Mathematics Commons^™

Structure-Activity Relationship Of Novel Diphenyl Ureas Targeting Mycobacterium, Piper Burghduf

Student Scholars Day Posters

In 2017, the World Health Organization reported that 10 million people were infected with tuberculosis, 1.6 million of whom died. Tuberculosis is caused by a bacterium called Mycobacterium tuberculosis, which primarily infects an individual’s lungs. Unfortunately, failure to adhere to the long and arduous drug regimen has contributed to the emergence of antibiotic-resistant strains of M. tuberculosis. Therefore, the need for novel antibiotics is imperative to saving millions of lives. Our lab has recently developed a family of diphenyl ureas that exhibited increased antimicrobial activity toward Mycobacterium. Reported herein is the continuation of our previous research involving the synthesis of …

A Permutation Test And Spatial Cross-Validation Approach To Assess Models Of Interspecific Competition Between Trees, David Allen, Albert Y. Kim

Statistical and Data Sciences: Faculty Publications

Measuring species-specific competitive interactions is key to understanding plant communities. Repeat censused large forest dynamics plots offer an ideal setting to measure these interactions by estimating the species-specific competitive effect on neighboring tree growth. Estimating these interaction values can be difficult, however, because the number of them grows with the square of the number of species. Furthermore, confidence in the estimates can be overestimated if any spatial structure of model errors is not considered. Here we measured these interactions in a forest dynamics plot in a transitional oak-hickory forest. We analytically fit Bayesian linear regression models of annual tree radial …

Describing Quasi-Graphic Matroids, Nathan Bowler, Daryl Funk, Dan Slilaty

Mathematics and Statistics Faculty Publications

The class of quasi-graphic matroids recently introduced by Geelen, Gerards, and Whittle generalises each of the classes of frame matroids and liftedgraphic matroids introduced earlier by Zaslavsky. For each biased graph (G, B) Zaslavsky defined a unique lift matroid L(G, B) and a unique frame matroid F(G, B), each on ground set E(G). We show that in general there may be many quasi-graphic matroids on E(G) and describe them all: for each graph G and partition (B, L, F) of its cycles such that B satisfies the theta property and each cycle in L meets each cycle in F, there …

Sufficient Dimension Folding In Regression Via Distance Covariance For Matrix‐Valued Predictors, Wenhui Sheng, Qingcong Yuan

Mathematical and Statistical Science Faculty Research and Publications

In modern data, when predictors are matrix/array‐valued, building a reasonable model is much more difficult due to the complicate structure. However, dimension folding that reduces the predictor dimensions while keeps its structure is critical in helping to build a useful model. In this paper, we develop a new sufficient dimension folding method using distance covariance for regression in such a case. The method works efficiently without strict assumptions on the predictors. It is model‐free and nonparametric, but neither smoothing techniques nor selection of tuning parameters is needed. Moreover, it works for both univariate and multivariate response cases. In addition, we …

Mathematical Modelling Of The Tuberculosis Epidemiology, Ally Yeketi Ayinla

Student Works (2020-2029)

This project analyses the tuberculosis (TB) epidemic mathematically using compartmental modelling approach. Three models are presented to discuss drug susceptible and multi-drug resistant TB. The first model presented has 4 compartments; susceptible, exposed, infectious and recovered. The relevance of the exposed class in managing TB is analysed and found to be useful in delaying the eventual onset of the infection. Compared to previous researches, our results significantly show that when efforts are made such that no infected individual bypasses the exposed class and progresses directly to the infectious, the TB epidemic is successfully combatted. Also, the model is used to …

Art, Artfulness, Or Artifice?: A Review Of The Art Of Statistics: How To Learn From Data, By David Spiegelhalter, Jason Makansi

Numeracy

David Spiegelhalter. 2019. The Art of Statistics: How to Learn From Data. (London: The Penguin Group). 444 pp. ISBN 978-1541618510

The author successfully eases the reader away from the rigor of statistical methods and calculations and into the realm of statistical thinking. Despite an engaging style and attention-grabbing examples, the reader of The Art of Statistics will need more than a casual grounding in statistics to get what Spiegelhalter, I believe, intends from his book. It should be viewed as a companion to a more rigorous textbook on statistical methods but not necessarily a book that makes statistics any …

