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Analisis Risiko Karakteristik, Sosial Ekonomi, Perilaku Dan Kondisi Lingkungan Rumah Terhadap Kejadian Malaria, Susy Sriwahyuni Sukiswo, Rinidar Rinidar, Sugito Sugito

Kesmas

Malaria merupakan penyakit menular yang menjadi perhatian global. Kecamatan Arongan Lambalek merupakan daerah rawan malaria di Kabupaten Aceh Barat dengan kategori Medium Incidence Area dengan nilai Annual Parasite Incidence (API) 3,67 per 1000 penduduk masih di atas target API Nasional pada fase eliminasi API kurang dari 1 per 1000 penduduk tahun 2013. Penelitian ini bertujuan menganalisis karakteristik, sosial ekonomi, perilaku, dan kondisi lingkungan rumah yang berpengaruh terhadap kejadian malaria di Kecamatan Arongan Lambalek, Kabupaten Aceh Barat. Jenis penelitian ini adalah observasional analitik dengan pendekatan kasus kontrol dengan metode penarikan sampel yaitu purposive sampling. Jumlah sampel dalam penelitian ini terdiri 33 …

Mutu Pelayanan Puskesmas Perawatan Yang Berstatus Badan Layanan Umum Daerah, Putu Ayu Indrayathi, Rina Listyowati, Ni Made Sri Nopiyani, Luh Putu Sinthya Ulandari

Kesmas

Kebijakan pusat pelayanan kesehatan masyarakat (puskesmas) sebagai Badan Layanan Umum Daerah (BLUD) diimplentasikan untuk meningkatkan kualitas pelayanan kesehatan dasar. Kebijakan BLUD puskesmas telah diterapkan di Kabupaten Gianyar sejak tahun 2010 dan berlaku pada puskesmas perawatan maupun nonperawatan. Pelaksanaan BLUD puskesmas tidak selalu meningkatkan mutu layanan. Penelitian ini bertujuan mengetahui gambaran mutu pelayanan puskesmas perawatan yang berstatus BLUD di Kabupaten Gianyar. Penelitian ini merupakan penelitian potong lintang dengan pendekatan kuantitatif dan kualitatif. Tempat dan waktu penelitian ini dilakukan di Kabupaten Gianyar, Agustus hingga Desember 2013. Data kuantitatif dikumpulkan melalui penyebaran kuesioner kepada 105 pengguna layanan di empat puskesmas yang dipilih dengan …

Kondisi Kesehatan Lingkungan Pesantren Dan Perilaku Hidup Bersih Dan Sehat Siswa Dengan Kejadian Hepatitis, Ii Sumarni, Dewi Susanna

Kesmas

Kejadian luar biasa hepatitis A di Kabupaten Ciamis telah terjadi beberapa kali, satu di antaranya terjadi di Pondok Pesantren X. Penelitian ini bertujuan untuk menganalisis kondisi kesehatan lingkungan serta perilaku hidup bersih dan sehat dengan kejadian hepatitis A siswa/siswi di Pondok Pesantren X Kabupaten Ciamis. Rancangan penelitian menggunakan desain kasus kontrol dengan jumlah kasus 40 orang dan kontrol 80 orang, total sampel 120 orang. Populasi penelitian adalah siswa/siswi madrasah tsanawiyah dan madrasah aliyah negeri yang tinggal di asrama pondok pesantren. Data kasus merupakan data sekunder yang diperoleh dari Tim Surveilans Kabupaten Ciamis, dengan hasil pemeriksaan serologis positif. Sedangkan kontrol berdasarkan …

Determinants Of Multimorbidity Among The Elderly Population In Indonesia, Yeni Mahwati

