose a graphical display, the selection impact (SI) curve, that shows the population response rate as a function of treatment selection criteria based on the marker. The curve can be useful for …

The Psychological Characteristics Of Obese Children, Thomas Taylor Mitchell

Loma Linda University Electronic Theses, Dissertations & Projects

Several studies along with the surgeon general of the United States have identified obesity as a national health issue. Research indicates that adult obesity treatment has relatively poor long-term effects. Consequently increased attention has been given to addressing obesity in children. This focus is particularly vital due to the fact that children are one of the populations showing the most rapid increase in overweight and obesity. The purpose of this study was to identify the some of the unique psychological characteristics of obese children by analyzing the intake data of children and adolescents attending the Loma Linda University Growing Fit …

The Radiopacity Of 29 Resin Restorative Materials Compared To Enamel, Peter Lubisich Iv

Loma Linda University Electronic Theses, Dissertations & Projects

The radiodensity of a composite resin can greatly influence a clinician's ability to analyze a restoration for failure. The purpose of this study was to determine the relative radiopacities of 29 resin restorative materials compared to enamel, and to verify the comparable radiopacity between shades of 23 of the restorative composite resin materials. Composite resin discs measuring >5mm in diameter and 2 mm in thickness were made and polymerized. Radiographs were taken of the composite resin discs, which included an aluminum step wedge for calibration and a densitometer was used to measure the radiodensity of the composite resin samples. The …

Quantification Of Bone Deposition In Onlay Bone Grafting, Gregory Alan Kammeyer

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to quantitatively evaluate; 1) mandibular posterior mono-cortical block onlay bone graft success rates 2) the amount of grafted bone retained after initial resorption in radiographic projections. Seven consecutive patients with 14 mandibular posterior implant sites requiring bone augmentation for implants of a standard 3.8mm x 10mm dimension were sought. Mono-cortical block bone grafts from the ipsilateral ascending ramus were placed then observed with two standardized CT scans, dividing them into two groups: Group A had the first CT at 4 weeks after graft placement and a second taken before Prosthodontic reconstruction, 36.7 weeks later. …

Il-10 And Alveolar Bone Loss, Abdulaziz Saud Al-Rasheed

Loma Linda University Electronic Theses, Dissertations & Projects

Interleukin-10 (IL-10) is a cytokine with anti-inflammatory activities. IL-10 knockout (KO) mice exhibit severe intestinal inflammation in the presence of normal gut flora. We hypothesized that IL-10 KO mice would also be susceptible to inflammatory periodontal disease resulting in alveolar bone loss (ABL). The purpose of this study was to compare naturally occurring ABL in IL-10 KO and wild type (WT) mice. Twelve IL-10 KO and 12 WT mice, age-(7 months) and sex-(male) matched, were used. Half of the mice were on 129/SvEv and half on C57BL/6J background. Animal heads were defleshed and treated to remove all organic material. ABL …

Mandibular Asymmetry In Unilateral Class Ii Malocclusion : A Cephalometric Study, Raed Z. Moussa

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to evaluate skeletal and dental asymmetry in unilateral class II malocclusion. A study group of 25 unilateral subdivision patients was compared to 25 class I malocclusion patients serving as the control group. Submento-vertical and frontal radiographs were used for the evaluation. Symmetry was evaluated by comparing measurements between right and left sides for both groups and matching the middle points with the midsagittal axis. Statistical paired and simple t-test were used to evaluate the difference between the two sides for both groups. The measurements showed no significant skeletal and dental asymmetries except for three …

Soft Tissue Changes Of The Upper Lip Following Isolated Le Fort I Osteotomies, Kendall E. James

Loma Linda University Electronic Theses, Dissertations & Projects

Pre-operative (T-1) and post-operative (T-3) radiographs were obtained and traced for fifty-one non-growing patients who had undergone isolated Le Fort I osteotomies. These tracings were then digitized with the results arranged in a data file and subjected to statistical analysis. The purpose of this study was to establish ratios for certain hard to soft tissue movements that could be used to aid the clinician in post-surgical soft tissue profile prediction. The results showed that even though a large sample was used, individual patient variability remained high particularly in the horizontal directions. Most ratios found in this study were consistent with …

The Accuracy Of Sonographic Imaging (Dolphintm Digigraph) And Standard Lateral Cephalometric Radiographs : A Comparative Study, Michael D. Teichman

Loma Linda University Electronic Theses, Dissertations & Projects

Radiation due to x-ray exposure is a concern, and the development of the Dolphin™ DigiGraph represents an attempt to limit this exposure. The purpose of this paper was to compare measurements (using Ricketts analysis) obtained from conventional radiographic cephalometric tracings with those obtained by computerized digitizing with the DigiGraph. Forty-six patients from the Loma Linda University School of Dentistry graduate orthodontic clinic were digitized, and the results were compared to the x-ray tracings of these patients. The results showed that seven of the twenty-one variables examined exhibited a statistical similarity between the two methods (DigiGraph and x-ray tracing). An examination …

Correlates Of Birth Weight And Gestation Age : Baseline Data For Health Education, Adanetch Kidanemariam

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose. The study examined the correlation of maternal occupation, urinary tract infection, smoking, and working during pregnancy with infant birth weight and gestational age in order to generate baseline data for development of a health education intervention program protocol for pregnant women In the work place.

