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Articles 1 - 30 of 142
Full-Text Articles in Multivariate Analysis
Learning Ordinal Geometry: Semantic–Aware Kernels For Ordered Categorical Data, Ernest Fokoue
Learning Ordinal Geometry: Semantic–Aware Kernels For Ordered Categorical Data, Ernest Fokoue
Articles
Ordinal data arise ubiquitously in survey research, psychology, medicine, economics, and recommender systems, yet kernel methods for such data typically rely on either nominal encodings or arbitrary numeric codings. The former discards order information; the lat- ter imposes a fictitious metric structure. This paper develops a principled framework for kernel design on ordinal scales and introduces a new class of Semantic–Aware Ordinal Ker- nels (SAOK) that simultaneously capture ordinal order and semantic proximity between categories. We begin by formalizing order–preserving embeddings of finite chains and characterizing a broad family of chain distances that are conditionally negative definite. Through Schoen- berg …
Statistical Analysis Of Log Transformation Effectiveness In Air Traffic Movement Forecasting During Covid-19 In South Africa, John Lehlaka Masekoameng
Statistical Analysis Of Log Transformation Effectiveness In Air Traffic Movement Forecasting During Covid-19 In South Africa, John Lehlaka Masekoameng
Journal of Aviation Technology and Engineering
This study evaluates the effectiveness of log transformation in enhancing multiple regression models used to forecast air traffic movements (ATMs) in South Africa during the COVID-19 pandemic. Using 60 monthly observations from October 2016 to September 2021, the analysis incorporates variables such as revenue, lockdown levels, COVID-19 metrics, exchange rates, gross domestic product, and population. Two models are compared: one using raw ATMs and another with log-transformed ATMs as the dependent variable.
While the untransformed model shows stronger explanatory power (R² = 0.904, adjusted R² = 0.891) compared to the log-transformed model (R² = 0.772, adjusted R² = 0.741), the …
Modeling Housing Prices: Which Features Matter Most?, Alex Ruvolo
Modeling Housing Prices: Which Features Matter Most?, Alex Ruvolo
Williams Honors College, Honors Research Projects
This paper attempts to find the biggest factors and traits that influence the cost of housing. This will include the lot size, type of street, utilities, neighborhood, year built, heating, electrical, yard size, number of different rooms, age, condition, and others. I will attempt to answer the question of whether the prices of houses have changed within the last 5 to 10 years, and obviously this is an easy question to answer. However, the bigger question beyond this is are the main factors affecting housing prices all important in explaining this relationship? Is one factor more important than the rest …
A Geospatial Assessment Of Groundwater Salinization In A Multi-Aquifer System: Durango, Mexico, Juan Lopez-Sierra
A Geospatial Assessment Of Groundwater Salinization In A Multi-Aquifer System: Durango, Mexico, Juan Lopez-Sierra
Graduate Theses/Dissertations
Groundwater salinization poses a critical environmental concern for water resource sustainability in arid and semi-arid regions. This study evaluates spatial and temporal patterns of groundwater salinity across the state of Durango, Mexico, using total dissolved solids (TDS), sodium adsorption ratio (SAR), as salinity indicators and nitrate-nitrogen (NO₃–N) as an anthropogenic indicator. Groundwater quality data were obtained from (CONAGUA), a Mexican water agency. To assess salinity variations with respect to time, while minimizing interannual sampling bias, two multi-year sampling periods were selected: 2012-2013, and 2020-2021. Final datasets consisted of 122 wells for 2012–2013 and 131 wells for 2020–2021. The wells were …
Applications Of Machine Learning For Evaluating Downward-Coupled Stratosphere-Troposphere Interactions And Subseasonal Forecasts Of Opportunity, Elena M. Fernandez
Applications Of Machine Learning For Evaluating Downward-Coupled Stratosphere-Troposphere Interactions And Subseasonal Forecasts Of Opportunity, Elena M. Fernandez
Electronic Theses & Dissertations (2024 - present)
Wintertime stratospheric dynamics provide key information for understanding atmospheric teleconnections and improving subseasonal-to-seasonal (S2S) predictions on timescales of two weeks to two months. Periods of enhanced predictability, often referred to as forecasts of opportunity, arise from large-scale teleconnected variability, within which the stratosphere serves as an important precursor for tropospheric states, such as near-surface temperatures. While traditional diagnostics of downward coupled stratosphere-troposphere interactions typically rely on zonal-mean representations of wind and geopotential height, this dissertation presents an alternative vortex-centric framework through metrics that capture the daily geometric and dynamical evolution of the stratospheric polar vortex. The proposed stratospheric …
