Statistics and Probability Commons^™

Adaptive Randomization Designs, Jenna Colavincenzo

Statistics

Adaptive design methodologies use prior information to develop a clinical trial design. The goal of an adaptive design is to maintain the integrity and validity of the study while giving the researcher flexibility in identifying the optimal treatment. An example of an adaptive design can be seen in a basic pharmaceutical trial. There are three phases of the overall trial to compare treatments and experimenters use the information from the previous phase to make changes to the subsequent phase before it begins.

Adaptive design methods have been in practice since the 1970s, but have become increasingly complex ever since. One …

Involvement Of Microrna Families In Cancer, Stefan Wuchty, Dolores Arjona, Serdar Bozdag, Peter O. Bauer

Mathematics, Statistics and Computer Science Faculty Research and Publications

Collecting representative sets of cancer microRNAs (miRs) from the literature we show that their corresponding families are enriched in sets of highly interacting miR families. Targeting cancer genes on a statistically significant level, such cancer miR families strongly intervene with signaling pathways that harbor numerous cancer genes. Clustering miR family-specific profiles of pathway intervention, we found that different miR families share similar interaction patterns. Resembling corresponding patterns of cancer miRs families, such interaction patterns may indicate a miR family’s potential role in cancer. As we find that the number of targeted cancer genes is a naı¨ve proxy for a cancer …

Rank-Based Estimation And Prediction For Mixed Effects Models In Nested Designs, Yusuf K. Bilgic

Dissertations

Hierarchical designs frequently occur in many research areas. The experimental design of interest is expressed in terms of fixed effects but, for these designs, nested factors are a natural part of the experiment. These nested effects are generally considered random and must be taken into account in the statistical analysis. Traditional analyses are quite sensitive to outliers and lose considerable power to detect the fixed effects of interest.

This work proposes three rank-based fitting methods for handling random, fixed and scale effects in k-level nested designs for estimation and inference. An algorithm, which iteratively obtains robust prediction for both scale …

Simplified Models Of Vector Control Impact Upon Malaria Transmission By Zoophagic Mosquitoes, Samson S. Kiware, Nakul Chitnis, Sarah J. Moore, Gregor J. Devine, Silas Majambere, Stephen Merrill, Gerry F. Killeen

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background

High coverage of personal protection measures that kill mosquitoes dramatically reduce malaria transmission where vector populations depend upon human blood. However, most primary malaria vectors outside of sub-Saharan Africa can be classified as “very zoophagic,” meaning they feed occasionally (

Methods and Findings

We extended a published malaria transmission model to examine the relationship between transmission, control, and the baseline proportion of bloodmeals obtained from humans (human blood index). The lower limit of the human blood index enables derivation of simplified models for zoophagic vectors that (1) Rely on only three field-measurable parameters. (2) Predict immediate and delayed (with …

Second-Order Convex Splitting Schemes For Gradient Flows With Ehrlich-Schwoebel Type Energy: Application To Thin Film Epitaxy, Jie Shen, Cheng Wang, Xiaoming Wang, Steven M. Wise

Mathematics and Statistics Faculty Research & Creative Works

We construct unconditionally stable, unconditionally uniquely solvable, and second order accurate (in time) schemes for gradient flows with energy of the form {equation presented} dx. the construction of the schemes involves the appropriate combination and extension of two classical ideas: (i) appropriate convex-concave decomposition of the energy functional and (ii) the secant method. as an application, we derive schemes for epitaxial growth models with slope selection (F(y) = 1/4 (|y| 2 - 1) 2) or without slope selection (F(y) = -1/2 ln(1 + |y| 2)). Two types of unconditionally stable uniquely solvable second-order schemes are presented. the first type inherits …

Long Time Stability Of A Classical Efficient Scheme For Two-Dimensional Navier-Stokes Equations, S. Gottlieb, F. Tone, C. Wang, X. Wang, D. Wirosoetisno

