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Articles 61 - 90 of 144
Full-Text Articles in Theory and Algorithms
Formalization Of A Security Framework Design For A Health Prescription Assistant In An Internet Of Things System, Thomas Rolando Mellema
Formalization Of A Security Framework Design For A Health Prescription Assistant In An Internet Of Things System, Thomas Rolando Mellema
Electronic Theses and Dissertations
Security system design flaws will create greater risks and repercussions as the systems being secured further integrate into our daily life. One such application example is incorporating the powerful potential of the concept of the Internet of Things (IoT) into software services engineered for improving the practices of monitoring and prescribing effective healthcare to patients. A study was performed in this application area in order to specify a security system design for a Health Prescription Assistant (HPA) that operated with medical IoT (mIoT) devices in a healthcare environment. Although the efficiency of this system was measured, little was presented to …
Asteroidal Sets And Dominating Targets In Graphs, Oleksiy Al-Saadi
Asteroidal Sets And Dominating Targets In Graphs, Oleksiy Al-Saadi
School of Computing: Dissertations, Theses, and Student Research
The focus of this PhD thesis is on various distance and domination properties in graphs. In particular, we prove strong results about the interactions between asteroidal sets and dominating targets. Our results add to or extend a plethora of results on these properties within the literature. We define the class of strict dominating pair graphs and show structural and algorithmic properties of this class. Notably, we prove that such graphs have diameter 3, 4, or contain an asteroidal quadruple. Then, we design an algorithm to to efficiently recognize chordal hereditary dominating pair graphs. We provide new results that describe the …
Comparative Predictive Analysis Of Stock Performance In The Tech Sector, Asaad Sendi
Comparative Predictive Analysis Of Stock Performance In The Tech Sector, Asaad Sendi
LSU New Orleans Theses and Dissertations
This study compares the performance of deep learning models, including Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), and Transformer, in predicting stock prices across five companies (AAPL, CSCO, META, MSFT, and TSLA) from July 2019 to July 2023. Key findings reveal that GRU models generally exhibit the lowest Mean Absolute Error (MAE), indicating higher precision, particularly notable for CSCO with a remarkably low MAE. While LSTM models often show slightly higher MAE values, they outperform Transformer models in capturing broader trends and variance in stock prices, as evidenced by higher R-squared (R2) values. Transformer models generally exhibit higher MAE …
Choreographing The Rhythms Of Observation: Dynamics For Ranged Observer Bipartite-Unipartite Spatiotemporal (Robust) Networks, Edward A. Holmberg Iv
Choreographing The Rhythms Of Observation: Dynamics For Ranged Observer Bipartite-Unipartite Spatiotemporal (Robust) Networks, Edward A. Holmberg Iv
LSU New Orleans Theses and Dissertations
Existing network analysis methods struggle to optimize observer placements in dynamic environments with limited visibility. This dissertation introduces the novel ROBUST (Ranged Observer Bipartite-Unipartite SpatioTemporal) framework, offering a significant advancement in modeling, analyzing, and optimizing observer networks within complex spatiotemporal domains. ROBUST leverages a unique bipartite-unipartite approach, distinguishing between observer and observable entities while incorporating spatial constraints and temporal dynamics.