Multivariate Quantile Autoregression-Mixed Data Sampling (Mvqar-Midas) Modeling Of Cost Of Living And Supply Chain Dynamics In Canada., Patrick Gbolonyo
Multivariate Quantile Autoregression-Mixed Data Sampling (Mvqar-Midas) Modeling Of Cost Of Living And Supply Chain Dynamics In Canada., Patrick Gbolonyo
Theses and Dissertations (Comprehensive)
In recent years, the rising cost of living as a result of persistent inflationary pressures, disruptions in the global supply chains, and changes in the macroeconomic landscape has become a critical topic of discussion. To address this, we move beyond a mean-based framework and employ a quantile regression approach. This allows the persistence of each series and the transmis- sion of shocks between the Consumer Price Index (CPI) (the total CPI which is a percentage change over the past 12 months), the Interest Rate (IR)(the target for the overnight rate), the New Housing Price Index (NHPI), and high-frequency supply chain …
Modeling Private Debt Using U.S. Consumer Expenditure Data, Stsiapan Dziamentsyeu
Modeling Private Debt Using U.S. Consumer Expenditure Data, Stsiapan Dziamentsyeu
Honors Capstones
This project models private household debt among U.S. consumers using data from the Consumer Expenditure Survey (CES) between 2013 and 2023. The analysis focuses on identifying how demographic and economic characteristics, such as income, housing expenditures, education, and occupation, relate to non-mortgage “other” loan balances. After initial model development produced poor residual behavior due to zero-inflation from imputed debt values, the analysis was refined to include only households reporting verifiable debt. Multiple modeling techniques, including AIC-based variable selection and Lasso regularization, were compared under a five-fold cross-validation framework. The Lasso model achieved superior predictive accuracy (RMSE = 1.55, MAE = …
Coupled Machine Learning Models: Combining Observations And Numerical Analysis In A Physics-Regularized Approach, Austin B. Schmidt
Coupled Machine Learning Models: Combining Observations And Numerical Analysis In A Physics-Regularized Approach, Austin B. Schmidt
LSU New Orleans Theses and Dissertations
This dissertation investigates surrogate modeling for fixed-location environmental forecasting using novel data-combination techniques. The work surveys the landscape of observational measurements and numerically generated data, identifying similar research and gaps in current methodologies. The ratio-coupled training framework is introduced to combine two data sources per predicted feature through a tunable parameter that weights training signal strength. An optimization scheme is developed to simultaneously tune surrogate weights and the coupled signal ratio, allowing relative influence between signals to act as an explicit regularizer. Three case studies demonstrate the methodology and approach in a variety of contexts. The first study is based …
Spatiotemporal Modeling Of Maternal Mortality In South Carolina 2018-2023, Leah Wood, Ray Bai, Emily Mann
Spatiotemporal Modeling Of Maternal Mortality In South Carolina 2018-2023, Leah Wood, Ray Bai, Emily Mann
Senior Theses
Maternal death serves as a public health indicator due to fact that it is considered preventable with the availability of modern biomedicine, however, it persists broadly throughout the United States. Current literature outlines national trends in maternal mortality with complicating, preexisting conditions, and structural upstream factors often cited as being the largest contributors to increased risk. This study utilizes publicly available, county-level data for maternal death in addition to demographic and descriptive data in order to estimate maternal mortality rates in each of South Carolina’s 46 counties from 2018 to 2023. In order to address sparsity in the outcome variable …
Performance Of The Two Sample Likelihood Ratio Test Under A Nested Dirichlet: A Simulation Study, Edwina Agyeman
Performance Of The Two Sample Likelihood Ratio Test Under A Nested Dirichlet: A Simulation Study, Edwina Agyeman
Electronic Theses and Dissertations
Compositional data analysis (CoDA) addresses multivariate data constrained to a constant sum, such as proportions or percentages. Originating from early warnings regarding misinterpretation by Pearson (1897), the field was formalized by John Aitchison in 1986, whose foundational work remains highly influential. Over time, new modeling techniques and visualization tools have advanced the field, as noted by Greenacre et al. More recently, Turner et al. proposed an approach based on the Nested Dirichlet Distribution (NDD), which accommodates more flexible dependence structures than the standard Dirichlet model. This thesis builds on the methodology of Turner et al. Chapter 1 introduces the nature …
Multivariate Mixture Regression Models With Known Group Membership And Informative Priors, Pahalapathirage Dona Kalani Hasanthika