Mathematics and Statistics Faculty Research & Creative Works

This paper considers the long-time stability property of a popular semi-implicit scheme for the two-dimensional incompressible Navier-Stokes equations in a periodic box that treats the viscous term implicitly and the nonlinear advection term explicitly. We consider both the semi discrete (discrete in time but continuous in space) and fully discrete schemes with either Fourier Galerkin spectral or Fourier pseudo spectral (collocation) methods. We prove that in all cases, the scheme is long time stable provided that the timestep is sufficiently small. the long-time stability in the L 2 and H 1 norms further leads to the convergence of the global …

Interactive Concept To Aid In Understanding Dimensional Analysis, Alicia Hicks

Symposium 2012

Many students struggle with learning how to utilize dimensional analysis. This confusion is due to not understanding the concept of dose per volume, leading to difficulty when starting the sequencing. This could be one of the contributing causes to medication errors in clinical practice. Does using models, such as Play-doh and pebbles, help students learn the concept of milligrams per milliliters when calculating dosages using dimensional analysis method? A series of pre- and post-tests are used to measure learning growth in each of the treatment groups. Three treatment groups were utilized: Control: one group had no intervention between the pre …

A Study Of Women Working In The Actuarial Field, Jillian Emberg

Honors Projects in Mathematics

The goal of this project is to examine how women fit into the actuarial career path and how cultural expectations, biological factors, and personal aspirations affect their experiences in the field. Dramatic changes in the profession have occurred since its emergence in the nineteenth century to become more welcoming to women who choose to enter the profession. However, despite the equalizing demographic shifts of the field, it is still a male-dominated profession. This paper attempts to analyze why some of the changes in the demographics of the field have occurred as well as explain what factors contribute to women’s underrepresentation …

Translation Representations And Scattering By Two Intervals, Palle Jorgensen, Steen Pedersen, Feng Tian

Mathematics and Statistics Faculty Publications

Studying unitary one-parameter groups in Hilbert space (U(t), H), we show that a model for obstacle scattering can be built, up to unitary equivalence, with the use of translation representations for L²-functions in the complement of two finite and disjoint intervals. The model encompasses a family of systems (U(t), H). For each, we obtain a detailed spectral representation, and we compute the scattering operator and scattering matrix. We illustrate our results in the Lax-Phillips model where (U(t), H) represents an acoustic wave equation …

Human Gene Copy Number Spectra Analysis In Congenital Heart Malformations, Aoy Tomita-Mitchell, Donna K. Mahnke, Craig Struble, Maureen E. Tuffnell, Karl D. Stamm, Mats Hidestrand, Susan Harris, Mary A. Goetsch, Pippa Simpson, David P. Bick, Ulrich Broeckel, Andrew N. Pelech, James S. Tweddell, Michael Mitchell

Mathematics, Statistics and Computer Science Faculty Research and Publications

The clinical significance of copy number variants (CNVs) in congenital heart disease (CHD) continues to be a challenge. Although CNVs including genes can confer disease risk, relationships between gene dosage and phenotype are still being defined. Our goal was to perform a quantitative analysis of CNVs involving 100 well-defined CHD risk genes identified through previously published human association studies in subjects with anatomically defined cardiac malformations. A novel analytical approach permitting CNV gene frequency “spectra” to be computed over prespecified regions to determine phenotype-gene dosage relationships was employed. CNVs in subjects with CHD (n = 945), subphenotyped into 40 …

Genomic Analysis Of Immune Response Against Vibrio Cholerae Hemolysin In Caenorhabditis Elegans, Surasri N. Sahu, Jada Lewis, Isha Patel, Serdar Bozdag, Jeong H. Lee, Joseph E. Leclerc, Hediye Nese Cinar

