Multivariate Analysis Commons^™

Statistical Methods In Genetic Studies, Cheng Gao

Dissertations, Master's Theses and Master's Reports

This dissertation includes three Chapters. A brief description of each chapter is organized as follows.

In Chapter 1, we proposed a new method, called MF-TOWmuT, for genome-wide association studies with multiple genetic variants and multiple phenotypes using family samples. MF-TOWmuT uses kinship matrix to account for sample relatedness. It is worth mentioning that in simulations, we considered hidden polygenic effects and varied the proportion of variance contributed by it to generate phenotypes. Simulation studies show that MF-TOWmuT can preserve the type I error rates and is more powerful than several existing methods in different simulation scenarios, MFTOWmuT is also quite …

Variation In Personality Among Semi-Wild Myanmar Timber Elephants, Sateesh Venkatesh

Theses and Dissertations

This study examines two personality traits: exploration and neophobia, which could influence human-elephant conflicts. Thirty-one semi-wild elephants were tested over two trials using a custom novel puzzle tube containing three tasks and three rewards. Our studies show that elephants do vary significantly between individuals in both exploration and neophobia.

A Geochemical And Statistical Investigation Of The Big Four Springs Region In Southern Missouri, Jordan Jasso Vega

Graduate Theses/Dissertations

The Big Four Springs region hosts four major first-order magnitude springs in southern Missouri and northern Arkansas. These springs are Big Spring (Carter County, MO), Greer Spring (Oregon County, MO), Mammoth Spring (Fulton County, AR), and Hodgson Mill Spring (Ozark County, MO). Based on historic dye traces and hydrogeological investigations, these springs drain an area of approximately 1500 square miles and collectively discharge an average of 780 million gallons of water per day. The rocks from youngest to oldest that are found in Big Four Springs region are the Cotter and Jefferson City Dolomite (Ordovician), Roubidoux Formation (Ordovician), Gasconade Dolomite …

Improving The Quality And Design Of Retrospective Clinical Outcome Studies That Utilize Electronic Health Records, Oliwier Dziadkowiec, Jeffery Durbin, Vignesh Jayaraman Muralidharan, Megan Novak, Brendon Cornett

HCA Healthcare Journal of Medicine

Electronic health records (EHRs) are an excellent source for secondary data analysis. Studies based on EHR-derived data, if designed properly, can answer previously unanswerable clinical research questions. In this paper we will highlight the benefits of large retrospective studies from secondary sources such as EHRs, examine retrospective cohort and case-control study design challenges, as well as methodological and statistical adjustment that can be made to overcome some of the inherent design limitations, in order to increase the generalizability, validity and reliability of the results obtained from these studies.

Assessing Differential Item Functioning In The Perceived Stress Scale, Nana Amma Berko Asamoah

Graduate Theses and Dissertations

When an item on a test functions differently for subgroups of respondents with respect to an exogenous variable (or covariate) after conditioning on the latent variable of interest, the item is said to exhibit Differential Item Functioning (DIF). The 10-item Perceived Stress Scale (PSS10) is administered to respondents via MTurk to quantify “perceived stress” and identify if items on the scale function differently for specific subgroups defined by age, sex, race, marital status, number of children, employment status and social media usage.

The purpose of this study was to compare traditional DIF detection approaches (Mantel-Haenszel, logistic regression, likelihood ratio test …

Learning Networks With Categorical Data Using Distance Correlation, And A Novel Graph-Based Multivariate Test, Jian Tinker

Graduate Theses and Dissertations

We study the use of distance correlation for statistical inference on categorical data, especially the induction of probability networks. Szekely et al. first defined distance correlation for continuous variables in [42], and Zhang translated the concept into the categorical setting in [57] by defining dCor(X,Y) for categorical variables X = (x1,...,xI) and Y = (y1,...,yJ) where P(X=xi)=[pi]i and P(Y=yi)=[pi]j with the formula [Please open the document]

Part I of the dissertation covers the background we need to understand this formula, and prepares us to analyze the properties and performance of its applications.

