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Articles 1 - 3 of 3
Full-Text Articles in Biostatistics
Dietary Inflammatory Index And Colorectal Cancer Risk – A Meta-Analysis, Nitin Shivappa, Justyna Godos, James R. Hébert, Michael David Wirth, Gabriele Piuri, Attilio Speciani, Giuseppe Grosso
Dietary Inflammatory Index And Colorectal Cancer Risk – A Meta-Analysis, Nitin Shivappa, Justyna Godos, James R. Hébert, Michael David Wirth, Gabriele Piuri, Attilio Speciani, Giuseppe Grosso
Faculty Publications
Diet and chronic inflammation of the colon have been suggested to be risk factors in the development of colorectal cancer (CRC). The possible link between inflammatory potential of diet, measured through the Dietary Inflammatory Index (DII®), and CRC has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from nine studies were eligible, of which five were case-control and four were cohort studies. Results from meta-analysis showed a positive association between increasing DII scores, indicating a pro-inflammatory diet, and CRC. Individuals in the highest versus …
The Battle Against Malaria: A Teachable Moment, Randy K. Schwartz
The Battle Against Malaria: A Teachable Moment, Randy K. Schwartz
Journal of Humanistic Mathematics
Malaria has been humanity’s worst public health problem throughout recorded history. Mathematical methods are needed to understand which factors are relevant to the disease and to develop counter-measures against it. This article and the accompanying exercises provide examples of those methods for use in lower- or upper-level courses dealing with probability, statistics, or population modeling. These can be used to illustrate such concepts as correlation, causation, conditional probability, and independence. The article explains how the apparent link between sickle cell trait and resistance to malaria was first verified in Uganda using the chi-squared probability distribution. It goes on to explain …
Alcohol Consumption And Breast Tumor Gene Expression, Jun Wang, Yujing J. Heng, A. Heather Eliassen, Rull M. Tamimi, Aditi Hazra, Vincent J. Carey, Christine B. Ambrosone, Victor P. De Andrade, Adam Brufsky, Fergus J. Couch, Tari A. King, Francesmary Modugno, Celine M. Vachon, David J. Hunter, Andrew H. Beck, Susan E. Hankinson
Alcohol Consumption And Breast Tumor Gene Expression, Jun Wang, Yujing J. Heng, A. Heather Eliassen, Rull M. Tamimi, Aditi Hazra, Vincent J. Carey, Christine B. Ambrosone, Victor P. De Andrade, Adam Brufsky, Fergus J. Couch, Tari A. King, Francesmary Modugno, Celine M. Vachon, David J. Hunter, Andrew H. Beck, Susan E. Hankinson
Biostatistics and Epidemiology Faculty Publications Series
Background
Alcohol consumption is an established risk factor for breast cancer and the association generally appears stronger among estrogen receptor (ER)-positive tumors. However, the biological mechanisms underlying this association are not completely understood.
Methods
We analyzed messenger RNA (mRNA) microarray data from both invasive breast tumors (N = 602) and tumor-adjacent normal tissues (N = 508) from participants diagnosed with breast cancer in the Nurses’ Health Study (NHS) and NHSII. Multivariable linear regression, controlling for other known breast cancer risk factors, was used to identify differentially expressed genes by pre-diagnostic alcohol intake. For pathway analysis, we performed gene …