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Harvard University Biostatistics Working Paper Series

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Articles 1 - 14 of 14

Full-Text Articles in Categorical Data Analysis

Powerful Snp Set Analysis For Case-Control Genome Wide Association Studies, Michael C. Wu, Peter Kraft, Michael P. Epstein, Deanne M. Taylor, Stephen J. Chanock, David J. Hunter, Xihong Lin May 2010

Powerful Snp Set Analysis For Case-Control Genome Wide Association Studies, Michael C. Wu, Peter Kraft, Michael P. Epstein, Deanne M. Taylor, Stephen J. Chanock, David J. Hunter, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.


Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin Apr 2010

Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.


A New Class Of Minimum Power Divergence Estimators With Applications To Cancer Surveillance, Nirian Martin, Yi Li Nov 2009

A New Class Of Minimum Power Divergence Estimators With Applications To Cancer Surveillance, Nirian Martin, Yi Li

Harvard University Biostatistics Working Paper Series

No abstract provided.


Measurement Error Caused By Spatial Misalignment In Environmental Epidemiology, Alexandros Gryparis, Christopher J. Paciorek, Ariana Zeka, Joel Schwartz, Brent A. Coull Sep 2008

Measurement Error Caused By Spatial Misalignment In Environmental Epidemiology, Alexandros Gryparis, Christopher J. Paciorek, Ariana Zeka, Joel Schwartz, Brent A. Coull

Harvard University Biostatistics Working Paper Series

No abstract provided.


Estimating Time-To-Event From Longitudinal Categorical Data Using Random Effects Markov Models: Application To Multiple Sclerosis Progression, Micha Mandel, Rebecca A. Betensky Jun 2007

Estimating Time-To-Event From Longitudinal Categorical Data Using Random Effects Markov Models: Application To Multiple Sclerosis Progression, Micha Mandel, Rebecca A. Betensky

Harvard University Biostatistics Working Paper Series

No abstract provided.


Structural Inference In Transition Measurement Error Models For Longitudinal Data, Wenqin Pan, Xihong Lin, Donglin Zeng Aug 2006

Structural Inference In Transition Measurement Error Models For Longitudinal Data, Wenqin Pan, Xihong Lin, Donglin Zeng

Harvard University Biostatistics Working Paper Series

No abstract provided.


Estimation In Semiparametric Transition Measurement Error Models For Longitudinal Data, Wenqin Pan, Donglin Zeng, Xihong Lin Aug 2006

Estimation In Semiparametric Transition Measurement Error Models For Longitudinal Data, Wenqin Pan, Donglin Zeng, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.


Nonparametric Regression Using Local Kernel Estimating Equations For Correlated Failure Time Data, Zhangsheng Yu, Xihong Lin Aug 2006

Nonparametric Regression Using Local Kernel Estimating Equations For Correlated Failure Time Data, Zhangsheng Yu, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.


Causal Inference In Hybrid Intervention Trials Involving Treatment Choice, Qi Long, Rod Little, Xihong Lin Aug 2006

Causal Inference In Hybrid Intervention Trials Involving Treatment Choice, Qi Long, Rod Little, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.


A Comparison Of Methods For Estimating The Causal Effect Of A Treatment In Randomized Clinical Trials Subject To Noncompliance, Rod Little, Qi Long, Xihong Lin Aug 2006

A Comparison Of Methods For Estimating The Causal Effect Of A Treatment In Randomized Clinical Trials Subject To Noncompliance, Rod Little, Qi Long, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.


A Computationally Tractable Multivariate Random Effects Model For Clustered Binary Data, Brent A. Coull, E. Andres Houseman, Rebecca A. Betensky Jun 2006

A Computationally Tractable Multivariate Random Effects Model For Clustered Binary Data, Brent A. Coull, E. Andres Houseman, Rebecca A. Betensky

Harvard University Biostatistics Working Paper Series

No abstract provided.


A Diagnostic Test For The Mixing Distribution In A Generalised Linear Mixed Model, Eric J. Tchetgen, Brent A. Coull Mar 2006

A Diagnostic Test For The Mixing Distribution In A Generalised Linear Mixed Model, Eric J. Tchetgen, Brent A. Coull

Harvard University Biostatistics Working Paper Series

We introduce a diagnostic test for the mixing distribution in a generalised linear mixed model. The test is based on the difference between the marginal maximum likelihood and conditional maximum likelihood estimates of a subset of the fixed effects in the model. We derive the asymptotic variance of this difference, and propose a test statistic that has a limiting chi-square distribution under the null hypothesis that the mixing distribution is correctly specified. For the important special case of the logistic regression model with random intercepts, we evaluate via simulation the power of the test in finite samples under several alternative …


Feature-Specific Penalized Latent Class Analysis For Genomic Data, E. Andres Houseman, Brent A. Coull, Rebecca A. Betensky Sep 2005

Feature-Specific Penalized Latent Class Analysis For Genomic Data, E. Andres Houseman, Brent A. Coull, Rebecca A. Betensky

Harvard University Biostatistics Working Paper Series

No abstract provided.


A Nonstationary Negative Binomial Time Series With Time-Dependent Covariates: Enterococcus Counts In Boston Harbor, E. Andres Houseman, Brent Coull, James P. Shine Sep 2005

A Nonstationary Negative Binomial Time Series With Time-Dependent Covariates: Enterococcus Counts In Boston Harbor, E. Andres Houseman, Brent Coull, James P. Shine

Harvard University Biostatistics Working Paper Series

Boston Harbor has had a history of poor water quality, including contamination by enteric pathogens. We conduct a statistical analysis of data collected by the Massachusetts Water Resources Authority (MWRA) between 1996 and 2002 to evaluate the effects of court-mandated improvements in sewage treatment. Motivated by the ineffectiveness of standard Poisson mixture models and their zero-inflated counterparts, we propose a new negative binomial model for time series of Enterococcus counts in Boston Harbor, where nonstationarity and autocorrelation are modeled using a nonparametric smooth function of time in the predictor. Without further restrictions, this function is not identifiable in the presence …