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Full-Text Articles in Biostatistics
Dose-Response And Finding In Phase Ii Clinical Studies — Mcp-Mod Methodologies, Zhao Yang
Dose-Response And Finding In Phase Ii Clinical Studies — Mcp-Mod Methodologies, Zhao Yang
Zhao (Tony) Yang, Ph.D.
This presentation give an overall introduction to the MCP-Mod methodology with detailed step-by-step demonstration.
On The Exact Size Of Multiple Comparison Tests, Chris Lloyd
On The Exact Size Of Multiple Comparison Tests, Chris Lloyd
Chris J. Lloyd
No abstract provided.
On The Size Accuracy Of Combination Tests, Chris Lloyd
On The Size Accuracy Of Combination Tests, Chris Lloyd
Chris J. Lloyd
One element of the analysis of adaptive clinical trials is combining the evidence from several (often two) stages. When the endpoint is binary, standard single stage tests statistics do not control size well. Yet the combined test might not be valid if the single stage tests are not. The purpose of this paper is to numerically and theoretically examine the extent to which combining basic tests statistics mitigates or magnifies the size violation of the final test.