Longitudinal Data Analysis and Time Series Commons^™

Role Of Misclassification Estimates In Estimating Disease Prevalence And A Non-Linear Approach To Study Synchrony Using Heart Rate Variability In Chickens, Dola Pathak

Department of Statistics: Dissertations, Theses, and Student Work

Infectious disease assays can be imperfect. When estimating disease prevalence, these imperfections are accounted for by incorporating assay sensitivity and specificity into point and variance estimates. Unfortunately, these accuracy measures are often treated as fixed constants, rather than acknowledging that they are estimates from an assay validation process. The purpose of this study is to show the detrimental effect of not taking into account this sampling variability when samples are obtained through group testing (aka, pooled testing). We show that confidence interval coverage can dramatically decline as the sample size increases for the main sample of interest. As a remedy …