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Full-Text Articles in Computer Sciences

Deep Reinforcement Learning For Open Multiagent System, Tianxing Zhu Jan 2022

Deep Reinforcement Learning For Open Multiagent System, Tianxing Zhu

Honors Papers

In open multiagent systems, multiple agents work together or compete to reach the goal while members of the group change over time. For example, intelligent robots that are collaborating to put out wildfires may run out of suppressants and have to leave the place to recharge; the rest of the robots may need to change their behaviors accordingly to better control the fires. Thus, openness requires agents not only to predict the behaviors of others, but also the presence of other agents. We present a deep reinforcement learning method that adapts the proximal policy optimization algorithm to learn the optimal …


Healthcare 5.0 Security Framework: Applications, Issues And Future Research Directions, Mohammad Wazid, Ashok Kumar Das, Noor Mohd, Youngho Park Jan 2022

Healthcare 5.0 Security Framework: Applications, Issues And Future Research Directions, Mohammad Wazid, Ashok Kumar Das, Noor Mohd, Youngho Park

VMASC Publications

Healthcare 5.0 is a system that can be deployed to provide various healthcare services. It does these services by utilising a new generation of information technologies, such as Internet of Things (IoT), Artificial Intelligence (AI), Big data analytics, blockchain and cloud computing. Due to the introduction of healthcare 5.0, the paradigm has been now changed. It is disease-centered to patient-centered care where it provides healthcare services and supports to the people. However, there are several security issues and challenges in healthcare 5.0 which may cause the leakage or alteration of sensitive healthcare data. This demands that we need a robust …


Ascp-Iomt: Ai-Enabled Lightweight Secure Communication Protocol For Internet Of Medical Things, Mohammad Wazid, Jaskaran Singh, Ashok Kumar Das, Sachin Shetty, Muhammad Khurram Khan, Joel J.P.C. Rodrigues Jan 2022

Ascp-Iomt: Ai-Enabled Lightweight Secure Communication Protocol For Internet Of Medical Things, Mohammad Wazid, Jaskaran Singh, Ashok Kumar Das, Sachin Shetty, Muhammad Khurram Khan, Joel J.P.C. Rodrigues

VMASC Publications

The Internet of Medical Things (IoMT) is a unification of smart healthcare devices, tools, and software, which connect various patients and other users to the healthcare information system through the networking technology. It further reduces unnecessary hospital visits and the burden on healthcare systems by connecting the patients to their healthcare experts (i.e., doctors) and allows secure transmission of healthcare data over an insecure channel (e.g., the Internet). Since Artificial Intelligence (AI) has a great impact on the performance and usability of an information system, it is important to include its modules in a healthcare information system, which will be …


Post-Quantum Secure Identity-Based Encryption Scheme Using Random Integer Lattices For Iot-Enabled Ai Applications, Dharminder Dharminder, Ashok Kumar Das, Sourav Saha, Basudeb Bera, Athanasios V. Vasilakos Jan 2022

Post-Quantum Secure Identity-Based Encryption Scheme Using Random Integer Lattices For Iot-Enabled Ai Applications, Dharminder Dharminder, Ashok Kumar Das, Sourav Saha, Basudeb Bera, Athanasios V. Vasilakos

VMASC Publications

Identity-based encryption is an important cryptographic system that is employed to ensure confidentiality of a message in communication. This article presents a provably secure identity based encryption based on post quantum security assumption. The security of the proposed encryption is based on the hard problem, namely Learning with Errors on integer lattices. This construction is anonymous and produces pseudo random ciphers. Both public-key size and ciphertext-size have been reduced in the proposed encryption as compared to those for other relevant schemes without compromising the security. Next, we incorporate the constructed identity based encryption (IBE) for Internet of Things (IoT) applications, …


A Novel Tropical Geometry-Based Interpretable Machine Learning Method: Pilot Application To Delivery Of Advanced Heart Failure Therapies, Heming Yao, Harm Derkson, Jessica R. Golbus, Justin Zhang, Keith D. Aaronson, Jonathan Gryak, Kayvan Najarian Jan 2022

A Novel Tropical Geometry-Based Interpretable Machine Learning Method: Pilot Application To Delivery Of Advanced Heart Failure Therapies, Heming Yao, Harm Derkson, Jessica R. Golbus, Justin Zhang, Keith D. Aaronson, Jonathan Gryak, Kayvan Najarian

