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Full-Text Articles in Biostatistics
Predictive Accuracy Of Risk Factors And Markers: A Simulation Study Of The Effect Of Novel Markers On Different Performance Measures For Logistic Regression Models, Peter C. Austin
Peter Austin
The change in c-statistic is frequently used to summarize the change in predictive accuracy when a novel risk factor is added to an existing logistic regression model. We explored the relationship between the absolute change in the c-statistic, Brier score, generalized R(2) , and the discrimination slope when a risk factor was added to an existing model in an extensive set of Monte Carlo simulations. The increase in model accuracy due to the inclusion of a novel marker was proportional to both the prevalence of the marker and to the odds ratio relating the marker to the outcome but inversely …