Part II then presents the main results of …

Effect Of Predictor Dependence On Variable Selection For Linear And Log-Linear Regression, Apu Chandra Das

Graduate Theses and Dissertations

We propose a Bayesian approach to the Dirichlet-Multinomial (DM) regression model, which uses horseshoe, Laplace, and horseshoe plus priors for shrinkage and selection. The Dirichlet-Multinomial model can be used to find the significant association between a set of available covariates and taxa for a microbiome sample. We incorporate the covariates in a log-linear regression framework. We design a simulation study to make a comparison among the performance of the three shrinkage priors in terms of estimation accuracy and the ability to detect true signals. Our results have clearly separated the performance of the three priors and indicated that the horseshoe …

Novel Inference Methods For Generalized Linear Models Using Shrinkage Priors And Data Augmentation., Arinjita Bhattacharyya

Electronic Theses and Dissertations

Generalized linear models have broad applications in biostatistics and sociology. In a regression setup, the main target is to find a relevant set of predictors out of a large collection of covariates. Sparsity is the assumption that only a few of these covariates in a regression setup have a meaningful correlation with an outcome variate of interest. Sparsity is incorporated by regularizing the irrelevant slopes towards zero without changing the relevant predictors and keeping the resulting inferences intact. Frequentist variable selection and sparsity are addressed by popular techniques like Lasso, Elastic Net. Bayesian penalized regression can tackle the curse of …

Quantitative Model For Setting Manufacturer's Suggested Retail Price, Peter Byrd, Jonathan Knowles, Dmitry Andreev, Jacob Turner, Brian Mente, Laroux Wallace

SMU Data Science Review

In this paper, we present a quantitative approach to model the manufacturer’s suggested retail price (MSRP) for children’s doll- houses and establish relationships among key features that contribute most to establishing MSRP. Determination of the MSRP is a critical step in how consumers respond with their wallets when purchasing an item. KidKraft, a global leader in toys and juvenile products, sets MSRP subjectively using product experts. The process is arduous and time consuming requiring the focus of specialized resources and knowledge of the interaction between key attributes and their impact on consumer value. An accurate prediction of MSRP during the …

Theory Of Principal Components For Applications In Exploratory Crime Analysis And Clustering, Daniel Silva

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this paper is to develop the theory of principal components analysis succinctly from the fundamentals of matrix algebra and multivariate statistics. Principal components analysis is sometimes used as a descriptive technique to explain the variance-covariance or correlation structure of a dataset. However, most often, it is used as a dimensionality reduction technique to visualize a high dimensional dataset in a lower dimensional space. Principal components analysis accomplishes this by using the first few principal components, provided that they account for a substantial proportion of variation in the original dataset. In the same way, the first few principal …

Zero-Inflated Longitudinal Mixture Model For Stochastic Radiographic Lung Compositional Change Following Radiotherapy Of Lung Cancer, Viviana A. Rodríguez Romero

Theses and Dissertations

Compositional data (CD) is mostly analyzed as relative data, using ratios of components, and log-ratio transformations to be able to use known multivariable statistical methods. Therefore, CD where some components equal zero represent a problem. Furthermore, when the data is measured longitudinally, observations are spatially related and appear to come from a mixture population, the analysis becomes highly complex. For this matter, a two-part model was proposed to deal with structural zeros in longitudinal CD using a mixed-effects model. Furthermore, the model has been extended to the case where the non-zero components of the vector might a two component mixture …

Nonparametric Analysis Of Clustered And Multivariate Data, Yue Cui

Theses and Dissertations--Statistics

In this dissertation, we investigate three distinct but interrelated problems for nonparametric analysis of clustered data and multivariate data in pre-post factorial design.