Publications and Research

Abstract—A model’s interpretability is essential to many practical applications such as clinical decision support systems. In this paper, a novel interpretable machine learning method is presented, which can model the relationship between input variables and responses in humanly understandable rules. The method is built by applying tropical geometry to fuzzy inference systems, wherein variable encoding functions and salient rules can be discovered by supervised learning. Experiments using synthetic datasets were conducted to demonstrate the performance and capacity of the proposed algorithm in classification and rule discovery. Furthermore, we present a pilot application in identifying heart failure patients that are eligible …


Artificial Intelligence In The Pediatric Echocardiography Laboratory: Automation, Physiology, And Outcomes, Minh B Nguyen, Olivier Villemain, Mark K Friedberg, Lasse Lovstakken, Craig G Rusin, Luc Mertens Jan 2022

Artificial Intelligence In The Pediatric Echocardiography Laboratory: Automation, Physiology, And Outcomes, Minh B Nguyen, Olivier Villemain, Mark K Friedberg, Lasse Lovstakken, Craig G Rusin, Luc Mertens

Faculty, Staff and Students Publications

Artificial intelligence (AI) is frequently used in non-medical fields to assist with automation and decision-making. The potential for AI in pediatric cardiology, especially in the echocardiography laboratory, is very high. There are multiple tasks AI is designed to do that could improve the quality, interpretation, and clinical application of echocardiographic data at the level of the sonographer, echocardiographer, and clinician. In this state-of-the-art review, we highlight the pertinent literature on machine learning in echocardiography and discuss its applications in the pediatric echocardiography lab with a focus on automation of the pediatric echocardiogram and the use of echo data to better …


Security Hardening Of Intelligent Reflecting Surfaces Against Adversarial Machine Learning Attacks, Ferhat Ozgur Catak, Murat Kuzlu, Haolin Tang, Evren Catak, Yanxiao Zhao Jan 2022

Security Hardening Of Intelligent Reflecting Surfaces Against Adversarial Machine Learning Attacks, Ferhat Ozgur Catak, Murat Kuzlu, Haolin Tang, Evren Catak, Yanxiao Zhao

Engineering Technology Faculty Publications

Next-generation communication networks, also known as NextG or 5G and beyond, are the future data transmission systems that aim to connect a large amount of Internet of Things (IoT) devices, systems, applications, and consumers at high-speed data transmission and low latency. Fortunately, NextG networks can achieve these goals with advanced telecommunication, computing, and Artificial Intelligence (AI) technologies in the last decades and support a wide range of new applications. Among advanced technologies, AI has a significant and unique contribution to achieving these goals for beamforming, channel estimation, and Intelligent Reflecting Surfaces (IRS) applications of 5G and beyond networks. However, the …


Defensive Distillation-Based Adversarial Attack Mitigation Method For Channel Estimation Using Deep Learning Models In Next-Generation Wireless Networks, Ferhat Ozgur Catak, Murat Kuzlu, Evren Catak, Umit Cali, Ozgur Guler Jan 2022

Defensive Distillation-Based Adversarial Attack Mitigation Method For Channel Estimation Using Deep Learning Models In Next-Generation Wireless Networks, Ferhat Ozgur Catak, Murat Kuzlu, Evren Catak, Umit Cali, Ozgur Guler

Engineering Technology Faculty Publications

Future wireless networks (5G and beyond), also known as Next Generation or NextG, are the vision of forthcoming cellular systems, connecting billions of devices and people together. In the last decades, cellular networks have dramatically grown with advanced telecommunication technologies for high-speed data transmission, high cell capacity, and low latency. The main goal of those technologies is to support a wide range of new applications, such as virtual reality, metaverse, telehealth, online education, autonomous and flying vehicles, smart cities, smart grids, advanced manufacturing, and many more. The key motivation of NextG networks is to meet the high demand for those …


Application Of Artificial Intelligence And Machine Learning For Hiv Prevention Interventions, Yang Xiang, Jingcheng Du, Kayo Fujimoto, Fang Li, John Schneider, Cui Tao Jan 2022

Application Of Artificial Intelligence And Machine Learning For Hiv Prevention Interventions, Yang Xiang, Jingcheng Du, Kayo Fujimoto, Fang Li, John Schneider, Cui Tao

