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Articles 3571 - 3600 of 3613
Full-Text Articles in Computer Sciences
Stability Regions In Time Delayed Two-Area Lfc System Enhanced By Evs, Ausnain Naveed, Şahi̇n Sönmez, Saffet Ayasun
Stability Regions In Time Delayed Two-Area Lfc System Enhanced By Evs, Ausnain Naveed, Şahi̇n Sönmez, Saffet Ayasun
Turkish Journal of Electrical Engineering and Computer Sciences
With the extensive usage of open communication networks, time delays have become a great concern in load frequency control (LFC) systems since such inevitable large delays weaken the controller performance and even may lead to instabilities. Electric vehicles (EVs) have a potential tool in the frequency regulation. The integration of a large number of EVs via an aggregator amplifies the adverse effects of time delays on the stability and controller design of LFC systems. This paper investigates the impacts of the EVs aggregator with communication time delay on the stability. Primarily, a graphical method characterizing stability boundary locus is implemented. …
An Active Contour Model Using Matched Filter And Hessian Matrix For Retinalvessels Segmentation, Mahtab Shabani, Hossein Pourghassem
An Active Contour Model Using Matched Filter And Hessian Matrix For Retinalvessels Segmentation, Mahtab Shabani, Hossein Pourghassem
Turkish Journal of Electrical Engineering and Computer Sciences
Medical image analysis, especially of the retina, plays an important role in diagnostic decision support tools. The properties of retinal blood vessels are used for disease diagnoses such as diabetes, glaucoma, and hypertension. There are some challenges in the utilization of retinal blood vessel patterns such as low contrast and intensity inhomogeneities. Thus, an automatic algorithm for vessel extraction is required. Active contour is a strong method for edge extraction. However, it cannot extract thin vessels and ridges very well. In this research, we propose an improved active contour method that uses discrete wavelet transform for energy minimization to solve …
Stressed Or Just Running? Differentiation Of Mental Stress And Physical Activityby Using Machine Learning, Yekta Sai̇d Can
Stressed Or Just Running? Differentiation Of Mental Stress And Physical Activityby Using Machine Learning, Yekta Sai̇d Can
Turkish Journal of Electrical Engineering and Computer Sciences
Recently, modern people have excessive stress in their daily lives. With the advances in physiological sensors and wearable technology, people?s physiological status can be tracked, and stress levels can be recognized for providing beneficial services. Smartwatches and smartbands constitute the majority of wearable devices. Although they have an excellent potential for physiological stress recognition, some crucial issues need to be addressed, such as the resemblance of physiological reaction to stress and physical activity, artifacts caused by movements and low data quality. This paper focused on examining and differentiating physiological responses to both stressors and physical activity. Physiological data are collected …
Spectrum Sensing With Energy Detection In Multiple Alternating Time Slots, Călin Vlădeanu, Alexandru Marţian, Dimitrie C. Popescu
Spectrum Sensing With Energy Detection In Multiple Alternating Time Slots, Călin Vlădeanu, Alexandru Marţian, Dimitrie C. Popescu
Electrical & Computer Engineering Faculty Publications
Energy detection (ED) represents a low complexity approach used by secondary users (SU) to sense spectrum occupancy by primary users (PU) in cognitive radio (CR) systems. In this paper, we present a new algorithm that senses the spectrum occupancy by performing ED in K consecutive sensing time slots starting from the current slot and continuing by alternating before and after the current slot. We consider a PU traffic model specified in terms of an average duty cycle value, and derive analytical expressions for the false alarm probability (FAP) and correct detection probability (CDP) for any value of K . Our …
Exploratory Programming In The Arts And Humanities [Book Review], Kelly Hammond
Exploratory Programming In The Arts And Humanities [Book Review], Kelly Hammond
Publications and Research
Exploratory Programming is a testament to what open-access can mean, especially in an e-learning environment. Used in full, it is a free course (that relies on free and open software) from a gifted MIT professor whose pedagogy is clear in structure and tone. He scaffolds, promotes predictive thinking, lauds collaborative learning, and urges readers to do not just to read. Used in part, it can be equally powerful.