Markov Chain Epidemic Models And Parameter Estimation, Oluwatobiloba Ige

Theses, Dissertations and Capstones

Over the years, various parts of the world have experienced disease outbreaks. Mathematical models are used to describe these outbreaks. We study the transmission of disease in simple cases of disease outbreaks by using compartmental models with Markov chains. First, we explore the formulation of compartmental SIS (Susceptible-Infectious-Susceptible) and SIR (Susceptible-Infectious-Recovered) disease models. These models are the basic building blocks of other compartmental disease models. Second, we build SIS and SIR disease models using both discrete and continuous time Markov chains. In discrete time models, transmission occurs at fixed time steps, and in continuous time models, transmission may occur at …

A Tutorial Of Bland Altman Analysis In A Bayesian Framework, Krissina M. Alari, Steven B. Kim, Jeffrey O. Wand

Mathematics and Statistics Faculty Publications and Presentations

There are two schools of thought in statistical analysis, frequentist, and Bayesian. Though the two approaches produce similar estimations and predictions in large-sample studies, their interpretations are different. Bland Altman analysis is a statistical method that is widely used for comparing two methods of measurement. It was originally proposed under a frequentist framework, and it has not been used under a Bayesian framework despite the growing popularity of Bayesian analysis. It seems that the mathematical and computational complexity narrows access to Bayesian Bland Altman analysis. In this article, we provide a tutorial of Bayesian Bland Altman analysis. One approach we …

Existence And Multiplicity Of Weak Solutions For A Neumann Elliptic Problem With -Laplacian, Martin Bohner, Giuseppe Caristi, Fariba Gharehgazlouei, Shapour Heidarkhani

Mathematics and Statistics Faculty Research & Creative Works

We are interested in the existence of multiple weak solutions for the Neumann elliptic problem involving the anisotropic -Laplacian operator, on a bounded domain with smooth boundary. We work on the anisotropic variable exponent Sobolev space, and by using a consequence of the local minimum theorem due to Bonanno, we establish existence of at least one weak solution under algebraic conditions on the nonlinear term. Also, we discuss existence of at least two weak solutions for the problem, under algebraic conditions including the classical Ambrosetti-Rabinowitz condition on the nonlinear term. Furthermore, by employing a three critical point theorem due to …

Comparative Survival Of Asian And White Metastatic Castration-Resistant Prostate Cancer Men Treated With Docetaxel, Susan Halabi, Sandipan Dutta, Catherine M. Tangen, Mark Rosenthal, Daniel P. Petrylak, Ian M. Thompson Jr., Kim N. Chi, Johann S. De Bono, John C. Araujo, Christopher Logothetis, Mario A. Eisenberger, David I. Quinn, Karim Fizazi, Michael J. Morris, Celestia S. Higano, Ian F. Tannock, Eric J. Small, William Kevin Kelly

Mathematics & Statistics Faculty Publications

There are few data regarding disparities in overall survival (OS) between Asian and white men with metastatic castration-resistant prostate cancer (mCRPC). We compared OS of Asian and white mCRPC men treated in phase III clinical trials with docetaxel and prednisone (DP) or a DP-containing regimen. Individual participant data from 8820 men with mCRPC randomly assigned on nine phase III trials to receive DP or a DP-containing regimen were combined. Men enrolled in these trials had a diagnosis of prostate adenocarcinoma. The median overall survival was 18.8 months (95% confidence interval [CI] = 17.4 to 22.1 months) and 21.2 months (95% …

Fuzzy Logistic Regression For Detecting Differential Dna Methylation Regions, Tarek M. Bubaker Bennaser

Doctoral Dissertations

“Epigenetics is the study of changes in gene activity or function that are not related to a change in the DNA sequence. DNA methylation is one of the main types of epigenetic modifications, that occur when a methyl chemical group attaches to a cytosine on the DNA sequence. Although the sequence does not change, the addition of a methyl group can change the way genes are expressed and produce different phenotypes. DNA methylation is involved in many biological processes and has important implications in the fields of biomedicine and agriculture.