Mathematics, Statistics and Computer Science Faculty Research and Publications

Vibrio cholerae cytolysin (VCC) is among the accessory V. cholerae virulence factors that may contribute to disease pathogenesis in humans. VCC, encoded by hlyA gene, belongs to the most common class of bacterial toxins, known as poreforming toxins (PFTs). V. cholerae infects and kills Caenorhabditis elegans via cholerae toxin independent manner. VCC is required for the lethality, growth retardation and intestinal cell vacuolation during the infection. However, little is known about the host gene expression responses against VCC. To address this question we performed a microarray study in C. elegans exposed to V. cholerae strains with intact and deleted hlyA …

H-Colouring Bipartite Graphs, John Engbers, David Galvin

Mathematics, Statistics and Computer Science Faculty Research and Publications

For graphs G and H, an H-colouring of G (or homomorphism from G to H) is a function from the vertices of G to the vertices of H that preserves adjacency. H-colourings generalize such graph theory notions as proper colourings and independent sets. For a given H, k∈V(H) and G we consider the proportion of vertices of G that get mapped to k in a uniformly chosen H-colouring of G. Our main result concerns this quantity when G is regular and bipartite. We find numbers 0⩽a−(k)⩽a+(k)⩽1 with the property that for all such G, with high probability the proportion is …

Assessing Changes In The Abundance Of The Continental Population Of Scaup Using A Hierarchical Spatio-Temporal Model, Beth E. Ross

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

In ecological studies, the goal is often to describe and gain further insight into ecological processes underlying the data collected during observational studies. Because of the nature of observational data, it can often be difficult to separate the variation in the data from the underlying process or 'state dynamics.' In order to better address this issue, it is becoming increasingly common for researchers to use hierarchical models. Hierarchical spatial, temporal, and spatio-temporal models allow for the simultaneous modeling of both first and second order processes, thus accounting for underlying autocorrelation in the system while still providing insight into overall spatial …

Ignoring The Spatial Context In Intro Statistics Classes - And Some Simple Graphical Remedies, Nathan Voge

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Statistical data often have a spatial (geographic) context, be it countries of the world, states in the US, counties within a state, cities across the globe, or locations where measurements have been taken. However, most introductory statistics books do not even suggest that such data often are not independent from location, but rather are eected by some spatial association. Remedies are simple: Display data via various map views and brie y discuss which additional information can be extracted from such a graphical representation. In this report, we will visit a variety of popular introductory statistics textbooks and show how some …

K-8 Preservice Teachers’ Inductive Reasoning In The Problem-Solving Contexts, Marta Magiera

Mathematics, Statistics and Computer Science Faculty Research and Publications

This paper reports the results from an exploratory study of K-8 pre-service teachers’ inductive reasoning. The analysis of 130 written solutions to seven tasks and 77 reflective journals completed by 20 pre-service teachers lead to descriptions of inductive reasoning processes, i.e. specializing, conjecturing, generalizing, and justifying, in the problem-solving contexts. The uncovered characterizations of the four inductive reasoning processes were further used to describe pathways of successful generalizations. The results highlight the importance of specializing and justifying in constructing powerful generalizations. Implications for teacher education are discussed.

Mathematical Dispositions And Student Learning: A Metaphorical Analysis, Jinfa Cai, Victoria Robison, John Moyer, Ning Wang, Bikai Nie

Mathematics, Statistics and Computer Science Faculty Research and Publications

No abstract provided.

A Common Framework For Restriction Semigroups And Regular *-Semigroups, Peter R. Jones

Mathematics, Statistics and Computer Science Faculty Research and Publications

Left restriction semigroups have appeared at the convergence of several flows of research, including the theories of abstract semigroups, of partial mappings, of closure operations and even in logic. For instance, they model unary semigroups of partial mappings on a set, where the unary operation takes a map to the identity map on its domain. This perspective leads naturally to dual and two-sided versions of the restriction property. From a varietal perspective, these classes of semigroups–more generally, the corresponding classes of Ehresmann semigroups–derive from reducts of inverse semigroups, now taking a to a⁺=aa⁻¹ (or, dually, …

