Statistics and Probability Commons^™

A Flow Cytometric Analysis Of Immunocyte Populations In Peripheral Blood And Pleural Effusions Of Patients With Cancer, Mandy L. Bohn

Loma Linda University Electronic Theses, Dissertations & Projects

Two-color flow cytometric analysis was performed on paired samples of peripheral blood (PB) and pleural effusions (PE) of patients with metastatic malignancies. The purpose of these analyses was to test the hypothesis that there are significant differences in the distribution of immunocyte populations in the PE compared to that of the PB.

The majority of the pleural fluid immunocytes were CD3+ cells. The ratio of CD4+ to CD8+ cells was higher in the PE compared to PB. Levels of CD8+, CD19+ and CD14+ cells were not significantly different in the PE compared to the levels in the PB. CD16+CD56+ cells …

The Role Of T Cells In The Pathogenesis Of Periapical Lesions, John B. Wallstrom

Loma Linda University Electronic Theses, Dissertations & Projects

The pulps of mandibular molars of 15 athymic and 15 conventional rats were surgically exposed and left open to their oral flora. Each group was divided into 3 subgroups of 5 animals each. The rats were sacrificed after their pulps were exposed for 2, 4, or 8 weeks. After fixing, decalcifying, and embedding, the specimens were sectioned and stained with H and E. They were then examined under a microscopic grid and quantified by percentages of surface areas of bone, connective tissue, bone marrow, intrabony spaces, periapical lesions, and numbers of osteoclasts. This was done using a DataVoice computerized data …

The Fracture Strength Of Ceramic Brackets : An Update And Comparison, Christian P. Manley

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to compare the fracture strength of ceramic brackets which are currently on the market with ceramic brackets tested in a previous study at Loma Linda. Fracture strengths of standard edgewise ceramic brackets vs. pre-torqued ceramic brackets and bicuspid ceramic brackets vs. central incisor ceramic brackets were also compared.

A total of 160 Polycrystalline brackets, 8 categories in groups if 20, were tested for fracture strength. Each bracket was tested using the same testing model that was used in the previous study at Loma Linda. The brackets were tested by torquing a wire within the …

The Accuracy Of Sonographic Imaging (Dolphintm Digigraph) And Standard Lateral Cephalometric Radiographs : A Comparative Study, Michael D. Teichman

Loma Linda University Electronic Theses, Dissertations & Projects

Radiation due to x-ray exposure is a concern, and the development of the Dolphin™ DigiGraph represents an attempt to limit this exposure. The purpose of this paper was to compare measurements (using Ricketts analysis) obtained from conventional radiographic cephalometric tracings with those obtained by computerized digitizing with the DigiGraph. Forty-six patients from the Loma Linda University School of Dentistry graduate orthodontic clinic were digitized, and the results were compared to the x-ray tracings of these patients. The results showed that seven of the twenty-one variables examined exhibited a statistical similarity between the two methods (DigiGraph and x-ray tracing). An examination …

A Modified Nance Unilateral Molar Distalizer, Tracy J. Reiner

Loma Linda University Electronic Theses, Dissertations & Projects

This clinical study evaluated a modified Nance appliance designed by the author to distalize molars unilaterally for Class II correction. This fixed appliance did not rely upon extraoral traction or intraoral elastics. Twelve unilateral Class II patients aged 13 to 17 were treated nonextraction with the appliance. Pretreatment and posttreatment photographs were taken of the palatal soft tissue and did not reveal any untoward changes as a result of the Nance acrylic button. All molars were corrected to an Angle's Class I relationship. Molar correction was evaluated visually and molar distalization was measured using an acrylic jig fitted to the …

Effect Of Photoperiod On Developmental Morphology And Enolase Isoenzyme Immunohistochemistry In Rat And Djungarian Hamster Superficial Pineal Glands, Chalmer D. Mcclure

Loma Linda University Electronic Theses, Dissertations & Projects

The best understood functional activity of the pineal gland is its diurnal production of melatonin in response to environmental lighting cues. Several enzymes of the melatonin pathway respond to daily photoperiod changes, for example hydroxyindole-O-methyltransferase (HIOMT) and serotonin N-acetyltransferase (SNAT). Increased levels of the glycolytic enzyme neuron-specific enolase (NSE) are thought to reflect increased physiological demands placed on neurons and neuroendocrine tissues. Homodimer non-neuronal enolase isoenzyme (NNE) is immunolocalized to cells, and the hybrid enolase (consisting of subunits from NSE and NNE) has been seen in cerebellar stellate and basket cells. Although not rate limiting, concentrations of both NSE and …