Statistical methods have been developed to compare DNA methylation at …

Stochastic Technique For Solutions Of Non-Linear Fin Equation Arising In Thermal Equilibrium Model, Iftikhar Ahmad, Hina Qureshi, Muhammad Bilal, Muhammad Usman

Mathematics Faculty Publications

In this study, a stochastic numerical technique is used to investigate the numerical solution of heat transfer temperature distribution system using feed forward artificial neural networks. Mathematical model of fin equation is formulated with the help of artificial neural networks. The effect of the heat on a rectangular fin with thermal conductivity and temperature de-pendent internal heat generation is calculated through neural networks optimization with optimizers like active set technique, interior point technique, pattern search, genetic algorithm and a hybrid approach of pattern search - interior point technique, genetic algorithm - active set technique, genetic algorithm - interior point technique, …

Teaching Introductory Statistics With Datacamp, Benjamin Baumer, Andrew P. Bray, Mine Çetinkaya-Rundel, Johanna S. Hardin

Statistical and Data Sciences: Faculty Publications

We designed a sequence of courses for the DataCamp online learning platform that approximates the content of a typical introductory statistics course. We discuss the design and implementation of these courses and illustrate how they can be successfully integrated into a brick-and-mortar class. We reflect on the process of creating content for online consumers, ruminate on the pedagogical considerations we faced, and describe an R package for statistical inference that became a by-product of this development process. We discuss the pros and cons of creating the course sequence and express our view that some aspects were particularly problematic. The issues …

Algebraic And Geometric Properties Of Hierarchical Models, Aida Maraj

Theses and Dissertations--Mathematics

In this dissertation filtrations of ideals arising from hierarchical models in statistics related by a group action are are studied. These filtrations lead to ideals in polynomial rings in infinitely many variables, which require innovative tools. Regular languages and finite automata are used to prove and explicitly compute the rationality of some multivariate power series that record important quantitative information about the ideals. Some work regarding Markov bases for non-reducible models is shown, together with advances in the polyhedral geometry of binary hierarchical models.

Modelling Interactions Among Offenders: A Latent Space Approach For Interdependent Ego-Networks, Isabella Gollini, Alberto Caimo, Paolo Campana

Articles

Illegal markets are notoriously difficult to study. Police data offer an increasingly exploited source of evidence. However, their secondary nature poses challenges for researchers. A key issue is that researchers often have to deal with two sets of actors: targeted and non-targeted. This work develops a latent space model for interdependent ego-networks purposely created to deal with the targeted nature of police evidence. By treating targeted offenders as egos and their contacts as alters, the model (a) leverages on the full information available and (b) mirrors the specificity of the data collection strategy. The paper then applies this approach to …

Predicting Student Success In Arcadia University’S Math Courses, Chutong Wu, Tong Zhu, Yijin Qiu

Capstone Showcase

This project examines the relative efficacy of Arcadia’s math placement test and math SAT scores in predicting student success, and explores whether SAT scores alone might suffice for certain courses.

An Introduction To Copulas, Yifan Guo, Geng Zhang

Capstone Showcase

Copulas are the mathematical functions that connect the distribution functions of univariate random variables to form multivariate distributions. We define copulas, present some of their key properties, and provide examples of their applications.

Genetic Algorithm Guidance Of A Constraint Programming Solver For The Multiple Traveling Salesman Problem, Jessica M. Rudd, Andrew M. Henshaw, Lauren Staples, Sanjoosh Akkineni, Lin Li, Joe Demaio

Published and Grey Literature from PhD Candidates

This project developed a metaheuristic approach to the Multiple Traveling Salesman Problem that pairs a custom genetic algorithm with a conventional combinatorial optimization solver. This combined approach was used to build an optimal route for two popular radio show hosts to visit each of the 37 Atlanta area Jersey Mike's Subs in one day. This supported a fundraising eort to send children with chronic and terminal illnesses to Disney World through an organization called Bert's Big Adventure. Atlanta-area Jersey Mike's locations donated 100% of proceeds earned on this Day of Giving to Bert's Big Adventure. With the suggested route developed …