This research extends spatiotemporal network theory by introducing novel graph-based measures, including myopic degree, spatial closeness centrality, and edge length proportion. These measures, coupled with advanced clustering techniques like Proximal Recurrence, provide insights into network structure, resilience, and the effectiveness …
Algorithms For Canvas-Based Attention Scheduling With Resizing, Yigong Hu, Ila Gokarn, Shengzhong Liu, Archan Misra, Tarek Adbelzaher
Algorithms For Canvas-Based Attention Scheduling With Resizing, Yigong Hu, Ila Gokarn, Shengzhong Liu, Archan Misra, Tarek Adbelzaher
Research Collection School Of Computing and Information Systems
Canvas-based attention scheduling was recently pro-posed to improve the efficiency of real-time machine perception systems. This framework introduces a notion of focus locales, referring to those areas where the attention of the inference system should “allocate its attention”. Data from these locales (e.g., parts of the input video frames containing objects of interest) are packed together into a smaller canvas frame which is processed by the downstream machine learning algorithm. Compared with processing the entire input data frame, this practice saves resources while maintaining inference quality. Previous work was limited to a simplified solution where the focus locales are quantized …
An Adaptive Large Neighborhood Search For The Multi-Vehicle Profitable Tour Problem With Flexible Compartments And Mandatory Customers, Vincent F. Yu, Nabila Yuraisyah Salsabila, Aldy Gunawan, Anggun Nurfitriani Handoko
An Adaptive Large Neighborhood Search For The Multi-Vehicle Profitable Tour Problem With Flexible Compartments And Mandatory Customers, Vincent F. Yu, Nabila Yuraisyah Salsabila, Aldy Gunawan, Anggun Nurfitriani Handoko
Research Collection School Of Computing and Information Systems
The home-refill delivery system is a business model that addresses the concerns of plastic waste and its impact on the environment. It allows customers to pick up their household goods at their doorsteps and refill them into their own containers. However, the difficulty in accessing customers’ locations and product consolidations are undeniable challenges. To overcome these issues, we introduce a new variant of the Profitable Tour Problem, named the multi-vehicle profitable tour problem with flexible compartments and mandatory customers (MVPTPFC-MC). The objective is to maximize the difference between the total collected profit and the traveling cost. We model the proposed …
Knowledge Enhanced Multi-Intent Transformer Network For Recommendation, Ding Zou, Wei Wei, Feida Zhu, Chuanyu Xu, Tao Zhang, Chengfu Huo
Knowledge Enhanced Multi-Intent Transformer Network For Recommendation, Ding Zou, Wei Wei, Feida Zhu, Chuanyu Xu, Tao Zhang, Chengfu Huo
Research Collection School Of Computing and Information Systems
Incorporating Knowledge Graphs (KGs) into Recommendation has attracted growing attention in industry, due to the great potential of KG in providing abundant supplementary information and interpretability for the underlying models. However, simply integrating KG into recommendation usually brings in negative feedback in industry, mainly due to the ignorance of the following two factors: i) users' multiple intents, which involve diverse nodes in KG. For example, in e-commerce scenarios, users may exhibit preferences for specific styles, brands, or colors. ii) knowledge noise, which is a prevalent issue in Knowledge Enhanced Recommendation (KGR) and even more severe in industry scenarios. The irrelevant …
Reinforcement Nash Equilibrium Solver, Xinrun Wang, Chang Yang, Shuxin Li, Pengdeng Li, Xiao Huang, Hau Chan, Bo An
Reinforcement Nash Equilibrium Solver, Xinrun Wang, Chang Yang, Shuxin Li, Pengdeng Li, Xiao Huang, Hau Chan, Bo An
Research Collection School Of Computing and Information Systems
Nash Equilibrium (NE) is the canonical solution concept of game theory, which provides an elegant tool to understand the rationalities. Computing NE in two- or multi-player general-sum games is PPAD-Complete. Therefore, in this work, we propose REinforcement Nash Equilibrium Solver (RENES), which trains a single policy to modify the games with different sizes and applies the solvers on the modified games where the obtained solution is evaluated on the original games. Specifically, our contributions are threefold. i) We represent the games as ��-rank response graphs and leverage graph neural network (GNN) to handle the games with different sizes as inputs; …
Quantum Machine Learning For Credit Scoring, Nikolaos Schetakis, Davit Aghamalyan, Micheael Boguslavsky, Agnieszka Rees, Marc Rakotomalala, Paul Robert Griffin
Quantum Machine Learning For Credit Scoring, Nikolaos Schetakis, Davit Aghamalyan, Micheael Boguslavsky, Agnieszka Rees, Marc Rakotomalala, Paul Robert Griffin
Research Collection School Of Computing and Information Systems
This study investigates the integration of quantum circuits with classical neural networks for enhancing credit scoring for small- and medium-sized enterprises (SMEs). We introduce a hybrid quantum–classical model, focusing on the synergy between quantum and classical rather than comparing the performance of separate quantum and classical models. Our model incorporates a quantum layer into a traditional neural network, achieving notable reductions in training time. We apply this innovative framework to a binary classification task with a proprietary real-world classical credit default dataset for SMEs in Singapore. The results indicate that our hybrid model achieves efficient training, requiring significantly fewer epochs …
Subject Analysis Ex Machina: Developing A Subject Heading Recommendation Service For Jmu Libraries, Steven W. Holloway
Subject Analysis Ex Machina: Developing A Subject Heading Recommendation Service For Jmu Libraries, Steven W. Holloway
Libraries
Results of a 2022 evaluation of ANNIF, open-source software designed to generate controlled vocabulary subject headings, using James Madison University Libraries resources.