Faculty, Staff and Student Publications

In 2019, the US Government announced its goal to end the HIV epidemic within 10 years, mirroring the initiatives set forth by UNAIDS. Public health prevention interventions are a crucial part of this ambitious goal. However, numerous challenges to this goal exist, including improving HIV awareness, increasing early HIV infection detection, ensuring rapid treatment, optimising resource distribution, and providing efficient prevention services for vulnerable populations. Artificial intelligence has had a pivotal role in revolutionising health care and has shown great potential in developing effective HIV prevention intervention strategies. Although artificial intelligence has been used in a few HIV prevention intervention …


Monitoring Plants Growth In Indoor Vertical Farms Using Computer Vision And Ai Techniques, Bhama Krishna Pillutla Jan 2022

Monitoring Plants Growth In Indoor Vertical Farms Using Computer Vision And Ai Techniques, Bhama Krishna Pillutla

Graduate Research Theses & Dissertations

Climatic conditions like temperature, drought, and heavy metals disturb plant cell structures and, ultimately, plant growth that significantly affects crop production. Due to increasing climate change, maize crop yields are projected to decline by 24% by the end of century. With the increase in food demands and decrease in agricultural land and water resources, the space for effective farming is left much desired. Though limited to a few crops at this moment, Indoor Vertical Farming is one technique that requires much less land space, water, soil, and sunlight when compared to traditional farming. Vertical farming allows artificial control of temperature, …


Part I - Ai And Data As Medical Devices, W. Nicholson Price Ii Jan 2022

Part I - Ai And Data As Medical Devices, W. Nicholson Price Ii

Other Publications

It may seem counterintuitive to open a book on medical devices with chapters on software and data, but these are the frontiers of new medical device regulation and law. Physical devices are still crucial to medicine, but they – and medical practice as a whole – are embedded in and permeated by networks of software and caches of data. Those software systems are often mindbogglingly complex and largely inscrutable, involving artificial intelligence and machine learning. Ensuring that such software works effectively and safely remains a substantial challenge for regulators and policymakers. Each of the three chapters in this part examines …


Online Deep Learning From Doubly-Streaming Data, Heng Lian, John S. Atwood, Bo-Jian Hou, Jian Wu, Yi He Jan 2022

Online Deep Learning From Doubly-Streaming Data, Heng Lian, John S. Atwood, Bo-Jian Hou, Jian Wu, Yi He

Computer Science Faculty Publications

This paper investigates a new online learning problem with doubly-streaming data, where the data streams are described by feature spaces that constantly evolve, with new features emerging and old features fading away. A plausible idea to deal with such data streams is to establish a relationship between the old and new feature spaces, so that an online learner can leverage the knowledge learned from the old features to better the learning performance on the new features. Unfortunately, this idea does not scale up to high-dimensional multimedia data with complex feature interplay, which suffers a tradeoff between onlineness, which biases shallow …


Machine Infelicity In A Poignant Visitor Setting: Comparing Human And Ai’S Ability To Analyze Discourse, Martin Maccarthy, Hairong Shan Jan 2022

Machine Infelicity In A Poignant Visitor Setting: Comparing Human And Ai’S Ability To Analyze Discourse, Martin Maccarthy, Hairong Shan

Research outputs 2014 to 2021

This study compares the efficacy of computer and human analytics in a commemorative setting. Both deductive and inductive reasoning are compared using the same data across both methods. The data comprises 2490 non-repeated, non-dialogical social media comments from the popular touristic site Tripadvisor. Included in the analysis is participant observation at two Anzac commemorative sites, one in Western Australia and one in Northern France. The data is then processed using both Leximancer V4.51 and Dialectic Thematic Analysis. The findings demonstrate artificial intelligence (AI) was incapable of insight beyond metric-driven content analysis. While fully deduced by human analysis the metamodel was …


Artificial Intelligence And Machine Learning In Optical Information Processing: Introduction To The Feature Issue, Khan Iftekharuddin, Chrysanthe Preza, Abdul Ahad S. Awwal, Michael E. Zelinski Jan 2022

Artificial Intelligence And Machine Learning In Optical Information Processing: Introduction To The Feature Issue, Khan Iftekharuddin, Chrysanthe Preza, Abdul Ahad S. Awwal, Michael E. Zelinski

Electrical & Computer Engineering Faculty Publications

This special feature issue covers the intersection of topical areas in artificial intelligence (AI)/machine learning (ML) and optics. The papers broadly span the current state-of-the-art advances in areas including image recognition, signal and image processing, machine inspection/vision and automotive as well as areas of traditional optical sensing, interferometry and imaging.


