Other Physics Commons^™

Commissioning And Validation Of An Electron Treatment Planning System: Following Mppg.5.B Guidelines, Hailey N. Reaux

LSU Master's Theses

Purpose: The purpose of this work was to commission and validate the electron treatment planning system ElectronRT (eRT) (.decimal, Sanford, FL) for clinical use following the recommendations outlined in the American Association of Physicists in Medicine (AAPM) Medical Physics Practice Guideline (MPPG) 5.b (2022). The system’s ability to accurately calculate electron dose distributions was evaluated under normal and oblique beam incidence, varying field sizes and source-to-surface distances (SSDs), and irregular surface geometries.

Methods: The eRT beam model was configured using commissioning data from an Elekta Infinity linear accelerator at Mary Bird Perkins Cancer Center (MBPCC). Validation measurements were performed for …

Improving Stem Assessments: Strategies For Increasing The Accessibility And Adoption Of Two-Stage Exams, Kristina Callaghan

LSU Doctoral Dissertations

Over three decades of research have shown that students taught using active learning strategies achieve better learning outcomes compared to those taught using traditional methods. Two-stage exams, which pair a traditional exam with a group component, are an increasingly popular method for incorporating active learning within the assessment component of a course. Previous studies have shown this assessment strategy provides a variety of benefits for students, including increased engagement and collaboration, immediate feedback, and potentially increased content retention. However, the unique circumstances of each instructor can pose a non-trivial barrier to the implementation of two-stage exams. In this thesis, we …

Practical Real-Time Permanent Magnet Energy Spectrometer Using A Diode Array For Therapeutic Electron Beam Tuning And Quality Assurance, Mason W. Heath

LSU Doctoral Dissertations

Purpose: Develop a practical, real-time permanent magnet electron energy spectrometer and evaluate it for beam tuning and quality assurance (QA) of therapeutic electron beams.

Methods: Aim 1: A 0.55 T permanent magnet was coupled to Sun Nuclear SRS MapCHECK® PC boards, providing two interlaced diode arrays. Detector response, R_meas(z_diode) versus diode position z_diode, was extracted from raw diode array readings, correcting for diode sensitivity and other factors. Using Monte Carlo (MC) computed, monoenergetic detector response functions, a curve-fitting algorithm extracted the energy spectrum, from R_meas(z_diode). The energy spectra for 7-20 …

Dose Characterization Of Galactic Cosmic Rays In The Human Brain: A Phits-Based Study With A Segmented Anatomical Phantom, Shanice N. Manning

LSU Master's Theses

Astronauts aboard the International Space Station (ISS) are chronically exposed to a complex space radiation environment composed of galactic cosmic rays (GCR), solar particles, and Earth's trapped radiation. These high-energy particles interact with spacecraft shielding, producing secondary particles that can penetrate inside and deposit energy in sensitive tissues. Although animal studies have been useful in assessing space radiation risks, anatomical and physiological differences limit their applicability to human anatomy especially neuroanatomy. To address this gap, we developed a computational framework to model radiation dose distribution within the human brain using Monte Carlo simulations in Particle and Heavy Ion Transport code …

Post-Modeling Adjustments And Delivered Dose Verification Of The 6fff Beam Model Commissioned For The Monaco Treatment Planning System, Grant C. Debevec

LSU Master's Theses

External beam radiation therapy has been shown to be an effective treatment method for tumors and abnormalities of the spine and vertebral region. Treating the spine using a stereotactic body radiation therapy (SBRT) technique can reduce toxicity to the spinal cord. The 6 MV flattening filter free (6FFF) beam model is currently used to plan and calculate dose for SBRT treatment plans, and the treatment plans are delivered using a linear accelerator (LINAC).

The commissioned beam model represents an invariant component of a LINAC. For volumetric modulated arc therapy (VMAT) treatment plans, the multileaf collimator (MLC) positions are changing throughout …

Entanglement In The Hawking Effect: From Astrophysical To Optical Black Holes, Dimitrios Kranas

LSU Doctoral Dissertations

The Hawking effect is an exciting physical prediction lying at the intersection of the two most successful theories of the past century, namely, Einstein’s theory of relativity and quantum mechanics. In this dissertation, we put special emphasis on the quantum aspects of the Hawking process encoded in the entanglement shared by the emitted fluxes of created quanta. In particular, we employ sharp tools from quantum information theory to quantify the entanglement produced by the Hawking effect throughout the black hole evaporation process. Our framework allows us to extend previous calculations of entanglement to a larger set of cases, for instance, …

Experiments And Data Analysis For Modulated Phase Gratings In X-Rays, Sydney B. Carr

LSU Master's Theses

Purpose: Modulated Phase Grating (MPG) interferometry has been shown in theory and simulations to produce observable fringes on a clinical detector without requiring fluence absorbing analyzer. In this work, we will experimentally show that the MPG X-ray system produces observable fringes and multi-modal X-ray images.