In the first project, we propose a nonparametric approach for one-sample clustered data in pre-post intervention design. In particular, we consider the situation where for some clusters all members are only observed at either pre or post intervention but not both. This type of clustered data is referred to us as partially complete clustered data. Unlike most of its parametric counterparts, we do not assume specific models for data distributions, intra-cluster dependence structure or variability, in effect …

Nonparametric Tests Of Lack Of Fit For Multivariate Data, Yan Xu

Theses and Dissertations--Statistics

A common problem in regression analysis (linear or nonlinear) is assessing the lack-of-fit. Existing methods make parametric or semi-parametric assumptions to model the conditional mean or covariance matrices. In this dissertation, we propose fully nonparametric methods that make only additive error assumptions. Our nonparametric approach relies on ideas from nonparametric smoothing to reduce the test of association (lack-of-fit) problem into a nonparametric multivariate analysis of variance. A major problem that arises in this approach is that the key assumptions of independence and constant covariance matrix among the groups will be violated. As a result, the standard asymptotic theory is not …

Three Essays On Health Economics And Policy Evaluation, Shishir Shakya

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation consists of three essays on the U.S. Health care policy. Each paragraph below refers to the three abstracts for the three chapters in this dissertation, respectively. I provide quantitative evidence on how much Prescription Drug Monitoring Programs (PDMPs) affects the retail opioid prescribing behaviors. Using the American Community Survey (ACS), I retrieve county-level high dimensional panel data set from 2010 to 2017. I employ three separate identification strategies: difference-in-difference, double selection post-LASSO, and spatial difference-in-difference. I compare how the retail opioid prescribing behaviors of counties, that are mandatory for prescribers to check the PDMP before prescribing controlled substances …

Function Space Tensor Decomposition And Its Application In Sports Analytics, Justin Reising

Electronic Theses and Dissertations

Recent advancements in sports information and technology systems have ushered in a new age of applications of both supervised and unsupervised analytical techniques in the sports domain. These automated systems capture large volumes of data points about competitors during live competition. As a result, multi-relational analyses are gaining popularity in the field of Sports Analytics. We review two case studies of dimensionality reduction with Principal Component Analysis and latent factor analysis with Non-Negative Matrix Factorization applied in sports. Also, we provide a review of a framework for extending these techniques for higher order data structures. The primary scope of this …

Habitat Associations And Reproduction Of Fishes On The Northwestern Gulf Of Mexico Shelf Edge, Elizabeth Marie Keller

LSU Doctoral Dissertations

Several of the northwestern Gulf of Mexico (GOM) shelf-edge banks provide critical hard bottom habitat for coral and fish communities, supporting a wide diversity of ecologically and economically important species. These sites may be fish aggregation and spawning sites and provide important habitat for fish growth and reproduction. Already designated as habitat areas of particular concern, many of these banks are also under consideration for inclusion in the expansion of the Flower Garden Banks National Marine Sanctuary. This project aimed to gain a more comprehensive understanding of the communities and fish species on shelf-edge banks by way of gonad histology, …

Classification Of Coronary Artery Disease In Non-Diabetic Patients Using Artificial Neural Networks, Demond Handley

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Identifying Risk Factors Related To Premature Birth Through Binary Logistic And Proportional Odds Ordinal Logistic Regression, Clayton Elwood

Electronic Theses and Dissertations

Premature birth has been identified as the single greatest cause of death worldwide in children under the age of five. This thesis will implement binary logistic regression and proportional odds ordinal logistic regression to predict different levels of premature birth and identify associated risk factors. The models will be built from the Center for Disease Control and Prevention's 2014 Vital Statistics Natality Birth Data containing nearly 4 million live births within the United States. Odds ratios and confidence intervals on risk factors were produced utilizing binary logistic regression.

