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Full-Text Articles in Biostatistics
Comparing The Cohort Design And The Nested Case-Control Design In The Presence Of Both Time-Invariant And Time-Dependent Treatment And Competing Risks: Bias And Precision, Peter C. Austin
Peter Austin
Purpose: Observational studies using electronic administrative health care databases are often used to estimate the effects of treatments and exposures. Traditionally, a cohort design has been used to estimate these effects, but increasingly studies are using a nested case-control (NCC) design. The relative statistical efficiency of these two designs has not been examined in detail.
Methods: We used Monte Carlo simulations to compare these two designs in terms of the bias and precision of effect estimates. We examined three different settings: (A): treatment occurred at baseline and there was a single outcome of interest; (B): treatment was time-varying and there …