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Full-Text Articles in Biostatistics
On Partial Identification Of The Pure Direct Effect, Caleb Miles, Phyllis Kanki, Seema Meloni, Eric Tchetgen Tchetgen
On Partial Identification Of The Pure Direct Effect, Caleb Miles, Phyllis Kanki, Seema Meloni, Eric Tchetgen Tchetgen
Harvard University Biostatistics Working Paper Series
No abstract provided.
A Unification Of Mediation And Interaction: A Four-Way Decomposition, Tyler J. Vanderweele
A Unification Of Mediation And Interaction: A Four-Way Decomposition, Tyler J. Vanderweele
Harvard University Biostatistics Working Paper Series
It is shown that the overall effect of an exposure on an outcome, in the presence of a mediator with which the exposure may interact, can be decomposed into four components: (i) the effect of the exposure in the absence of the mediator, (ii) the interactive effect when the mediator is left to what it would be in the absence of exposure, (iii) a mediated interaction, and (iv) a pure mediated effect. These four components, respectively, correspond to the portion of the effect that is due to neither mediation nor interaction, to just interaction (but not mediation), to both mediation …
Mediation Analysis With Time-Varying Exposures And Mediators, Tyler J. Vanderweele, Eric Tchetgen Tchetgen
Mediation Analysis With Time-Varying Exposures And Mediators, Tyler J. Vanderweele, Eric Tchetgen Tchetgen
Harvard University Biostatistics Working Paper Series
In this paper we consider mediation analysis when exposures and mediators vary over time. We give non-parametric identification results, discuss parametric implementation, and also provide a weighting approach to direct and indirect effects based on combining the results of two marginal structural models. We also discuss how our results give rise to a causal interpretation of the effect estimates produced from longitudinal structural equation models. When there are no time-varying confounders affected by prior exposure and mediator values, identification of direct and indirect effects is achieved by a longitudinal version of Pearl's mediation formula. When there are time-varying confounders affected …
On The Causal Interpretation Of Race In Regressions Adjusting For Confounding And Mediating Variables, Tyler J. Vanderweele, Whitney Robinson
On The Causal Interpretation Of Race In Regressions Adjusting For Confounding And Mediating Variables, Tyler J. Vanderweele, Whitney Robinson
Harvard University Biostatistics Working Paper Series
We consider different possible interpretations of the “effect of race” when regressions are run with race as an exposure variable, controlling also for various confounding and mediating variables. When adjustment is made for socioeconomic status early in a person's life, we discuss under what contexts the regression coefficients for race can be interpreted as corresponding to the extent to which a racial disparity would remain if various socioeconomic distributions early in life across racial groups could be equalized. When adjustment is also made for adult socioeconomic status, we note how the overall disparity can be decomposed into the portion that …
A Unification Of Mediation And Interaction, Tyler J. Vanderweele
A Unification Of Mediation And Interaction, Tyler J. Vanderweele
Harvard University Biostatistics Working Paper Series
We show that the overall effect of an exposure on an outcome, in the presence of a mediator with which the exposure may interact, can be decomposed into four components: (i) the effect of the exposure in the absence of the mediator, (ii) the interactive effect when the mediator is left to what is would be in the absence of exposure, (iii) a mediated interaction and (iv) a pure mediated effect. These four components respectively correspond to the portion of the effect that is due to neither mediation nor interaction, to just interaction (but not mediation), to both mediation and …