Multivariate Mixture Regression Models With Known Group Membership And Informative Priors, Pahalapathirage Dona Kalani Hasanthika
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
We introduced couple different novel approaches to incorporate latent variable information to multivariate mixture regression models with both Gaussian and count data. We also evaluated the performance of these models with existing best approaches with simulated data from various sampling structures and also evaluated one of the models performance with rice metabolite data that provided some novel insights as well as validating existing literature about performance and behavior of these metabolites. We validated the method using extensive simulations and a real-world application. In both quantitative covariate designs and complex treatment design simulations, our method consistently outperformed established tools like limma, …
The Nature Of Anthropogenically Driven River Drying: Spatiotemporal Causes And Consequences, Eliza Inez Gilbert
The Nature Of Anthropogenically Driven River Drying: Spatiotemporal Causes And Consequences, Eliza Inez Gilbert
Biology ETDs
Streambed drying naturally occurs in over 60% of rivers and streams worldwide. Climate change and human regulation of surface and groundwater have increased drying in naturally intermittent systems and caused perennial systems to transition to intermittency, impacting water security, water quality, and biodiversity. To understand human-induced drying dynamics, we used 12 years of daily drying data along a 154-km regulated reach of the Rio Grande. We conceptualized river drying as a regime analogous to the natural flow regime paradigm and quantified drying magnitude, rate of change, and duration. Although linear models predicting drying magnitude and rate of change were uninterpretable, …
Syntax-Enhanced Boundary-Aware Named Entity Recognition Model, Chuanming Yu, Bin Deng, Zhengang Zhang
Syntax-Enhanced Boundary-Aware Named Entity Recognition Model, Chuanming Yu, Bin Deng, Zhengang Zhang
Journal of Scientific Information Research
[Purpose/significance] This study addresses the issue of inadequate perception of entity boundaries in traditional character-level modeling-based named entity recognition models by integrating syntax information containing entity boundary features into the task using a multi-head graph attention network with dense connections. This integration enhances the effectiveness of named entity recognition.
[Method/process] This study proposes a Syntax-enhanced Boundary-aware Named Entity Recognition Model (SynBNER), which utilizes BERT for text semantic representation and integrates syntax information using a dense-connected graph attention network. This integration incorporates implicit entity boundary information from syntax information into word representations, thereby enhancing the model's entity boundary perception capability.
[Result/conclusion] …
(R2119) New Algorithms For Independent Component Analysis Based On A General Class Of Dependence Criteria, Fatemeh Asadi, Hamzeh Torabi, Hossein Nadeb
(R2119) New Algorithms For Independent Component Analysis Based On A General Class Of Dependence Criteria, Fatemeh Asadi, Hamzeh Torabi, Hossein Nadeb
Applications and Applied Mathematics: An International Journal (AAM)
The objective function of numerous well-established Independent Component Analysis (ICA) algorithms calculate based on specific dependence criteria. This study introduces a distinctive dependence criterion based on the cumulative distribution function (CDF) for characterizing the independence between two random variables and some of its properties are examined. Then, we propose a class of ICA algorithms based on the introduced dependence criterion. The performance of the algorithm is systematically compared to some previous similar algorithms. The results indicate that the suggested algorithm have fruitful performance rather than some similar previous known algorithms. Subsequently, the proposed algorithms are applied to real-time series data, …
Welfare Implication Of Alternative Tax Rates Adjustment Policy In Nigeria: A Dsge Analysis, Umar B. Ibrahim, Isah F. Abubakar
Welfare Implication Of Alternative Tax Rates Adjustment Policy In Nigeria: A Dsge Analysis, Umar B. Ibrahim, Isah F. Abubakar
CBN Journal of Applied Statistics (JAS)
This study sets out to determine the desirable policy adjustment in the tax rate for Nigeria that ensures the least welfare cost. A calibrated small open-economy New Keynesian Dynamic Stochastic General Equilibrium (NKDSGE) model of the Nigerian economy is applied to achieve this objective. Within this framework, we examined the impact of an increase in value-added tax (VAT) rate from 7.5 to 15 percent on key macroeconomic variables relative to the impact of an increase in company income tax (CIT) rate from 30 to 35 percent on macroeconomic variables. Furthermore, we examined the welfare costs of the increases in the …