A Cautionary Note On Generalized Linear Models For Covariance Of Unbalanced Longitudinal Data, Jianhua Z. Huang, Min Chen, Mehdi Maadooliat, Mohsen Pourahmadi

Mathematics, Statistics and Computer Science Faculty Research and Publications

Missing data in longitudinal studies can create enormous challenges in data analysis when coupled with the positive-definiteness constraint on a covariance matrix. For complete balanced data, the Cholesky decomposition of a covariance matrix makes it possible to remove the positive-definiteness constraint and use a generalized linear model setup to jointly model the mean and covariance using covariates (Pourahmadi, 2000). However, this approach may not be directly applicable when the longitudinal data are unbalanced, as coherent regression models for the dependence across all times and subjects may not exist. Within the existing generalized linear model framework, we show how to overcome …

Physiologic Noise Regression, Motion Regression, And Toast Dynamic Field Correction In Complex-Valued Fmri Time Series, Andrew D. Hahn, Daniel B. Rowe

Mathematics, Statistics and Computer Science Faculty Research and Publications

As more evidence is presented suggesting that the phase, as well as the magnitude, of functional MRI (fMRI) time series may contain important information and that there are theoretical drawbacks to modeling functional response in the magnitude alone, removing noise in the phase is becoming more important. Previous studies have shown that retrospective correction of noise from physiologic sources can remove significant phase variance and that dynamic main magnetic field correction and regression of estimated motion parameters also remove significant phase fluctuations. In this work, we investigate the performance of physiologic noise regression in a framework along with correction for …

Model Reduction Of Linear Pde Systems: A Continuous Time Eigensystem Realization Algorithm, John R. Singler

Mathematics and Statistics Faculty Research & Creative Works

The Eigensystem Realization Algorithm (ERA) is a well known system identification and model reduction algorithm for discrete time systems. Recently, Ma, Ahuja, and Rowley (Theoret. Comput. Fluid Dyn. 25(1) : 233-247, 2011) showed that ERA is theoretically equivalent to the balanced POD algorithm for model reduction of discrete time systems. We propose an ERA for model reduction of continuous time linear partial differential equation systems. The algorithm differs from other existing approaches as it is based on a direct approximation of the Hankel integral operator of the system. We show that the algorithm produces accurate balanced reduced order models for …

Mathematical Modeling And Simulation Of Biologically Inspired Hair Receptor Arrays In Laminar Unsteady Flow Separation, John R. Singler, Belinda A. Batten, Benjamin T. Dickinson

Mathematics and Statistics Faculty Research & Creative Works

Bats possess arrays of distributed flow-sensitive hair-like mechanoreceptors on their dorsal and ventral wing surfaces. Bat wing hair receptors are known to play a significant role in flight maneuverability and are directionally most sensitive to reversed flow over the wing. in this work, we consider the mechanics of flexible hair-like structures for the time accurate detection and visualization of hydrodynamic images associated with unsteady near surface flow phenomena. a nonlinear viscoelastic model of a hair-like structure coupled to an unsteady nonuniform flow is proposed. Writing the hair model in nondimensional form, we identify five dimensionless groups that govern hair behavior. …

A Linear Energy Stable Scheme For A Thin Film Model Without Slope Selection, Wenbin Chen, Sidafa Conde, Cheng Wang, Xiaoming Wang, Steven M. Wise

Mathematics and Statistics Faculty Research & Creative Works

We present a linear numerical scheme for a model of epitaxial thin film growth without slope selection. the PDE, which is a nonlinear, fourth-order parabolic equation, is the L2 gradient flow of the energy ∫Ω(-1/2 ln(1 + |ø|2) + ε2 2 |Ø(x)|2) dx. the idea of convex-concave decomposition of the energy functional is applied, which results in a numerical scheme that is unconditionally energy stable, i.e., energy dissipative. the particular decomposition used here places the nonlinear term in the concave part of the energy, in contrast to a previous convexity splitting scheme. as a result, the numerical scheme is fully …

