Statistics and Probability Commons^™

Perspective—Surface-Display Techniques In Electrochemical Biosensor Designs For Health Monitoring, Courtney J. Weber, Megan D. Whisonant, Olivia M. Clay, Olja Simoska

Faculty Publications

Enzymatic and microbial electrochemical biosensors integrate enzymes and microorganisms as biological recognition elements into the sensor design and functionality. Enzyme-based sensors offer high sensitivity and selectivity for target analyte detection. However, these have limited stability necessary for continuous analyte monitoring. Contrarily, microbe-based electrochemical sensors provide a means for continuous analyte sensing but are associated with challenges related to analyte selectivity in complex samples. To address these limitations, surface-display methods, which bind enzymes to microbial surfaces, enhance biosensor selectivity and sensitivity. This perspective outlines the application of surface-display techniques, offering a promising avenue for health monitoring.

Employing Digital Pcr For Enhanced Detection Of Perinatal Toxoplasma Gondii Infection: A Cross-Sectional Surveillance And Maternal-Infant Outcomes Study In El Salvador, Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F. Torres-Romero, Hanson Cowan, Madeleine M. Meyer, Willber D. Castro-Godoy, Mufaro Kanyangarara Ph.D., Stella Coker Watson Self Ph.D., Ms, Berry A. Campbell, Melissa Nolan Ph.D., Mph

Faculty Publications

Toxoplasma gondii is a parasitic infection that can be transmitted in utero, resulting in fetal chorioretinitis and other long-term neurological outcomes. If diagnosed early, pregnancy-safe chemotherapeutics can prevent vertical transmission. Unfortunately, diagnosis of acute, primary infection among pregnant women remains neglected, particularly in low-and-middle-income countries. Clinically actionable diagnosis is complex due to the commonality of infection during childhood and early adulthood which spawn long-last antibody titers and historically unreliable direct molecular diagnostics. The current study employed a cross-sectional T. gondii perinatal surveillance study using digital PCR, a next generation molecular diagnostic platform, and a maternal-fetal outcomes survey to ascertain …

Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander

Student Theses and Dissertations

Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H₂O₂ (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …

Time Scale Separation In Life-Long Ovarian Follicles Population Dynamics Model, Romain Yvinec, Frédérique Clément, Guillaume Ballif

Biology and Medicine Through Mathematics Conference

No abstract provided.

Multi-Type Branching Processes In Time-Varying Environments, Arash Jamshidpey

Biology and Medicine Through Mathematics Conference

No abstract provided.

Exchangeability And A Model Of Biological Evolution, Renee Haddad

Honors Scholar Theses

A sequence of random variables (RVs) is exchangeable if its distribution is invariant under permutations. For example, every sequence of independent and identically distributed (IID) RVs is exchangeable. The main result on exchangeable sequences of random variables is de Finetti's theorem, which identifies exchangeable sequences as conditionally IID. In this thesis, we explore exchangeability, provide an elementary proof of de Finetti's theorem, and present two applications: the classical Polya's urn model and a toy model for biological evolution.

Modeling Human Temporal Eeg Responses To Vr Visual Stimuli, Richard R. Foster, Connor Delaney, Dean J. Krusienski, Cheng Ly

Biology and Medicine Through Mathematics Conference

No abstract provided.

Improved Rational Approximation Of Near-To-Far Propagation Kernels For The Wave Equation, Sampson Owusu

Mathematics & Statistics ETDs

The 3-space, 1-time dimensional scalar wave equation, or 3+1 wave equation, describes the propagation of scalar or acoustic waves. The unforced homogeneous equation admits a class of outgoing solutions relative to a chosen fixed center, so called “multipole” solutions. This thesis examines near-to-far signal propagation in the context of these multipole solutions. Given a time-series (history of values) for a multipole solution recorded at a radius r1, near- to-far signal propagation recovers the corresponding time-series at larger radius r2 ≫ r1. This propagation takes into account both the appropriate time delay r2 − r1 and corrections to the wave shape. …

Nidus Idearum. Scilogs, Xiii: Structure / Neutrostructure / Antistructure, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this thirteenth book of scilogs – one may find topics on Neutrosophy, Plithogeny, Physics, Mathematics, Philosophy – email messages to research colleagues, or replies, notes, comments, remarks about authors, articles, or books, spontaneous ideas, and so on. It presents new types of soft sets and new types of topologies.