Motivation:Nearly 1 in 8 women in the US will develop invasive breast cancer in their lifetime, accounting for approximately 40,000 deaths each year [1-2]. In order to pursue the best treatment option available, cancer itself must be adequately imaged and staged, based on size and level of metastasis, on the order of Stage I-IV. …

Reconstruction Of Volumetric Modulated Arc Therapy-Computed Tomography, Chia-Lung Chien

LSU Doctoral Dissertations

Purpose: Volumetric modulated arc therapy-computed tomography (VMAT-CT) was proposed in 2010 as the CBCT reconstruction technique using portal images collected during VMAT. Yet, its clinical applications were impeded by the poor image quality due to motion blurs from fast movements of multi-leaf collimator (MLC) and projection data deficiency due to truncations from MLC. The goal of this study is to develop systematic preprocessing methods, and a novel iterative reconstruction algorithm to generate quality VMAT-CT and lower the number of failure cases of VMAT-CT reconstruction.

Methods: Systematic image preprocessing methods, including Online region-based active contouring (ORACM), MLC motion modeling and outlier …

Effective Connectivity Of Functional Mri Via Deep Learning Methods, Kai-Cheng Chuang

LSU Doctoral Dissertations

Effective connectivity, based on functional magnetic resonance imaging (fMRI) time series signals, is the quantification of how strongly brain activity in a certain source brain region contributes to brain activity in a target brain region, independent of the contributions of other source regions. Current methods to solve this problem have several limitations. They are either unable to model nonlinear relationships between source and target signals, unable to efficiently quantify time lags in source-target relationships, unable to identify time-varying relationships, or fail to account for variability in the hemodynamic response function that converts neuron activity to a measurable signal. In this …

Hybrid Modulated-Phase-Grating For Phase Contrast X-Ray For A Varying Fringe Period Clinical Interferometry System, Elizabeth Jeong Park

LSU Master's Theses

Phase contrast x-rays are of use due to the range of imaging they can provide. Not only are they useful for attenuation they also can provide phase and small angle scatter X-ray (SAXS) information simultaneously which adds additional contrast and information to the original attention image. In prior work, a phase contrast system with Modulated Phase Grating was shown to eliminate the need for analyzer in standard Talbot Lau Xray Interferometers (TLXI). The system is clinically compatible in footprint due to its length being limited to

Accident Simulation Study For Nuclear Power Plants Impacting Louisiana, Michael D. Mcmahon

LSU Master's Theses

INTRODUCTION: Louisiana has aligned its radiological emergency program with the 2017 Environmental Protection Agency Protective Action Guides Manual, but has added a child thyroid dose evacuation threshold in lieu of distributing Potassium Iodide to the public. The nuclear power plants will continue to align with the 1992 manual for the foreseeable future, so that under some accident scenarios the state recommendations will differ from those of the utility.

OBJECTIVE: The objective of this study is to predict what accident and weather conditions will lead to a differing set of recommendations.

METHODS: More than 1000 simulations were performed of low-filtration nuclear …

In-Phantom Film Measurements Of Two Treatment Planning Systems For Single-Fraction Spine Sbrt, Michael J. Taylor

LSU Master's Theses

Purpose: Treatment planning accuracy for spine stereotactic body radiation therapy (SBRT) varies depending on the dose calculation algorithm utilized in the treatment planning system (TPS). This project compared the end-to-end accuracy between spine SBRT plans calculated in a convolution-superposition based TPS (TPS_CS) and Monte Carlo based TPS (TPS_MC) with radiochromic film measurements. The hypothesis was that TPS_MC would calculate the dose gradient in the critical region between the vertebral body and the spinal cord more accurately than TPS_CS.

