Physics Commons^™

The Role Of N-Terminal Acidic Inserts On The Dynamics Of The Tau Protein., Miranda Redmond

Graduate College Dissertations and Theses

Alzheimer’s disease (AD), the most prevalent neurodegenerative disease, is characterized in part by disruptions in axonal transport. Axonal transport is a process by which motor proteins carry organelles and other cargo made in the neuronal cell body along microtubule tracks to distal regions of the axon. The microtubule-associated protein (MAP) Tau plays a crucial role in regulating axonal transport, and is implicated in the development of AD and other types of dementia collectively known as Tauopathies. Tau is a neuronal-specific MAP that has six isoforms alternatively spliced from a single gene. These isoforms differ by the presence of zero, one, …