Techniques To Detect Fake Profiles On Social Media Using The New Age Algorithms – A Survey, A K M Rubaiyat Reza Habib, Edidiong Elijah Akpan
Techniques To Detect Fake Profiles On Social Media Using The New Age Algorithms – A Survey, A K M Rubaiyat Reza Habib, Edidiong Elijah Akpan
ATU Scholars Symposium
This research explores the growing issue of fake accounts in Online Social Networks [OSNs]. While platforms like Twitter, Instagram, and Facebook foster connections, their lax authentication measures have attracted many scammers and cybercriminals. Fake profiles conduct malicious activities, such as phishing, spreading misinformation, and inciting social discord. The consequences range from cyberbullying to deceptive commercial practices. Detecting fake profiles manually is often challenging and causes considerable stress and trust issues for the users. Typically, a social media user scrutinizes various elements like the profile picture, bio, and shared posts to identify fake profiles. These evaluations sometimes lead users to conclude …
Rescape: Transforming Coral-Reefscape Images For Quantitative Analysis, Zachary Ferris, Eraldo Ribeiro, Tomofumi Nagata, Robert Van Woesik
Rescape: Transforming Coral-Reefscape Images For Quantitative Analysis, Zachary Ferris, Eraldo Ribeiro, Tomofumi Nagata, Robert Van Woesik
Ocean Engineering and Marine Sciences Faculty Publications
Ever since the first image of a coral reef was captured in 1885, people worldwide have been accumulating images of coral reefscapes that document the historic conditions of reefs. However, these innumerable reefscape images suffer from perspective distortion, which reduces the apparent size of distant taxa, rendering the images unusable for quantitative analysis of reef conditions. Here we solve this century-long distortion problem by developing a novel computer-vision algorithm, ReScape, which removes the perspective distortion from reefscape images by transforming them into top-down views, making them usable for quantitative analysis of reef conditions. In doing so, we demonstrate the …
Towards Erasing The Distinction Between The Computational And Syntactic Accounts Of Scientific Theories, Timothy Luft
Towards Erasing The Distinction Between The Computational And Syntactic Accounts Of Scientific Theories, Timothy Luft
Theses
One of the main goals of philosophy of science is to give a proper account of scientific theories and their structure. One way that accounts of the structure of scientific theories can be distinguished is by the mathematical or logical structures that they involve. For instance, syntactic accounts of scientific theories hold that theories are axioms in a logical framework, whereas semantic accounts are more liberal in the range of mathematical and logical structures they take as pertinent to the structure of scientific theories. Paul Thagard (1988) offers a computational account of scientific theories, which holds that theories are complex …
Mathematically Rigorous Deep Learning Paradigms For Data-Driven Scientific Modeling, Owen Nicholas Davis
Mathematically Rigorous Deep Learning Paradigms For Data-Driven Scientific Modeling, Owen Nicholas Davis
Mathematics & Statistics ETDs
This dissertation explores the crucial role of data-driven modeling in science and engineering, with a focus on developing surrogate models to accelerate large-scale computational tasks, aiding in both outer-loop functions like uncertainty quantification and expensive inner-loop tasks within broader computational frameworks. Challenges arise with increased problem dimension and sparse, noisy training data, particularly significant when constructing surrogates for very expensive computational models where acquiring sufficient high-fidelity training data is unfeasible. In such scenarios, training surrogates from an ensemble of multifidelity information sources of varying accuracy and cost becomes essential. We emphasize neural network-based modeling paradigms, which are flexible in integrating …
Enabling Sustainable Mining Via Ai-Based Techniques, Nurul Asyikeen Binte Azhar
Enabling Sustainable Mining Via Ai-Based Techniques, Nurul Asyikeen Binte Azhar
Dissertations and Theses Collection (Open Access)
The precedence-constrained production scheduling problem (PCPSP) in Long-Term Mine Planning (LTMP) is NP-hard and conventionally prioritizes the Net Present Value (NPV) of profits. Even so, heightened sustainability concerns necessitate heightened sustainable practices. Yet, research still lags. This dissertation addresses this paucity by integrating sustainability elements through Multi-Objective Optimization (MOO), introducing novel algorithms and proposing an uncertainty assessment within a dual Multi-Objective Evolutionary Algorithm (MOEA) setup.