M2lens: Visualizing And Explaining Multimodal Models For Sentiment Analysis, Xingbo Wang, Jianben He, Zhihua Jin, Muqiao Yang, Yong Wang, Huamin Qu
M2lens: Visualizing And Explaining Multimodal Models For Sentiment Analysis, Xingbo Wang, Jianben He, Zhihua Jin, Muqiao Yang, Yong Wang, Huamin Qu
Research Collection School Of Computing and Information Systems
Multimodal sentiment analysis aims to recognize people's attitudes from multiple communication channels such as verbal content (i.e., text), voice, and facial expressions. It has become a vibrant and important research topic in natural language processing. Much research focuses on modeling the complex intra- and inter-modal interactions between different communication channels. However, current multimodal models with strong performance are often deep-learning-based techniques and work like black boxes. It is not clear how models utilize multimodal information for sentiment predictions. Despite recent advances in techniques for enhancing the explainability of machine learning models, they often target unimodal scenarios (e.g., images, sentences), and …
Orchestration Or Automation: Authentication Flaw Detection In Android Apps, Siqi Ma, Juanru Li, Surya Nepal, Diethelm Ostry, David Lo, Sanjay K. Jha, Robert H. Deng, Elisa Bertino
Orchestration Or Automation: Authentication Flaw Detection In Android Apps, Siqi Ma, Juanru Li, Surya Nepal, Diethelm Ostry, David Lo, Sanjay K. Jha, Robert H. Deng, Elisa Bertino
Research Collection School Of Computing and Information Systems
Passwords are pervasively used to authenticate users' identities in mobile apps. To secure passwords against attacks, protection is applied to the password authentication protocol (PAP). The implementation of the protection scheme becomes an important factor in protecting PAP against attacks. We focus on two basic protection in Android, i.e., SSL/TLS-based PAP and timestamp-based PAP. Previously, we proposed an automated tool, GLACIATE, to detect authentication flaws. We were curious whether orchestration (i.e., involving manual-effort) works better than automation. To answer this question, we propose an orchestrated approach, AUTHEXPLOIT and compare its effectiveness GLACIATE. We study requirements for correct implementation of PAP …
On The Reproducibility And Replicability Of Deep Learning In Software Engineering, Chao Liu, Cuiyun Gao, Xin Xia, David Lo, John C. Grundy, Xiaohu Yang
On The Reproducibility And Replicability Of Deep Learning In Software Engineering, Chao Liu, Cuiyun Gao, Xin Xia, David Lo, John C. Grundy, Xiaohu Yang
Research Collection School Of Computing and Information Systems
Context: Deep learning (DL) techniques have gained significant popularity among software engineering (SE) researchers in recent years. This is because they can often solve many SE challenges without enormous manual feature engineering effort and complex domain knowledge.Objective: Although many DL studies have reported substantial advantages over other state-of-the-art models on effectiveness, they often ignore two factors: (1) reproducibility—whether the reported experimental results can be obtained by other researchers using authors’ artifacts (i.e., source code and datasets) with the same experimental setup; and (2) replicability—whether the reported experimental result can be obtained by other researchers using their re-implemented artifacts with a …
A Practical Fog-Based Privacy-Preserving Online Car-Hailing Service System, Jianfei Sun, Guowen Xu, Tianwei Zhang, Mamoun Alazab, Robert H. Deng
A Practical Fog-Based Privacy-Preserving Online Car-Hailing Service System, Jianfei Sun, Guowen Xu, Tianwei Zhang, Mamoun Alazab, Robert H. Deng
Research Collection School Of Computing and Information Systems
Aiming for minimizing passengers’ waiting time and vehicles’ vacancy rate, online car-hailing service systems with fog computing has been deployed in various scenarios. In this paper, we focus on addressing the security and privacy issues in such a promising system by customizing a new cryptographic primitive to provide the following security guarantees: (1) private, finegrained and bilateral order matching between passengers and drivers; (2) authenticity verification of passengers’ orders in the form of ciphertext, and (3) temporal assurance of passengers’ ciphertext orders. To the best of our knowledge, no previous system has been designed to meet all three requirements. Existing …