Mortgage Default Classification Modeling For Variable Analysis, Brendan R. Goggins
Mortgage Default Classification Modeling For Variable Analysis, Brendan R. Goggins
Honors College Theses
The financial crisis of the early 2000’s is a prime example of the severe consequences that mortgage default and borrower insolvency can have on economies at large. Mortgage default specifically is a prime case with the popularization of mortgage backed securities and the commonality of this loan structure. Multiple hypotheses and models have been formed to understand the reasons, causes, and consequences of mortgage default. This paper uses both machine learning and statistical classification models to inform an understanding of the variables most significant and impactful to the default outcome of mortgages. Consideration is given to both loan-level microeconomic variables …
A Text Mining And Sentiment Analysis Of Valuable Cie Texts Using R, Eric Sugarman, Ethan Turber-Ortiz, Hannah Quinn
A Text Mining And Sentiment Analysis Of Valuable Cie Texts Using R, Eric Sugarman, Ethan Turber-Ortiz, Hannah Quinn
Mathematics, Computer Science & Statistics Presentations
The purpose of this project was to perform a sentiment analysis of three texts used in Ursinus College's Common Intellectual Experience (CIE) course: Between the World and Me by Ta-Nehisi Coates, The New Jim Crow by Michelle Alexander and Discourse on Method by Rene Descartes. Word count and word cloud analysis were also performed on the texts as well as term frequency and bigram analysis.
A Machine-Learning Tool-Supported Methodology For Nonprofit Donor Analysis, Corbin Weiss
A Machine-Learning Tool-Supported Methodology For Nonprofit Donor Analysis, Corbin Weiss
Campus Research Month
We developed a machine-learning tool-supported methodology for modeling the nonprofit donor relationship. This approach was demonstrated in the case of a US-based nonprofit. Conclusions were drawn from this example and tool-support provided for use by other nonprofits.
Urban Heat Dynamics In Pune: The Influence Of Land Cover And Local Climate, Arpit Tiwari, Preethi Nanjundan, Ravi Ranjan Kumar, Ananya Karmakar, Satyaban Bishoyi Ratna
Urban Heat Dynamics In Pune: The Influence Of Land Cover And Local Climate, Arpit Tiwari, Preethi Nanjundan, Ravi Ranjan Kumar, Ananya Karmakar, Satyaban Bishoyi Ratna
Northeast Journal of Complex Systems (NEJCS)
Urban areas with high population density and extensive infrastructure development have been experiencing an increasing strain on the local heat budget, leading to a surge in heat-related illnesses and discomfort. This study examined the impact of climate and land use as heat islands in Pune, India, from 2012 to 2023 at six different locations representing varying degree of urbanization. Satellite land cover observations revealed that 55.17% of the total area was urbanized in the city itself, which was limited to 44.8% in 2012. This urbanization has significantly impacted the increasing tendency of maximum temperature (Tmax; 0.13℃ to 1.63℃ …
Analysis Of Systematic Trade-Offs Between Military And Healthcare Expenditure Alongside Gdp Growth Of Select Asian And Western Exporting Economies In The 21st Century, Rahul Balamurugan, Carlos Gershenson, Preethi Nanjundan, Hiroki Sayama
Analysis Of Systematic Trade-Offs Between Military And Healthcare Expenditure Alongside Gdp Growth Of Select Asian And Western Exporting Economies In The 21st Century, Rahul Balamurugan, Carlos Gershenson, Preethi Nanjundan, Hiroki Sayama
Northeast Journal of Complex Systems (NEJCS)
This study explores the complexity in the trade-offs between military expenditure, healthcare expenditure, and GDP growth across select Asian nations and major weapon-exporting countries, examining how nations allocate finite resources between national security and human well-being over the past two decades. Using a systems science approach, the research integrates Granger causality testing to analyze temporal and directional relationships among GDP growth, military expenditure, and healthcare expenditure, uncovering their dynamic interdependencies. The methodology includes trend and slope analysis, Granger causality testing, outlier detection, and clustering to identify heterogeneity in resource allocation strategies. Developed, weapon-exporting nations exhibit complementary trends, with strong causality …
Kroger Post-Pandemic Customer Segmentation, Mario Mata, Joey Truitt, Renn Spigelmyer, Dhanuja Kasturiratna, Lisa Holden, Nitish Baidya, Hanna Tafari
Kroger Post-Pandemic Customer Segmentation, Mario Mata, Joey Truitt, Renn Spigelmyer, Dhanuja Kasturiratna, Lisa Holden, Nitish Baidya, Hanna Tafari
Posters-at-the-Capitol
The grocery retail industry landscape has changed greatly in the wake of the pandemic. Specifically, delivery and pickup services have become more popular and customer buying habits have evolved. At the same time, improvements in data collection and analysis have allowed grocery marketing strategies to become highly individualized.