Misfit Between Motivational Style And Type Of Job Demand As A Factor In Developing Occupational Stress, Arlene Gray Blix

Loma Linda University Electronic Theses, Dissertations & Projects

Occupational stress is costly in terms of human suffering and impaired organizational effectiveness. Occupational stress involves the interface between the individual worker and the work environment. The purpose of the study was to analyze the fit between motivational style and the type of job demands as a contributing factor in developing occupational stress symptoms. A literature review of occupational stress models was conducted. The six models compared and contrasted included the Person-Environment fit model (French, Rodgers, & Cobb, 1974), Integrative Transactional Model (Schuler, 1982), Organizational Stress Models (Ivancevich & Matteson, 1987; Parker & DeCotiis, 1983), Facet Analysis Model (Beehr & …

Feasibility Of An Extraoral Method For Predicting Manibular Incisor Relapse, Mark J. Saylor

Loma Linda University Electronic Theses, Dissertations & Projects

The author undertook to develop an extraoral model for predicting mandibular incisor relapse similar to the model described by Harvey and Sheldon Peck. Whereas the Peck and Peck method involves intraoral measurements, the method described in this paper relied on the taking of measurements from the patient's pre-treatment plaster models. Two hundred and sixty teeth were measured both orally and on plaster casts, and several statistical tests were performed to isolate any differences between the intraoral and extraoral methods. The principal difference was identified as the faciolingual measurement of the incisor, due to the height of contour often being subgingival …

Anthropometric Parameters In Public School Students And Seventh-Day Adventist Vegetarian And Meat-Eating Students, Joan Sabaté-Casellas

Loma Linda University Electronic Theses, Dissertations & Projects

Concerns have been expressed for the ability of some vegetarian diets to support normal growth of children. Animal protein or meat intake showed a positive relationship to attained height in children from developing countries. In this study, the relationship between meat intake/vegetarian status and physical growth was investigated in children living in California.

Height and weight were collected on 2,272 Caucasian children aged 6-18 years attending Seventh-day Adventist (SDA) or public schools who participated in a two year longitudinal study. Age-, sex-, and school-specific mean heights and weights were at or above the national reference values. Sex-specific, age-adjusted regression analysis …

Facial Typing Methods : A Comparative Study, James A. Grabow

Loma Linda University Electronic Theses, Dissertations & Projects

Facial typing methods are used to determine to which of three basic facial pattern categories an individual patient belongs. These three categories are mesofacial, brachyfacial, and dolichofacial. It is important to establish the correct facial type because the reaction to treatment mechanics and the stability of the denture is dependent upon the analysis of the facial patterns. The purpose of this paper was to show a comparative study of facial typing classification methods used on 100 patients (47 boys and 53 girls). The eight different methods used were as follows: Bioprogressive, Ricketts LLU1, LLU2, QuickCeph™, Jarabak, Facial-Mandibular Index, and Steiner. …

Decreased Triiodothyronine Binding To The Hepatic Nuclear Thyroid Hormone Receptor In The Diabetic Mouse, Thomas J. Dewind

Loma Linda University Electronic Theses, Dissertations & Projects

The diabetic C57BL/KsJ-db m mouse has abnormal thyroid hormone levels and indications of thyroid hormone resistance. To investigate the basis of these abnormalities, the hepatic nuclear thyroid hormone receptor was extracted with 0.4 M KCl, 1.1 mM MgCl₂, 20 mM Tris/HCl, pH 7.9 from hepatocyte nuclei of normal C57BL/KsJ, heterozygous C57BL/KsJ-db m (db/m), and diabetic C57BL/KsJ-db m (db/db) mice. Normal and heterozygous mice were grouped together as the controls. Triiodothyronine (T₃) binding studies at 4°C using nitrocellulose filtration to separate free T₃ from receptor bound T₃ demonstrated an …