Journey With Ting Peng Liang In Pacific Asia Information Systems Field, J. Lee, J. Jiang, P. Chau, A. Kankanhalli, M. Nelson, W. Huang, K. Wei, C. Sia, D. Vogel, M. Myers, G. Gable, N. Shen, C. Wei, S. Hung, Keng Siau, D. Liang
Journey With Ting Peng Liang In Pacific Asia Information Systems Field, J. Lee, J. Jiang, P. Chau, A. Kankanhalli, M. Nelson, W. Huang, K. Wei, C. Sia, D. Vogel, M. Myers, G. Gable, N. Shen, C. Wei, S. Hung, Keng Siau, D. Liang
Research Collection School Of Computing and Information Systems
Our respectful old friend Professor Ting-Peng Liang (in short, TP) whom we loved suddenly passed away on May 20, 2021. But we cannot forget his smile and passion, and his inerasable footprints in PACIS, PAJAIS, and AIS Community. He was the founder of PACIS, founding editor-in-chief of PAJAIS, and past president of AIS to list just a few. He was the pioneer who received the first AIS Fellow and the first LEO Award from Asia Pacific. That is why the leaders of the information systems field organized the first ever special tribute session in PACIS 2021 in memory of TP
An Empirical Study Of Developers' Discussions About Security Challenges Of Different Programming Languages, Roland Croft, Yongzheng Xie, Mansooreh Zahedi, Muhammad Ali Babar, Christoph Treude
An Empirical Study Of Developers' Discussions About Security Challenges Of Different Programming Languages, Roland Croft, Yongzheng Xie, Mansooreh Zahedi, Muhammad Ali Babar, Christoph Treude
Research Collection School Of Computing and Information Systems
In collaborative software development projects, work items are used as a mechanism to coordinate tasks and track shared development work. In this paper, we explore how “tagging,” a lightweight social computing mechanism, is used to communicate matters of concern in the management of development tasks. We present the results from two empirical studies over 36 and 12 months, respectively, on how tagging has been adopted and what role it plays in the development processes of several professional development projects with more than 1,000 developers in total. Our research shows that the tagging mechanism was eagerly adopted by the teams, and …
Github Discussions: An Exploratory Study Of Early Adoption, Hideaki Hata, Nicole Novielli, Sebastian Baltes, Raula Kula, Christoph Treude
Github Discussions: An Exploratory Study Of Early Adoption, Hideaki Hata, Nicole Novielli, Sebastian Baltes, Raula Kula, Christoph Treude
Research Collection School Of Computing and Information Systems
Discussions is a new feature of GitHub for asking questions or discussing topics outside of specific Issues or Pull Requests. Before being available to all projects in December 2020, it had been tested on selected open source software projects. To understand how developers use this novel feature, how they perceive it, and how it impacts the development processes, we conducted a mixed-methods study based on early adopters of GitHub discussions from January until July 2020. We found that: (1) errors, unexpected behavior, and code reviews are prevalent discussion categories; (2) there is a positive relationship between project member involvement and …
Cross-Modal Food Retrieval: Learning A Joint Embedding Of Food Images And Recipes With Semantic Consistency And Attention Mechanism, Hao Wang, Doyen Sahoo, Chenghao Liu, Ke Shu, Palakorn Achananuparp, Ee-Peng Lim, Steven C. H. Hoi
Cross-Modal Food Retrieval: Learning A Joint Embedding Of Food Images And Recipes With Semantic Consistency And Attention Mechanism, Hao Wang, Doyen Sahoo, Chenghao Liu, Ke Shu, Palakorn Achananuparp, Ee-Peng Lim, Steven C. H. Hoi
Research Collection School Of Computing and Information Systems