The Economic Determinants Of American Professional Sports Franchise Valuations, Ryan Flora

Mahurin Honors College Capstone Experience/Thesis Projects

This thesis seeks to analyze the impact of regional identities on American professional sports team valuations. Regional identities are classified as any name of a team that is not tied directly to the city that they reside in. For example, the Carolina Panthers have a regional identity because they are not based out of “Carolina”, they are based out of Charlotte, North Carolina. Another example would be the Arizona Cardinals, whose name encompasses the whole state of Arizona rather than Phoenix, the city they are based out of. The leagues that will be involved in this study are the National …

Evaluating An Ordinal Output Using Data Modeling, Algorithmic Modeling, And Numerical Analysis, Martin Keagan Wynne Brown

Murray State Theses and Dissertations

Data and algorithmic modeling are two different approaches used in predictive analytics. The models discussed from these two approaches include the proportional odds logit model (POLR), the vector generalized linear model (VGLM), the classification and regression tree model (CART), and the random forests model (RF). Patterns in the data were analyzed using trigonometric polynomial approximations and Fast Fourier Transforms. Predictive modeling is used frequently in statistics and data science to find the relationship between the explanatory (input) variables and a response (output) variable. Both approaches prove advantageous in different cases depending on the data set. In our case, the data …

Cubic Rank Transmuted Modified Burr Iii Distribution: Development, Properties, Characterizations And Applications, Fiaz Ahmad Bhatti, Gholamhossein Hamedani, Seyed Morteza Najibi, Munir Ahmad

Mathematical and Statistical Science Faculty Research and Publications

We propose a lifetime distribution with flexible hazard rate called cubic rank transmuted modified Burr III (CRTMBIII) distribution. We develop the proposed distribution on the basis of the cubic ranking transmutation map. The density function of CRTMBIII is symmetrical, right-skewed, left-skewed, exponential, arc, J and bimodal shaped. The flexible hazard rate of the proposed model can accommodate almost all types of shapes such as unimodal, bimodal, arc, increasing, decreasing, decreasing-increasing-decreasing, inverted bathtub and modified bathtub. To show the importance of proposed model, we present mathematical properties such as moments, incomplete moments, inequality measures, residual life function and stress strength reliability …

Technological Software In Mathematics, Courtney Kish

Williams Honors College, Honors Research Projects

Technology has been advancing significantly over the years. One area that has been affected is mathematics. Technological software has been developed that has allowed for mathematics to be done using software programs. For example, WebAssign allows students to complete online math homework and example practice problems, as well as watch videos to explain topics in math. However, like all things, this is not without downfalls. While this technology offers students access to online lectures and instant feedback, cheating and costly expenses also come with it.

In this research paper, I will discuss the benefits and shortcomings of different technological software …

Tropical Cyclone Hazards In Relation To Propagation Speed, Jiehao Huang

Dissertations and Theses

As the population and infrastructure along the US East Coast increase, it becomes increasingly important to study the characteristics of tropical cyclones that can impact the coast. A recent study shows that the propagation speed of tropical cyclones has slowed over the past 60 years, which can lead to greater accumulation of precipitation and greater storm surge impacts. The study presented herein is meant to examine and analyze the relationships that exist between the propagation speed of tropical cyclones, their surface wind strength, displacement angles, and cyclone averaged winds. This analysis is focused on tropical cyclones spanning from 1950-2015 in …

Cosmic: Us-Based Conversion Master's Degree In Computing, Gary S. Krenz, Thomas Kaczmarek

Mathematical and Statistical Science Faculty Research and Publications

COSMIC is an NSF S-STEM graduate curriculum initiative/conversion program that strives to provide an accelerated pathway to a Master of Science (MS) degree for individuals who do not have an undergraduate degree in computing, but who wish to cross over into the computing field. The structure of our conversion program, the context that motivated it, and insights from conversion students' instructors are presented. Program successes with students from under-represented populations and the limitations that are also experienced are discussed. Our conversion program is based on a highly focused summer bridge course, combined with a customized curriculum pathway that enables people …