Time Delayed Protein Complementation, Diana L. Lakusta

Loma Linda University Electronic Theses, Dissertations & Projects

The time delayed complementation of plant proteins was tested in weanling Sprague-Dawley male rats by measuring growth rates as well as plasma and tissue free amino acids. Diets of pinto beans with rice, corn or wheat were pair-fed in combination or alternating 4 times a day at 6 and 11 am, and 4 and 9 pm for 4 weeks. Plasma, liver and muscle samples were obtained 2 hours postprandial, a time determined most suitable for sacrifice, and analyzed for free amino acids via ion-exchange chromatography. There were no significant differences in growth of rats fed combination or alternating diets.during week …

The Incidence And Magnitude Of Tooth-Size Discrepancies In Caucasians, Blacks And Hispanics, Dana R. Shaltry

Loma Linda University Electronic Theses, Dissertations & Projects

The present investigation utilized the Bolton Analysis to determine the incidence and magnitude of tooth-size discrepancy in a sample of 227 orthodontic patients. Sliding calipers were used to measure the mesiodistal width of the permanent dentition on pretreatment study models of 120 Caucasian, 51 Black, and 56 Hispanic patients. The overall and anterior ratios were analyzed and the frequency and magnitude of excess maxillary and mandibular tooth structure was determined. Each racial group demonstrated a significant incidence of tooth-size discrepancy in the maxillary and mandibular arches of a magnitude (> 0.5mm) which would require some form of correction. In addition, …

The Determination Of Antibody Levels In Endodontic Patients Against Eleven Microorganisms Using Ifa And Elisa Techniques, William C. Payne

Loma Linda University Electronic Theses, Dissertations & Projects

Endodontic (root canal) infections are generally considered to be caused by the invasion of microorganisms which destroy pulp tissue and extend to the periapical region. No definitive study has identified a specific bacterium or group of bacteria as etiological agents. We quantitively measured antibodies present in the serum of 30 normal individuals and patients with either chronic (n = 30) or acute (n = 30) periapical lesions with the indirect fluorescent antibody (IFA) and enzyme-linked immunosorbent assay (ELISA) for IgG and IgM against 11 oral microorganisms routinely isolated from such lesions. The results were analyzed statistically. Analysis of variance of …

Case-Control Study Of Vitamin A Intake And Colorectal Cancer In Seventh-Day Adventists, John William Morgan

Loma Linda University Electronic Theses, Dissertations & Projects

Colorectal cancer is the second most common cause of cancer deaths in Americans; producing approximately 60,000 deaths in Americans each year. Studies of high and low risk populations have suggested a dietary etiology for colorectal cancer, although investigations of specific dietary factors have produced inconsistent results.

Population based studies of California Seventh-day Adventists demonstrate dietary variety regarding factors suspected as important in the etiology of colorectal cancer. These studies document a substantially reduced mortality and incidence from colorectal cancer in Seventh-day Adventists when compared to other California Populations. Although specific reasons for this difference remain obscure, the 'Unique lifestyle and …

The Effect Of Dietary Fat Level On Tumor Development And Immunity In Balb/C Mice Fed Casein Of Wheat Gluten As Protein And Challenged With Herpes Type 2-Transformed Cells, Helen Drakou

Loma Linda University Electronic Theses, Dissertations & Projects

A high percentage of fat in the diet has been implicated through epidemiological studies in several human cancers. Studies in experimental animals have produced evidence that increasing the fat in the diet decreases the animal’s ability to restrict tumor development and growth. In previous work done in this laboratory with BALB/c mice injected with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which restricted tumor growth. The latter, a low (5%) fat, low protein diet, in which the protein was casein, was also found to produce a …

Amount Of Root Shortening Related To Type Of Fixed Appliance : A Comparison Of The 0.018" And 0.022" Bracket Slot, Thomas L. Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine if a different incidence and severity of maxillary incisor apical root resorption occurs in cases treated with the 0.018 inch versus 0.022 inch slot in standard edgewise mechanics. A consecutively treated sample of 240 patients (98 boys and 142 girls), with a mean age of 13.4 years from the orthodontic clinic at Loma Linda University were studied. 120 of the cases were treated using 0.018" bracket slot with standard edgewise mechanics and 120 were treated using 0.022" non-torqued full banded standard edgewise mechanics. 60 of the cases in each of the above …

Correlates Of Birth Weight And Gestation Age : Baseline Data For Health Education, Adanetch Kidanemariam

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose. The study examined the correlation of maternal occupation, urinary tract infection, smoking, and working during pregnancy with infant birth weight and gestational age in order to generate baseline data for development of a health education intervention program protocol for pregnant women In the work place.