Kesmas

Multimorbiditas adalah kehadiran dua atau lebih penyakit kronis pada satu orang. Prevalensi multimorbiditas meningkat dengan usia, terutama pada lanjut usia (lansia). Penelitian ini bertujuan untuk mengetahui prevalensi dan determinan multimorbiditas pada lansia di Indonesia. Data diambil dari survei keempat Indonesian Family Life Survey (IFLS) yang diadakan pada tahun 2007. IFLS adalah survei sosial ekonomi dan kesehatan longitudinal di Indonesia. Sampel yang digunakan dalam analisis adalah 2.960 lansia (³ 60 tahun). Regresi logistik dilakukan untuk menentukan prevalensi dan determinan multimorbiditas pada lansia. Hasil penelitian menunjukkan prevalensi multimorbiditas sebesar 15,8%, dengan prevalensi lebih tinggi pada lansia yang overweight/obesitas, tingkat pendidikan rendah, tidak …

Pemakaian Kelambu Berinsektisida Pada Anak Usia 0-4 Tahun Terhadap Kejadian Malaria, Raden Ayu Aisyah, Dewi Susanna

Kesmas

Penelitian ini bertujuan untuk mengetahui hubungan pemakaian kelambu berinsektisida dengan kejadian malaria pada anak usia 0-4 tahun di wilayah Puskesmas Galang Kecamatan Galang Kota Batam tahun 2013. Desain penelitian adalah potong lintang pada 132 responden. Hasil penelitian membuktikan bahwa pada tingkat signifikansi 5% terdapat hubungan bermakna antara jenis kelambu (OR = 4,6), lama pemakaian kelambu (OR = 2,9), cara pencucian kelambu (OR = 3,6), cara menjemur kelambu (OR = 2,8), dan pencelupan ulang kelambu (OR = 3,6) memiliki hubungan yang bermakna dengan kejadian malaria. Pendidikan (OR = 2,9), pekerjaan (OR = 2,8), dan lama bermukim (OR = 3,1) memiliki hubungan …

Efek Samping Obat Terhadap Kepatuhan Pengobatan Antiretroviral Orang Dengan Hiv/Aids, Fachri Latif, Ida Leida Maria, Muhammad Syafar

Kesmas

Tingkat kepatuhan pengobatan antiretroviral di Indonesia sangat rendah, yaitu 40 - 70%, yang masih di bawah target nasional dengan tingkat kepatuhan 95%. Berbeda dengan rata-rata nasional, Puskesmas Jumpandang Baru justru memiliki tingkat kepatuhan pengobatan antiretroviral pasien HIV/AIDS di atas 95%. Penelitian ini bertujuan untuk menganalisis faktor yang paling berpengaruh terhadap kepatuhan pengobatan antiretroviral orang dengan HIV/AIDS (ODHA). Jenis penelitian bersifat observasional analitik dengan pendekatan potong lintang. Populasi penelitian adalah 121 ODHA yang aktif menjalani pengobatan antiretroviral di Puskesmas Jumpandang Baru yang dipilih dengan menggunakan teknik exhaustive sampling. Sampel dalam penelitian ini adalah 121 sampel. Penelitian dilakukan pada 22 April hingga …

Prevalensi Sindrom Metabolik Pada Pekerja Perusahaan, Zahtamal Zahtamal, Yayi Suryo Prabandari, Lientje Setyawati

Kesmas

Sindrom metabolik adalah masalah kesehatan yang prevalensinya cenderung meningkat pada pekerja. Penelitian ini bertujuan memaparkan prevalensi kasus sindrom metabolik yang terjadi pada pekerja perusahaan. Penelitian ini dilakukan pada tahun 2014 pada dua perusahaan di Provinsi Riau dengan rancangan potong lintang. Sumber data adalah rekam medis pekerja yang melakukan medical check up periode Oktober 2013 hingga Februari 2014. Populasi adalah pekerja yang menderita sindrom metabolik sebanyak 131 orang. Sampel penelitian dipilih dengan cara total sampling yakni 131 orang. Instrumen adalah kuesioner, international physical activity questionnaire, tabel 24 hours food recall, dan tabel bantu pencatatan komponen sindrom metabolik. Pengelolaan data dilakukan secara …

