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Articles 1 - 3 of 3
Full-Text Articles in Biostatistics
Effect Of Renin-Angiotensin System Inhibitors On Acute Kidney Injury Among Patients Undergoing Cardiac Surgery: A Review And Meta-Analysis, Han Zhou, Jingui Xie, Zhichao Zheng, Oon Cheong Ooi, Haidong Luo
Effect Of Renin-Angiotensin System Inhibitors On Acute Kidney Injury Among Patients Undergoing Cardiac Surgery: A Review And Meta-Analysis, Han Zhou, Jingui Xie, Zhichao Zheng, Oon Cheong Ooi, Haidong Luo
Research Collection Lee Kong Chian School Of Business
Acute kidney injury (AKI) is a frequent complication of cardiac surgery, which can lead to higher mortality and long-term renal function impairment. The effect of perioperative renin-angiotensin system inhibitors (RASi) therapy on AKI incidence in patients undergoing cardiac surgery remains controversial. We reviewed related studies in PubMed, Scopus, and Cochrane Library from inception to February 2020. Two randomized controlled trials and 21 cohort studies were included in the meta-analysis, involving 76,321 participants. The pooled odds ratio and 95% confidence interval were calculated using the DerSimonian and Laird random-effects model. The results showed no significant association between perioperative RASi therapy and …
Activation Of Trpa1 Nociceptor Promotes Systemic Adult Mammalian Skin Regeneration, Jenny J. Wei, Hali S. Kim, Casey A. Spencer, Donna Brennan-Crispi, Ying Zheng, Nicolette M. Johnson, Misha Rosenbach, Christopher Miller, Denis H. Y. Leung, George Cotsarelis, Thomas H. Leung
Activation Of Trpa1 Nociceptor Promotes Systemic Adult Mammalian Skin Regeneration, Jenny J. Wei, Hali S. Kim, Casey A. Spencer, Donna Brennan-Crispi, Ying Zheng, Nicolette M. Johnson, Misha Rosenbach, Christopher Miller, Denis H. Y. Leung, George Cotsarelis, Thomas H. Leung
Research Collection School Of Economics
Adult mammalian wounds, with rare exception, heal with fibrotic scars that severely disrupt tissue architecture and function. Regenerative medicine seeks methods to avoid scar formation and restore the original tissue structures. We show in three adult mouse models that pharmacologic activation of the nociceptor TRPA1 on cutaneous sensory neurons reduces scar formation and can also promote tissue regeneration. Local activation of TRPA1 induces tissue regeneration on distant untreated areas of injury, demonstrating a systemic effect. Activated TRPA1 stimulates local production of interleukin-23 (IL-23) by dermal dendritic cells, leading to activation of circulating dermal IL-17–producing γδ T cells. Genetic ablation of …
Fast, Accurate, And Reliable Molecular Docking With Quickvina 2, Amr Alhossary, Stephanus Daniel Handoko, Yuguang Mu, Chee-Keong Kwoh
Fast, Accurate, And Reliable Molecular Docking With Quickvina 2, Amr Alhossary, Stephanus Daniel Handoko, Yuguang Mu, Chee-Keong Kwoh
Research Collection School Of Computing and Information Systems
Motivation: The need for efficient molecular docking tools for high-throughput screening is growing alongside the rapid growth of drug-fragment databases. AutoDock Vina ('Vina') is a widely used docking tool with parallelization for speed. QuickVina ('QVina 1') then further enhanced the speed via a heuristics, requiring high exhaustiveness. With low exhaustiveness, its accuracy was compromised. We present in this article the latest version of QuickVina ('QVina 2') that inherits both the speed of QVina 1 and the reliability of the original Vina.Results: We tested the efficacy of QVina 2 on the core set of PDBbind 2014. With the default exhaustiveness level …