Primary Hypotheses. (1) The four maternal risk factors: (a) occupation during lifetime, (b) reported urinary tract infection, (c) cigarette smoking, (d) working, are individually and interactively correlated with infant birth weight and gestational age. (2) The effects of the interactive associations are greater on birth weight than gestational age.

Procedure. A sample of …

The Effects Of An Intervention Program On Nursing Burnout, Maria Rosa-Morales

Loma Linda University Electronic Theses, Dissertations & Projects

The risk for professional burnout has become commonly recognized and in the past several years has been a focus of research efforts. Nursing is one of the professions generating a high level of stress which results in burnout.

The purpose of this study was to test the effects of an intervention program for nurses who felt they were experiencing burnout. Nursing burnout was defined as a chronic condition of stress among nurses, which leads to a syndrome of emotional exhaustion, depersonalization, and lack of personal accomplishment. The design used was a true experiment. Fifty-two nurses served as voluntary participants who …

A Sensitivity Analysis Of The Coefficients For The Transformation Of The Electrocardiographic Orthogonal Three-Lead System (Frank) To The Standard Twelve-Lead System, Rasa Ona Draugelis

Loma Linda University Electronic Theses, Dissertations & Projects

The SENSITIVITY ANALYSIS is performed on the transformation coefficients of the Frank XYZ signals generating standard 12-lead ECG with respect to diagnosis. The analysis is adapted for the individual waveform and per each lead. The disease/abnormality categories are described in terms of discrete pattern classes based on criteria used by Marquette Electronics, Inc. The nonlinear global sensitivity analysis method developed by Shuler, et al, is selected for this project. The diagnostic change in the waveform is denoted by a distance measurement from the pattern class boundary corresponding to the best-experimental coefficient estimates (Dower coefficients) to the alternate coefficient specification measurement …

Smoking Behavior Among Alabama Student Nurses : The Role Of Behavioral Beliefs And Normative Referencing, Judith Rausch

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine predictors of smoking behavior for the senior student nurses in the state of Alabama using Ajzen and Fishbein's Theory of Reasoned Action. Smoking prevalence by level of educational preparation and selected health behaviors were examined for relationship to cigarette use.

A sample of 11 schools of nursing were selected from Alabama's 34, using a random numbers table. There were 13 total programs as two of the schools had both A.D. and B.S. nursing programs. Thirty-two percent (N=555) of senior A.D., B.S. & diploma students nurses in Alabama responded to an 87 item …

The Modified Index Of Severity Scale, Marion Gamundoy

Loma Linda University Electronic Theses, Dissertations & Projects

[No Abstract Included]

Measuring The Effectiveness Of Patient Teaching In Postpartum Patients, Nancy Racine

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Third Molar Eruption Prediction, Michael L. Jacobsen

Loma Linda University Electronic Theses, Dissertations & Projects

The diagnosis and treatment of third molars has often been cited as a special problem to the orthodontist. If the prognosis of third molars could be determined, orthodontic treatment could progress on a more positive basis.

This study was designed to provide a method of deciding whether developing third molars will erupt or become impacted.

Records from 130 orthodontically treated cases of Dr. Fredsall⁸ were studied. Several factors were evaluated and measured using the patients' cephalometric radiographs.

