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Full-Text Articles in Biostatistics
Flavonoid Intake And Plasma Sex Steroid Hormones, Prolactin, And Sex Hormone-Binding Globulin In Premenopausal Women, You Wu, Susan E. Hankinson, Stephanie A. Smith-Warner, Molin Wang, A. Heather Eliassen
Flavonoid Intake And Plasma Sex Steroid Hormones, Prolactin, And Sex Hormone-Binding Globulin In Premenopausal Women, You Wu, Susan E. Hankinson, Stephanie A. Smith-Warner, Molin Wang, A. Heather Eliassen
Biostatistics and Epidemiology Faculty Publications Series
Background: Flavonoids potentially exert anti-cancer effects, as suggested by their chemical structures and supported by animal studies. In observational studies, however, the association between flavonoids and breast cancer, and potential underlying mechanisms, remain unclear. Objective: To examine the relationship between flavonoid intake and sex hormone levels using timed blood samples in follicular and luteal phases in the Nurses’ Health Study II among premenopausal women. Methods: Plasma concentrations of estrogens, androgens, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), prolactin, and sex hormone-binding globulin (SHBG) were measured in samples collected between 1996 and 1999. Average flavonoid were calculated from semiquantitative food frequency questionnaires …