Primary Hypotheses. (1) The four maternal risk factors: (a) occupation during lifetime, (b) reported urinary tract infection, (c) cigarette smoking, (d) working, are individually and interactively correlated with infant birth weight and gestational age. (2) The effects of the interactive associations are greater on birth weight than gestational age.

Procedure. A sample of …

Third Molar Eruption Prediction, Michael L. Jacobsen

Loma Linda University Electronic Theses, Dissertations & Projects

The diagnosis and treatment of third molars has often been cited as a special problem to the orthodontist. If the prognosis of third molars could be determined, orthodontic treatment could progress on a more positive basis.

This study was designed to provide a method of deciding whether developing third molars will erupt or become impacted.

Records from 130 orthodontically treated cases of Dr. Fredsall⁸ were studied. Several factors were evaluated and measured using the patients' cephalometric radiographs.

The actual fate of the third molars were recorded in the hope it could be used to predict what to expect from …

Mandibular Repositioning With Frankel Appliance Therapy, Clark E. Schneekluth

Loma Linda University Electronic Theses, Dissertations & Projects

A sample of twelve Frankel appliance (FR-2) treated patients, in the mixed dentition stage, were selectively chosen by an orthodontist based on the Class II correction and evaluated from before treatment and end of treatment laminagraphic and lateral cephalometric radiographs. The average treatment period was 22 months (1 yr. 10 mos.). The average pre-treatment age was 9.5 years with a range from 8 to 11 years old, while the average post-treatment age was 11.3 years with a range of 10 to 13 years.

Frankel appliance therapy was the only form of mechanics used in this study.

The before treatment lateral …

The Effect Of Natural Measures To Aid In Sleep As Compared With The Use Of Flurazepam 30 Milligrams As Seen In The Hospitalized Male Patient, Myra Ladd Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

Sleep is necessary for physical and psychological restoration of the body. Studies indicate that tissue repair is augmented during sleep, showing that rates of protein synthesis and of mitotic division are higher at times of rest and sleep. Studies evaluating sleep-deprived subjects reveal that after loss of normal sleep, some types of memory and learning processes are impaired. These subjects generally become anxious and irritable, especially after loss of dreaming sleep.

Sleeping medications have been implicated by observers and researchers to be a cause of altered sleep patterns. These medications not only disrupt normal sleep cycles, but their continued use …

Treatment Of Persistent Open-Bite Malocclusions With Interarch Elastic Fixation, Kent L. Phillips

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to investigate the changes in the facial complex after treatment of persistent anterior open-bites with Dr. R. M. Ricketts' "squeeze treatment." This treatment method requires heavy elastic fixation for one month in conjunction with placement of T-loop arches.

Twelve open-bite patients were selected for the study. Quantative[sic] measurements from lateral cephalometric and laminagraphs of the temporomandibular joint were also evaluated. Qualitative observations were obtained from the periapical radiographs, models, and photos.

Tooth extrusion occurred in varying amounts followed by alveolar crest and apical repair.

Statistical significance was shown in the correction of incisor overbite, …

A Study Of Treatment And Cephalometric Variables In Relation To Facial Axis Change During Treatment In A Dolichofacial Sample, Laurence A. Seifert

Loma Linda University Electronic Theses, Dissertations & Projects

The change in the facial axis in a sample of fifth-three dolichofacial patients, was compared with a number of pretreatment cephalometric variables. A number of treatment variables were also compared with the amount of facial axis change that occurred during orthodontic treatment.

The cephalometric variables measured were:

1. Facial axis
2. Upper face height (maxillary height)
3. Lower face height
4. Posterior face height
5. Mandibular arc
6. Palatal-mandibular plane
7. Palatal-occlusal plane
8. Occlusal-mandibular plane
9. Overbite
10. Upper first molar to palatal plane
11. Lower first molar to mandibular plane
12. Lower incisor to mandibular plane
13. Incisal edge of lower incisor to mandibular plane
14. Xi point to occlusal plane

Treatment …

The Effect Of Endodontic Therapy On The Incidence Of Radiation Caries In Dogs, James A. Abbott

Loma Linda University Electronic Theses, Dissertations & Projects

Endodontic therapy was evaluated as a possible control or prevention modality of radiation type dental caries in dogs. Two adult male dogs with permanent dentitions had endodontic therapy performed on alternating teeth in each jaw. The nontreated teeth served as controls.