The actual fate of the third molars were recorded in the hope it could be used to predict what to expect from …

Chronic Respiratory Disease Symptom Effects Of Long-Term Cumulative Exposure To Passive Tobacco Smoke And To Ambient Levels Of Tsp, Oxidants, So2, And No2 In Southern California, Gary L. Euler

Loma Linda University Electronic Theses, Dissertations & Projects

To assess risk of chronic respiratory disease symptoms due to long-term exposure to the ambient levels of TSP, oxidants, SO2 and NO2 in photochemical air pollution, symptoms were ascertained using NHLBI questions on 8,572 Southern California Seventh-day Adventist, nonsmokers, 25 years and older, who lived eleven years or longer in their 1977 residential area. Tobacco smoke, active and passive, and occupational exposures were measured by questionnaires, as well as lifestyle characteristics relative to pollution exposure such as time spent outside and residence history. A pulmonary function feasibility study was done on a subsample of 86 women 50-64 years of age …

The Effect Of Dietary Alpha - Linolenic Acid On Apparent Risk Factors Of Cardiovascular Disease, Kelvin D. Lindbeck

Loma Linda University Electronic Theses, Dissertations & Projects

Eight healthy male lacto-ovo-vegetarian subjects averaging 28.0 ± 3.6 years of age (22 to 53 years) were fed a diet rich in α-linolenic acid (18:3 ω 3) for four weeks. Arterial blood pressure and body weight were recorded each week. Plasma 6-keto-prostaglandin F_1α (6-keto- PGF_1α ), thromboxane B₂ (TXB₂), total cholesterol, triglyceride, and total phospholipid fatty acid composition were analyzed at 0, 2 and 4 weeks.

Systolic blood pressure increased significantly between weeks 0 and 1 (106.5 ± 2.7 mmHg to 114.0 ± 3.7 mmHg; p < 0.003), but decreased to 107.3 t 2.6 mrHg (p < 0.02) at week 2. There was an insignificant increase in both systolic and diastolic blood pressures after four weeks. There was no significant change in either total cholesterol or triglyceride levels during the four weeks.

Plasma 6-keto-PGF_1α levels increased significantly from 60.13 ± …

Cost-Benefit Analysis Of Computer Systems In Community Hospital Food Service, Beverly Kittle

Loma Linda University Electronic Theses, Dissertations & Projects

Cost containment has always been a major concern to managers. Therefore, any system which decreases costs by reducing labor time is given serious evaluation.

A five week comparison was made between financial record keeping by the manual method and by the computerized method. A continuous time study was utilized to make this comparison.

Over the five weeks, an average overall time savings of 245 minutes for the computerized versus the manual method was observed. The net savings to the institution was 223 minutes per week which translates to approximately $140.00 per month over a 5 year period.

The rapid payback …

Mandibular Repositioning With Frankel Appliance Therapy, Clark E. Schneekluth

Loma Linda University Electronic Theses, Dissertations & Projects

A sample of twelve Frankel appliance (FR-2) treated patients, in the mixed dentition stage, were selectively chosen by an orthodontist based on the Class II correction and evaluated from before treatment and end of treatment laminagraphic and lateral cephalometric radiographs. The average treatment period was 22 months (1 yr. 10 mos.). The average pre-treatment age was 9.5 years with a range from 8 to 11 years old, while the average post-treatment age was 11.3 years with a range of 10 to 13 years.

Frankel appliance therapy was the only form of mechanics used in this study.

The before treatment lateral …

Orthodontic Information Systems : A Developmental Study, Gary D. Sheldon

Loma Linda University Electronic Theses, Dissertations & Projects

The intent of this study was to design and implement a computer-based orthodontic system providing an integrated information environment throughout the entire patient treatment process.

Total system integration was achieved by restructuring the entire information gathering process. A complete, evaluation of patient diagnosis and treatment evaluation procedures established five major information categories and a critical information list for proper patient management. Information organization was outlined to provide a logical progression in the information gathering process and patient chart forms were designed to implement this. Defining the computer system's performance identified three functions as follows: 1) entry and editing of individual …

Conformational Analysis Of Nonsteroidal Estrogen Analogs, Robert N. Spady

Loma Linda University Electronic Theses, Dissertations & Projects

In target tissue, estrogens initiate a series of events, ending in protein synthesis, by binding to a cytoplasmic receptor. Once the estrogen binds, the receptor complex is activated--a process including dimerization of the estrogen complex with another subunit. In order to study the possible receptor-ligand interactions, conformational analysis was performed on several nonsteroidal estrogen analogs, using the CAMSEQ8 molecular mechanics program.

The probability that a molecule will exist in a given conformational energy well depends both on the energy and the shape of the well. A method has been previously worked out to calculate probabilities using both of these variables, …