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Full-Text Articles in Optics
Live Cell Biomass Tracking For Basic, Translational, And Clinical Research, Graeme Murray
Live Cell Biomass Tracking For Basic, Translational, And Clinical Research, Graeme Murray
Theses and Dissertations
Single cell mass is tightly regulated throughout generations and the cell cycle, making it an important marker of cell health. Abnormal changes in cell size can be the first indication of dysfunction in response to environmental stimuli such as cytotoxic drugs. Described here is the further development of high-speed live cell interferometry (HSLCI) to concurrently measure the changes in single cell mass of thousands of cells over time. Critically, the high-throughput nature of HSLCI provides realistic pictures of tumor heterogeneity. This throughput enabled HSLCI to correctly predict in vivo carboplatin sensitivity of three triple negative breast cancer patient derived xenografts, …
Zernike Piston Statistics In Turbulent Multi-Aperture Optical Systems, Joshua J. Garretson
Zernike Piston Statistics In Turbulent Multi-Aperture Optical Systems, Joshua J. Garretson
Theses and Dissertations
There is currently a lack of research into how the atmosphere effects Zernike piston. This Zernike piston is a coefficient related to the average phase delay of a wave. Usually Zernike piston can be ignored over a single aperture because it is merely a delay added to the entire wavefront. For multi-aperture interferometers though piston cannot be ignored. The statistics of Zernike piston could supplement and improve atmospheric monitoring, adaptive optics, stellar interferometers, and fringe tracking. This research will focus on developing a statistical model for Zernike piston introduced by atmospheric turbulence.
Quantitative Analysis And Process Of High Speed Live Cell Interferometry Measurements, Daniel Guest
Quantitative Analysis And Process Of High Speed Live Cell Interferometry Measurements, Daniel Guest
Theses and Dissertations
The application of auto focus, using an optical beam deflection technique, to existing live cell interferometry measurements was developed and examined. The benefit to relevant experiments, currently being performed, is shown as well as its performance across various magnifications. Enough information is given so that the system can be reproduced to fit any end users needs.
Tunable Optical Delay In Doppler-Broadened Cesium Vapor, Monte D. Anderson
Tunable Optical Delay In Doppler-Broadened Cesium Vapor, Monte D. Anderson
Theses and Dissertations
Variable-delay tunable optical delay line or optical buffers are critical for the development of all-optical networks components as well as interferometry and analytic instruments. Recent research on slow light may hold the key for the development of the first practical tunable optical delay device. In this research the linear dispersion delay effects in an alkali vapor. The hyperfine relaxation observations present insight into the complex bleach wave dynamics during a high-intensity pulsed pump in DPAL systems.
Characterization Of Spatial And Temporal Anisotropy In Turbulent Mixing Layers Using Optical Techniques, Patrick J. Gardner
Characterization Of Spatial And Temporal Anisotropy In Turbulent Mixing Layers Using Optical Techniques, Patrick J. Gardner
Theses and Dissertations
The optical aberrations induced by mixing layers of dissimilar gases are recorded and analyzed in order to characterize the spatial and temporal properties of the flow. Laser light was propagated through a mixing layer of Helium and Nitrogen gas, having velocities of 8.5 m/sec and 1.5 m/sec, respectively. The light was propagated in a direction perpendicular to the plane of the mixing layer. The mixing layer was evaluated in two experimental regimes: free turbulent mixing, where the mixing layer spreads into the surrounding air; and channel flow, where the mixing layer is confined to a rectangular channel. The optical perturbations …