Food retrieval is an important task to perform analysis of food-related information, where we are interested in retrieving relevant information about the queried food item such as ingredients, cooking instructions, etc. In this paper, we investigate cross-modal retrieval between food images and cooking recipes. The goal is to learn an embedding of images and recipes in a common feature space, such that the corresponding image-recipe embeddings lie close to one another. Two major challenges in addressing this problem are 1) large intra-variance and small inter-variance across cross-modal food data; and 2) difficulties in obtaining discriminative recipe representations. To address these …
Enhancing Zero-Shot And Few-Shot Text Classification Using Pre-Trained Language Models, Yanan Chen
Enhancing Zero-Shot And Few-Shot Text Classification Using Pre-Trained Language Models, Yanan Chen
Theses and Dissertations (Comprehensive)
In recent years, the community of natural language processing (NLP) has seen amazing progress in the development of pre-trained language models (PLMs). The novel paradigm of PLMs does not require labeled data, allowing us to experiment with increased training scale through employing freely available colossal online self-training corpus to push the limits. Language models (LMs), such as GPT, BERT and T5, have achieved high performance on a wide range of NLP tasks. Meanwhile, research on zero-shot and few-shot text classification has received increasing attention. As labelling can be costly and time-consuming, how to perform data augmentation (DA) and enhance the …
Effect Of Freestream Noise On Hypersonic Crossflow-Induced Boundary-Layer Transition, Andrew Bustard, Thomas J. Juliano, Harrison B. Yates, Mark Noftz, Joseph Jewell
Effect Of Freestream Noise On Hypersonic Crossflow-Induced Boundary-Layer Transition, Andrew Bustard, Thomas J. Juliano, Harrison B. Yates, Mark Noftz, Joseph Jewell
Publications
Between the windward and leeward rays, boundary-layer transition on cones at angle of attack in hypersonic flow is dominated by the crossflow instability [1, 2], wherein stationary and/or traveling crossflow vortices develop and can breakdown into turbulence [3]. Stationary crossflow modes are caused by surface roughness or any other steady forcing and produce disturbances that are fixed in place on the surface [3–6]. Stationary vortices create a generalized inflection point in the velocity profile that is inviscidly unstable [7]. This distorted mean flow develops secondary instabilities, whose growth and breakdown is one path to turbulence [8–10]. Traveling crossflow modes are …
Artificial Intelligence (Ai): The New Look Of Customer Service In A Cybersecurity World, Sharon L. Burton
Artificial Intelligence (Ai): The New Look Of Customer Service In A Cybersecurity World, Sharon L. Burton
Publications
Cybersecurity leaders are not adequately developed to guide the re-engineering of quality customer service (QCS) workflows, designed with automation and AI, that interrelate with people through customers’ perceptions. Realizing re-engineering processes should be a team effort with well-versed leadership and stakeholders guiding the successful design through a follow-up process. Leaders must shape compelling and straightforward needs to learn and teach employees and chat boxes indispensable customer service skills demonstrating patience, self-discipline, flexibility, and resourcefulness in communication with irritated customers or difficult circumstances. Whether the analysis, design, development, and implementation struggles are vacuums in cybersecurity knowledge, skill, and abilities or a …
Biometric Security: A Novel Ear Recognition Approach Using A 3d Morphable Ear Model, Md Mursalin, Mohiuddin Ahmed, Paul Haskell-Dowland
Biometric Security: A Novel Ear Recognition Approach Using A 3d Morphable Ear Model, Md Mursalin, Mohiuddin Ahmed, Paul Haskell-Dowland
Research outputs 2022 to 2026
Biometrics is a critical component of cybersecurity that identifies persons by verifying their behavioral and physical traits. In biometric-based authentication, each individual can be correctly recognized based on their intrinsic behavioral or physical features, such as face, fingerprint, iris, and ears. This work proposes a novel approach for human identification using 3D ear images. Usually, in conventional methods, the probe image is registered with each gallery image using computational heavy registration algorithms, making it practically infeasible due to the time-consuming recognition process. Therefore, this work proposes a recognition pipeline that reduces the one-to-one registration between probe and gallery. First, a …