Application Of Artificial Intelligence To Plasma Metabolomics Profiles To Predict Response To Neoadjuvant Chemotherapy In Triple-Negative Breast Cancer, Ehsan Irajizad, Ranran Wu, Jody Vykoukal, Eunice Murage, Rachelle Spencer, Jennifer B Dennison, Stacy Moulder, Elizabeth Ravenberg, Bora Lim, Jennifer Litton, Debu Tripathym, Vicente Valero, Senthil Damodaran, Gaiane M Rauch, Beatriz Adrada, Rosalind Candelaria, Jason B White, Abenaa Brewster, Banu Arun, James P Long, Kim Anh Do, Sam Hanash, Johannes F Fahrmann Jan 2022

Application Of Artificial Intelligence To Plasma Metabolomics Profiles To Predict Response To Neoadjuvant Chemotherapy In Triple-Negative Breast Cancer, Ehsan Irajizad, Ranran Wu, Jody Vykoukal, Eunice Murage, Rachelle Spencer, Jennifer B Dennison, Stacy Moulder, Elizabeth Ravenberg, Bora Lim, Jennifer Litton, Debu Tripathym, Vicente Valero, Senthil Damodaran, Gaiane M Rauch, Beatriz Adrada, Rosalind Candelaria, Jason B White, Abenaa Brewster, Banu Arun, James P Long, Kim Anh Do, Sam Hanash, Johannes F Fahrmann

Faculty, Staff and Student Publications

There is a need to identify biomarkers predictive of response to neoadjuvant chemotherapy (NACT) in triple-negative breast cancer (TNBC). We previously obtained evidence that a polyamine signature in the blood is associated with TNBC development and progression. In this study, we evaluated whether plasma polyamines and other metabolites may identify TNBC patients who are less likely to respond to NACT. Pre-treatment plasma levels of acetylated polyamines were elevated in TNBC patients that had moderate to extensive tumor burden (RCB-II/III) following NACT compared to those that achieved a complete pathological response (pCR/RCB-0) or had minimal residual disease (RCB-I). We further applied …


Camouflaged Poisoning Attack On Graph Neural Networks, Chao Jiang, Yi He, Richard Chapman, Hongyi Wu Jan 2022

Camouflaged Poisoning Attack On Graph Neural Networks, Chao Jiang, Yi He, Richard Chapman, Hongyi Wu

Computer Science Faculty Publications

Graph neural networks (GNNs) have enabled the automation of many web applications that entail node classification on graphs, such as scam detection in social media and event prediction in service networks. Nevertheless, recent studies revealed that the GNNs are vulnerable to adversarial attacks, where feeding GNNs with poisoned data at training time can lead them to yield catastrophically devastative test accuracy. This finding heats up the frontier of attacks and defenses against GNNs. However, the prior studies mainly posit that the adversaries can enjoy free access to manipulate the original graph, while obtaining such access could be too costly in …


Long Term Predictive Modeling On Big Spatio-Temporal Data, Yong Zhuang Dec 2021

Long Term Predictive Modeling On Big Spatio-Temporal Data, Yong Zhuang

Graduate Doctoral Dissertations

In the era of massive data, one of the most promising research fields involves the analysis of large-scale Spatio-temporal databases to discover exciting and previously unknown but potentially useful patterns from data collected over time and space. A modeling process in this domain must take temporal and spatial correlations into account, but with the dimensionality of the time and space measurements increasing, the number of elements potentially contributing to a target sharply grows, making the target's long-term behavior highly complex, chaotic, highly dynamic, and hard to predict. Therefore, two different considerations are taken into account in this work: one is …


Robotic Olfactory-Based Navigation With Mobile Robots, Lingxiao Wang Dec 2021

Robotic Olfactory-Based Navigation With Mobile Robots, Lingxiao Wang

Doctoral Dissertations and Master's Theses

Robotic odor source localization (OSL) is a technology that enables mobile robots or autonomous vehicles to find an odor source in unknown environments. It has been viewed as challenging due to the turbulent nature of airflows and the resulting odor plume characteristics. The key to correctly finding an odor source is designing an effective olfactory-based navigation algorithm, which guides the robot to detect emitted odor plumes as cues in finding the source. This dissertation proposes three kinds of olfactory-based navigation methods to improve search efficiency while maintaining a low computational cost, incorporating different machine learning and artificial intelligence methods.