Statistical Analysis Of Demographic Effects On Insurance Coverage Of Perinatal And Neonatal Morbidity, Madeline Durbin

Undergraduate Honors Thesis Projects

In the United States of America, Ohio has one of the worst neonatal and perinatal death rates. Within Ohio, Montgomery County has an above average neonatal and perinatal death rate. This statistic can be lowered if more women in Montgomery County have health insurance. They would be more likely to seek out prenatal health care, since they would no longer have to pay as much money out-of-pocket. This would allow medical professionals to be able to diagnose and treat any potential issues in the mother or child earlier. Having health insurance would also prevent mothers-to-be from seeking out other potentially …

Artificial Neural Network Models For Pattern Discovery From Ecg Time Series, Mehakpreet Kaur

College of Graduate Studies: Theses & Dissertations

Artificial Neural Network (ANN) models have recently become de facto models for deep learning with a wide range of applications spanning from scientific fields such as computer vision, physics, biology, medicine to social life (suggesting preferred movies, shopping lists, etc.). Due to advancements in computer technology and the increased practice of Artificial Intelligence (AI) in medicine and biological research, ANNs have been extensively applied not only to provide quick information about diseases, but also to make diagnostics accurate and cost-effective. We propose an ANN-based model to analyze a patient's electrocardiogram (ECG) data and produce accurate diagnostics regarding possible heart diseases …

Introduction To Game Theory: A Discovery Approach, Jennifer Firkins Nordstrom

Linfield Authors Book Gallery

Game theory is an excellent topic for a non-majors quantitative course as it develops mathematical models to understand human behavior in social, political, and economic settings. The variety of applications can appeal to a broad range of students. Additionally, students can learn mathematics through playing games, something many choose to do in their spare time! This text also includes an exploration of the ideas of game theory through the rich context of popular culture. It contains sections on applications of the concepts to popular culture. It suggests films, television shows, and novels with themes from game theory. The questions in …

How We Can Extend The Standard Deviation Notion With Neutrosophic Interval And Quadruple Neutrosophic Numbers, Victor Christianto, Florentin Smarandache, Muhammad Aslam

Branch Mathematics and Statistics Faculty and Staff Publications

During scientific demonstrating of genuine specialized framework we can meet any sort and rate model vulnerability. Its reasons can be incognizance of modelers or information mistake. In this way, characterization of vulnerabilities, as for their sources, recognizes aleatory and epistemic ones. The aleatory vulnerability is an inalienable information variety related with the researched framework or its condition. Epistemic one is a vulnerability that is because of an absence of information on amounts or procedures of the framework or the earth [7]. Right now, we examine fourfold neutrosophic numbers and their potential application for practical displaying of physical frameworks, particularly in …

Neutroalgebra Is A Generalization Of Partial Algebra, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this paper we recall, improve, and extend several definitions, properties and applications of our previous 2019 research referred to NeutroAlgebras and AntiAlgebras (also called NeutroAlgebraic Structures and respectively AntiAlgebraic Structures). Let be an item (concept, attribute, idea, proposition, theory, etc.). Through the process of neutrosphication, we split the nonempty space we work on into three regions {two opposite ones corresponding to and , and one corresponding to neutral (indeterminate) (also denoted ) between the opposites}, which may or may not be disjoint – depending on the application, but they are exhaustive (their union equals the whole space). A NeutroAlgebra …

Inventory Models For Perishable Items Under Markdown Policy, Nurzahara Atika Kamaruzaman

Student Works (2020-2029)

As expected, the demand for a fresh product depends on how fresh it is, therefore, it is important to take expiration date into consideration. Based on marketing and economic theory, several factors such as price, inventory level and advertisement play a crucial role in influencing the demand. Hence, we study the effect of these factors in influencing the demand in the inventory model. Since the demand for perishable product declines over time, markdown policy is offered to increase the demand and profit while reducing the inventory. Salvage value is incorporated to the deteriorating units. In this research, we extend previous …