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Full-Text Articles in Biostatistics
Childhood And Adulthood Passive And Active Smoking, And The Abo Group As Risk Factors For Pancreatic Cancer In Women, Anne-Laure Vedie, Nasser Laouali, Amandine Gelot, Gianluca Severi, Marie-Christine Boutron-Ruault, Vinciane Rebours
Childhood And Adulthood Passive And Active Smoking, And The Abo Group As Risk Factors For Pancreatic Cancer In Women, Anne-Laure Vedie, Nasser Laouali, Amandine Gelot, Gianluca Severi, Marie-Christine Boutron-Ruault, Vinciane Rebours
Biostatistics and Epidemiology Faculty Publications Series
Objectives
Active smoking and the A blood group are associated with pancreatic adenocarcinoma (PC) risk. However, potential interactions between those risk factors and the role of passive smoking have been little investigated. We aimed to explore specific and joint associations of passive and active smoking, and effect modification by the ABO blood group in French women.
Methods
The study included 96,594 women from the E3N prospective cohort, mean age: 49 years (SD 6.7). Information on active and passive smoking was reported at inclusion and throughout follow-up. Cases were classified according to the International Classification of Diseases 10. Associations with passive …
Alcohol Consumption And Breast Tumor Gene Expression, Jun Wang, Yujing J. Heng, A. Heather Eliassen, Rull M. Tamimi, Aditi Hazra, Vincent J. Carey, Christine B. Ambrosone, Victor P. De Andrade, Adam Brufsky, Fergus J. Couch, Tari A. King, Francesmary Modugno, Celine M. Vachon, David J. Hunter, Andrew H. Beck, Susan E. Hankinson
Alcohol Consumption And Breast Tumor Gene Expression, Jun Wang, Yujing J. Heng, A. Heather Eliassen, Rull M. Tamimi, Aditi Hazra, Vincent J. Carey, Christine B. Ambrosone, Victor P. De Andrade, Adam Brufsky, Fergus J. Couch, Tari A. King, Francesmary Modugno, Celine M. Vachon, David J. Hunter, Andrew H. Beck, Susan E. Hankinson
Biostatistics and Epidemiology Faculty Publications Series
Background
Alcohol consumption is an established risk factor for breast cancer and the association generally appears stronger among estrogen receptor (ER)-positive tumors. However, the biological mechanisms underlying this association are not completely understood.
Methods
We analyzed messenger RNA (mRNA) microarray data from both invasive breast tumors (N = 602) and tumor-adjacent normal tissues (N = 508) from participants diagnosed with breast cancer in the Nurses’ Health Study (NHS) and NHSII. Multivariable linear regression, controlling for other known breast cancer risk factors, was used to identify differentially expressed genes by pre-diagnostic alcohol intake. For pathway analysis, we performed gene …