A. …


Ai And The Future Of Work: What We Know Today, Steven M. Miller, Thomas H. Davenport Dec 2021

Ai And The Future Of Work: What We Know Today, Steven M. Miller, Thomas H. Davenport

Research Collection School Of Computing and Information Systems

To contribute to a better understanding of the contemporary realities of AI workplace deployments, the authors recently completed 29 case studies of people doing their everyday work with AI-enabled smart machines. Twenty-three of these examples were from North America, mostly in the US. Six were from Southeast Asia, mostly in Singapore. In this essay, we compare our findings on job and workplace impacts to those reported in the MIT Task Force on the Work of the Future report, as we consider that to be the most comprehensive recent study on this topic.


From Mdp To Alphazero, David Robert Sewell Nov 2021

From Mdp To Alphazero, David Robert Sewell

Dissertations and Theses

In this paper I will explain the AlphaGo family of algorithms starting from first principles and requiring little previous knowledge from the reader. The focus will be upon one of the more recent versions AlphaZero but I hope to explain the core principles that allowed these algorithms to be so successful. I will generally refer to AlphaZero as theses [sic] core set of principles and will make it clear when I am referring to a specific algorithm of the AlphaGo family. AlphaZero in short combines Monte Carlo Tree Search (MCTS) with Deep learning and self-play. We will see how these …


The Ratio Method: Addressing Complex Tort Liability In The Fourth Industrial Revolution, Harrison C. Margolin, Grant H. Frazier Oct 2021

The Ratio Method: Addressing Complex Tort Liability In The Fourth Industrial Revolution, Harrison C. Margolin, Grant H. Frazier

St. Mary's Law Journal

Emerging technologies of the Fourth Industrial Revolution show fundamental promise for improving productivity and quality of life, though their misuse may also cause significant social disruption. For example, while artificial intelligence will be used to accelerate society’s processes, it may also displace millions of workers and arm cybercriminals with increasingly powerful hacking capabilities. Similarly, human gene editing shows promise for curing numerous diseases, but also raises significant concerns about adverse health consequences related to the corruption of human and pathogenic genomes.

In most instances, only specialists understand the growing intricacies of these novel technologies. As the complexity and speed of …


Check Your Tech - The Ethics Of Deepfakes In A Political Context, Dympna O'Sullivan, Damian Gordon, Ioannis Stavrakakis, Michael Collins Oct 2021

Check Your Tech - The Ethics Of Deepfakes In A Political Context, Dympna O'Sullivan, Damian Gordon, Ioannis Stavrakakis, Michael Collins

Conference papers

No abstract provided.


Ai: Friend Or Foe? (And What Business Leaders Need To Know), Singapore Management University Oct 2021

Ai: Friend Or Foe? (And What Business Leaders Need To Know), Singapore Management University

Perspectives@SMU

Artificial intelligence presents significant opportunities for business – as well as not insignificant threats to humanity – and governance frameworks are urgently needed to create a fair and equitable future under AI


Measuring Data Collection Diligence For Community Healthcare, Galawala Ramesha Samurdhi Karunasena, M. S. Ambiya, Arunesh Sinha, R. Nagar, S. Dalal, Abdullah. H., D. Thakkar, D. Narayanan, M. Tambe Oct 2021

Measuring Data Collection Diligence For Community Healthcare, Galawala Ramesha Samurdhi Karunasena, M. S. Ambiya, Arunesh Sinha, R. Nagar, S. Dalal, Abdullah. H., D. Thakkar, D. Narayanan, M. Tambe

Research Collection School Of Computing and Information Systems

Data analytics has tremendous potential to provide targeted benefit in low-resource communities, however the availability of highquality public health data is a significant challenge in developing countries primarily due to non-diligent data collection by community health workers (CHWs). Our use of the word non-diligence here is to emphasize that poor data collection is often not a deliberate action by CHW but arises due to a myriad of factors, sometime beyond the control of the CHW. In this work, we define and test a data collection diligence score. This challenging unlabeled data problem is handled by building upon domain expert’s guidance …


