Statistics and Probability Commons^™

Optimizing Tumor Xenograft Experiments Using Bayesian Linear And Nonlinear Mixed Modelling And Reinforcement Learning, Mary Lena Bleile

Statistical Science Theses and Dissertations

Tumor xenograft experiments are a popular tool of cancer biology research. In a typical such experiment, one implants a set of animals with an aliquot of the human tumor of interest, applies various treatments of interest, and observes the subsequent response. Efficient analysis of the data from these experiments is therefore of utmost importance. This dissertation proposes three methods for optimizing cancer treatment and data analysis in the tumor xenograft context. The first of these is applicable to tumor xenograft experiments in general, and the second two seek to optimize the combination of radiotherapy with immunotherapy in the tumor xenograft …

Development Of Bayesian Hierarchical Methods Involving Meta-Analysis, Jackson Barth

Statistical Science Theses and Dissertations

When conducting statistical analysis in the Bayesian paradigm, the most critical decision made by the researcher is the identification of a prior distribution for a parameter. Despite the mathematical soundness of the Bayesian approach, a wrongly specified prior can lead to biased and incorrect results. To avoid this, prior distributions should be based on real data, which are easily accessible in the "big data" era. This dissertation explores two applications of Bayesian hierarchical modelling that incorporate information obtained from a meta-analysis.

The first of these applications is in the normalization of genomics data, specifically for nanostring nCounter datasets. A meta-analysis …

Empirical Likelihood Ratio Tests For Homogeneity Of Distributions Of Component Lifetimes From System Lifetime Data With Known System Structures, Jingjing Qu

Statistical Science Theses and Dissertations

In system reliability, practitioners may be interested in testing the homogeneity of the component lifetime distributions based on system lifetimes from multiple data sources for various reasons, such as identifying the component supplier that provides the most reliable components.

In the first part of the dissertation, we develop distribution-free hypothesis testing procedures for the homogeneity of the component lifetime distributions based on system lifetime data when the system structures are known. Several nonparametric testing statistics based on the empirical likelihood method are proposed for testing the homogeneity of two or more component lifetime distributions. The computational approaches to obtain the …

Bridging The Chasm Between Fundamental, Momentum, And Quantitative Investing, Allen Hoskins, Jeff Reed, Robert Slater

SMU Data Science Review

A chasm exists between the active public equity investment management industry's fundamental, momentum, and quantitative styles. In this study, the researchers explore ways to bridge this gap by leveraging domain knowledge, fundamental analysis, momentum, crowdsourcing, and data science methods. This research also seeks to test the developed tools and strategies during the volatile time period of 2020 and 2021.

Comparison Of Sampling Methods For Predicting Wine Quality Based On Physicochemical Properties, Robert Burigo, Scott Frazier, Eli Kravez, Nibhrat Lohia

SMU Data Science Review

Using the physicochemical properties of wine to predict quality has been done in numerous studies. Given the nature of these properties, the data is inherently skewed. Previous works have focused on handful of sampling techniques to balance the data. This research compares multiple sampling techniques in predicting the target with limited data. For this purpose, an ensemble model is used to evaluate the different techniques. There was no evidence found in this research to conclude that there are specific oversampling methods that improve random forest classifier for a multi-class problem.

Extending The M3-Competition: Category And Interval-Specific Time Series Forecasting, Will Sherman, Kati Schuerger, Randy Kim, Bivin Sadler

SMU Data Science Review

The M3-Competition found that simple models outperform more complex ones for time series forecasting. As part of these competitions, several claims were made that statistical models exceeded machine learning (ML) techniques, such as recurrent neural networks (RNN), in prediction performance. These findings may over-generalize the capabilities of statistical models since the analysis measured the total forecasting accuracy across a wide range of industries and fields and with different interval lengths. This investigation aimed to assess how statistical and ML methods compared when individuating series by category and time interval. Utilizing the M3 data and building individual models using Facebook© Prophet …

Influence Diagnostics For Generalized Estimating Equations Applied To Correlated Categorical Data, Louis Vazquez

