Biometry Commons^™

Meta-Analysis Of Gene Expression Studies, Umaporn Siangphoe

Theses and Dissertations

Combining effect sizes from individual studies using random-effects models are commonly applied in high-dimensional gene expression data. However, unknown study heterogeneity can arise from inconsistency of sample qualities and experimental conditions. High heterogeneity of effect sizes can reduce statistical power of the models. We proposed two new methods for random effects estimation and measurements for model variation and strength of the study heterogeneity. We then developed a statistical technique to test for significance of random effects and identify heterogeneous genes. We also proposed another meta-analytic approach that incorporates informative weights in the random effects meta-analysis models. We compared the proposed …

An Easy Access Interactive Statistical System For Use And Training In Biometry, Amos Addison Slaymaker Jr.

Theses and Dissertations

One of the most important tools of the applied statistician is the digital computer. It is natural, therefore, for the instructor in applied statistics to want his students to become familiar with the use of computers. If his students are going to get actual experience in using a computer for statistical analysis, he often has only two alternatives. The students can be required to write their own statistical programs or they can use programs already available through a computer facility.

If the course is to be taught such that each student is responsible for his own programs, the instructor must …