We worked with 84.51, an analytics firm, to identify customer segments for the Kroger Company based on data from 2023. Using clustering techniques, we organized customers into groups, or segments, based on similar characteristics. We identified and profiled four distinct groups of customers. Three segments were characterized by high frequency and spending …
Hybrid Mixtures Of Factor Analyzers For High Dimensional Data, Kazeem Abiodun Kareem
Hybrid Mixtures Of Factor Analyzers For High Dimensional Data, Kazeem Abiodun Kareem
Dissertations, Master's Theses and Master's Reports
Factor analysis is a powerful tool for modeling latent structures in high-dimensional data, traditional approaches assume a single global structure, limiting their ability to capture heterogeneity. The Mixture of Factor Analyzers (MFA) extends classical factor analysis by modeling data as a mixture of Gaussian-distributed local subspaces, effectively uncovering cluster-specific latent structures. However, MFA relies on Gaussian mixtures, making it sensitive to outliers and ill-suited for heavy-tailed data. The Mixture of $t$-Factor Analyzers (M$t$FA) addresses these limitations by incorporating multivariate $t$-distributions, improving robustness. Despite their advantages, both MFA and M$t$FA face significant computational challenges in high-dimensional settings, particularly due to costly …
Calculation And Statistical Analysis Of Wins Above Replacement, Joshua Taylor
Calculation And Statistical Analysis Of Wins Above Replacement, Joshua Taylor
Departmental Honors & Graduate Capstone Projects
The Wins Above Replacement (WAR) statistic in Major League Baseball is a prominent metric used to estimate player value by quantifying all aspects of play in terms of wins added to a baseball team. We will use R to calculate WAR for all players from 1871 to 2012 and use data from those years to construct multivariate predictive models to attempt to estimate WAR for players from 2013 to 2024. We find strong correlations between predicted and actual WAR values for most models, with the exception of the polynomial predictive model for non-qualified pitchers.
Bayesian And Deep Generative Modeling In Immunology, Yuqiu Yang
Bayesian And Deep Generative Modeling In Immunology, Yuqiu Yang
Statistical Science Theses and Dissertations
Due to the accumulation of a large volume of data of different natures such as sequencing data, proteomics data, and clinical data, statistical methods and deep learning algorithms have become increasingly important in the field of immunology. By leveraging the diverse datasets as well as interdisciplinary knowledge from areas like biology and public health, these quantitative methods have revolutionized this field by providing powerful tools for data analysis, modeling, and prediction. This has led to a deeper understanding of the immune system, accelerated the development of novel therapies, and paved the way for personalized and precision medicine approaches in immunology. …
Value Added Tax Rate Variation, Import Demand And Sectoral Output In Nigeria, Joshua K. Nomkuha, Aondoawase Asooso, Philip T. Abachi
Value Added Tax Rate Variation, Import Demand And Sectoral Output In Nigeria, Joshua K. Nomkuha, Aondoawase Asooso, Philip T. Abachi
CBN Journal of Applied Statistics (JAS)
This study employs computable general equilibrium (CGE) model to estimate the effect of increase in value added tax (VAT), from 5 per cent to 7.5 per cent, on import demand and sectoral output in Nigeria. The study uses 2020 as the base year for the data analysis. The results show that increase in VAT affects import demand negatively, based on import penetration ratios, with mixed effect across six sectors. The implication of the result is that the VAT policy discourage consumption of foreign products, and constitute excess burden to consumers of such products in Nigeria. The results further reveal that …
Trade Liberalization, Non-Oil Export And Economic Growth In Nigeria, Jerome T. Andohol, Terhemen Tarzoor, Dennis T. Nomor
Trade Liberalization, Non-Oil Export And Economic Growth In Nigeria, Jerome T. Andohol, Terhemen Tarzoor, Dennis T. Nomor
CBN Journal of Applied Statistics (JAS)
The study examines the impact of trade liberalization and non-oil exports on economic growth in Nigeria from 1986 to 2021. The study utilizes an autoregressive distributed lag model and found the combined effect of trade liberalization and non-oil exports to be positive and statistical significant. While trade liberalization alone may have negative consequences, its synergy with a robust non-oil export can drive sustainable economic growth. The study recommends that strategies to enhance non-oil exports should be encouraged to support the effectiveness of trade liberalization in promoting growth.