Statistical Science Theses and Dissertations

Influence diagnostics in regression analysis allow analysts to identify observations that have a strong influence on model fitted probabilities and parameter estimates. The most common influence diagnostics, such as Cook’s Distance for linear regression, are based on a deletion approach where the results of a model with and without observations of interest are compared. Here, deletion-based influence diagnostics are proposed for generalized estimating equations (GEE) for correlated, or clustered, nominal multinomial responses. The proposed influence diagnostics focus on GEEs with the baseline-category logit link function and a local odds ratio parameterization of the association structure. Formulas for both observation- and …

Fraud Pattern Detection For Nft Markets, Andrew Leppla, Jorge Olmos, Jaideep Lamba

SMU Data Science Review

Non-Fungible Tokens (NFTs) enable ownership and transfer of digital assets using blockchain technology. As a relatively new financial asset class, NFTs lack robust oversight and regulations. These conditions create an environment that is susceptible to fraudulent activity and market manipulation schemes. This study examines the buyer-seller network transactional data from some of the most popular NFT marketplaces (e.g., AtomicHub, OpenSea) to identify and predict fraudulent activity. To accomplish this goal multiple features such as price, volume, and network metrics were extracted from NFT transactional data. These were fed into a Multiple-Scale Convolutional Neural Network that predicts suspected fraudulent activity based …

Self-Learning Algorithms For Intrusion Detection And Prevention Systems (Idps), Juan E. Nunez, Roger W. Tchegui Donfack, Rohit Rohit, Hayley Horn

SMU Data Science Review

Today, there is an increased risk to data privacy and information security due to cyberattacks that compromise data reliability and accessibility. New machine learning models are needed to detect and prevent these cyberattacks. One application of these models is cybersecurity threat detection and prevention systems that can create a baseline of a network's traffic patterns to detect anomalies without needing pre-labeled data; thus, enabling the identification of abnormal network events as threats. This research explored algorithms that can help automate anomaly detection on an enterprise network using Canadian Institute for Cybersecurity data. This study demonstrates that Neural Networks with Bayesian …

Regression Modeling Of Complex Survival Data Based On Pseudo-Observations, Rong Rong

Statistical Science Theses and Dissertations

The restricted mean survival time (RMST) is a clinically meaningful summary measure in studies with survival outcomes. Statistical methods have been developed for regression analysis of RMST to investigate impacts of covariates on RMST, which is a useful alternative to the Cox regression analysis. However, existing methods for regression modeling of RMST are not applicable to left-truncated right-censored data that arise frequently in prevalent cohort studies, for which the sampling bias due to left truncation and informative censoring induced by the prevalent sampling scheme must be properly addressed. Meanwhile, statistical methods have been developed for regression modeling of the cumulative …

Classification Of Breast Cancer Histopathological Images Using Semi-Supervised Gans, Balaji Avvaru, Nibhrat Lohia, Sowmya Mani, Vijayasrikanth Kaniti

SMU Data Science Review

Breast cancer is diagnosed more frequently than skin cancer in women in the United States. Most breast cancer cases are diagnosed in women, while children and men are less likely to develop the disease. Various tissues in the breast grow uncontrollably, resulting in breast cancer. Different treatments analyze microscopic histopathology images for diagnosis that help accurately detect cancer cells. Deep learning is one of the evolving techniques to classify images where accuracy depends on the volume and quality of labeled images. This study used various pre-trained models to train the histopathological images and analyze these models to create a new …

Stock Forecasts With Lstm And Web Sentiment, Michael Burgess, Faizan Javed, Nnenna Okpara, Chance Robinson

SMU Data Science Review

Traditional time-series techniques, such as auto-regressive and moving average models, can have difficulties when applied to stock data due to the randomness inherent to the markets. In this study, Long Short-Term Memory Recurrent Neural Networks, or LSTMs, have been applied to pricing data along with sentiment scores derived from web sources such as Twitter and other financial media outlets. The project team utilized this approach to complement the technical indicators observed at the end of each trading day for three stocks from the NASDAQ stock exchange over a 12-year span. A common benchmark to assess model performance on time series …

Predicting Insulin Pump Therapy Settings, Riccardo L. Ferraro, David Grijalva, Alex Trahan