Perubahan Pola Konsumsi Pangan Sumber Zat Goitrogenik Sianida Dan Cara Pengolahannya Melalui Penyuluhan Gizi, Farida Wahyu Ningtyias, Ahmad Husain Asdie, Madarina Julia, Yayi Suryo Prabandari

Kesmas

Kabupaten Jember masih menghadapi masalah gizi gangguan akibat kekurangan iodium (GAKI), sebagian besar kecamatannya termasuk dalam kategori daerah endemik GAKI. Salah satu penyebabnya adalah faktor goitrogenik sianida yang mengganggu pembentukan hormon tiroid. Keberadaannya pada beberapa sayuran yang biasa dikonsumsi masyarakat menyebabkan diperlukannya pola konsumsi dan proses pengolahan yang baik agar aman dikonsumsi. Penelitian ini bertujuan mengubah pola konsumsi goitrogenik sianida dan cara pengolahannya melalui penyuluhan gizi dan demonstrasi cara pengolahan pangan sumber goitrogenik sianida yang benar. Penelitian ini adalah sebuah penelitian kuasi eksperimental dengan rancangan pretest-posttest control design. Jumlah sampel sebanyak 196 ibu rumah tangga, terdiri dari 98 orang di …

Upaya Peningkatan Status Gizi Balita Malnutrisi Akut Berat Melalui Program Home Care, Titih Huriah, Laksono Trisnantoro, Fitri Haryanti, Madarina Julia

Kesmas

Malnutrisi pada balita masih merupakan permasalahan di Indonesia termasuk di Daerah Istimewa Yogyakarta. Berdasarkan indikator berat badan menurut tinggi badan, 2,6% balita mengalami malnutrisi akut berat. Pada beberapa dekade terakhir, telah terjadi pergeseran paradigma dalam penanganan balita malnutrisi, yang sebelumnya berbasis pendekatan fasilitas kesehatan bergeser menjadi pendekatan berbasis komunitas. Tujuan penelitian ini adalah untuk menganalisis pengaruh program home care terhadap peningkatan status gizi balita malnutrisi pada anak usia 6-60 bulan. Penelitian menggunakan desain kuasi eksperimen dengan pretest dan posttest control group melalui tiga tahap pendampingan yaitu intensif, mandiri, dan penguatan dengan pendekatan asuhan keperawatan. Sampel adalah 56 balita malnutrisi akut …

Perbedaan Pendidikan Kelompok Sebaya Tentang Pendewasaan Usia Perkawinan Di Perkotaan Dan Perdesaan, Willa Follona, Ardini S. Raksanagara, Benny Hasan Purwara

Kesmas

Remaja berisiko terhadap pernikahan usia dini namun informasi tentang pendewasaan usia perkawinan masih kurang. Pendidikan kelompok sebaya merupakan metode pendidikan kesehatan yang sesuai untuk remaja, namun belum terlaksana di lingkungan masyarakat baik perkotaan maupun perdesaan. Selain itu, belum terfokus pada pendewasaan usia perkawinan, sehingga perlu diketahui perbedaan pengetahuan dan sikap tentang pendewasaan usia perkawinan setelah pendidikan kelompok sebaya pada remaja di perkotaan dan perdesaan. Tujuan penelitian ini adalah untuk menganalisis perbedaan pendidikan kelompok sebaya tentang pengetahuan dan sikap mengenai pendewasaan usia perkawinan antara remaja di wilayah perkotaan dan perdesaan. Penelitian ini merupakan eksperimen semu dengan desain pretest-posttest pada 60 remaja …

Tempat Penampungan Air Dan Kepadatan Jentik Aedes Sp. Di Daerah Endemis Dan Bebas Demam Berdarah Dengue, Wanti Wanti, Menofeltus Darman