Exchanging ideas with Mohammad Abobala, Ishfaq Ahmad, Ibrahim M. Almanjahie, Fatimah Alshahrani, Nizar Altounji, Muhammad Aslam, Said Broumi, Victor Christianto, R. Diksh, Feng Liu, Frank Julian Gelli, Erick Gonzalez Caballero, Riad Hamido, Yaser Al-Hasan, Ahmed Hatip, Yasin Karmouta, Nivetha Martin, Preda Mihăilescu, V. Lakshmana Gomathi Nayagam, Ze Carlos Tiago de …

Assessing Reproducibility Of Brain-Behavior Associations Using Bootstrap Aggregation Methods, Zhetao Chen

Arts & Sciences Graduate Student Theses and Dissertations

在本论文中，随着越来越多地利用静息态功能连接 MRI (rs-fcMRI) 将神经活动与病理状况联系起来，我们面临着对此类数据可靠性的普遍担忧。我们的探索集中于提高人类连接组计划（HCP）数据集框架内大脑行为关联的可重复性。我们采用两种不同的引导聚合方法来研究功能连接可靠性的增强：使用循环块引导（CBB）的单独时间序列装袋和使用线性支持向量回归（LSVR）模型的主题级装袋。我们对 CBB 个体时间序列 bagging 的调查表明，这种方法并不能显着增强大脑行为关联的可重复性。这一发现指出了实现可靠的功能连接措施的复杂性以及某些聚合方法在克服这一挑战方面的局限性。相比之下，我们的学科水平考试 通过 LSVR 模型装袋呈现出更有希望的结果。这种方法显着增强了分析之间模型权重的可靠性，证明了其在提高数据稳健性和可重复性方面的功效。两种方法的这种不同影响强调了适当的分析策略在提高神经影像数据可靠性方面的关键作用。通过描述这两种方法的结果，本论文有助于对神经影像领域的数据可靠性进行更广泛的讨论。它强调了在不同数据集上持续进行方法创新和验证的必要性，以提高 rs-fcMRI 研究的可靠性和可解释性。

Capturing Higher-Order Relationships Through Information Decomposition, Aobo Lyu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Mutual information between two random variables is a well-studied notion, whose understanding is fairly complete. Mutual information between one random variable and a pair of other random variables, however, is a far more involved notion. Specifically, Shannon's mutual information does not capture fine-grained interactions between those three variables, resulting in limited insights in complex systems. To capture these fine-grained higher-order interactions among variables, Williams and Beer proposed a framework called Partial Information Decomposition (PID) to decompose this mutual information to information atoms, called unique, redundant, and synergistic, and proposed several operational axioms that these atoms must satisfy. This conceptual …

Robust Prediction Of Charpy Toughness Of Additively Manufactured Kovar Using Deep Convolutional Neural Networks, Nathan R. Bianco

Mathematics & Statistics ETDs

Understanding the reason for mechanical failures of manufactured parts in their operating environments is critical to prevention of future failures. However, in-situ post-mortem evaluation of physical properties, such as fracture toughness, is time consuming and alters the condition of the material, leading to potentially misleading findings. In this study, additively manufactured test coupons were produced over a wide range of process conditions to test the impact toughness of a material. The Charpy V-Notch toughness was measured on over 200 samples alongside corresponding optical images of both sides of the fracture surface. Convolutional neural network models were trained to correlate fracture …

Statistical Approaches For The Early Detection Of Colorectal Cancer Using Longitudinal Biomarkers, Emily Berry

Statistical Science Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States [45]. CRC is believed to advance from adenomatous polyps creating a unique opportunity for both early detection and cancer prevention [4, 23]. Like other diseases, CRC screening reduces mortality by detecting cancer at earlier, more treatable stages; however, it can also reduce incidence through the removal of precancerous lesions [4]. As a result, screening is recommended for average-risk adults ≥ 45 years of age and includes a variety of tests [4, 12]. Despite alternate screening options, colonoscopy capacity is often cited as a barrier to …

The Performance Of Arima And Arfima In Modelling The Exchange Rate Of Nigeria Currency To Other Currencies, Adewole Ayoade I.