Methods: Single-fraction spine SBRT treatments following RTOG 0631 and local institutional guidelines were planned in …

Structural Shielding Considerations For Vmat, Ana Lucia Dieguez

LSU Master's Theses

Introduction: As noted in National Council on Radiation Protection and Measurements (NCRP) Report 151, the medical physicist or other qualified expert has the responsibility to keep abreast of any new technology or treatment method that could potentially impact structural shielding design. Volumetric arc therapy (VMAT) became prevalent after the publication of Report 151 and thus was not explicitly addressed in Report 151. If the shielding-related characteristics of VMAT differ enough from the expectations of Report 151, especially in the circumstance of a vault utilized exclusively for VMAT, a shielding design based on Report 151 could potentially be inadequate. The …

Modeling Anatomic Changes For Adaptive Radiotherapy In Locally Advanced Lung Cancer Patient Population, James Alexander Kavanaugh

LSU Doctoral Dissertations

Anatomic changes occurring mid-treatment for patients undergoing radiation therapy for locally advanced lung cancer can degrade the quality of the intended treatment plan. These changes include tumor regression, geometric misalignment, and lung density changes (atelectasis and pleural effusion), and are visible on the daily 3D cone beam CT (CBCT). To maintain the intended treatment quality, adaptive radiotherapy (ART) can be employed to modify the treatment plan to account for these anatomic changes. However, the evaluation on when to adapt is currently completed manually by the treating clinicians, resulting in a subjective and inconsistent application. To address these limitations, a series …

Visualization Of Brown Fat Using X-Ray Dark Field Imaging, Troy D. Jacobs

LSU Master's Theses

Introduction: Obesity has become a major societal issue. Many researchers are looking for ways to combat this growing epidemic. Brown adipose tissue (BAT) might be a way to help individuals overcome the challenges associated with weight loss and maintenance of weight loss, but a better understanding of BAT and how to control and utilize it is needed. BAT differs from white adipose tissue (WAT) in that BAT is rich with mitochondria and therefore is metabolically active. BAT is a source of non-shivering thermogenesis and can be activated both by cold exposure and pharmacologically. Current methods of assessing BAT activity are …

Analytical Setup Margin For Spinal Sbrt Based On Measured Errors, Audrey Copeland

LSU Master's Theses

Purpose: No consensus currently exists in the radiotherapy community about the correct margin size to use for spinal SBRT. Margins have been proposed to account for various errors individually, but not with all errors combined to result in a single margin value. The purpose of this work was to determine a setup margin for spinal SBRT based on known and measurable errors during radiotherapy to achieve at least 90% coverage of the clinical target volume (CTV) with the prescription dose for at least 90% of patients and not exceed a 30 Gy point dose or 23 Gy to 10% of …

Accurate Tracking Of Position And Dose During Vmat Based On Vmat-Ct, Xiaodong Zhao

LSU Doctoral Dissertations

Purpose: Local tomography reconstruction is achievable with EPID images acquired during VMAT and was named as VMAT-CT. However, it did not gain popularity due to multiple limitations and technical challenges. The goal of this study was to extend VMAT-CT concept, generate complete 3D or 4D CT images and dose, track and adapt VMAT plan based on updated images and dose.

Methods: We considered collimator angle and removed blurred areas in EPID images for VMAT-CT reconstruction to reduce artifacts and improve image quality. VMAT-CT+ images were generated by fusing VMAT-CT and planning CT using rigid or deformable registration. For 4D SBRT …

X-Ray Interferometry Without Analyzer For Breast Ct Application, A Simulation Study, Jingzhu Xu

LSU Doctoral Dissertations

We investigated a novel analyzer-less X-ray interferometer with a spatially modulated phase-grating (MPG) which produces three types of images (attenuation image, phase image and scatter image) for Breast computed tomography (CT). The system provides the three complimentary X-ray images with the goals of limiting the dose to the object and achieving similar attenuation image sensitivity as a standard absorption-only Breast CT. The MPG system features an X-ray source, a source-grating, a single phase-grating, and a detector. No analyzer grating is necessary, compared to other geometries such as Talbot-Lau X-ray interferometry (TLXI). Thus, there is a ~2 times improvement in X-ray …

Evaluation Of Neutron Skyshine Contributions During Injection At An Electron Synchrotron Facility Using Fluka, Andrew D. Hastings