SMU Data Science Review

Millions of people live with diabetes worldwide [7]. To mitigate some of the many symptoms associated with diabetes, an estimated 350,000 people in the United States rely on insulin pumps [17]. For many of these people, how effectively their insulin pump performs is the difference between sleeping through the night and a life threatening emergency treatment at a hospital. Three programmed insulin pump therapy settings governing effective insulin pump function are: Basal Rate (BR), Insulin Sensitivity Factor (ISF), and Carbohydrate Ratio (ICR). For many people using insulin pumps, these therapy settings are often not correct, given their physiological needs. While …

Classification Of Pixel Tracks To Improve Track Reconstruction From Proton-Proton Collisions, Kebur Fantahun, Jobin Joseph, Halle Purdom, Nibhrat Lohia

SMU Data Science Review

In this paper, machine learning techniques are used to reconstruct particle collision pathways. CERN (Conseil européen pour la recherche nucléaire) uses a massive underground particle collider, called the Large Hadron Collider or LHC, to produce particle collisions at extremely high speeds. There are several layers of detectors in the collider that track the pathways of particles as they collide. The data produced from collisions contains an extraneous amount of background noise, i.e., decays from known particle collisions produce fake signal. Particularly, in the first layer of the detector, the pixel tracker, there is an overwhelming amount of background noise that …

Cov-Inception: Covid-19 Detection Tool Using Chest X-Ray, Aswini Thota, Ololade Awodipe, Rashmi Patel

SMU Data Science Review

Since the pandemic started, researchers have been trying to find a way to detect COVID-19 which is a cost-effective, fast, and reliable way to keep the economy viable and running. This research details how chest X-ray radiography can be utilized to detect the infection. This can be for implementation in Airports, Schools, and places of business. Currently, Chest imaging is not a first-line test for COVID-19 due to low diagnostic accuracy and confounding with other viral pneumonia. Different pre-trained algorithms were fine-tuned and applied to the images to train the model and the best model obtained was fine-tuned InceptionV3 model …

Application Of Probabilistic Ranking Systems On Women’S Junior Division Beach Volleyball, Cameron Stewart, Michael Mazel, Bivin Sadler

SMU Data Science Review

Women’s beach volleyball is one of the fastest growing collegiate sports today. The increase in popularity has come with an increase in valuable scholarship opportunities across the country. With thousands of athletes to sort through, college scouts depend on websites that aggregate tournament results and rank players nationally. This project partnered with the company Volleyball Life, who is the current market leader in the ranking space of junior beach volleyball players. Utilizing the tournament information provided by Volleyball Life, this study explored replacements to the current ranking systems, which are designed to aggregate player points from recent tournament placements. Three …

Dynamic Prediction For Alternating Recurrent Events Using A Semiparametric Joint Frailty Model, Jaehyeon Yun

Statistical Science Theses and Dissertations

Alternating recurrent events data arise commonly in health research; examples include hospital admissions and discharges of diabetes patients; exacerbations and remissions of chronic bronchitis; and quitting and restarting smoking. Recent work has involved formulating and estimating joint models for the recurrent event times considering non-negligible event durations. However, prediction models for transition between recurrent events are lacking. We consider the development and evaluation of methods for predicting future events within these models. Specifically, we propose a tool for dynamically predicting transition between alternating recurrent events in real time. Under a flexible joint frailty model, we derive the predictive probability of …

Adjusting Community Survey Data Benchmarks For External Factors, Allen Miller, Nicole M. Norelli, Robert Slater, Mingyang N. Yu

SMU Data Science Review

Abstract. Using U.S. resident survey data from the National Community Survey in combination with public data from the U.S. Census and additional sources, a Voting Regressor Model was developed to establish fair benchmark values for city performance. These benchmarks were adjusted for characteristics the city cannot easily influence that contribute to confidence in local government, such as population size, demographics, and income. This adjustment allows for a more meaningful comparison and interpretation of survey results among individual cities. Methods explored for the benchmark adjustment included cluster analysis, anomaly detection, and a variety of regression techniques, including random forest, ridge, decision …