Firstly, our systematic review of past LTMP research focused on the PCPSP and highlighted sustainability elements. Overall, it furnished real-world components incorporated into mathematical formulations, trends, quality of solutions (efficacy) and computation time (efficiency) of …
Predicting Biomolecular Properties And Interactions Using Numerical, Statistical And Machine Learning Methods, Elyssa Sliheet
Predicting Biomolecular Properties And Interactions Using Numerical, Statistical And Machine Learning Methods, Elyssa Sliheet
Mathematics Theses and Dissertations
We investigate machine learning and electrostatic methods to predict biophysical properties of proteins, such as solvation energy and protein ligand binding affinity, for the purpose of drug discovery/development. We focus on the Poisson-Boltzmann model and various high performance computing considerations such as parallelization schemes.
On Adaptivity And Randomness For Streaming Algorithms, Manuel Stoeckl
On Adaptivity And Randomness For Streaming Algorithms, Manuel Stoeckl
Dartmouth College Ph.D Dissertations
A streaming algorithm has a limited amount of memory and reads a long sequence (data stream) of input elements, one by one, and computes an output depending on the input. Such algorithms may be used in an online fashion, producing a sequence of intermediate outputs corresponding to the prefixes of the data stream. Adversarially robust streaming algorithms are required to give correct outputs with a desired probability even when the data stream is adaptively generated by an adversary that can see all intermediate outputs of the algorithm. This thesis binds together research on a variety of problems related to the …
Adaptive Content-Aware Influence Maximization Via Online Learning To Rank, Konstantinos Theocharidis, Panagiotis Karras, Manolis Terrovitis, Spiros Skiadopoulos, Hady Wirawan Lauw
Adaptive Content-Aware Influence Maximization Via Online Learning To Rank, Konstantinos Theocharidis, Panagiotis Karras, Manolis Terrovitis, Spiros Skiadopoulos, Hady Wirawan Lauw
Research Collection School Of Computing and Information Systems
How can we adapt the composition of a post over a series of rounds to make it more appealing in a social network? Techniques that progressively learn how to make a fixed post more influential over rounds have been studied in the context of the Influence Maximization (IM) problem, which seeks a set of seed users that maximize a post’s influence. However, there is no work on progressively learning how a post’s features affect its influence. In this article, we propose and study the problem of Adaptive Content-Aware Influence Maximization (ACAIM), which calls to find k features to form a …
Gradual Memory Safety, Jack Phillips
Gradual Memory Safety, Jack Phillips
All NMU Master's Theses
This paper extends the theory of Gradual Types to include memory safe Region-Types and Region-Based Memory Management. It also makes advancements in the capabilities of Region-Based systems. Lastly, it presents the Svejk language and Hasek Type System.
Deep Reinforcement Learning For Dynamic Algorithm Selection: A Proof-Of-Principle Study On Differential Evolution, Hongshu Guo, Yining Ma, Zeyuan Ma, Jiacheng Chen, Xinglin Zhang, Zhiguang Cao, Jun Zhang, Yue-Jiao Gong
Deep Reinforcement Learning For Dynamic Algorithm Selection: A Proof-Of-Principle Study On Differential Evolution, Hongshu Guo, Yining Ma, Zeyuan Ma, Jiacheng Chen, Xinglin Zhang, Zhiguang Cao, Jun Zhang, Yue-Jiao Gong
Research Collection School Of Computing and Information Systems
Evolutionary algorithms, such as differential evolution, excel in solving real-parameter optimization challenges. However, the effectiveness of a single algorithm varies across different problem instances, necessitating considerable efforts in algorithm selection or configuration. This article aims to address the limitation by leveraging the complementary strengths of a group of algorithms and dynamically scheduling them throughout the optimization progress for specific problems. We propose a deep reinforcement learning-based dynamic algorithm selection framework to accomplish this task. Our approach models the dynamic algorithm selection a Markov decision process, training an agent in a policy gradient manner to select the most suitable algorithm according …
Towards Low-Resource Rumor Detection: Unified Contrastive Transfer With Propagation Structure, Hongzhan Lin, Jing Ma, Ruichao Yang, Zhiwei Yang, Mingfei Cheng
Towards Low-Resource Rumor Detection: Unified Contrastive Transfer With Propagation Structure, Hongzhan Lin, Jing Ma, Ruichao Yang, Zhiwei Yang, Mingfei Cheng
Research Collection School Of Computing and Information Systems
The truth is significantly hampered by massive rumors that spread along with breaking news or popular topics. Since there is sufficient corpus gathered from the same domain for model training, existing rumor detection algorithms show promising performance on yesterday's news. However, due to a lack of substantial training data and prior expert knowledge, they are poor at spotting rumors concerning unforeseen events, especially those propagated in different languages (i.e., low-resource regimes). In this paper, we propose a simple yet effective framework with unified contrastive transfer learning, to detect rumors by adapting the features learned from well-resourced rumor data to that …