Eye Movement And Pupil Measures: A Review, Bhanuka Mahanama, Yasith Jayawardana, Sundararaman Rengarajan, Gavindya Jayawardena, Leanne Chukoskie, Joseph Snider, Sampath Jayarathna
Eye Movement And Pupil Measures: A Review, Bhanuka Mahanama, Yasith Jayawardana, Sundararaman Rengarajan, Gavindya Jayawardena, Leanne Chukoskie, Joseph Snider, Sampath Jayarathna
Computer Science Faculty Publications
Our subjective visual experiences involve complex interaction between our eyes, our brain, and the surrounding world. It gives us the sense of sight, color, stereopsis, distance, pattern recognition, motor coordination, and more. The increasing ubiquity of gaze-aware technology brings with it the ability to track gaze and pupil measures with varying degrees of fidelity. With this in mind, a review that considers the various gaze measures becomes increasingly relevant, especially considering our ability to make sense of these signals given different spatio-temporal sampling capacities. In this paper, we selectively review prior work on eye movements and pupil measures. We first …
Streaminghub: Interactive Stream Analysis Workflows, Yasith Jayawardana, Vikas G. Ashok, Sampath Jayarathna
Streaminghub: Interactive Stream Analysis Workflows, Yasith Jayawardana, Vikas G. Ashok, Sampath Jayarathna
Computer Science Faculty Publications
Reusable data/code and reproducible analyses are foundational to quality research. This aspect, however, is often overlooked when designing interactive stream analysis workflows for time-series data (e.g., eye-tracking data). A mechanism to transmit informative metadata alongside data may allow such workflows to intelligently consume data, propagate metadata to downstream tasks, and thereby auto-generate reusable, reproducible analytic outputs with zero supervision. Moreover, a visual programming interface to design, develop, and execute such workflows may allow rapid prototyping for interdisciplinary research. Capitalizing on these ideas, we propose StreamingHub, a framework to build metadata propagating, interactive stream analysis workflows using visual programming. We conduct …
M-Cubes: An Efficient And Portable Implementation Of Multi-Dimensional Integration For Gpus, Ioannis Sakiotis, Kamesh Arumugam, Marc Paterno, Desh Ranjan, Balŝa Terzić, Mohammad Zubair
M-Cubes: An Efficient And Portable Implementation Of Multi-Dimensional Integration For Gpus, Ioannis Sakiotis, Kamesh Arumugam, Marc Paterno, Desh Ranjan, Balŝa Terzić, Mohammad Zubair
Computer Science Faculty Publications
The task of multi-dimensional numerical integration is frequently encountered in physics and other scientific fields, e.g., in modeling the effects of systematic uncertainties in physical systems and in Bayesian parameter estimation. Multi-dimensional integration is often time-prohibitive on CPUs. Efficient implementation on many-core architectures is challenging as the workload across the integration space cannot be predicted a priori. We propose m-Cubes, a novel implementation of the well-known Vegas algorithm for execution on GPUs. Vegas transforms integration variables followed by calculation of a Monte Carlo integral estimate using adaptive partitioning of the resulting space. mCubes improves performance on GPUs by maintaining relatively …
Introducing A Real-Time Advanced Eye Movements Analysis Pipeline, Gavindya Jayawardana
Introducing A Real-Time Advanced Eye Movements Analysis Pipeline, Gavindya Jayawardana
Computer Science Faculty Publications
Real-Time Advanced Eye Movements Analysis Pipeline (RAEMAP) is an advanced pipeline to analyze traditional positional gaze measurements as well as advanced eye gaze measurements. The proposed implementation of RAEMAP includes real-time analysis of fixations, saccades, gaze transition entropy, and low/high index of pupillary activity. RAEMAP will also provide visualizations of fixations, fixations on AOIs, heatmaps, and dynamic AOI generation in real-time. This paper outlines the proposed architecture of RAEMAP.