Kesmas

Tingkat kepadatan jentik merupakan indikasi diketahuinya kepadatan nyamuk Aedes sp yang akan menularkan virus dengue sebagai penyebab penyakit demam berdarah dengue (DBD) dan juga sebagai salah satu indikator keberhasilan kegiatan pengendalian vektor. Penelitian ini bertujuan mengetahui karakteristik tempat penampungan air (TPA) dan perbedaan kepadatan jentik House Index, Container Index, Breatau Index (HI, CI, BI) di Kelurahan Alak sebagai daerah endemis dan Kelurahan Belo sebagai daerah bebas DBD di Kota Kupang Tahun 2011. Penelitian observasional analitik ini menggunakan rancangan studi potong lintang. Variabel penelitian adalah jenis, kondisi, letak, bahan TPA dan kepadatan jentik Aedes sp. Data dikumpulkan dengan observasi langsung pada …

An Efficient Algorithm To Explore Liquid Association On A Genome-Wide Scale, Tina Gunderson, Yen Yi Ho

Faculty Publications

Background: The growing wealth of public available gene expression data has made the systemic studies of how genes interact in a cell become more feasible. Liquid association (LA) describes the extent to which coexpression of two genes may vary based on the expression level of a third gene (the controller gene). However, genome-wide application has been difficult and resource-intensive. We propose a new screening algorithm for more efficient processing of LA estimation on a genome-wide scale and apply its use to a data set. Results: On a test subset of the data, the fast screening algorithm achieved >99.8 agreement with …

Quantifying An Adherence Path-Specific Effect Of Antiretroviral Therapy In The Nigeria Pepfar Program, Caleb Miles, Ilya Shpitser, Phyllis Kanki, Seema Meloni, Eric J. Tchetgen Tchetgen

Harvard University Biostatistics Working Paper Series

No abstract provided.

On The Restricted Mean Survival Time Curve Survival Analysis, Lihui Zhao, Brian Claggett, Lu Tian, Hajime Uno, Marc A. Pfeffer, Scott D. Solomon, Lorenzo Trippa, L. J. Wei

Harvard University Biostatistics Working Paper Series

No abstract provided.

A Review Of Software For Analyzing Molecular Sequences, Haema Nilakanta, Kimberly L. Drews, Suzanne Firrell, Mary A. Foulkes, Kathleen A. Jablonski

GW Biostatistics Center

Background Over the past ten years, there has been an explosion of microbiome research. Many software packages for analyzing microbial sequences such as the 16S gene from 454 sequencers and Illumina platforms are available. But for a new researcher, it is difficult to know which package to choose. We present a systematic review of packages for the analysis of molecular sequences used to describe and compare microbial communities. This review gives students and researchers information to help choose the best analytic pipeline for their project. To the best of our knowledge, this is the first review of such software.

Findings …

Top Of The Order: Modeling The Optimal Locations Of Minor League Baseball Teams, W. Coleman Conley

Undergraduate Economic Review

Over the last twenty-five years, minor league baseball franchises have defined firm mobility. Revisiting the work of Michael C. Davis (2006), I construct a logistic regression model to predict which cities house minor league baseball teams. Six variables are tested for inclusion in the model, including population, income level, the number of major-league professional sports teams in a city, five-year population change, and distance from the closest professional team. Based on the model's predicted probabilities, cities are ranked in order of highest probability of having a team at each of the different levels from Class A to Class AAA.

Wordless Intervention For Epilepsy In Learning Disabilities (Wield): Study Protocol For A Randomized Controlled Feasibility Trial, Marie-Anne Durand, Bob Gates, Georgina Parkes, Asif Zia

Dartmouth Scholarship

Epilepsy is the most common neurological problem that affects people with learning disabilities. The high seizure frequency, resistance to treatments, associated skills deficit and co-morbidities make the management of epilepsy particularly challenging for people with learning disabilities. The Books Beyond Words booklet for epilepsy uses images to help people with learning disabilities manage their condition and improve quality of life. Our aim is to conduct a randomized controlled feasibility trial exploring key methodological, design and acceptability issues, in order to subsequently undertake a large-scale randomized controlled trial of the Books Beyond Words booklet for epilepsy.