Productivity Formulae Of An Infinite-Conductivity Hydraulically Fractured Well Producing At Constant Wellbore Pressure Based On Numerical Solutions Of A Weakly Singular Integral Equation Of The First Kind, Chaolang Hu, Jing Lu, Xiaoming He

Mathematics and Statistics Faculty Research & Creative Works

In order to increase productivity, it is important to study the performance of a hydraulically fractured well producing at constant wellbore pressure. This paper constructs a new productivity formula, which is obtained by solving a weakly singular integral equation of the first kind, for an infinite-conductivity hydraulically fractured well producing at constant pressure. And the two key components of this paper are a weakly singular integral equation of the first kind and a steady-state productivity formula. A new midrectangle algorithm and a Galerkin method are presented in order to solve the weakly singular integral equation. The numerical results of these …

Almost Oscillatory Three Dimensional Dynamic Systems, Elvan Akin, Zuzana Dosla, Bonita Lawrence

Mathematics and Statistics Faculty Research & Creative Works

In this article, we investigate oscillation and asymptotic properties for 3D systems of dynamic equations. We show the role of nonlinearities and we apply our results to the adjoint dynamic systems.

A Study Of The Gam Approach To Solve Laminar Boundary Layer Equations In The Presence Of A Wedge, Rahmat Ali Khan, Muhammad Usman

Mathematics Faculty Publications

We apply an easy and simple technique, the generalized ap- proximation method (GAM) to investigate the temperature field associated with the Falkner-Skan boundary-layer problem. The nonlinear partial differ- ential equations are transformed to nonlinear ordinary differential equations using the similarity transformations. An iterative scheme for the non-linear ordinary differential equations associated with the velocity and temperature profiles are developed via GAM. Numerical results for the dimensionless ve- locity and temperature profiles of the wedge flow are presented graphically for different values of the wedge angle and Prandtl number.

Changes Across 25 Years Of Statistics In Medicine, Johanna S. Hardin

Pomona Faculty Publications and Research

[This piece is a series of interviews with giants in the field of medicine on their views of how statistics is changing medicine. I interviewed the editor of the New England Journal of Medicine, a preeminent doctor/researcher of lung cancer, the director of the LA County Department of Public Health, and a Harvard statistician who sits on the editorial board of the New England Journal of Medicine.]

Medicine, Statistics, And Education: The Inextricable Link, Katharine K. Brieger '11, Johanna S. Hardin

Pomona Faculty Publications and Research

No abstract provided.

Absolute Differentiation In Metric Spaces, W. J. Charatonik, Matt Insall

Mathematics and Statistics Faculty Research & Creative Works

In this article, we introduce a new notion of (strong) absolute derivative, for functions derived between metric spaces, and we investigate various properties and uses of this concept, especially regarding the geometry of abstract metric spaces carrying no other structure.

Equivalent Circuit Model Of Coaxial Probes For Patch Antennas, Y. S. Hu, Yanzhi Zhang, Jun Fan

Mathematics and Statistics Faculty Research & Creative Works

An equivalent circuit model of coaxial probes is derived directly from the intrinsic via circuit model. as all the higher-order evanescent modes have been included analytically in the parasitic circuit elements, only the propagating mode needs to be considered by the simplest uniform-current model of a coaxial probe in numerical solvers such as -nite element method (FEM) or -nite divergence time domain (FDTD). This avoids dense meshes or sub-gridding techniques and greatly reduces the computational efforts for accurate calculation of the probe input impedance. the derived equivalent circuit model and the new feeding technique have been validated by both analytical …

Various Characterizations Of Modified Weibull And Log Modified Distributions, Gholamhossein Hamedani

Mathematics, Statistics and Computer Science Faculty Research and Publications

Various characterizations of the well-known modified Weibull and log-modified Weibull distributions are presented. These characterizations are based on a simple relationship between two truncated moments; on the hazard function and on functions of the order statistics.