Camouflaged Poisoning Attack On Graph Neural Networks, Chao Jiang, Yi He, Richard Chapman, Hongyi Wu
Camouflaged Poisoning Attack On Graph Neural Networks, Chao Jiang, Yi He, Richard Chapman, Hongyi Wu
Computer Science Faculty Publications
Graph neural networks (GNNs) have enabled the automation of many web applications that entail node classification on graphs, such as scam detection in social media and event prediction in service networks. Nevertheless, recent studies revealed that the GNNs are vulnerable to adversarial attacks, where feeding GNNs with poisoned data at training time can lead them to yield catastrophically devastative test accuracy. This finding heats up the frontier of attacks and defenses against GNNs. However, the prior studies mainly posit that the adversaries can enjoy free access to manipulate the original graph, while obtaining such access could be too costly in …
Completing Single-Cell Dna Methylome Profiles Via Transfer Learning Together With Kl-Divergence, Sanjeeva Dodlapati, Zongliang Jiang, Jiangwen Sun
Completing Single-Cell Dna Methylome Profiles Via Transfer Learning Together With Kl-Divergence, Sanjeeva Dodlapati, Zongliang Jiang, Jiangwen Sun
Computer Science Faculty Publications
The high level of sparsity in methylome profiles obtained using whole-genome bisulfite sequencing in the case of low biological material amount limits its value in the study of systems in which large samples are difficult to assemble, such as mammalian preimplantation embryonic development. The recently developed computational methods for addressing the sparsity by imputing missing have their limits when the required minimum data coverage or profiles of the same tissue in other modalities are not available. In this study, we explored the use of transfer learning together with Kullback-Leibler (KL) divergence to train predictive models for completing methylome profiles with …
Visual Descriptor Extraction From Patent Figure Captions: A Case Study Of Data Efficiency Between Bilstm And Transformer, Xin Wei, Jian Wu, Kehinde Ajayi, Diane Oyen
Visual Descriptor Extraction From Patent Figure Captions: A Case Study Of Data Efficiency Between Bilstm And Transformer, Xin Wei, Jian Wu, Kehinde Ajayi, Diane Oyen
Computer Science Faculty Publications
Technical drawings used for illustrating designs are ubiquitous in patent documents, especially design patents. Different from natural images, these drawings are usually made using black strokes with little color information, making it challenging for models trained on natural images to recognize objects. To facilitate indexing and searching, we propose an effective and efficient visual descriptor model that extracts object names and aspects from patent captions to annotate benchmark patent figure datasets. We compared two state-of-the-art named entity recognition (NER) models and found that with a limited number of annotated samples, the BiLSTM-CRF model outperforms the Transformer model by a significant …
Multi-User Eye-Tracking, Bhanuka Mahanama
Multi-User Eye-Tracking, Bhanuka Mahanama
Computer Science Faculty Publications
The human gaze characteristics provide informative cues on human behavior during various activities. Using traditional eye trackers, assessing gaze characteristics in the wild requires a dedicated device per participant and therefore is not feasible for large-scale experiments. In this study, we propose a commodity hardware-based multi-user eye-tracking system. We leverage the recent advancements in Deep Neural Networks and large-scale datasets for implementing our system. Our preliminary studies provide promising results for multi-user eye-tracking on commodity hardware, providing a cost-effective solution for large-scale studies.