Aspect-Based Sentiment Analysis Of Movie Reviews, Samuel Onalaja, Eric Romero, Bosang Yun

SMU Data Science Review

This study investigates a comparison of classification models used to determine aspect based separated text sentiment and predict binary sentiments of movie reviews with genre and aspect specific driving factors. To gain a broader classification analysis, five machine and deep learning algorithms were compared: Logistic Regression (LR), Naive Bayes (NB), Support Vector Machine (SVM), and Recurrent Neural Network Long-Short-Term Memory (RNN LSTM). The various movie aspects that are utilized to separate the sentences are determined through aggregating aspect words from lexicon-base, supervised and unsupervised learning. The driving factors are randomly assigned to various movie aspects and their impact tied to …

Predicting Power Using Time Series Analysis Of Power Generation And Consumption In Texas, Joshua Eysenbach, Bodie Franklin, Andrew J. Larsen, Joel Lindsey

SMU Data Science Review

Due to the recent power events in Texas, power forecasting has been brought national attention. Accurate demand forecasting is necessary to be sure that there is adequate power supply to meet consumer's needs. While Texas has a forecasting model created by the Electricity Reliability Council of Texas (ERCOT), constant efforts are required to ensure that the model stays at the state-of-the-art and is producing the most reliable forecasts possible. This research seeks to provide improved short- and medium-term forecasting models, bringing in state-of-the-art deep learning models to compare to ERCOT’s forecasts. A model that is more accurate than ERCOT’s own …

Identification And Characterization Of Forest Fire Risk Zones Leveraging Machine Learning Methods, Joshua Balson, Matt Chinchilla, Cam Lu, Jeff Washburn, Nibhrat Lohia

SMU Data Science Review

Across the United States, record numbers of wildfires are observed costing billions of dollars in property damage, polluting the environment, and putting lives at risk. The ability of emergency management professionals, city planners, and private entities such as insurance companies to determine if an area is at higher risk of a fire breaking out has never been greater. This paper proposes a novel methodology for identifying and characterizing zones with increased risks of forest fires. Methods involving machine learning techniques use the widely available and recorded data, thus making it possible to implement the tool quickly.

Sars-Cov-2 Pandemic Analytical Overview With Machine Learning Predictability, Anthony Tanaydin, Jingchen Liang, Daniel W. Engels

SMU Data Science Review

Understanding diagnostic tests and examining important features of novel coronavirus (COVID-19) infection are essential steps for controlling the current pandemic of 2020. In this paper, we study the relationship between clinical diagnosis and analytical features of patient blood panels from the US, Mexico, and Brazil. Our analysis confirms that among adults, the risk of severe illness from COVID-19 increases with pre-existing conditions such as diabetes and immunosuppression. Although more than eight months into pandemic, more data have become available to indicate that more young adults were getting infected. In addition, we expand on the definition of COVID-19 test and discuss …

Bayesian Semi-Supervised Keyphrase Extraction And Jackknife Empirical Likelihood For Assessing Heterogeneity In Meta-Analysis, Guanshen Wang

Statistical Science Theses and Dissertations

This dissertation investigates: (1) A Bayesian Semi-supervised Approach to Keyphrase Extraction with Only Positive and Unlabeled Data, (2) Jackknife Empirical Likelihood Confidence Intervals for Assessing Heterogeneity in Meta-analysis of Rare Binary Events.

In the big data era, people are blessed with a huge amount of information. However, the availability of information may also pose great challenges. One big challenge is how to extract useful yet succinct information in an automated fashion. As one of the first few efforts, keyphrase extraction methods summarize an article by identifying a list of keyphrases. Many existing keyphrase extraction methods focus on the unsupervised setting, …

Examining Multiple Imputation For Measurement Error Correction In Count Data With Excess Zeros, Shalima Zalsha

Statistical Science Theses and Dissertations

Measurement error and missing data are two common problems in wildlife population surveys. These data are collected from the environment and may be missing or measured with error when the observer’s ability to see the animal is obscured. Methods such as video transects for estimating red snapper abundance and aerial surveys for estimating moose population sizes are highly affected by these problems since total abundance will be underestimated if missing/mismeasured counts are ignored. We shall refer to this problem as visibility bias; it occurs when the true counts are observed when visibility is high, partially observed when visibility is low …

Improved Statistical Methods For Time-Series And Lifetime Data, Xiaojie Zhu

Statistical Science Theses and Dissertations

In this dissertation, improved statistical methods for time-series and lifetime data are developed. First, an improved trend test for time series data is presented. Then, robust parametric estimation methods based on system lifetime data with known system signatures are developed.