Improving Educational Delivery And Content In Juvenile Detention Centers, Yomna Elmousalami
Improving Educational Delivery And Content In Juvenile Detention Centers, Yomna Elmousalami
Undergraduate Research Symposium
Students in juvenile detention centers have the greatest need to receive improvements in educational delivery and content; however, they are one of the “truly disadvantaged” populations in terms of receiving those improvements. This work presents a qualitative data analysis based on a focus group meeting with stakeholders at a local Juvenile Detention Center. The current educational system in juvenile detention centers is based on paper worksheets, single-room style teaching methods, outdated technology, and a shortage of textbooks and teachers. In addition, detained students typically have behavioral challenges that are deemed "undesired" in society. As a result, many students miss classes …
Multi-Modality Transformer For E-Commerce: Inferring User Purchase Intention To Bridge The Query-Product Gap, Srivatsa Mallapragada
Multi-Modality Transformer For E-Commerce: Inferring User Purchase Intention To Bridge The Query-Product Gap, Srivatsa Mallapragada
Dissertations
The rapid growth of e-commerce has necessitated the development of sophisticated product retrieval systems that can effectively match user queries with relevant products. However, the semantic gap between queries and products remains a significant challenge, as traditional retrieval methods often fail to capture the nuances of user purchase intentions. E-commerce click-stream data and product catalogs offer critical user behavior insights and product knowledge that are untapped in the current product search algorithms. This dissertation presents learning strategies that leverage the query-product transaction logs to enrich the pipeline of our proposed multi-modal transformer model, which transforms initial user queries into pseudo …
Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin
Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin
Research Symposium
Carbon–carbon (C–C) bond activation has gained increased attention as a direct method for the synthesis of pharmaceuticals. Due to the thermodynamic stability and kinetic inaccessibility of the C–C bonds, however, activation of C–C bonds by homogeneous transition-metal catalysts under mild homogeneous conditions is still a challenge. Most of the systems in which the activation occurs either have aromatization or relief of ring strain as the primary driving force. The activation of unstrained C–C bonds of phosphaalkynes does not have this advantage. This study employs Density Functional Theory (DFT) calculations to elucidate Pt(0)-mediated C–CP bond activation mechanisms in phosphaalkynes. Investigating the …
The Impact Of Data Preparation And Model Complexity On The Natural Language Classification Of Chinese News Headlines, Torrey J. Wagner, Dennis Guhl, Brent T. Langhals
The Impact Of Data Preparation And Model Complexity On The Natural Language Classification Of Chinese News Headlines, Torrey J. Wagner, Dennis Guhl, Brent T. Langhals
Faculty Publications
Given the emergence of China as a political and economic power in the 21st century, there is increased interest in analyzing Chinese news articles to better understand developing trends in China. Because of the volume of the material, automating the categorization of Chinese-language news articles by headline text or titles can be an effective way to sort the articles into categories for efficient review. A 383,000-headline dataset labeled with 15 categories from the Toutiao website was evaluated via natural language processing to predict topic categories. The influence of six data preparation variations on the predictive accuracy of four algorithms was …
Intelligent Algorithm Safety: Concepts, Scientific Problems And Prospects, Xueqi Cheng, Wei Chen, Huawei Shen, Shiguang Shan, Xilin Chen, Guojie Li
Intelligent Algorithm Safety: Concepts, Scientific Problems And Prospects, Xueqi Cheng, Wei Chen, Huawei Shen, Shiguang Shan, Xilin Chen, Guojie Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
Intelligent algorithms refer to the methods embodied in the computational processes that realize intelligence. These methods are often characterized by being data-driven, involving uncertain computations, and with unexplainable model inferences. These characteristics simultaneously introduce potential safety risks to the application of intelligent algorithms and AI. This study firstly explores the concepts of intelligent algorithm safety. Specifically, intelligent algorithm safety, based on the degree of human-machine integration, extends from the univariate safety of the algorithm itself to the bivariate applicational safety when the algorithm serves humans, and finally evolves into the multivariate systemic safety arises within complex socio-technical systems of human-machine …
Wang Tilings In Arbitrary Dimensions, Ian Tassin
Wang Tilings In Arbitrary Dimensions, Ian Tassin
Rose-Hulman Undergraduate Mathematics Journal
This paper makes a new observation about arbitrary dimensional Wang Tilings,
demonstrating that any d -dimensional tile set that can tile periodically along d − 1 axes must be able to tile periodically along all axes.
