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Biological and Chemical Physics Commons™
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Full-Text Articles in Biological and Chemical Physics
Chlorhexidine-Induced Elastic And Adhesive Changes Of Escherichia Coli Cells Within A Biofilm, Anne E. Murdaugh, Nicole Rodgers
Chlorhexidine-Induced Elastic And Adhesive Changes Of Escherichia Coli Cells Within A Biofilm, Anne E. Murdaugh, Nicole Rodgers
Faculty Publications
Chlorhexidine is a widely used, commercially available cationic antiseptic. Although its mechanism of action on planktonic bacteria has been well explored, far fewer studies have examined its interaction with an established biofilm. The physical effects of chlorhexidine on a biofilm are particularly unknown. Here, the authors report the first observations of chlorhexidine-induced elastic and adhesive changes to single cells within a biofilm. The elastic changes are consistent with the proposed mechanism of action of chlorhexidine. Atomic force microscopy and force spectroscopy techniques were used to determine spring constants and adhesion energy of the individual bacteria within an Escherichia coli biofilm. …
Quantifying The Locomotion Of C. Elegans And Their Response To Photo Stimulation, Ian Seddon
Quantifying The Locomotion Of C. Elegans And Their Response To Photo Stimulation, Ian Seddon
Honors Program Theses
Identifying the function of different locomotive genes in model organisms is crucial for genetics research. One popular approach is to analyze the behavior and motion of animals in hope of understanding subtle genetic or neural mechanisms. The nematode C. elegans has emerged as an increasingly popular organism for the study of sensory systems, specifically photo transduction, due to the fact it is still photosensitive without having eyes. Light stimulus has been shown to elicit evasive locomotive behavior in C. elegans, however little has been done to quantify this movement. Modeling the worm motion as a static sine wave, we used …