In the first part of this dissertation, we consider a test for the monotonic trend in time series data proposed by Brillinger (1989). It has been shown that when there are highly correlated residuals or short record lengths, Brillinger’s test procedure tends to have significance level much higher than the nominal level. This could be related to the discrepancy between …

Time Series Analysis Of Offshore Buoy Light Detection And Ranging (Lidar) Windspeed Data, Aditya Garapati, Charles J. Henderson, Carl Walenciak, Brian T. Waite

SMU Data Science Review

In this paper, modeling techniques for the forecasting of wind speed using historical values observed by Light Detection and Ranging (LIDAR) sensors in an offshore context are described. Both univariate time series and multivariate time series modeling techniques leveraging meteorological data collected simultaneously with the LIDAR data are evaluated for potential contributions to predictive ability. Accurate and timely ability to predict wind values is essential to the effective integration of wind power into existing power grid systems. It allows for both the management of rapid ramp-up / down of base production capacity due to highly variable wind power inputs and …

Compressed Dna Representation For Efficient Amr Classification, John Partee, Robert Hazell, Anjli Solsi, John Santerre

SMU Data Science Review

In this paper, we explore a representation methodology for the compression of DNA isolates. Using lossless string compression via tokenization of frequently repeated segments of DNA, we reduce the length of the isolates to be counted as k-mers for classification. With this new representation, we apply a previously established feature sampling method to dramatically reduce the feature space. In understanding the genetic diversity, we also look at conserving biological function across these spaces. Using a random forest model we were able to predict the resistance or susceptibility of bacteria with 85-90\% accuracy, with a 30-50\% reduction in overall isolate length, …

Cell Assembly Detection In Low Firing-Rate Spike Train Data, Phan Minh Duc Truong

Mathematics Theses and Dissertations

Cell assemblies, defined as groups of neurons forming temporal spike coordination, are thought to be fundamental units supporting major cognitive functions. However, detecting cell assemblies is challenging since they can occur at a range of time scales and with a range of precisions, from synchronous spikes to co-variations in firing rate. In this dissertation, we use a recently published cell assembly detection (CAD) algorithm that is capable of detecting assemblies at a range of time scales and precisions. We first showed that the CAD method can be applied to sparser spike train data than what have previously been reported. This …

Sensitivity Analysis For Incomplete Data And Causal Inference, Heng Chen

Statistical Science Theses and Dissertations

In this dissertation, we explore sensitivity analyses under three different types of incomplete data problems, including missing outcomes, missing outcomes and missing predictors, potential outcomes in \emph{Rubin causal model (RCM)}. The first sensitivity analysis is conducted for the \emph{missing completely at random (MCAR)} assumption in frequentist inference; the second one is conducted for the \emph{missing at random (MAR)} assumption in likelihood inference; the third one is conducted for one novel assumption, the ``sixth assumption'' proposed for the robustness of instrumental variable estimand in causal inference.

Evaluation Of The Utility Of Informative Priors In Bayesian Structural Equation Modeling With Small Samples, Hao Ma

Education Policy and Leadership Theses and Dissertations

The estimation of parameters in structural equation modeling (SEM) has been primarily based on the maximum likelihood estimator (MLE) and relies on large sample asymptotic theory. Consequently, the results of the SEM analyses with small samples may not be as satisfactory as expected. In contrast, informative priors typically do not require a large sample, and they may be helpful for improving the quality of estimates in the SEM models with small samples. However, the role of informative priors in the Bayesian SEM has not been thoroughly studied to date. Given the limited body of evidence, specifying effective informative priors remains …