Al-Bahir

Economic performance of a nation depends majorly on the stability of foreign exchange rate; the economic viability hangs on the exchange rate of local currencies against other currencies across the globe. Box – Jenkins Approach was employed to model the Naira exchange rate to other major currencies using Autoregressive Integrated Moving Average (ARIMA) and The autoregressive fractional integral moving average (ARFIMA) models. This studies aimed on measuring forecast ability of Autoregressive Integrated Moving Average (ARIMA) (p,d,q) and autoregressive fractional integral moving average (ARFIMA) (p, fd, q) models for stationary type series that exhibit features of Long memory properties. Results indicate …

Testing The Hypothesis That Tennis Points Are Independent And Identically Distributed Using Statistical Methods, Ernesto Ugona Santana

Senior Honors Theses

Most research on the probability of winning a tennis match is based on the assumption that the points are independent and identically distributed, treating each point as a Bernoulli trial with fixed probability of success. This assumption, however, seems to contradict experience. Players' performance appears to fluctuate as the match progresses due to the psychological effect of past performance. To test this counterintuitive yet central assumption, previous research has attempted to test the independence hypothesis. However, there exists a research gap in evaluating the identicality-of-distribution hypothesis, a question of broader scope than that of independence. Hence, the purpose of this …

Reasonable Construction Method For Grade Ⅳ Surrounding Rock In Single‑Hole Four‑Lane Super‑Span Highway Tunnel, Li Heyin, Gao Jingming, Li Yanfeng, Xun Wenjie, Dong Fangfang, Zhang Jiangang

Journal of China & Foreign Highway

In order to study the reasonable constr uction method of super-span highway tunnels，the Xinghuacun No.1 tunnel included in the reconstruction and expansion project of the Xiaocaohu –Urumqi section of the Lianyungang –Khorgos Expressway in Xinjiang was studied.The numerical simulation method was used to analyze the deformation and stress of the supporting structure of the Grade tisurrounding rock in the super-span highway tunnel constructed by the center diaphragm （CD） method，the upper-bench CD method，and the three-bench and seven-step excavation method.Under the premise that the deformation and the stress of the supporting structure met the design requirements，the advantages and disadvantages of each construction …

Intelligent Bridge Lifecycl E Maintenance System Based On Long‑Term Inspection, Ye Zhiwei, Zhang Jiaxin, Tan Haishan, Fan Lei, He Wen, Dong You, Wu Wanglin

Journal of China & Foreign Highway

The current bridge maintenance sy stem in China primarily relies on bridge inspection data to prioritize the state of bridges and allocate a limited budget accordingly.This strategy focuses on repairing bridges with low performance，concentrating on restorative maintenance but ignoring preventive maintenance.In view of the total lifecycle cost，the repair-oriented method may require a lower initial investment but leads to significant resource consumption in the mid to late stages.Based on existing highway bridge maintenance systems，an intelligent maintenance system relying on Chinese standards and bridge inspection data and combining repair and prevention was developed.The system model mainly consisted of two modules：the bridge performance …

Mechanical And Deformation Characteristics Of Piles In Coastal Soft Soil Areas Considering Softening Effect, Wang Fei, Yan Yu, Jiao Lidong, Shen Fengqi, Chen Lu, Liu Jianhua

Journal of China & Foreign Highway

In order to discuss the mechanical and deformation behavior of piles in coastal soft soil areas under horizontal load，the corresponding simplified mechanical model was established according to the loading characteristics of piles in coastal soft soil areas.Secondly，the softening effect of coastal soft soil was considered to modify the existing p-y curve model.On this basis，the differential equation of pile deflection in coastal soft soil areas was derived，and its internal force and displacement were solved by the transfer matrix method.A nonlinear calculation method of piles in coastal soft soil areas considering the softening effect was obtained.Finally，the influence of softening parameters，pile diameter，and elastic …

Experimental Study On Fracture Performance Of Emulsified Asphalt Cold Recycled Mixture, Chu Chenfeng, Deng Jun, Zhou Chen, Wang Zi ’Ang, Kuang Ao, Liu Hongfu

Journal of China & Foreign Highway

Cracking in emulsified asphalt cold recycled pavements is one of the main constraints on their large-scale application in road engineering.To study the fracture performance indicators of cold recycled asphalt mixture and the improvement measures of crack resistance performance，this study investigated three types of mixtures：ordinary emulsified asphalt，basalt fiber，and styrene-butadiene rubber （SBR） modified emulsified asphalt.This study conducted a four-point bending strength test on notched beams，and acoustic emission tests of the beam with prefabricated cracks were carried out to evaluate the fracture performance of three different emulsified asphalt cold recycled mixtures in road engineering.The evaluation criteria included strain energy release rate，stress intensity factor，energy …

Experiment On Strength And Deformation Characteristics Of Marine Silt Cement Soil And Their Relationship, Deng Wu, Liu Weizheng, Chen Tie, Ge Mengyuan