LSU Master's Theses

The Center for Advanced Microstructures and Devices (CAMD) is a 1.5 giga-electron volt (GeV) electron synchrotron research facility under the jurisdiction of Louisiana State University (LSU). When originally constructed in 1992, CAMD was surrounded by pasture and woodland. Over the past several years, urban development of the area has found CAMD bracketed by a shopping center, apartment complex, and business offices. These developments raised concerns amongst the CAMD radiation safety personnel regarding an increased potential for public exposure to radiation. To ensure compliance with the annual public effective dose equivalent limit of 1 milli-sievert (mSv), the radiation monitoring program was …

Comprehensive Investigation Of Radiation Techniques For Whole Breast And Post-Mastectomy Irradiations, Yibo Xie

LSU Doctoral Dissertations

Purpose: The purpose of this dissertation is to compare treatment outcomes and cost-effectiveness of various radiotherapy techniques for post-mastectomy radiotherapy (PMRT) and whole breast radiotherapy (WBRT) patients.

Methods: Treatment planning comparison of standard volumetric modulated arc therapy (STD-VMAT), multiple arc VMAT (MA-VMAT), non-coplanar VMAT (NC-VMAT), intensity modulated radiotherapy (IMRT), helical tomotherapy (HT), mixed beam therapy and proton therapy was performed for 9 PMRT patients, and cost-effectiveness of those PMRT techniques compared to standard of care (SOC) were evaluated using a Markov model. Treatment planning comparison of SOC, field-in-field (FIF), hybrid IMRT, full IMRT, STD-VMAT, MA-VMAT and NC-VMAT was performed …

High Power And Optomechanics In Advanced Ligo Detectors, Terra Christine Hardwick

LSU Doctoral Dissertations

In September 2015, a new era of astronomy began with the first direct detection of grav- itational waves from a binary black hole coalescence. The event was captured by the Laser Interferometer Gravitational-wave Observatory, comprised of two long-baseline interferometers, one in Livingston, LA and one in Hanford, WA. At the time of the first detection, the interferometers were part way through an upgrade to an advanced configuration and were operating with a strain sensitivity of just better than 10⁻²³/Hz^1/2 around 100Hz. The full Advanced LIGO design calls for sensitivity of a few parts in 10⁻²⁴/Hz …

Visualization And Quantitation Of Radioiodine Distribution In Silver Zeolite Cartridges, Daniel Dimarco

LSU Master's Theses

Iodine 131 is a major fission product released during a nuclear incident. This isotope provides a serious health hazard for humans and the environment, therefore nuclear power plants must monitor releases using air sampling. The air sampling is accomplished using air filter cartridges using silver zeolite as a filter media. During an emergency situation, silver zeolite is useful for its affinity to I-131 without adsorbing other radioactive gases. After leaving the plume, these cartridges are counted in a low background area. This measurement does not take into account the distribution of radioiodine in the cartridge. This study explores two methods …

Assessment Of Excess Thyroid Cancer Risk Following A Hypothetical Radiological Incident In Louisiana And Best-Case Risk Reduction Achieved By Thyroid Blockade, Garrett A. Otis

LSU Master's Theses

Radioactive isotopes of iodine are produced by nuclear power plants as a byproduct of nuclear fission reactions. If these isotopes are released into the environment, such as during a breach of containment, they constitute a health risk to exposed individuals. To mitigate the risk of thyroid cancer due to exposure to radioactive iodine, “iodide prophylaxis,” also known as “thyroid blockade,” can be used, usually by administration of potassium iodide (KI). In some areas of the world, KI has been provided to the general public by their governments as a precautionary measure against potential nuclear power plant incidents. However, in the …

Determination Of Scatter Fractions, Albedos, And Tenth Value Layers For Shielding Of Synchrotron Beamline Hutches, Bethany Lynn Broekhoven

LSU Master's Theses

Synchrotron facilities require substantial amounts of shielding to protect facility staff and researchers. To meet mandatory exposure limits, the traditional combination of time, distance, and shielding of the radiation source are utilized. Because of continuous 24-7 operation of most synchrotrons, time is the least useful tool. The experimental stations for synchrotron x-ray beamlines, called hutches, enforce a minimum distance from the source, but shielding provided by hutch walls is still the principal tool for a synchrotron facility. Currently there is no single resource for synchrotron beamline hutch shielding design in the literature; most hutch shielding is designed through either over-simplified …