The dogs were irradiated with 7000 rad Cobalt-60 radiation fractionated over an eight week period. The dogs were killed at 60 and 182 days post-irradiation. The teeth were removed from the jaws and immersed in methylene blue dye, sectioned, and the dye penetration pattern photographed. Diffusion of the dye into the tooth structure was quantified and statistically analyzed.

A …

Apical Closure Induction Using Bone Growth Factors And Mineral Trioxide Aggregate, Kenneth W. Tittle

Loma Linda University Electronic Theses, Dissertations & Projects

This study compared the ability of three different bone growth factor combinations with that of Ca(OH)₂ to stimulate apical closure as well as the effectiveness of Mineral Trioxide Aggregate (MTA) as an apical barrier. Fifty-six roots of second and fourth mandibular premolars of seven six- month old beagle dogs were used. Periradicular lesions were created over a four week period. The canals were cleaned and shaped and filled with Ca(OH)₂ for one week. They were then irrigated and received one of seven different treatments in a balanced design. Growth factors were placed in a carboxymethylcellulose carrier and delivered …

A Cephalometric Study Of Mandibulo-Facial Disostosis In Monozygotic Twins Using Computerized Methods, Lyn M. Lamberton

Loma Linda University Electronic Theses, Dissertations & Projects

An investigation using computerized cephalometrics has been conducted to consider the cephalometric factors responsible for the characteristic appearance evident in individuals afflicted with Mandibulo-Facial Dysostosis. A pair of Negro monozygotic affected twins were studied using the other 10 non-affected members of the family as a control to minimize the environmental and hereditary factors. The Rocky Mountain Data System was utilized to analyze the lateral and frontal cephalometric radiographs of each individual using Ricketts Analysis and the data were subjected to statistical tests to determine the factors contributory to the syndrome. Age and size were considered and adjustments were made to …

A Method Of Analyzing Mandibular Movement, Richard B. Mccoy

Loma Linda University Electronic Theses, Dissertations & Projects

Mandibular movement is considered to be a fundamental factor in the study, analysis, and treatment of occlusion. For many years, dentists have realized that dental health depends upon the compatibility of mandibular movements and occlusion. This realization has led to the development of new methods and techniques for recording accurately and scientifically the movements of the mandible. In order for this data to be of scientific value, it must be stored in a usable form which is easily available for analysis.

The purpose of this research project was to develop a procedure for storing and recalling mandibular-movement information. Before such …

A Comparative Roentgenographic Cephalometric Study Of The Facial Profile Of Orthodontic Patients Treated At Loma Linda University With Winners Of The "Smiles Of The Year" Contest, Romeo I. Stoll

Loma Linda University Electronic Theses, Dissertations & Projects

The "Smiles of the Year" winners and patients treated at Loma Linda University by the extraction or non-extraction approach were compared by linear and angular variables of skeletal, dental and soft tissue components. These findings were analyzed statistically to determine significant differences in the profile and detect the relationship between the integument and hard structures.

The following conclusions were drawn from this investigation to reflect the trend of treatment at Loma Linda University.

1. After treatment the patients had less skeletal convexity, but were more convexity than established standards.
2. The incisors of the patients treated by the extraction approach were less …

Masseter Muscle Position Relative To Skeletal Open Bite And Skeletal Closed Bite, Alonzo David Proctor

Loma Linda University Electronic Theses, Dissertations & Projects

Modification of cephalometric roentgenographic procedures provided a means to identify the anterior borders of the right and left masseter muscles and relate them to surrounding dentoskeletal elements. Attachment of short, stiff, wires to the cheeks in a position superficial to the anterior borders of the muscles, subsequent to palpation and prior to exposure of the roentgenographic film, was the procedure used. The bi-lateral images projected on the film were averaged and traced along with dentoskeletal elements including those associated with skeletal type. This line representing the anterior border of the musculature was used to assess muscle position in the vertical …

An Anthropometric Study Of The Face And Dentition Of The Pima Indian Population At The Stewart Indian School, Carson City, Nevada, Wilmonte Lee Penner

Loma Linda University Electronic Theses, Dissertations & Projects

Study casts and cephalograms were obtained on 18 female and 21 male Pima Indian students from the Stewart Indian Boarding School, Carson City, Nevada. Dentitional characteristics were assessed both clinically and by study casts. Cranio-facial analyses were performed by utilizing the skeletal and denture pattern variables suggested by the Downs and Riedel cephalometric analyses.

The purpose of this study was two-fold: (1) to determine the extent to which the Pima conforms to the Mongoloid master pattern, and (2) to test whether or not significant differences exist between the Pima and other Mongoloid groups which would allow discrimination.

The results of …