Optimal Design For A Causal Structure, Zaher Kmail

Department of Statistics: Dissertations, Theses, and Student Research

Linear models and mixed models are important statistical tools. But in many natural phenomena, there is more than one endogenous variable involved and these variables are related in a sophisticated way. Structural Equation Modeling (SEM) is often used to model the complex relationships between the endogenous and exogenous variables. It was first implemented in research to estimate the strength and direction of direct and indirect effects among variables and to measure the relative magnitude of each causal factor.

Historically, traditional optimal design theory focuses on univariate linear, nonlinear, and mixed models. There is no current literature on the subject of …

Leveraging Reviews To Improve User Experience, Anthony Schams, Iram Bakhtiar, Cristina Stanley

SMU Data Science Review

In this paper, we will explore and present a method of finding characteristics of a restaurant using its reviews through machine learning algorithms. We begin by building models to predict the ratings of individual reviews using text and categorical features. This is to examine the efficacy of the algorithms to the task. Both XGBoost and logistic regression will be examined. With these models, our goal is then to identify key phrases in reviews that are correlated with positive and negative experience. Our analysis makes use of review data publicly made available by Yelp. Key bigrams extracted were non-specific to the …

Unified Methods For Feature Selection In Large-Scale Genomic Studies With Censored Survival Outcomes, Lauren Spirko-Burns, Karthik Devarajan

COBRA Preprint Series

One of the major goals in large-scale genomic studies is to identify genes with a prognostic impact on time-to-event outcomes which provide insight into the disease's process. With rapid developments in high-throughput genomic technologies in the past two decades, the scientific community is able to monitor the expression levels of tens of thousands of genes and proteins resulting in enormous data sets where the number of genomic features is far greater than the number of subjects. Methods based on univariate Cox regression are often used to select genomic features related to survival outcome; however, the Cox model assumes proportional hazards …

Predicting Unplanned Medical Visits Among Patients With Diabetes Using Machine Learning, Arielle Selya, Eric L. Johnson

SDSU Data Science Symposium

Diabetes poses a variety of medical complications to patients, resulting in a high rate of unplanned medical visits, which are costly to patients and healthcare providers alike. However, unplanned medical visits by their nature are very difficult to predict. The current project draws upon electronic health records (EMR’s) of adult patients with diabetes who received care at Sanford Health between 2014 and 2017. Various machine learning methods were used to predict which patients have had an unplanned medical visit based on a variety of EMR variables (age, BMI, blood pressure, # of prescriptions, # of diagnoses on problem list, A1C, …

Nonparametric Depth And Quantile Regression For Functional Data, Joydeep Chowdhury, Probal Chaudhuri

Journal Articles

We investigate nonparametric regression methods based on spatial depth and quantiles when the response and the covariate are both functions. As in classical quantile regression for finite dimensional data, regression techniques developed here provide insight into the influence of the functional covariate on different parts, like the center as well as the tails, of the conditional distribution of the functional response. Depth and quantile based nonparametric regression methods are useful to detect heteroscedasticity in functional regression. We derive the asymptotic behavior of the nonparametric depth and quantile regression estimates, which depend on the small ball probabilities in the covariate space. …

Step Away From Stepwise, Gary N. Smith

Pomona Economics

Stepwise regression is a popular data-mining tool that uses statistical significance to select the explanatory variables to be used in a multiple-regression model. A fundamental problem with stepwise regression is that some real explanatory variables that have causal effects on the dependent variable may happen to not be statistically significant, while nuisance variables may be coincidentally significant. As a result, the model may fit the data well in-sample, but do poorly out-of-sample. Many Big-Data researchers believe that, the larger the number of possible explanatory variables, the more useful is stepwise regression for selecting explanatory variables. The reality is that stepwise …

The Dark Sky Character Of Archaeological Landscapes: Cultural Meaning And Conservation Strategies, Frank Prendergast

