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Full-Text Articles in Biostatistics
Multivariate Statistical Modeling For Radio-Genomics Study, Tiantian Zeng
Multivariate Statistical Modeling For Radio-Genomics Study, Tiantian Zeng
Theses and Dissertations--Statistics
Radiogenomics is a new direction in cancer research that focuses on the associations among radiomics, genomics and clinical outcome. Currently, the major challenge for Radiogenomics lies in the effective integration of genomics and imaging data for promising clinical outcome prediction. Herein, we propose a multivariate joint model that can integrate imaging and genomic data for better predicting the clinical outcome. Specifically, we jointly consider two multivariate group lasso models, one regresses imaging features on genomic features, and the other regresses patient’s clinical outcome on genomic features. An L1 penalty term is introduced for each variable, and weight in the penalty …