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- Adolescents (1)
- Air pollution (1)
- Asthma (1)
- Canadian Community Health Survey (1)
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- Co-morbid (1)
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- Hemolytic anemia (1)
- Hereditary spherocytosis (1)
- Joint models (1)
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Articles 1 - 3 of 3
Full-Text Articles in Biostatistics
Joint Modelling In Liver Transplantation, Elizabeth M. Renouf
Joint Modelling In Liver Transplantation, Elizabeth M. Renouf
Electronic Thesis and Dissertation Repository
In the setting of liver transplantation, clinical trials and transplant registries regularly collect repeated measurements of clinical biomarkers which may be strongly associated with a time-to-event such as graft failure or disease recurrence. Multiple time-to-event outcomes are routinely collected. However, joint models are rarely used. This thesis will describe important considerations for joint modelling in the setting of liver transplantation. We will focus on transplant registry data from the United States. We develop a new tool for joint modelling in the context where a critical health event can be tracked in the longitudinal biomarker and often presents as a non-linear …
Total Versus Partial Splenectomy In Pediatric Hereditary Spherocytosis: A Systematic Review And Meta-Analysis, Leonardo Guizzetti
Total Versus Partial Splenectomy In Pediatric Hereditary Spherocytosis: A Systematic Review And Meta-Analysis, Leonardo Guizzetti
Epidemiology and Biostatistics Publications
To compare the clinical effectiveness of total (TS) or partial (PS) splenectomy in pediatric hereditary spherocytosis, a systematic review and meta-analysis was performed (PROSPERO registration CRD42015030056). There were 14 observational studies comparing pre- and post- operative hematologic parameters. Secondary outcomes include in-hospital infections, surgical complications, symptomatic recurrence and biliary disease. TS is more effective than PS to increase hemoglobin (3.6 g/dL vs 2.2 g/dL) and reduce reticulocytes (12.5% vs 6.5%) after one year; outcomes following PS are stable for at least 6 years. There were no cases of overwhelming post-splenectomy sepsis. A population-based patient registry is needed for long-term follow-up.
A Link Between Paediatric Asthma And Obesity: Are They Caused By The Same Environmental Conditions?, Phylicia Gonsalves
A Link Between Paediatric Asthma And Obesity: Are They Caused By The Same Environmental Conditions?, Phylicia Gonsalves
Electronic Thesis and Dissertation Repository
The highly associated paediatric conditions of asthma and overweight have seen dramatic increases over the past few decades. This thesis explored air pollution exposure as a potential underlying mechanism of co-morbid asthma and overweight among adolescents aged 12 to 18 years. Data from the Canadian Community Health Survey were merged with a database containing estimates of air pollution as assessed by particulate matter ≤ 2.5 microns (PM2.5) concentrations at the postal code centroid in southwestern Ontario. Logistic regression was used to conduct the analysis. Adolescents were more likely to be overweight as PM2.5 concentrations increased. There was …