Journal of China & Foreign Highway

In order to study the compre ssive，flexural，and shear strength and deformation characteristics of marine silt cement soil，a series of laboratory mix ratio tests were carried out，so as to test the changes in unconfined compressive strength fcu，flexural strength ff，normalized shear strength τqg，normalized principal stress difference （σ1‒σ3）/σ3，and compression modulus Es under different dosage of curing agents，curing ages，and cement-to-lime ratios.In addition，the correlation between different parameters was investigated.The results show that the performance of the improved samples with cement and lime is 2%‒17% higher than that with cement alone under the same dosage.The strength of cement soil is proportional to the dosage and age …

Study On Compression Characteristics Of Solidified Mud‑Sand Mixed Fillers Considering Particle Breakage, Han Chao, Yu Yuezhong, Bai Bin, Xu Zhihao, Zhang Xianmeng, Liu Yinying, Kong Shuoying

Journal of China & Foreign Highway

The mixed filler of solidified mud and sand provides an ideal solution for the resourceful disposal of wasted engineering mud，and the compression characteristics of filling engineering are closely related to the strength characteristics and particle breakage characteristics of mixed fillers.This study conducted large size compression tests on mixed fillers with different particle gradations and established a discrete element method （DEM） model that incorporated particle breakage for the side-limited compression tests of solidified mud-sand mixed fillers.The changes in the compression modulus of the mixed fillers and the amount of solidified soil particle breakage during compaction were investigated.The study placed a special …

Mechanical Performance Of Uhpc Building Envelope Based On Topological Optimization And Modular Composition, Zhou Zhixuan, Jiang Youbao, Liu Jun, Xiang Yi, Zhou Hao

Journal of China & Foreign Highway

To ensure a safe，aesthetic，and lightweight building envelope，an ultra-high performance concrete （UHPC） building envelope and its node connection mode were proposed based on topological optimization and modular composition.Firstly，the UHPC building envelope was optimized by using the method of minimizing structural compliance subjected to given material volume constraints，and the mechanical performance before and after optimization was compared.The modular design was adopted，and the optimization result of the most unfavorable stress area in the model was taken as the basic configuration unit.Then，UHPC tenon and mortise nodes were proposed，which could be simply assembled into modules.By considering the weak mechanical performance of nodes，the finite element analysis …

Key Techniques For Demolition Of Multi‑Span Continuous Arch Bridge With Concrete‑Filled Steel Tubes, Wan Chengf U, Zeng Wenli

Journal of China & Foreign Highway

Taking the demolition project of Jianhu Bridge as the research background，the demolition of arch bridges with concrete-filled steel tubes under complex conditions was studied.First，the current bridge demolition methods and application status were introduced，and three bridge demolition schemes were put forward according to the difficulties of the bridge demolition.The appropriate demolition scheme for the bridge was selected after comparison，and the sequence of arch bridge demolition was explained.Then，the stress characteristics of the bridge at each construction stage were analyzed，and the theoretical and measured displacement and stress at the most unfavorable stage during demolition were compared.Finally，the influence of material strength and temperature on …

Parameter Sensitivity Analysis Of Single‑Tower Cable‑Stayed Bridge With Mixed Beam, Chen Kongliang, Ye Jianxin, Xu Yufeng, Huang Zhuobin, Guo Fengtao

Journal of China & Foreign Highway

To improve the efficiency of the review simulation model of the bridge monitoring unit and study the influence of different parameters of the single-tower mixed beam cable-stayed bridge on the bridge ’s completed state in the construction process，this paper，taking the cable-stayed bridge of Tongji Road in Foshan with a span of （200+68+46） m as the engineering background，adopted the single control variable method and response surface-Monte Carlo method for sensitivity analysis.Taking the main beam alignment，main tower alignment，main beam stress，and the variation of cable-stayed bridge force as control objectives，this paper studied the influence of the variation of main beam weight，initial tensile force，and …

Design And Installation Technology Of Hanging Basket For Long‑Span Concrete Girder Cable‑Stayed Bridge, Zeng Xianliu, Pang Jianguo, Chen Cheng

Journal of China & Foreign Highway

The main bridge of Zhungeer Yellow River Super Major Bridge is a （160+440+160） m double tower double cable plane full floating system concrete grider cable-stayed bridge.The main beam is a 28.4m wide double box prestressed concrete structure.It was constructed by cantilever pouring with a front fulcrum hanging basket.The maximum weight of the cantilever pouring section is 5 800 kN.To ensure the integral rigidity of the hanging basket，the hanging basket bearing platform adopted the steel box girder structure.The long and large components were connected by high-strength bolts made in sections to facilitate the transportation and installation of the hanging basket.The hanging …