Constrained Bayesian Estimation Of Inverse Probability Weights For Nonmonotone Missing Data, Baoluo Sun, Eric J. Tchetgen Tchetgen

Harvard University Biostatistics Working Paper Series

No abstract provided.

Testing Gene-Environment Interactions In The Presence Of Measurement Error, Chongzhi Di, Li Hsu, Charles Kooperberg, Alex Reiner, Ross Prentice

UW Biostatistics Working Paper Series

Complex diseases result from an interplay between genetic and environmental risk factors, and it is of great interest to study the gene-environment interaction (GxE) to understand the etiology of complex diseases. Recent developments in genetics field allows one to study GxE systematically. However, one difficulty with GxE arises from the fact that environmental exposures are often measured with error. In this paper, we focus on testing GxE when the environmental exposure E is subject to measurement error. Surprisingly, contrast to the well-established results that the naive test ignoring measurement error is valid in testing the main effects, we find that …

Personalized Evaluation Of Biomarker Value: A Cost-Benefit Perspective, Ying Huang, Eric Laber

UW Biostatistics Working Paper Series

For a patient who is facing a treatment decision, the added value of information provided by a biomarker depends on the individual patient’s expected response to treatment with and without the biomarker, as well as his/her tolerance of disease and treatment harm. However, individualized estimators of the value of a biomarker are lacking. We propose a new graphical tool named the subject-specific expected benefit curve for quantifying the personalized value of a biomarker in aiding a treatment decision. We develop semiparametric estimators for two general settings: i) when biomarker data are available from a randomized trial; and ii) when biomarker …

Identifying Genetic Variants For Heart Rate Variability In The Acetylcholine Pathway, Harriëtte Riese, Loretto M. Muñoz, Catharina A. Hartman, Xiuhua Ding, Shaoyong Su, Albertine J. Oldehinkel, Arie M. Van Roon, Peter J. Van Der Most, Joop Lefrandt, Ron T. Gansevoort, Pim Van Der Harst, Niek Verweij, Carmilla M. M. Licht, Dorret I. Boomsma, Jouke-Jan Hottenga, Gonneke Willemsen, Brenda W. J. H. Penninx, Ilja M. Nolte, Eco J. C. De Geus, Xiaoling Wang, Harold Snieder

Biostatistics Faculty Publications

Heart rate variability is an important risk factor for cardiovascular disease and all-cause mortality. The acetylcholine pathway plays a key role in explaining heart rate variability in humans. We assessed whether 443 genotyped and imputed common genetic variants in eight key genes (CHAT, SLC18A3, SLC5A7, CHRNB4, CHRNA3, CHRNA, CHRM2 and ACHE) of the acetylcholine pathway were associated with variation in an established measure of heart rate variability reflecting parasympathetic control of the heart rhythm, the root mean square of successive differences (RMSSD) of normal RR intervals. The association was studied in a …

Oscillation Of Second-Order Emden–Fowler Neutral Delay Differential Equations, Ravi P. Agarwal, Martin Bohner, Tongxing Li, Chenghui Zhang

Mathematics and Statistics Faculty Research & Creative Works

We establish some new criteria for the oscillation of second-order Emden–Fowler neutral delay differential equations. We study the case of super linear and the case of sublinear equations subject to various conditions. The results obtained show that the presence of a neutral term in a differential equation can cause or destroy oscillatory properties. Several examples are provided to illustrate the relevance of new theorems.

Cross-Design Synthesis For Extending The Applicability Of Trial Evidence When Treatment Effect Is Heterogeneous-I. Methodology, Ravi Varadhan, Carlos Weiss

Johns Hopkins University, Dept. of Biostatistics Working Papers

Randomized controlled trials (RCTs) provide reliable evidence for approval of new treatments, informing clinical practice, and coverage decisions. The participants in RCTs are often not a representative sample of the larger at-risk population. Hence it is argued that the average treatment effect from the trial is not generalizable to the larger at-risk population. An essential premise of this argument is that there is significant heterogeneity in the treatment effect (HTE). We present a new method to extrapolate the treatment effect from a trial to a target group that is inadequately represented in the trial, when HTE is present. Our method …