Book/Book Chapter

This paper presents the first ever study of light pollution at selected Irish prehistoric archaeological landscapes. The concepts of cosmology and landscape are first briefly described and followed by a summary of early human settlement of the island. Building on this, the extant corpus of early prehistoric megalithic burial tombs is illustrated to show their contrasting distribution patterns and typology. Analysis of tomb locations using nearest-neighbour statistical methods reveals evidence of intentional clustering. Further geo-statistical analysis identifies the geographical locations and the density ranking of these nucleated clusters - a feature especially evident in the passage tomb tradition on this …

Essays On Mixture Models, Trevor R. Camper

College of Graduate Studies: Theses & Dissertations

When considering statistical scenarios where one can sample from populations that are not of interest for the purposes of a study, bivariate mixture models can be used to study the effect that this missampling can have on parameter estimation. In this thesis, we will examine the behavior that bivariate mixture models have on two statistical constructs: Cronbach's alpha \cite{C51}, and Spearman's rho \cite{S04}. Chapter 1 will introduce notions of mixture models and the definition of bias under mixture models which will serve as the central concept of this thesis. Chapter 2 will investigate a particular psychometric issue known as insufficient …

Variable Selection In Accelerated Failure Time (Aft) Frailty Models: An Application Of Penalized Quasi-Likelihood, Sarbesh R. Pandeya

College of Graduate Studies: Theses & Dissertations

Variable selection is one of the standard ways of selecting models in large scale datasets. It has applications in many fields of research study, especially in large multi-center clinical trials. One of the prominent methods in variable selection is the penalized likelihood, which is both consistent and efficient. However, the penalized selection is significantly challenging under the influence of random (frailty) covariates. It is even more complicated when there is involvement of censoring as it may not have a closed-form solution for the marginal log-likelihood. Therefore, we applied the penalized quasi-likelihood (PQL) approach that approximates the solution for such a …

Biodiversity And Distribution Of Benthic Foraminifera In Harrington Sound, Bermuda: The Effects Of Physical And Geochemical Factors On Dominant Taxa, Nam Le

Honors Theses

Harrington Sound, Bermuda, is a nearly enclosed lagoon acting as a subtropical/tropical, carbonate-rich basin in which carbonate sediments, reef patches, and carbonate-producing organisms accumulate. Here, one of the most important calcareous groups is the Foraminifera. Analyses of common benthic orders, including miliolids (Quinqueloculina and Triloculina spp.) and rotaliids (Homotrema rubrum, Elphidium spp., and Ammonia beccarii), are essential in understanding past and present environmental conditions affecting the island's coastal environment. These taxa have been studied previously; however, factors explaining their individual patterns of abundance in the Sound are not well detailed. The goal of this study is …

Modeling Stochastically Intransitive Relationships In Paired Comparison Data, Ryan Patrick Alexander Mcshane

Statistical Science Theses and Dissertations

If the Warriors beat the Rockets and the Rockets beat the Spurs, does that mean that the Warriors are better than the Spurs? Sophisticated fans would argue that the Warriors are better by the transitive property, but could Spurs fans make a legitimate argument that their team is better despite this chain of evidence?

We first explore the nature of intransitive (rock-scissors-paper) relationships with a graph theoretic approach to the method of paired comparisons framework popularized by Kendall and Smith (1940). Then, we focus on the setting where all pairs of items, teams, players, or objects have been compared to …

Data Patterns Discovery Using Unsupervised Learning, Rachel A. Lewis

College of Graduate Studies: Theses & Dissertations

Self-care activities classification poses significant challenges in identifying children’s unique functional abilities and needs within the exceptional children healthcare system. The accuracy of diagnosing a child's self-care problem, such as toileting or dressing, is highly influenced by an occupational therapists’ experience and time constraints. Thus, there is a need for objective means to detect and predict in advance the self-care problems of children with physical and motor disabilities. We use clustering to discover interesting information from self-care problems, perform automatic classification of binary data, and discover outliers. The advantages are twofold: the advancement of knowledge on identifying self-care problems in …