Research On Road Performance Of Carbonaceous Shale Subgrade Filler, Zhang Mengjin, Huang Yafei, Wu Qian, Mao Xuesong, Zhang Jianxun, Chen Xinyi, Wang Yueyue

Journal of China & Foreign Highway

The application of carbonaceous shale for subgrade filling not only alleviates the shortage of subgrade filler in carbonaceous shale distribution areas but also meets the strategic requirements of “resource conservation and saving ” and “green development ” for infrastructure construction in China.However，such rocks are weak and susceptible to weathering and disintegration，and they exhibit significant strength deterioration when exposed to water.To fully apply them，their performance must be comprehensively understood.In this paper，the basic properties of the carbonaceous shale were studied，and filler gradation was designed.The tests on compaction characteristics of the filler and particle crushing characteristics after compaction，RCBR （California bearing ratio ） variation …

Mesoscopic Numerical Simulation Of Concrete Cracking Caused By Nonuniform Corrosion Of Strands, Zeng Tianbao, Chen Hong, Huang Xiaoqi, Tu Ronghui, Dai Lizhao

Journal of China & Foreign Highway

The non-uniform corrosion of spinning strands will induce concrete cracking.A non-uniform expansion model of corrosion products of strands was established，and a mesoscopic numerical model of concrete cracking caused by non-uniform corrosion of strands was built.Concrete was considered as a three-phase composite material composed of mortar matrix，aggregate，and interface layer.The concrete cracking behavior caused by the non-uniform corrosion of strands was simulated by embedding cohesive elements.The rationality of the proposed model was verified by existing experimental data，and the influence of protective layer thickness and aggregate content of concrete on the width of corrosion-induced cracks was discussed.The results show that the proposed non-uniform …

Research And Field Test On Ultra‑Thin Wearing Course Based On Balanced Design Concept, Gu Jianjun, Li Xia, Li Atan, Sun Qiang, Li Jie, Jiang Zhaowei

Journal of China & Foreign Highway

To address the application of an ultra-thin wearing course in expressway asphalt pavement maintenance engineering，the ultra-thin wearing course system based on the balance design concept was systematically studied.In this paper，the action mechanism and application characteristics of modifiers were analyzed，and the proportion design test of the ultra-thin wearing course was designed based on the balance design method.Finally，according to the proportion design test，the optimal proportion of the ultra-thin wearing course material was selected for test road paving.Research shows that the direct-cast high viscosity modifier is convenient for transportation and storage，improves the elastic recovery of asphalt mixtures and reduces permanent deformation.Under the condition …

Experimental Study On Static And Dynamic Mechanical Properties Of Pva Fiber‑Reinforced Coral Concrete, Zhou Jinyi, Long Zhilin, Guo Ruiqi, Kuang Dumin, Cai Yang, Chen Shasha, Chen Jinjie

Journal of China & Foreign Highway

To enhance the mechanical properties of coral concrete，static mechanical tests were conducted at five polyvinyl alcohol fiber volume fractions （0，0.5%，1%，1.5% and 2%）.The impact compression properties were investigated under four strain rates using a split Hopkinson pressure bar with a diameter of 100 mm.The results show that the incorporation of an appropriate number of fibers can significantly improve the static compressive strength and splitting tensile strength of concrete.Dynamic mechanical tests show that coral concrete has an obvious strain rate effect，and the incorporation of fibers can improve the sensitivity of the dynamic reinforcement factor to strain rate，with the reinforcement effect becoming saturated …

Influence Of Warm‑Mixed Flame Retardant Technology On Construction Environment Of Asphalt Pavement In Long Tunnel, Xian Jianglin, Li Yanxiang, Yang Qingyang

Journal of China & Foreign Highway

With the long tunnel as the research object，the variation of volatile organic compound （VOC） volume fraction，CO volume fraction，and illuminance in the construction area of the middle of the tunnel under the conditions of hot mix technology and warm-mixed flame retardant technology was tested respectively，and the influence of warm-mixed flame retardant technology on the construction environment of asphalt pavement in long tunnels was analyzed and evaluated.The results show that when the pavement of a long tunnel adopts hot mix technology，the mass concentration of asphalt fume in the whole operation area is relatively high，and that in some areas exceeds the threshold value.The …