The Effectiveness Of Monetary Policy Transmission In Nigeria: Evidence From The Monetary Policy Rate And The Cash Reserve Ratio, Abdulrahman A. Nadani, Auwal Isah
The Effectiveness Of Monetary Policy Transmission In Nigeria: Evidence From The Monetary Policy Rate And The Cash Reserve Ratio, Abdulrahman A. Nadani, Auwal Isah
CBN Journal of Applied Statistics (JAS)
This paper investigates the effectiveness of the Monetary Policy Rate (MPR) and Cash Reserve Ratio (CRR) as policy instruments in Nigeria. A structural VAR model is employed to simulate two distinct models measuring shocks from the MPR and the CRR using monthly data from January 2006 to December 2023. Findings show that contractionary monetary policy impulses using MPR and the CRR contract output and credit to the private sector, inflation remains largely positive in the two models, known as the “price puzzle”, but the puzzle is more persistent in the MPR equation. Moreover, shock to MPR strongly influences short-term interest …
Stock Market Volatility In The United Kingdom: Simulating Post-Covid-19 Recovery, Bala A. Dahiru, Mohammed Shuaibu, Najibullah Hassanov
Stock Market Volatility In The United Kingdom: Simulating Post-Covid-19 Recovery, Bala A. Dahiru, Mohammed Shuaibu, Najibullah Hassanov
CBN Journal of Applied Statistics (JAS)
This paper investigates the time it would take for the FTSE-100 index to reach its post-COVID-19 peak. The paper utilises an exponential generalised autoregressive conditional heteroscedasticity (EGARCH) model that accounts for leverage effect and asymmetries. The preferred models amongst competing variants was the Autoregressive Moving Average (ARMA)-EGARCH(2,1) specification and was used to predict daily FTSE-100 data from 5th January 2000 to 21st June 2024. The empirical exercise showed that the COVID-19-induced financial crisis negatively affected the United Kingdom’s stock market performance. The results show that the FTSE100 index could reach its post-pandemic peak around 27th August, 2024 (two months after …
A Novel Correction For The Multivariate Ljung-Box Test, Minhao Huang
A Novel Correction For The Multivariate Ljung-Box Test, Minhao Huang
Computational and Data Sciences (PhD) Dissertations
This research introduces an analytical improvement to the Multivariate Ljung-Box test that addresses significant deviations of the original test from the nominal Type I error rates under almost all scenarios. Prior attempts to mitigate this issue have been directed at modification of the test statistics or correction of the test distribution to achieve precise results in finite samples. In previous studies, focused on designing corrections to the univariate Ljung-Box, a method that specifically adjusts the test rejection region has been the most successful of attaining the best Type I error rates. We adopt the same approach for the more complex, …
Advancement Of Iterative Optimization Technology Algorithms Toward Calibration-Free Process Analytical Technology Applications, Adam Rish
Electronic Theses and Dissertations
The expansion of spectroscopic process analytical technology (PAT) tools within the pharmaceutical industry has the potential to elevate the current state-of-the-art of pharmaceutical manufacturing by offering opportunities for reduced quality testing times, enhanced process control, and greater production flexibility. Spectroscopic PAT tools are dependent on multivariate models to extract the relevant information from the spectral outputs. However, there is a substantial calibration burden for developing and maintaining these multivariate models that discourages the application of PAT, despite the encouragement from regulators. This has led to an interest in calibration-free methods such as iterative optimization technology (IOT) for spectroscopic PAT that …