Cross-Design Synthesis For Extending The Applicability Of Trial Evidence When Treatment Effect Is Heterogeneous. Part Ii. Application And External Validation, Carlos Weiss, Ravi Varadhan

Johns Hopkins University, Dept. of Biostatistics Working Papers

Randomized controlled trials (RCTs) generally provide the most reliable evidence. When participants in RCTs are selected with respect to characteristics that are potential treatment effect modifiers, the average treatment effect from the trials may not be applicable to a specific target population. We present a new method to project the treatment effect from a RCT to a target group that is inadequately represented in the trial when there is heterogeneity in the treatment effect (HTE). The method integrates RCT and observational data through cross-design synthesis. An essential component is to identify HTE and a calibration factor for unmeasured confounding for …

Retained-Components Factor Transformation: Factor Loadings And Factor Score Predictors In The Column Space Of Retained Components, André Beauducel, Frank Spohn

Journal of Modern Applied Statistical Methods

Factor loadings optimally account for the non-diagonal elements of the covariance matrix of observed variables. Principal component analysis leads to components accounting for a maximum of the variance of the observed variables. Retained-components factor transformation is proposed in order to combine the advantages of factor analysis and principal component analysis.

Pairwise Comparison In Repeated Measures, I.C.A. Oyeka, C. C. Nnanatu

Journal of Modern Applied Statistical Methods

Sometimes a random sample of subjects or patients may be exposed to a battery of diagnostic tests or medication over time and interest is on determining whether there is progressive remission of condition, disease or symptom. Also perhaps early in a program or experiment, subjects or candidates may be required to significantly improve in their performance rates at the current trial relative to an immediately preceding trial, otherwise they may have to withdraw from or drop out. The research interest would then be to determine some critical minimum marginal success rate to guide the management in decision making as well …

A Comparison Of Methods For Group Prediction With High Dimensional Data, Holmes Finch

Journal of Modern Applied Statistical Methods

High dimensional data is the situation in which the number of variables included in an analysis approaches or exceeds the sample size. In the context of group classification, researchers are typically interested in finding a model that can be used to correctly place an individual into their appropriate group; e.g. correctly diagnose individuals with depression. However, when the size of the training sample is small and the number of predictors used to differentiate the groups is larger, standard approaches such as discriminant analysis may not work well. In order to address this issue, statisticians have developed a number of tools …

Objective Priors For Estimation Of Extended Exponential Geometric Distribution, Pedro L. Ramos, Fernando A. Moala, Jorge A. Achcar

Journal of Modern Applied Statistical Methods

A Bayesian analysis was developed with different noninformative prior distributions such as Jeffreys, Maximal Data Information, and Reference. The aim was to investigate the effects of each prior distribution on the posterior estimates of the parameters of the extended exponential geometric distribution, based on simulated data and a real application.

Some General Guidelines For Choosing Missing Data Handling Methods In Educational Research, Jehanzeb R. Cheema

Journal of Modern Applied Statistical Methods

The effect of a number of factors, such as the choice of analytical method, the handling method for missing data, sample size, and proportion of missing data, were examined to evaluate the effect of missing data treatment on accuracy of estimation. A methodological approach involving simulated data was adopted. One outcome of the statistical analyses undertaken in this study is the formulation of easy-to-implement guidelines for educational researchers that allows one to choose one of the following factors when all others are given: sample size, proportion of missing data in the sample, method of analysis, and missing data handling method.

Bayesian Inference For Volatility Of Stock Prices, Juliet G. D'Cunha, K. A. Rao

Journal of Modern Applied Statistical Methods

Lognormal distribution is widely used in the analysis of failure time data and stock prices. Maximum likelihood and Bayes estimator of the coefficient of variation of lognormal distribution along with confidence/credible intervals are developed. The utility of Bayes procedure is illustrated by analyzing prices of selected stocks.