Framework For Algorithmically Optimizing Longitudinal Health Outcomes: Examples In Cancer Radiotherapy And Occupational Radiation Protection, Lydia Joyce Wilson

LSU Doctoral Dissertations

Background: Advancements in the treatment of non-infectious disease have enabled survival rates to steadily increase in recent decades (e.g., diabetes, heart disease, and cancer). Epidemiological studies have revealed that the treatments for these diseases can have life-threatening and/or life–altering effects. Thus, realizing the full beneficial potential of advanced treatments necessitates new tools to algorithmically consider all major components of the health outcome, including benefit and detriment. The goal of this dissertation was to develop a framework for improving projected health outcomes following planned radiation exposures in consideration of all beneficial and detrimental, early and late, and fatal and non-fatal …

Evaluation Of Ventilation Assistance For Improving Respiratory Reproducibility In Radiation Therapy, Cameron J. Sprowls

LSU Master's Theses

Background: Respiratory motion affects all tumor sites in the thorax and abdomen. Variations of the respiratory pattern cause variations of the tumor motion which can result in differences between the planned and delivered dose distributions. Previous breathing guidance techniques have been investigated to improve respiratory reproducibility; however, ventilation assistance has not been investigated. We evaluated using bi-level positive airway pressure (BIPAP) ventilation assistance for improving respiratory reproducibility in patients with tumor sites impacted by respiratory motion.

Methods: Written informed consent was obtained for 10 patients currently undergoing radiation therapy treatment. Patients participated in sessions over their course of treatment, which …

Determination Of Conversion Factors For Various Calibration Geometries Using Barium-133 In A Silver Zeolite Cartridge, Amin Hamideh

LSU Master's Theses

Iodine-131 (I-131) is a major fission product among other radionuclides released during a nuclear incident. This radioiodine has a half-life of 8.02 days and the primary organ of uptake through ingestion or inhalation is the thyroid gland. For these reasons, nuclear power plants must routinely monitor I-131 through air sampling. Currently, there are two adsorbing media to collect I-131: activated charcoal and silver zeolite cartridges. Silver zeolite cartridges are generally used during a post nuclear incident due to its affinity for iodine while not adsorbing noble gases such as krypton-85 and xenon-135. After an air sample is taken from a …

Third Generation Gamma Camera Spect System, Narayan Bhusal

LSU Master's Theses

Single Photon Emission Computed Tomography (SPECT) is a non-invasive imaging modality, frequently used in myocardial perfusion imaging. The biggest challenges facing the majority of clinical SPECT systems are low sensitivity, poor resolution, and the relatively high radiation dose to the patient. New generation systems (GE Discovery, DSPECT) dedicated to cardiac imaging improve sensitivity by a factor of 5-8. The purpose of this work is to investigate a new gamma camera design with 21 hemi-ellipsoid detectors each with a pinhole collimator for Cardiac SPECT for further improvement in sensitivity, resolution, imaging time, and radiation dose.

To evaluate the resolution of our …

Analytical Models Of Neutron Spectral Fluence, Kerma And Absorbed-Dose For Proton Therapy, Suman Shrestha

LSU Master's Theses

Abstract

Purpose: The accurate prediction of stray neutron dose has become increasingly important as it increases the risk of second cancer development after proton therapy. Previously reported analytical models predicted the quantity dose equivalent, which includes physical and biological considerations but does not explicitly take into account material dependence and variation in the radiation quality. The purpose of this study was to investigate the feasibility of an analytical model of absorbed dose to water from stray neutrons in proton therapy.

Methods: To calculate neutron absorbed dose and kerma in water, the authors developed analytical models of neutron spectral fluence and …

Verification And Evaluation Of A Passive Intensity Modulation Device For Bolus Conformal Therapy, Elizabeth Noel Hilliard

LSU Master's Theses

Purpose: Bolus electron conformal therapy (BECT) provides effective radiation treatment for superficial cancers and other diseases close to the skin surface, but can have as great as a 30% planning target volume (PTV) dose heterogeneity due to scattering from the irregular proximal bolus surface. Intensity modulated (IM) BECT can improve PTV dose homogeneity, but is not currently available. This study fabricated patient-specific passive intensity modulators and validated their delivering planned dose distributions calculated by a modified pencil beam redefinition algorithm (PBRA).

Methods: Two test-patterns and four patient-specific intensity modulators were designed, fabricated, and tested. Dose plans were generated …