Segmenting Technical Drawing Figures In Us Patents, Md Reshad Ul Hoque, Xin Wei, Muntabir Hasan Choudhury, Kehinde Ajayi, Martin Gryder, Jian Wu, Diane Oyen
Segmenting Technical Drawing Figures In Us Patents, Md Reshad Ul Hoque, Xin Wei, Muntabir Hasan Choudhury, Kehinde Ajayi, Martin Gryder, Jian Wu, Diane Oyen
Computer Science Faculty Publications
Image segmentation is the core computer vision problem for identifying objects within a scene. Segmentation is a challenging task because the prediction for each pixel label requires contextual information. Most recent research deals with the segmentation of natural images rather than drawings. However, there is very little research on sketched image segmentation. In this study, we introduce heuristic (point-shooting) and deep learning-based methods (U-Net, HR-Net, MedT, DETR) to segment technical drawings in US patent documents. Our proposed methods on the US Patent dataset achieved over 90% accuracy where transformer performs well with 97% segmentation accuracy, which is promising and computationally …
D-Lib Magazine Pioneered Web-Based Scholarly Communication, Michael L. Nelson, Herbert Van De Sompel
D-Lib Magazine Pioneered Web-Based Scholarly Communication, Michael L. Nelson, Herbert Van De Sompel
Computer Science Faculty Publications
The web began with a vision of, as stated by Tim Berners-Lee in 1991, “that much academic information should be freely available to anyone”. For many years, the development of the web and the development of digital libraries and other scholarly communications infrastructure proceeded in tandem. A milestone occurred in July, 1995, when the first issue of D-Lib Magazine was published as an online, HTML-only, open access magazine, serving as the focal point for the then emerging digital library research community. In 2017 it ceased publication, in part due to the maturity of the community it served as well as …
Customer Gaze Estimation In Retail Using Deep Learning, Shashimal Senarath, Primesh Pathirana, Dulani Meedeniya, Sampath Jayarathna
Customer Gaze Estimation In Retail Using Deep Learning, Shashimal Senarath, Primesh Pathirana, Dulani Meedeniya, Sampath Jayarathna
Computer Science Faculty Publications
At present, intelligent computing applications are widely used in different domains, including retail stores. The analysis of customer behaviour has become crucial for the benefit of both customers and retailers. In this regard, the concept of remote gaze estimation using deep learning has shown promising results in analyzing customer behaviour in retail due to its scalability, robustness, low cost, and uninterrupted nature. This study presents a three-stage, three-attention-based deep convolutional neural network for remote gaze estimation in retail using image data. In the first stage, we design a mechanism to estimate the 3D gaze of the subject using image data …
Spaghetti Tracer: A Framework For Tracing Semiregular Filamentous Densities In 3d Tomograms, Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers
Spaghetti Tracer: A Framework For Tracing Semiregular Filamentous Densities In 3d Tomograms, Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers
Computer Science Faculty Publications
Within cells, cytoskeletal filaments are often arranged into loosely aligned bundles. These fibrous bundles are dense enough to exhibit a certain regularity and mean direction, however, their packing is not sufficient to impose a symmetry between—or specific shape on—individual filaments. This intermediate regularity is computationally difficult to handle because individual filaments have a certain directional freedom, however, the filament densities are not well segmented from each other (especially in the presence of noise, such as in cryo-electron tomography). In this paper, we develop a dynamic programming-based framework, Spaghetti Tracer, to characterizing the structural arrangement of filaments in the challenging 3D …
Loss Of Acta2 In Cardiac Fibroblasts Does Not Prevent The Myofibroblast Differentiation Or Affect The Cardiac Repair After Myocardial Infarction, Yuxia Li, Chaoyang Li, Qianglin Liu, Leshan Wang, Adam X. Bao, Jangwook P. Jung, Sanjeev Dodlapati, Jingwen Sun, Peidong Gao, Xujia Zhang, Joseph Francis, Jeffery D. Molkentin, Xing Fu
Loss Of Acta2 In Cardiac Fibroblasts Does Not Prevent The Myofibroblast Differentiation Or Affect The Cardiac Repair After Myocardial Infarction, Yuxia Li, Chaoyang Li, Qianglin Liu, Leshan Wang, Adam X. Bao, Jangwook P. Jung, Sanjeev Dodlapati, Jingwen Sun, Peidong Gao, Xujia Zhang, Joseph Francis, Jeffery D. Molkentin, Xing Fu
Computer Science Faculty Publications
In response to myocardial infarction (MI), quiescent cardiac fibroblasts differentiate into myofibroblasts mediating tissue repair. One of the most widely accepted markers of myofibroblast differentiation is the expression of Acta2 which encodes smooth muscle alpha-actin (SMαA) that is assembled into stress fibers. However, the requirement of Acta2/SMαA in the myofibroblast differentiation of cardiac fibroblasts and its role in post-MI cardiac repair remained unknown. To answer these questions, we generated a tamoxifen-inducible cardiac fibroblast-specific Acta2 knockout mouse line. Surprisingly, mice that lacked Acta2 in cardiac fibroblasts had a normal post-MI survival rate. Moreover, Acta2 deletion did …