This work also summarizes work on Wang Tiles up to the present day, including
definitions for various aspects of Wang Tilings such as periodicity and the validity of a tiling. Additionally, we extend the familiar 2D definitions for Wang Tiles and associated properties into arbitrary dimensional spaces. While there has been previous discussion of arbitrary dimensional Wang Tiles in other works, it has been …
Sepsis Treatment: Reinforced Sequential Decision-Making For Saving Lives, Dipesh Tamboli, Jiayu Chen, Kiran Pranesh Jotheeswaran, Denny Yu, Vaneet Aggarwal
Sepsis Treatment: Reinforced Sequential Decision-Making For Saving Lives, Dipesh Tamboli, Jiayu Chen, Kiran Pranesh Jotheeswaran, Denny Yu, Vaneet Aggarwal
Graduate Industrial Research Symposium
Sepsis, a life-threatening condition triggered by the body's exaggerated response to infection, demands urgent intervention to prevent severe complications. Existing machine learning methods for managing sepsis struggle in offline scenarios, exhibiting suboptimal performance with survival rates below 50%. Our project introduces the "PosNegDM: Reinforcement Learning with Positive and Negative Demonstrations for Sequential Decision-Making" framework utilizing an innovative transformer-based model and a feedback reinforcer to replicate expert actions while considering individual patient characteristics. A mortality classifier with 96.7% accuracy guides treatment decisions towards positive outcomes. The PosNegDM framework significantly improves patient survival, saving 97.39% of patients and outperforming established machine learning …
Online Class-Incremental Learning For Real-World Food Image Classification, Siddeshwar Raghavan, Jiangpeng He, Fengqing Zhu
Online Class-Incremental Learning For Real-World Food Image Classification, Siddeshwar Raghavan, Jiangpeng He, Fengqing Zhu
Graduate Industrial Research Symposium
Food image classification is essential for monitoring health and tracking dietary in image-based dietary assessment methods. However, conventional systems often rely on static datasets with fixed classes and uniform distribution. In contrast, real-world food consumption patterns, shaped by cultural, economic, and personal influences, involve dynamic and evolving data. Thus, it requires the classification system to cope with continuously evolving data. Online Class Incremental Learning (OCIL) addresses the challenge of learning continuously from a single-pass data stream while adapting to the new knowledge and reducing catastrophic forgetting. Experience Replay (ER) based OCIL methods store a small portion of previous data and …
A Machine Learning Model Of Perturb-Seq Data For Use In Space Flight Gene Expression Profile Analysis, Liam F. Johnson, James Casaletto, Lauren Sanders, Sylvain Costes
A Machine Learning Model Of Perturb-Seq Data For Use In Space Flight Gene Expression Profile Analysis, Liam F. Johnson, James Casaletto, Lauren Sanders, Sylvain Costes
Graduate Industrial Research Symposium
The genetic perturbations caused by spaceflight on biological systems tend to have a system-wide effect which is often difficult to deconvolute it into individual signals with specific points of origin. Single cell multi-omic data can provide a profile of the perturbational effects, but does not necessarily indicate the initial point of interference within the network. The objective of this project is to take advantage of large scale and genome-wide perturbational datasets by using them to train a tuned machine learning model that is capable of predicting the effects of unseen perturbations in new data. Perturb-Seq datasets are large libraries of …