Deep Fakes: The Algorithms That Create And Detect Them And The National Security Risks They Pose, Nick Dunard Sep 2021

Deep Fakes: The Algorithms That Create And Detect Them And The National Security Risks They Pose, Nick Dunard

James Madison Undergraduate Research Journal (JMURJ)

The dissemination of deep fakes for nefarious purposes poses significant national security risks to the United States, requiring an urgent development of technologies to detect their use and strategies to mitigate their effects. Deep fakes are images and videos created by or with the assistance of AI algorithms in which a person’s likeness, actions, or words have been replaced by someone else’s to deceive an audience. Often created with the help of generative adversarial networks, deep fakes can be used to blackmail, harass, exploit, and intimidate individuals and businesses; in large-scale disinformation campaigns, they can incite political tensions around the …


How ‘Human’ Should Robots Be?, Singapore Management University Sep 2021

How ‘Human’ Should Robots Be?, Singapore Management University

Perspectives@SMU

Hotel guests like interaction with devices that look and sound like them, but they can spark displeasure after service failures, new CUHK study shows


Characterizing Convolutional Neural Network Early-Learning And Accelerating Non-Adaptive, First-Order Methods With Localized Lagrangian Restricted Memory Level Bundling, Benjamin O. Morris Sep 2021

Characterizing Convolutional Neural Network Early-Learning And Accelerating Non-Adaptive, First-Order Methods With Localized Lagrangian Restricted Memory Level Bundling, Benjamin O. Morris

Theses and Dissertations

This dissertation studies the underlying optimization problem encountered during the early-learning stages of convolutional neural networks and introduces a training algorithm competitive with existing state-of-the-art methods. First, a Design of Experiments method is introduced to systematically measure empirical second-order Lipschitz upper bound and region size estimates for local regions of convolutional neural network loss surfaces experienced during the early-learning stages. This method demonstrates that architecture choices can significantly impact the local loss surfaces traversed during training. Next, a Design of Experiments method is used to study the effects convolutional neural network architecture hyperparameters have on different optimization routines' abilities to …


Artificial Intelligence And Work: Two Perspectives, Steven Miller, Thomas H. Davenport Sep 2021

Artificial Intelligence And Work: Two Perspectives, Steven Miller, Thomas H. Davenport

Research Collection School Of Computing and Information Systems

One of the most important issues in contemporary societies is the impact of intelligent technologies on human work. For an empirical perspective on the issue, we recently completed 30 case studies of people collaborating with AI-enabled smart machines. Twenty-four were from North America, mostly in the US. Six were from Southeast Asia, mostly in Singapore. We compare some of our observations to one of the broadest academic examinations of the issue. In particular, we focus on our case study observations with regard to key findings from the MIT Task Force on the Work of the Future report.


Novel Statistical Modeling Methods For Traffic Video Analysis, Hang Shi Aug 2021

Novel Statistical Modeling Methods For Traffic Video Analysis, Hang Shi

Dissertations

Video analysis is an active and rapidly expanding research area in computer vision and artificial intelligence due to its broad applications in modern society. Many methods have been proposed to analyze the videos, but many challenging factors remain untackled. In this dissertation, four statistical modeling methods are proposed to address some challenging traffic video analysis problems under adverse illumination and weather conditions.

First, a new foreground detection method is presented to detect the foreground objects in videos. A novel Global Foreground Modeling (GFM) method, which estimates a global probability density function for the foreground and applies the Bayes decision rule …


Innovative Computational Methods For Pharmaceutical Problem Solving A Review Part I: The Drug Development Process, Heather R. Campbell, Robert A. Lodder Aug 2021

Innovative Computational Methods For Pharmaceutical Problem Solving A Review Part I: The Drug Development Process, Heather R. Campbell, Robert A. Lodder

Pharmaceutical Sciences Faculty Publications

Computational methods have provided pharmaceutical scientists and engineers a means to go beyond what's possible with experimental testing alone. Providing a means to study active pharmaceutical ingredients (API), excipients, and drug interactions at or near-atomic levels. This paper provides a review of this and other innovative computational methods used for solving pharmaceutical problems throughout the drug development process. Part one of two this paper will emphasize the role of computational methods and game theory in solving pharmaceutical challenges.