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Full-Text Articles in Biostatistics

Impact Of Inconsistent Imputation Models In Mediation Analysis, Bo Ye Aug 2021

Impact Of Inconsistent Imputation Models In Mediation Analysis, Bo Ye

Legacy Theses & Dissertations (2009 - 2024)

In this dissertation, we study the impact of inconsistent imputation methods in mediation analysis and its application. We present the study in three papers.


Conditional And Marginal Imputation Models For Multilevel Data, Gang Liu Aug 2021

Conditional And Marginal Imputation Models For Multilevel Data, Gang Liu

Legacy Theses & Dissertations (2009 - 2024)

This dissertation study extends sequential hierarchical regression imputation (SHRIMP) methods to multilevel datasets with three levels of nesting and proposes a marginal method based on marginalized multilevel model (MMM) framework. Specifically, the proposed model consists of two levels such that the first level relates the marginal mean of responses with covariates through a generalized regression model and the second level includes subject specific random effects within the same generalized regression model. To draw the inference on the population-averaged or subject-specified coefficients, the hierarchical regression and/or MMM is applied as the imputation and estimation models. We employ Markov Chain Monte Carlo …


Finite Mixture Models : Applications To Length Of Stay For Delivery Hospitalizations, Eva Williford Jan 2021

Finite Mixture Models : Applications To Length Of Stay For Delivery Hospitalizations, Eva Williford

Legacy Theses & Dissertations (2009 - 2024)

In the United States (U.S.), childbirth is the most common reason for hospitalization, and the maternal mortality rate per 100,000 (2017-2018) is markedly elevated in the U.S. (17.4) compared to neighboring Canada (10), the United Kingdom (7), and Japan (5) (Trends in Maternal Mortality, 2000 to 2017: Estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division). These data, the increased focus on addressing severe maternal morbidity and mortality to improve patient outcomes and reduce healthcare costs is well deserved. These women often have a longer delivery length of stay (LOS) and experience complications of varying …